Abstract
Up to 30% of acute lymphoblastic leukaemias (ALLs) and 10%–20% of non-Hodgkin’s lymphomas (NHLs) are of T cell lineage (Collins 1982). In many respects, much less is known of the T cell leukaemias and lymphomas then the B cell malignancies, and it is only recently that they have been studied in the detail previously accorded the B cell neoplasms. The classification of T cell malignancies is even more controversial than the classification of B cell malignancies. No more than a few authors have attempted to provide a comprehensive classification of this subject (Catovsky et al. 1982a; Collins 1982; Kadin et al. 1983; Leong 1984). As with the B cell neoplasms, it is not always possible to make a distinction between lymphoma and leukaemia. In fact, the overlap is even more pronounced in the T cell malignancies and the use of the term “lymphoma/leukaemia” is often more appropriate.
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References
Ackerman AB, Breza TS, Caplan DL (1974) Spongiotic simulants of mycosis fungoides. Arch Dermatol 109: 218–220
Aisenberg AC, Wilkes BM, Harris NL, Koh HK (1982) T-cell chronic lymphocytic leukemia. Report of a case studied with monoclonal antibody. Am J Med 72: 695–699
Aisenberg AC, Krontiris TG, Mak TW et al. (1985) Rearrangement of the gene for the p chain of the T-cell receptor in T-cell chronic lymphocytic leukemia and related disorders. N Engl J Med 313: 529–533
Anderson JK, Metzgar RS (1978) Detection and partial characterization of human T and B lymphocyte membrane antigens with antisera to HSB and SB cell lines. J Immunol 120: 262–271
Barcos MP, Lukes RJ (1975) Malignant lymphoma of convoluted lymphocytes: a new entity of possible T-cell type. In: Sinks LF, Godden JO (eds) Conflicts in childhood cancer. An evaluation of current management. Alan R Liss, New York, pp 147–178
Bernard A, Boumsell L, Bayle C et al. (1979) Subsets of malignant lymphomas in children related to the cell phenotype. Blood 54: 1058–1068
Bernard A, Boumsell L, Reinherz EL et al. (1981) Cell surface characterization of malignant T cells from lymphoblastic lymphoma using monoclonal antibodies: evidence for phenotypic differences between malignant T cells from patients with acute lymphoblastic leukemia and lymphoblastic lymphoma. Blood 57: 1105–1110
Bernard A, Raynal B, Lemerle J, Boumsell L (1982) Changes in surface antigens on malignant T cells from lymphoblastic lymphomas at relapse: an appraisal with monoclonal antibodies and microfluo-rometry. Blood 59: 809–815
Berrih S, Gaud C, Bach AM et al. (1981) Evaluation of T cell subsets in myasthenia gravis using anti-T cell monoclonal antibodies. Clin Exp Immunol 45: 1–8
Bertness V, Kirsch I, Hollis G et al. (1985) T-cell receptor gene rearrangements as clinical markers of human T-cell lymphomas. N Engl J Med 313: 534–538
Blayney DW, Jaffe ES, Fisher RI et al. (1983) The human T-cell leukemia/lymphoma virus, lymphoma, lytic bone lesions and hypercalcemia. Ann Intern Med 98: 144–151
Blue ML, Daley JF, Levine H, Schlossman SF (1985) Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry. J Immunol 134: 2281–2286
Bogomoletz WV, Bernard J, Capron F, Diebold J (1983) T-cell origin of Lennert’s lymphoma — immunohistochemical and immunologic study of one case. Arch Pathol Lab Med 107: 586–588
