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Diagnostic Histopathology

  • James Cressee Elphinstone Underwood

Abstract

In the twentieth century histopathology has developed into a major branch of clinical medicine. While surgeons and physicians continue to bear direct responsibility for the provision of clinical services, investigative and diagnostic specialists are now an integral part of the team that cares for patients. Histopathologists are increasingly involved in work that has a fundamental bearing on the immediate management of patients and are frequently party to therapeutic decisions. The modern histopathologist therefore requires both an intimate knowledge of biopsy appearances and the ability to interpret biopsies in the context of contemporary clinical practice. Before examining the various ways in which the histopathological interpretation of biopsies and surgical resections contributes to clinical practice, the origins of the discipline merit brief recapitulation.

Keywords

Liver Biopsy Clin Pathol Audit Committee Surgical Pathology Membranous Glomerulonephritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ackerman AB (1983) Shave biopsies: the good and right, the bad and wrong. Am J Dermatopathol 5: 211–212Google Scholar
  2. Bamforth J, Osborn GR (1958) Diagnosis from cells. J Clin Pathol 11:473–482PubMedCrossRefGoogle Scholar
  3. Bartels P, Bibbo M, Wied G (1976) Modeling of histologic images by Computer. Acta Cytol (Baltimore) 20:62–67PubMedGoogle Scholar
  4. Beale LS (1854) The microscope in medicine. Churchill, LondonGoogle Scholar
  5. Bennett JH (1845) Introductory address to a course of lectures on histology and the use of the microscope. Lancet I: 517–522Google Scholar
  6. Bohrod MG (1971) What is a pathologic diagnosis ? Pathol Annu 6:197–208Google Scholar
  7. Britton M (1974a) Diagnostic errors discovered at autopsy. Acta Med Scand 196:203–210PubMedCrossRefGoogle Scholar
  8. Britton M (1974b) Clinical diagnostics: experience from 383 autopsied cases. Acta Med Scand 196: 211–219PubMedCrossRefGoogle Scholar
  9. Cockel R, Colin-Jones DG, Schiller KFR (1982) Gastro-intestinal endoscopy services: a review of the 70s with predictions for the 80s. Health Trends 14: 46–49PubMedGoogle Scholar
  10. Coppleson LW, Factor RM, Strum SB, Graff PW, Rappaport H (1970) Observer disagreement in the Classification and histology of Hodgkin’s disease. J Natl Cancer Inst 45: 731–740PubMedGoogle Scholar
  11. Davies JD, Webb AJ (1982) Segmental lymph-node infarction after fine-needle aspiration. J Clin Pathol 35:855–857PubMedCrossRefGoogle Scholar
  12. DeLellis RA (1981) The future of research in surgical pathology. Am J Clin Pathol 75 [Suppl): 476–482PubMedGoogle Scholar
  13. Desjardins AU (1960) Is the pathologist infallible ? Arch Intern Med 106: 596–602PubMedGoogle Scholar
  14. Donaldson F (1853) The practical application of the microscope to the diagnosis of cancer. Am J Med Sci 25: 43–70CrossRefGoogle Scholar
  15. Feinstein AR (1967) Clinical judgement. Williams and Wilkins, Baltimore, p 80Google Scholar
  16. Feinstein AR, Gelfman NA, Yesner R (1970) Observer variability in the histopathologic diagnosis of lung cancer. Am Rev Respir Dis 101: 671–684Google Scholar
  17. Garceau AJ (1964) The natural history of cirrhosis. II. The influence of alcohol and prior hepatitis on pathology and prognosis. N Engl J Med 271:1173–1179Google Scholar
  18. Garland LH (1959) Studies on the accuracy of diagnostic procedures. AJR 82: 25–38Google Scholar
  19. Grossman SZ (1981) Legal implications of overdiagnosing malignant melanoma. Am J Dermatopathol 3:67Google Scholar
  20. Higginson J (1977) The role of the pathologist in environmental medicine and public health. Am J Pathol 86:460–484Google Scholar
  21. Hoffman DS, Silverberg SG (1983) Medicolegal principles and problems. In: Silverberg SG (ed) Principles and practice of surgical pathology. Wiley, New York, pp 21–25Google Scholar
