Abstract
Quantitative methods have an assured role in histopathological research, where the requirement for the numerical expression of morphological information is necessary to reduce observer bias and to permit the application of Statistical methods for the analysis of results. There is, however, an increasing interest in the application of quantitative methods to the Solution of diagnostic problems in clinical biopsies (Baak et al. 1982).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baak JPA, Kurver PHJ, Boon ME (1982) Computer-aided application of quantitative microscopy in diagnostic pathology. Pathol Annu 2: 287–306
Bohm N, Sandritter W (1975) DNA in human tumours: a cytophotometric study, Curr Top Pathol 60: 151–219
Breslow A (1970) Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg 172: 902–908
Chalkley HW (1943) Methods for the quantitative morphologic analysis of tissues. J Natl Cancer Inst 4: 47–53
Chalkley HW, Cornfield J, Park H (1949) A method for estimating volume-surface ratios. Science 110: 295–297
Dixon B, Stead RH (1977) Feulgen microdensitometry and analysis of S-phase cells in cervical tumour biopsies. J Clin Pathol 30: 907–913
Dunnill MS (1968) Quantitative methods in histology. In: Dyke SC (ed) Recent advances in clinical pathology, series V. Churchill, London, pp 401–416
Dunnill MS, Whitehead R (1972) A method for the quantitation of small intestinal biopsy specimens. J Clin Pathol 25: 243–246
Dunnill MS, Anderson JA, Whitehead R (1967) Quantitative histological studies on age changes in bone. J Pathol Bacteriol 94: 275–291
Ellis PE, Whitehead R (1981) Mitosis counting: a need for reappraisal. Hum Pathol 12: 3–4
Gerstl B, Switzer P, Yesner RA (1974) A morphometric study of pulmonary cancer. Cancer Res 34: 248–254
Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA (1983) Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 31: 1333 – 1335
Kamentsky LA, Melamed MR, Derman H (1965) Spectrophotometer: new instrument for ultrarapid cell analysis. Science 150: 630–631
Klein FA, Herr HW, Sogani PC, Whitmore WFJr, Melamed MR (1982) Detection and follow-up of Carcinoma of the urinary bladder by flow cytometry. Cancer 50: 389–395
Lovett EJ, Schnitzer B, Keren DF, Flint A, Hudson JL, McClatchey KD (1984) Application of flow cytometry to diagnostic pathology. Lab Invest 50: 115 – 140
Koenig SH, Brown RD, Kamentsky LA, Sedlis A, Melamed MR (1966) Efficacy of a rapid cell spectrophotometer in Screening for cervical cancer. Cancer 21: 1019–1026
Mayhew TM, Cruz Orive LM (1974) Caveat on the use of the Delesse principle of areal analysis for estimating component volume densities. J Microsc 102: 195–207
Reid L (1960) Measurement of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis. Thorax 15: 132 – 141
Silverberg SG (1976) Reproducibility of the mitosis count in the histologic diagnosis of smooth muscle tumours of the uterus. Hum Pathol 7: 451–454
Slavin G, Sowter C, Robertson K, McDermott S, Paton K (1980) Measurement in jejunal biopsies by computer-aided microscopy. J Clin Pathol 33: 254–261
Stenkvist B, Westman-Naeser S, Holmquist J, Nordin B, Bengtsson E, Vegelius J, Eriksson O, Fox CH (1978) Computerized nuclear morphometry as an objective method for characterizing human cancer cell populations. Cancer Res 38: 4688–4697
Underwood J CE (1972) A morphometric analysis of human breast carcinoma. Br J Cancer 26: 234–237
Van Dilla MA, Trujillo TT, Mullaney PF, Coulter JR (1969) Cell microfluorimetry: a method for rapid fluorescent measurements. Science 163: 1213 – 1214
Weibel ER (1963) Principles and methods for the morphometric study of the lung and other organs. Lab Invest 12: 1 31–155
Weibel ER (1969) Stereological principles for morphometry in electron microscope cytology. Int Rev Cytol 26: 235–302
Weibel ER, Elias H (1967) Introduction to stereologic principles. In: Weibel ER, Elias H (eds) Symposium on quantitative methods in morphology. Springer, Berlin Heidelberg New York, pp 89–98
Weibel ER, Kistler GS, Scherle WR (1966) Practical stereologic methods for morphometric cytology. J Cell Biol 30: 23–38
Woods CG, Morgan DB, Paterson CR, Gossman HH (1968) Measurement of osteoid in bone biopsy. J Pathol Bacteriol 95: 441–447
Woolley RC, Schreiber K, Koss LG, Karas M, Sherman M (1982) DNA distribution in human colonic carcinomas and its relationship to clinical behaviour. J Natl Cancer Inst 69: 15–22
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Underwood, J.C.E. (1987). Quantitative Methods. In: Introduction to Biopsy Interpretation and Surgical Pathology. Springer, London. https://doi.org/10.1007/978-1-4471-1473-4_10
Download citation
DOI: https://doi.org/10.1007/978-1-4471-1473-4_10
Publisher Name: Springer, London
Print ISBN: 978-3-540-17495-0
Online ISBN: 978-1-4471-1473-4
eBook Packages: Springer Book Archive