Borowitz MJ, Dowell BL, Boyett JM et al. (1985) Monoclonal antibody definition of T-cell acute leukemia: a Paediatric Oncology Group study. Blood 65: 785–788
Boumsell L, Bernard A, Reinherz EL et al. (1981) Surface antigens on malignant Sezary and T-CLL cells correspond to those of mature T cells. Blood 57: 526–530
Bradstock KF, Janossy G, Pizzolo G et al. (1980) Subpopulations of normal and leukemic human thymocytes: an analysis with the use of monoclonal antibodies. JNCI 65: 33–42
Brisbane JU, Berman LD, Osband ME, Neiman RS (1983) T8 chronic lymphocytic leukemia. A distinctive disorder related to T8 lymphocytosis. Am J Clin Pathol 80: 391–396
Broder S, Bunn PA Jr (1980) Cutaneous T-cell lymphomas. Semin Oncol 7: 310–331
Broder S, Edelson R, Lutzner M (1976) The Sézary syndrome. A malignant proliferation of helper T cells. J Clin Invest 58: 1297–1306
Brouet JC, Seligmann M (1978) The immunological classification of acute lymphoblastic leukemias. Cancer 42: 817–821
Brouet JC, Seligmann M (1981) T-derived chronic lymphocytic leukemia. Main clinical and immunological features Pathol Res Pract 171: 262–267
Brouet JC, Flandrin G, Sasportes M et al. (1975) Chronic lymphocytic leukaemia of T-cell origin. Lancet II: 890–893
Brouet JC, Valensi F, Daniel MT et al. (1976) Immunological classification of acute lymphoblastic leukaemias: evaluation of its clinical significance in 100 patients. Br J Haematol 33: 319–328
Bunn P Jr, Huberman M, Whang-Peng J et al. (1980) Prospective staging evaluation of patients with cutaneous T-cell lymphomas. Demonstration of a high frequency of extracutaneous dissemination. Ann Intern Med 93: 223–230
Canellos GP (1974) Hypercalcemia in malignant lymphoma and leukemia. Ann NY Acad Sci 230: 240–246
Catovsky D (1983) Prolymphocytic and hairy cell leukemias. In: Gunz FW, Henderson ES (eds) Leukemia, 4th edn. Grune and Stratton, New York, pp 759–781
Catovsky D, Pittmann S, O’Brien M et al. (1979) Multiparameter studies in lymphoid leukemias. Am J Clin Pathol 72: 736–745
Catovsky D, Linch DC, Beverley PCL (1982a) T cell disorders in haematological diseases. Clin Haematol 11: 661–695
Catovsky D, Rose M, Goolden AWG et al. (1982b) Adult T-cell lymphoma-leukaemia in blacks from the West Indies. Lancet I: 639–643
Cawley JC, Burns GF, Nash TA, Higgy KE, Child JA, Roberts BE (1978) Hairy cell leukemia with T cell features. Blood 51: 61–69
Chan WC, Check I J, Heffner LT et al. (1982) Prolymphocytic leukemia of helper cell phenotype: report of a case and review of the scientific literature. Am J Clin Pathol 77: 643–647
Chu A, Eisinger M, Lee JS, Takezaki S, Kung PC, Edelson RL (1982) Immunoelectron microscopic identification of Langerhans cells using a new antigen marker. J Invest Dermatol 78: 177–180
Cohen SR (1977) Mycosis fungoides — Clinicopathologic relationships, survival and therapy in 59 patients. Master of Public Health Thesis, Yale University
Collins RD (1982) T-neoplasms. Their significance in relation to the classification system of lymphoid neoplasms. Am J Surg Pathol 6: 745–754
Cossman J, Chused TM, Fisher RI, Magrath I, Bollum F, Jaffe ES(1983) Diversity of immunological phenotypes of lymphoblastic lymphoma. Cancer Res 43: 4486–4490
Costa JC, Jaffe ES, Tsokos M et al. (1980) Peripheral T-cell lymphoma with pulmonary involvement and erythrophagocytosis mimicking malignant histiocytosis. Lab Invest 42: 108
