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Abstract

In the twentieth century histopathology has developed into a major branch of clinical medicine. While surgeons and physicians continue to bear direct responsibility for the provision of clinical services, investigative and diagnostic specialists are now an integral part of the team that cares for patients. Histopathologists are increasingly involved in work that has a fundamental bearing on the immediate management of patients and are frequently party to therapeutic decisions. The modern histopathologist therefore requires both an intimate knowledge of biopsy appearances and the ability to interpret biopsies in the context of contemporary clinical practice. Before examining the various ways in which the histopathological interpretation of biopsies and surgical resections contributes to clinical practice, the origins of the discipline merit brief recapitulation.

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References

  • Ackerman AB (1983) Shave biopsies: the good and right, the bad and wrong. Am J Dermatopathol 5: 211–212

    Google Scholar 

  • Bamforth J, Osborn GR (1958) Diagnosis from cells. J Clin Pathol 11:473–482

    Article  PubMed  CAS  Google Scholar 

  • Bartels P, Bibbo M, Wied G (1976) Modeling of histologic images by Computer. Acta Cytol (Baltimore) 20:62–67

    PubMed  CAS  Google Scholar 

  • Beale LS (1854) The microscope in medicine. Churchill, London

    Google Scholar 

  • Bennett JH (1845) Introductory address to a course of lectures on histology and the use of the microscope. Lancet I: 517–522

    Google Scholar 

  • Bohrod MG (1971) What is a pathologic diagnosis ? Pathol Annu 6:197–208

    Google Scholar 

  • Britton M (1974a) Diagnostic errors discovered at autopsy. Acta Med Scand 196:203–210

    Article  PubMed  CAS  Google Scholar 

  • Britton M (1974b) Clinical diagnostics: experience from 383 autopsied cases. Acta Med Scand 196: 211–219

    Article  PubMed  CAS  Google Scholar 

  • Cockel R, Colin-Jones DG, Schiller KFR (1982) Gastro-intestinal endoscopy services: a review of the 70s with predictions for the 80s. Health Trends 14: 46–49

    PubMed  CAS  Google Scholar 

  • Coppleson LW, Factor RM, Strum SB, Graff PW, Rappaport H (1970) Observer disagreement in the Classification and histology of Hodgkin’s disease. J Natl Cancer Inst 45: 731–740

    PubMed  CAS  Google Scholar 

  • Davies JD, Webb AJ (1982) Segmental lymph-node infarction after fine-needle aspiration. J Clin Pathol 35:855–857

    Article  PubMed  CAS  Google Scholar 

  • DeLellis RA (1981) The future of research in surgical pathology. Am J Clin Pathol 75 [Suppl): 476–482

    PubMed  CAS  Google Scholar 

  • Desjardins AU (1960) Is the pathologist infallible ? Arch Intern Med 106: 596–602

    PubMed  CAS  Google Scholar 

  • Donaldson F (1853) The practical application of the microscope to the diagnosis of cancer. Am J Med Sci 25: 43–70

    Article  Google Scholar 

  • Feinstein AR (1967) Clinical judgement. Williams and Wilkins, Baltimore, p 80

    Google Scholar 

  • Feinstein AR, Gelfman NA, Yesner R (1970) Observer variability in the histopathologic diagnosis of lung cancer. Am Rev Respir Dis 101: 671–684

    Google Scholar 

  • Garceau AJ (1964) The natural history of cirrhosis. II. The influence of alcohol and prior hepatitis on pathology and prognosis. N Engl J Med 271:1173–1179

    Google Scholar 

  • Garland LH (1959) Studies on the accuracy of diagnostic procedures. AJR 82: 25–38

    Google Scholar 

  • Grossman SZ (1981) Legal implications of overdiagnosing malignant melanoma. Am J Dermatopathol 3:67

    Google Scholar 

  • Higginson J (1977) The role of the pathologist in environmental medicine and public health. Am J Pathol 86:460–484

    Google Scholar 

  • Hoffman DS, Silverberg SG (1983) Medicolegal principles and problems. In: Silverberg SG (ed) Principles and practice of surgical pathology. Wiley, New York, pp 21–25

    Google Scholar 

  • Iversen OH, Sandnes K (1971) The reliability of pathologists. A study of some cases of lymph node biopsies showing giant follicular hyperplasia or lymphoma. Acta Pathol Microbiol Immunol Scand [A] 79: 330–334

    Google Scholar 

  • King LS (1967a) What is a diagnosis ? JAMA 202:154–157

    Google Scholar 

  • King LS (1967b) How does a pathologist make a diagnosis ? Arch Pathol 84: 331–333