  22. Iversen OH, Sandnes K (1971) The reliability of pathologists. A study of some cases of lymph node biopsies showing giant follicular hyperplasia or lymphoma. Acta Pathol Microbiol Immunol Scand [A] 79: 330–334Google Scholar
  23. King LS (1967a) What is a diagnosis ? JAMA 202:154–157Google Scholar
  24. King LS (1967b) How does a pathologist make a diagnosis ? Arch Pathol 84: 331–333PubMedGoogle Scholar
  25. King LS, Meehan MC (1973) A history of the autopsy: a review. Am J Pathol 73: 514–544Google Scholar
  26. Kornberg A (1977) Pathology, pathologists and the new biology. Arch Pathol Lab Med 101: 397–399Google Scholar
  27. Kramer IRH (1975) Computer-aided analyses in diagnostic histopathology. Postgrad Med J 51: 690–694PubMedCrossRefGoogle Scholar
  28. Kramer IRH, El-Labban NG, Sonkodi S (1974) Further studies on lesions of the oral mueosa using computer-aided analysis of histological features. Br J Cancer 29: 223–231Google Scholar
  29. Lee G, Shepherd N (1983) Necrotizing granulomata in prostatic resection speeimens: a sequel to previous Operation. J Clin Pathol 36:1067–1070Google Scholar
  30. Lusted LB, Ledley RS (1960) Mathematical models in medical diagnosis. J Med Educ 35: 214–222Google Scholar
  31. Morson BC (1979) Prevention of colorectal cancer. Proc R Soc Med 27: 83–85Google Scholar
  32. Ober WB (1970) The case of the Kaiser’s cancer. Pathol Annu 5: 207–216Google Scholar
  33. O’Connor NTJ, Wainscoat JS, Weatherall DJ. (1985) Rearrangement of the T-cell-receptor ß-chain gene in the diagnosis of lymphoproliferative disorders. Lancet 1: 1295 – 1302Google Scholar
  34. Papanicolaou GN (1928) New cancer diagnosis. In: Proceedings of the 3rd Race Betterment Conference. Race Betterment Foundation, Battie Creek, Michigan, pp 528–534Google Scholar
  35. Pearse AGE (1975) The role of histochemistry in increasing objectivity in histopathology. Postgrad Med J 51:708–710PubMedCrossRefGoogle Scholar
  36. Silverberg SG (1981) The surgical pathologist as researcher. Am J Clin Pathol 75 [Suppl]: 453–456PubMedGoogle Scholar
  37. Sissons HA (1975) Agreement and disagreement between pathologists in histological diagnosis. Postgrad Med J 51: 685–689PubMedCrossRefGoogle Scholar
  38. Soloway RD, Bagenstoss AH, Schoenfield LJ, Summerskill WHJ (1971) Observer error and sampling variability in evaluation of hepatitis and cirrhosis by liver biopsy. Am J Dig Dis 16:1082–1086PubMedCrossRefGoogle Scholar
  39. Steele RJC, Blackie RAS, McGregor JD, Forrest APM (1983) The effect of breast biopsy on reactive changes in axillary lymph nodes. Br J Surg 70: 317–318PubMedCrossRefGoogle Scholar
  40. Symmers WStC (1968) Survey of the eventual diagnosis in 600 cases referred for a second histological opinion after an initial biopsy diagnosis of Hodgkin’s disease. J Clin Pathol 21: 650–65PubMedCrossRefGoogle Scholar
  41. Theodossi A, Knill-Jones RP, Silk DBA, Williams R (1977) Study of interobserver Variation between liver histopathologists. Gut 18: 953Google Scholar
  42. Virchow R (1887) Professor Virchow’s report on the portion of growth removed from the larynx of H.I.H. the Crown Prince of Germany by Dr. M. Mackenzie on June 28th. Br Med J II: 199Google Scholar
  43. Wright JR (1985) The development of the frozen section technique, the evolution of surgical biopsy, and the origins of surgical pathology. Bull Med Hist 59: 295–326Google Scholar
  44. Zajicek G, Maayan C, Rosenmann E (1977) The application of cluster analysis to glomerular histopathology. Comput Biomed Res 10: 471–481PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • James Cressee Elphinstone Underwood
    • 1
    • 2
  1. 1.University of Sheffield Medical SchoolSheffieldEngland
  2. 2.Royal Hallamshire HospitalSheffieldEngland

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