Costello C, Catovsky D, O’Brien M, Morilla R, Varadi S (1980) Chronic T-cell leukemias. I. Morphology, cytochemistry and ultrastructure. Leuk Res 4: 463–476
Edelson RL (1976) Cutaneous T-cell lymphomas: clues of a skin-thymus interaction. J Invest Dermatol 67: 419–424
Edelson RL (1980) Cutaneous T-cell lymphoma: mycosis fungoides, Sézary syndrome and other variants. J Am Acad Dermatol 2: 89–106
Epstein EH Jr, Levin DL, Croft JD et al. (1972) Mycosis fungoides. Survival, prognostic features, response to therapy and autopsy findings. Medicine (Baltimore) 15: 61–72
Ferrarini M, Romagnani S, Montesoro E et al. (1982) A lymphoproliferative disorder of the large granular lymphocytes with natural killer activity. J Clin Immunol 3: 30–36
Fischmann AB, Bunn PA Jr, Guccion JG, Matthews MJ, Minna JD (1979) Exposure to chemicals, physical agents, and biologic agents in mycosis fungoides and the Sézary syndrome. Cancer Treat Rep 63: 591–596
Foucar K, Carroll TJ, Tannous R et al. (1985) Non-endemic adult T-cell leukemia/lymphoma in the United States: report of two cases and review of the literature. Am J Clin Pathol 83: 18–26
Fuks ZY, Bagshaw MA, Farber EM (1973) Prognostic signs and the management of the mycosis fungoides. Cancer 32: 1385–1395
Gaeke ME, Vardiman JW, Miller W, Medenica M, Hopper JE, Rowley JD (1981) Human T-cell lymphoma with suppressor effects on the mixed lymphocyte reaction (MLR). I. Morphological and cytogenetic analysis. Blood 57: 634–641
Galili U, Polliack A, Okon E et al. (1980) Human pro thymocytes. Membrane properties, differentiation patterns, glucocorticoid sensitivity, and ultrastructural features. J Exp Med 152: 796–807
Gallo RC, Mann D, Broder S et al. (1982) Human T-cell leukemia-lymphoma virus (HTLV) is in T but not B lymphocytes from a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 79: 5680–5683
Geha RS, Rosen FS (1983) Immunoregulatory T-cell defects. Immunol Today 4: 233–236
Greaves MF, Janossy G, Peto J, Kay H (1981) Immunologically defined subclasses of acute lymphoblastic leukemia in children: their relationship to presentation features and prognosis. Br J Haematol 48: 179–197
Greene MH, Dalarger NA, Lamberg SI et al. (1979) Mycosis fungoides: epidemiologic observations. Cancer Treat Rep 63: 597–606
Grogan TM, Richter LC, Payne CM, Rangel CS (1985a) Signet-ring cell lymphoma of T-cell origin. An immunocytochemical and ultrastructural study relating giant vacuole formation to cytoplasmic sequestration of surface membrane. Am J Surg Pathol 9: 684–692
Grogan TM, Fielder K, Rangel C et al. (1985b) Peripheral T-cell lymphoma: aggressive disease with heterogenous immunotypes. Am J Clin Pathol 83: 279–288
Grossman B, Schechter GP, Horton JH et al. (1981) Hypercalcemia associated with T-cell lymphoma-leukemia. Am J Clin Pathol 75: 149–155
Guccion JG, Fischmann AB, Bunn PA Jr, Schechter GP, Patterson RH, Matthews MJ (1979) Ultrastructural appearance of cutaneous T cell lymphomas in skin, lymph nodes and peripheral blood. Cancer Treat Rep 63: 565–570
Guglielmi P, Preud’homme J, Flandrin G (1980) Phenotypic changes of phytohemoglutinin-stimulated hairy cells. Nature 286: 166–168
Habeshaw J A, Bailey D, Stansfeld AG, Greaves MF (1983) The cellular content of non Hodgkin lymphomas: a comprehensive analysis using monoclonal antibodies and other surface marker techniques. Br J Cancer 47: 327–351