    PubMed  CAS  Google Scholar 

  • King LS, Meehan MC (1973) A history of the autopsy: a review. Am J Pathol 73: 514–544

    Google Scholar 

  • Kornberg A (1977) Pathology, pathologists and the new biology. Arch Pathol Lab Med 101: 397–399

    Google Scholar 

  • Kramer IRH (1975) Computer-aided analyses in diagnostic histopathology. Postgrad Med J 51: 690–694

    Article  PubMed  CAS  Google Scholar 

  • Kramer IRH, El-Labban NG, Sonkodi S (1974) Further studies on lesions of the oral mueosa using computer-aided analysis of histological features. Br J Cancer 29: 223–231

    Google Scholar 

  • Lee G, Shepherd N (1983) Necrotizing granulomata in prostatic resection speeimens: a sequel to previous Operation. J Clin Pathol 36:1067–1070

    Google Scholar 

  • Lusted LB, Ledley RS (1960) Mathematical models in medical diagnosis. J Med Educ 35: 214–222

    Google Scholar 

  • Morson BC (1979) Prevention of colorectal cancer. Proc R Soc Med 27: 83–85

    Google Scholar 

  • Ober WB (1970) The case of the Kaiser’s cancer. Pathol Annu 5: 207–216

    Google Scholar 

  • O’Connor NTJ, Wainscoat JS, Weatherall DJ. (1985) Rearrangement of the T-cell-receptor ß-chain gene in the diagnosis of lymphoproliferative disorders. Lancet 1: 1295 – 1302

    Google Scholar 

  • Papanicolaou GN (1928) New cancer diagnosis. In: Proceedings of the 3rd Race Betterment Conference. Race Betterment Foundation, Battie Creek, Michigan, pp 528–534

    Google Scholar 

  • Pearse AGE (1975) The role of histochemistry in increasing objectivity in histopathology. Postgrad Med J 51:708–710

    Article  PubMed  CAS  Google Scholar 

  • Silverberg SG (1981) The surgical pathologist as researcher. Am J Clin Pathol 75 [Suppl]: 453–456

    PubMed  CAS  Google Scholar 

  • Sissons HA (1975) Agreement and disagreement between pathologists in histological diagnosis. Postgrad Med J 51: 685–689

    Article  PubMed  CAS  Google Scholar 

  • Soloway RD, Bagenstoss AH, Schoenfield LJ, Summerskill WHJ (1971) Observer error and sampling variability in evaluation of hepatitis and cirrhosis by liver biopsy. Am J Dig Dis 16:1082–1086

    Article  PubMed  CAS  Google Scholar 

  • Steele RJC, Blackie RAS, McGregor JD, Forrest APM (1983) The effect of breast biopsy on reactive changes in axillary lymph nodes. Br J Surg 70: 317–318

    Article  PubMed  CAS  Google Scholar 

  • Symmers WStC (1968) Survey of the eventual diagnosis in 600 cases referred for a second histological opinion after an initial biopsy diagnosis of Hodgkin’s disease. J Clin Pathol 21: 650–65

    Article  PubMed  Google Scholar 

  • Theodossi A, Knill-Jones RP, Silk DBA, Williams R (1977) Study of interobserver Variation between liver histopathologists. Gut 18: 953

    Google Scholar 

  • Virchow R (1887) Professor Virchow’s report on the portion of growth removed from the larynx of H.I.H. the Crown Prince of Germany by Dr. M. Mackenzie on June 28th. Br Med J II: 199

    Google Scholar 

  • Wright JR (1985) The development of the frozen section technique, the evolution of surgical biopsy, and the origins of surgical pathology. Bull Med Hist 59: 295–326

    Google Scholar 

  • Zajicek G, Maayan C, Rosenmann E (1977) The application of cluster analysis to glomerular histopathology. Comput Biomed Res 10: 471–481

    Article  PubMed  CAS  Google Scholar 

Download references

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© 1987 Springer-Verlag Berlin Heidelberg

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Underwood, J.C.E. (1987). Diagnostic Histopathology. In: Introduction to Biopsy Interpretation and Surgical Pathology. Springer, London. https://doi.org/10.1007/978-1-4471-1473-4_1

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  • DOI: https://doi.org/10.1007/978-1-4471-1473-4_1

  • Publisher Name: Springer, London

  • Print ISBN: 978-3-540-17495-0

  • Online ISBN: 978-1-4471-1473-4

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