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The Biology of Liver Metastasis

  • Robert Radinsky
  • Isaiah J. Fidler

Abstract

Metastasis—the spread of malignant tumour cells from a primary neoplasm to distant parts of the body where they multiply to form new growths—is a major cause of death from cancer. The treatment of metastatic cancer poses a major problem to clinical oncologists, because the presence of multiple metastases makes complete eradication by surgery, radiation or drugs nearly impossible. For most tumours, the presence of liver metastasis renders the patient essentially incurable. Modification of current treatment regimens is unlikely to significantly impact on the natural history of this disease. A better understanding of the biology of liver metastases and the molecular events leading to the metastatic phenotype is essential if new and innovative therapeutic approaches are to be developed to treat this disease.

Keywords

Epidermal Growth Factor Receptor Liver Metastasis Nude Mouse Natl Cancer Inst Metastatic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag London Limited 1998

Authors and Affiliations

  • Robert Radinsky
  • Isaiah J. Fidler

There are no affiliations available

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