Hanaoka M (1981) Clinical pathology of adult T-cell leukemia. Nippon Ketsueki Gakkai Zasshi 44: 1420–1430
Hanaoka M (1982) Progress in adult T-cell leukemia research. Acta Pathol Jpn 32 (suppl 1): 171–185
Harris M, Eyden B, Read G (1981) Signet ring cell lymphoma: a rare variant of follicular lymphoma. J Clin Pathol 34: 884–891
Hattori T, Uchiyama T, Toibana T et al. (1981) Surface phenotype of Japanese adult T-cell leukemia cells characterised by monoclonal antibodies. Blood 58: 645–647
Haynes BF, Eisenbarth GS, Fauci AS (1979) Human lymphocyte antigens: production of a monoclonal antibody that defines functional thymus-derived lymphocyte subsets. Proc Natl Acad Sci USA 76: 5829–5833
Haynes BF, Metzgar R, Minna J et al. (1981) Phenotypic characterization of cutaneous T-cell lymphoma. Use of monoclonal antibodies to compare to other malignant T cells. N Engl J Med 304: 1319–1323
Helbron D, Brittinger G, Lennert K (1979) T-zone lymphoma. Clinical features, therapy and prognosis (in German). Blut 39: 117–131
Henderson ES (1983) Clinical diagnosis. In: Gunz FW, Henderson ES (eds) Leukemia, 4th edn. Grune and Stratton, New York, pp 393–462
Hinuma Y, Nagata K, Hanaoka M et al. (1981) Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 78: 6476–6480
Hoffman R, Kopel S, Hsu SD, Dainiak N, Zanjani ED (1978) T-cell chronic lymphocytic leukemia: presence in bone marrow and peripheral blood of cells that suppress erythropoiesis in vitro. Blood 52: 255–260
Huberman M, Bunn PA Jr, Matthews MJ et al. (1979) Extracutaneous involvement in patients with cutaneous T-cell lymphomas (mycosis fungoides and Sezary syndrome). Proc AACR and ASCO 20: 410–418
Human Gene Mapping 8 (1985) Eighth international workshop on human gene mapping, Helsinki, Finland, 4–10 August, 1985 Cytogenet Cell Genet 40 (1–4): 1–823
Ishii Y, Fujimoto J, Kon S et al. (1982) Surface antigenic phenotypes of human T-cell leukemia corresponding to those of post-thymic T cells. Am J Hematol 12: 251–260
Itoh K, Tsuchikawa AK, Awataguchi T et al. (1983) A case of chronic lymphocytic leukemia with properties characteristic of natural killer cells. Blood 61: 940–948
Jaffe ES (1984) Pathologic and clinical spectrum of post-thymic T-cell malignancies. Cancer Invest 2: 413–426
Jaffe ES, Costa JC, Fauci AS (1981) Erythrophagocytic T γ lymphoma. N Engl J Med 305: 103–104
Jaffe ES, Strauchen JA, Berard CW (1982) Predictability of immunologic phenotype by morphologic criteria in diffuse aggressive non-Hodgkin’s lymphomas. Am J Clin Pathol 77: 46–49
Jaffe ES, Blayney DW, Blattner W et al. (1983) The human T-cell leukemia/lymphoma virus: its association with disease in the United States. Lab Invest 48: 40A
Jaffe ES, Blattner WA, Blayney DW et al. (1984) The pathologic spectrum of adult T-cell leukemia/lymphoma in the United States. Am J Surg Pathol 8: 263–275
Janossy G, Prentice HG (1982) T cell subpopulations monoclonal antibodies and their therapeutic applications. Clin Haematol 11: 631–660
Janossy G, Tidman N, Selby WS et al. (1980) Human T lymphocytes of inducer and suppressor type occupy different microenvironments. Nature 288: 81–86
Janossy G, Tidman N, Papageorgiou ES, Kung PC, Goldstein G (1981a) Distribution of T lymphocyte subsets in the human bone marrow and thymus: an analysis with monoclonal antibodies. J Immunol 126: 1608–1613
Janossy G, Panayi G, Duke O et al. (1981b) Rheumatoid arthritis: a disease of T-lymphocyte/macro-phage immunoregulation. Lancet II: 839–842
Jansen J, Le Bien TW, Kersey JH (1982) The phenotype of the neoplastic cells of hairy cell leukemia: studies with monoclonal antibodies. Blood 59: 609–614
Kadin MD, Kamoun M, Lamberg J (1981) Erythrophagocytic T y lymphoma. A clinicopathologic entity resembling malignant histiocytosis. N Engl J Med 304: 648–653
Kadin ME, Berard CW, Nanba K, Wakasa H (1983) Lymphoproliferative diseases in Japan and Western countries: proceedings of the United States-Japan Seminar, September 6th and 7th 1982 in Seattle, Washington. Hum Pathol 14: 745–772
Kalyanaraman V, Sarngadharan M, Robert-Guroff M et al. (1982) A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia. Science 218: 571–573
Kikuchi M, Mitsui T, Matsui N et al. (1979) T-cell malignancies in adults: histopathological studies of lymph nodes in 110 patients. Jpn J Clin Oncol 9 (suppl): 407–422
Kim H, Nathwani BN, Rappaport H (1980) So-called “Lennert’s lymphoma”. Is it a clinicopathologic entity? Cancer 45: 1379–1399
Knowles DM II, Halper JP (1982) Human T-cell malignancies. Correlative clinical, histopathologic, immunologic and cytochemical analysis of 23 cases. Am J Pathol 106: 187–203
Korsmeyer SJ, Greene WC, Crossman J et al. (1983) Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia. Proc Natl Acad Sci USA 80: 4522–4526
Kung P, Berger C, Goldstein G et al. (1981) Cutaneous T-cell lymphoma: characterisation by monoclonal antibodies. Blood 57: 261–266
Lennert K, Mestdagh J (1968) Lymphogranulomatosen mit konstant hohen Epithelioidzellgehalt. (Hodgkin’s disease with constantly high content of epithelioid cells.) Virchows Arch [Pathol Anat] 344: 1–20
Lennert K, Remmelle W (1958) Karyometrische Untersuchungen an Lymphknotenzellen des Menschen. I Germinoblasten Lymphoblasten und Lymphozyten. Acta Hematol (Basel) 19: 99–113
Lennert K, Stein H, Kaiserling E (1975) Cytological and functional criteria for the classification of malignant lymphoma. Br J Cancer 31 (suppl II): 29–43
Lennert K, Stein H, Feller AC, Gerdes J (1981) Morphology cytochemistry and immunohistology of T-cell lymphomas. In: Vitetta ES (ed) B and T-cell tumours. Academic, Orlando, Florida, pp 9–26
Leong AS-Y (1984) An evolving classification of malignancies of the T lymphocyte series. Pathology 16: 482–483
Leong AS-Y, Sage RE, Kinnear GC, Forbes IJ (1980) Preferential epidermotrophism in adult T-cell leukemia-lymphoma. Am J Surg Pathol 4: 421–430
Leong AS-Y, Dale BM, Liew SH et al. (1981) Node-based T cell lymphoma The clinical, immunological and morphological spectrum. Pathology 13: 79–95
Lever WF, Shaumberger-Lever G (1975) Histopathology of the skin, 5th edn. Lippincott, Philadelphia, p 698
Levi JA, Wiernik PH (1975) Management of mycosis fungoides: current status and future prospects. Medicine (Baltimore) 54: 73–88
Levin S, Russell E, McWilliams N et al. (1980) Receptors for peanut agglutinin (Arachus hypogea) in childhood acute lymphoblastic leukemia. Possible clinical significance. Blood 55: 37–41
Levine AM, Meyer PR, Lukes RJ, Feinstein DI (1981) Clinical and morphologic heterogeneity of T-cell chronic lymphocytic leukemia. Blood 58 (suppl 1): 144a (abstract)
Linch DC, Cawley JC, MacDonald SM et al. (1981) Acquired pure red cell aplasia associated with an increase of T cells bearing receptors for the Fc of IgG. Acta Haematol 65: 270–274
Lipton JM, Nadler LM, Canellos GP (1983) Evidence for genetic restriction in the suppression of erythropoiesis by a unique subset of T lymphocytes in man. J Clin Invest 72: 694–706
Loughfan TP, Kadin ME, Starkebaum G et al. (1985) Leukemia of large granular lymphocytes: association with clonal chromosomal abnormalities and autoimmune neutropenia, thrombocytopenia, and hemolytic anemia. Ann Intern Med 102: 169–175
Lukes RJ, Collins RD (1974) Immunologic characterization of human malignant lymphomas. Cancer 34: 1488–1503
Lukes RJ, Taylor CR, Parker JW (1982) Immunological surface marker studies in the histopathological diagnosis of non-Hodgkin’s lymphomas based on multiparameter studies of 790 cases. In: Rosenberg SA, Kaplan HS (eds) Malignant lymphoma aetiology, immunology, pathology and treatment. Academic, New York, pp 310–349
MacKie RM (1981) Initial event in mycosis fungoides of the skin is viral infection of epidermal Langerhans cells. Lancet II: 283–284
MacKie RM, Turbitt ML (1982) The use of a double-label immunoperoxidase monoclonal antibody technique in the investigation of patients with mycosis fungoides. Br J Dermatol 106: 379–384
Matsumoto M, Nomura K, Matsumoto T (1979) Adult T-cell leukemia/lymphoma in Kagoshima district South-western Japan: clinical and haematological characteristics. Jpn J Clin Oncol 9 (suppl): 325–336
McNutt N, Crain W (1981) Quantitative electron microscopic comparison of lymphocyte nuclear contours in mycosis fungoides and in benign infiltrate in skin. Cancer 47: 698–709
Meijer C, van der Loo E, van Vloten W et al. (1980) Early diagnosis of mycosis fungoides and Sezary’s syndrome by morphometric analysis of lymphoid cells in the skin. Cancer 45: 2864–2871
Miedema F, Terpstra FG, Smit JW et al. (1984) Functional properties of neoplastic T-cells in adult T-cell lymphoma/leukemia patients from the Caribbean. Blood 63: 477–481
Miller RA, Coleman CN, Fawcett HD et al. (1980) Sezary syndrome: a model for migration of T lymphocytes to skin. N Engl J Med 303: 89–92
Minowada J (1982) Membrane and other phenotypes of leukemia cells. In: Mirand EA, Hutchinson EB, Mihich E (eds) Proceedings of the 13th international cancer congress. Alan R Liss, New York, pp 213–217
Muller-Hermelink HK, Steinmann G, Stein H, Lennert K (1983) Malignant lymphoma of plasmacytoid T-cells. Morphologic and immunologic studies characterising a special type of T-cell. Am J Surg Pathol 7: 849–862
Myrie C, Zucker-Franklin D, Ramsey D (1980) Light-microscopic analysis of sectioned Sezary cells. Am J Pathol 99: 243–252
Nadler LM, Reinherz EL, Weinstein HJ, D’Orsi CJ, Schlossman SF (1980) Heterogeneity of T-cell lymphoblastic malignancies. Blood 55: 806–810
Naeim F, Gatti RA, Johnson CE Jr et al. (1978) “Hairy cell” leukemia. A heterogenous chronic lymphoproliferative disorder. Am J Med 65: 479–487
Nagasawa T, Abe T, Nakagawa T (1981) Pure red cell aplasia and hypogammaglobulinemia associated with T-cell chronic lymphocytic leukemia. Blood 57: 1025–1031
Nathwani BN, Kim H, Rappaport H (1976) Malignant lymphoma, lymphoblastic. Cancer 38: 964–983
Nathwani BN, Rappaport H, Moran EM, Pangalis GA, Kim H (1978) Malignant lymphoma arising in angioimmunoblastic lymphadenopathy. Cancer 41: 578–606
Navas-Palacios JJ, Valdes MD, Montalban Pallares MA et al. (1981) Lymphoblastic lymphoma/leukemia of T cell origin: ultrastructural, cytochemical, and immunologic features of ten cases. Cancer 48: 1982–1991
Newland AC, Catovsky D, Linch D et al. (1984) Chronic T-cell lymphocytosis: a review of 21 cases. Br J Haematol 58: 433–436
O’Brien C, Lampert IA, Catovsky D (1983) The histopathology of adult T-cell lymphoma/leukemia in blacks from the Caribbean. Histopathology 7: 349–364
Pandolfi F, De Rossi G, Semenzato G et al. (1982) Immunologic evaluation of T chronic lymphocytic leukemia cells: correlations among phenotype, functional activities and morphology. Blood 59: 688–695
Pandolfi F, De Rossi G, Lauria F et al. (1985) T-helper phenotype chronic lymphocytic leukaemia and “adult T-cell leukaemia” in Italy. Endemic HTLV-I-related T-cell leukaemias in Southern Europe. Lancet II: 633–636
Pangalis GA, Nathwani BN, Rappaport H, Rosen RB (1979) Acute lymphoblastic leukemia. The significance of nuclear convolutions. Cancer 43: 551–557
Payne CM, Nagle RB, Lynch PJ (1984) Quantitative electron microscopy in the diagnosis of mycosis fungoides. A simple analysis of lymphocytic nuclear convolutions. Arch Dermatol 120: 63–75
Phyliky RL, Li C-Y, Yam LT (1983) T-cell chronic lymphocytic leukemia with morphologic and immunologic characteristics of cytotoxic/suppressor phenotype. Mayo Clin Proc 58: 709–720
Pinkus GS, Said JW, Hargreaves H (1979) Malignant lymphoma T-cell type. A distinct morphologic variant with large multilobated nuclei, with a report of four cases. Am J Clin Pathol 72: 540–550
Pittman S, Morilla R, Catovsky D (1982) Chronic T-cell leukemias. II. Cytogenetic studies. Leuk Res 6: 33–42
Pizzoli G, Chilosi M, Cetto GL et al. (1982) Immunohistological analysis of bone marrow involvement in lymphoproliferative disorders. Br J Haematol 50: 95–100
Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC (1980) Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 77: 7415–7419
Poiesz BJ, Ruscetti FW, Reitz MS, Kalyanaraman VS, Gallo RC (1981) Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sezary T cell leukaemia. Nature 294: 268–271
Poppema S, Bhan AK, Reinherz EL et al. (1981) Distribution of T cell subsets in human lymph nodes. J Exp Med 153: 30–41
Prasthofer EF, Grizzle WE, Prchal JT, Grossi CE (1985) Plasmacytoid T-cell lymphoma associated with chronic myeloproliferative disorder. Am J Surg Pathol 9: 380–387
Pullen DJ, Falletta JM, Christ WM et al. (1981) Southwest Oncology Group experience with immunological phenotyping in acute lymphoblastic leukemia of childhood. Cancer Res 41: 4802–4809
Pullen DJ, Sullivan MP, Falletta JM et al. (1982) Modified LSA-2L2 treatment in 53 children with E-rosette positive T-cell leukemia: results and prognostic factors. Blood 60: 1159–1168
Pullen DJ, Christ WM, Falletta JM et al. (1983) A Paediatric Oncology Group classification protocol for acute lymphocytic leukemia: immunologic phenotypes and correlation with treatment results. In: Murphy SB, Gilbert JF (eds) Leukemia research: advances in cell biology and treatment. Elsevier, Amsterdam, p 221
Rappaport H, Thomas LB (1974) Mycosis fungoides: the pathology of extracutaneous involvement. Cancer 34: 1198–1229
Reinherz EL, Nadler LM, Rosenthal TS, Moloney WC, Schlossman SF (1979) T-cell subset characterisation of human T-CLL. Blood 53: 1066–1075
Reinherz EL, Kung PC, Goldstein G, Levey RH, Schlossman SF (1980) Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci 77: 1588–1592
Reynolds CW, Foon KA (1984) Ty lymphoproliferative disease and related disorders in humans and experimental animals: a review of the clinical, cellular and functional characteristics. Blood 64: 1146–1158
Ritz J, Pesando JM, Notis-McConarty J et al. (1980) A monoclonal antibody to human acute lymphoblastic leukemia antigen. Nature 283: 583–585
Roper M, Christ WM, Metzgar R et al. (1983) Monoclonal antibody characterization of surface antigens in childhood T-cell lymphoid malignancies. Blood 61: 830–837
Rowden G, Lewis MG (1976) Langerhans cells: involvement in the pathogenesis of mycosis fungoides. Br J Dermatol 95: 665–672
Rubenfeld M, Silverstone A, Knowles D et al. (1980) Induction of T-cell differentiation by human epidermal cells. Clin Res 28: 581a (abstract)
Rumke HC, Miedema F, tenBerge IJM et al. (1982) Functional properties of T cells in patients with chronic Ty lymphocytosis and chronic T cell neoplasia. J Immunol 129: 419–426
Safai B, Good RA, Towmey JJ, Lewis V, Goldstein G (1979) A novel lymphocyte differentiating factor in serum of patients with mycosis fungoides and Sezary syndrome. Blood 54: 837–841
Safai B, Incefy GS, Good RA (1980) T-cell differentiating activity in tissue cultures containing mycosis fungoides epidermal cells. N Engl J Med 303: 113
Saxon A, Stevens RH, Golde DW (1978) T-lymphocyte variant of hairy-cell leukemia. Ann Intern Med 88: 323–326
Saxon A, Stevens RH, Golde DW (1979) Helper and suppressor T-lymphocyte leukemia in ataxia telangiectasia. N Engl J Med 300: 700–704
Schechter GP, Bunn PA Jr, Fischmann AB et al. (1979) Blood and lymph node T lymphocytes in cutaneous T-cell lymphoma: evaluation by light microscopy. Cancer Treat Rep 63: 571–574
Schechter GP, Guccion J, Matthews M et al. (1981) Erythrophagocytic Ty lymphoma. N Engl J Med 305: 103
Schneider DR, Taylor CR, Parker JW, Cramer AC, Meyer PR, Lukes RL (1985) Immunoblastic sarcoma of T- and B-cell types: morphologic description and comparison. Hum Pathol 16: 885–900
Schwarzmeier J, Paitta E, Radaszkiewicz T et al. (1981) Proliferation kinetics of Sezary cells. Blood 57: 1049–1054
Selby SWS, Janossy G, Goldstein G, Jewell DP (1981) T lymphocyte subsets in human intestinal mucosa: the distribution and relationship to MHC-derived antigens. Clin Exp Immunol 44: 453–458
Sen L, Borella L (1975) Clinical importance of lymphoblasts with T markers in childhood acute leukemia. N Engl J Med 292: 828–832
Serra JM, Venuti A, Castane DM (1966) Mycosis fungoides en un lactante. Rev Argent Dermatol 30: 161–164
Shackney S, Edelson R, Bunn P Jr (1979) The kinetics of Sezary cell production. Cancer Treat Rep 63: 659–661
Shamoto M (1983) Langerhans cells increase in the dermal lesions of adult T cell leukemia in Japan. J Clin Pathol 36: 307–311
Shimoyama M, Minato K, Saito H et al. (1979a) Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma. Jpn J Clin Oncol 9 (suppl): 347–356
Shimoyama M, Minato K, Saito H et al. (1979b) Comparison of clinical morphologic and immunologic characteristics of adult T-cell leukemia-lymphoma and cutaneous T-cell lymphoma. Jpn J Clin Oncol 9 (suppl): 357–372
Siegal FP, Rambotti P, Siegal M et al. (1982) Helper cell function of leukemic Leu-2a + histamine receptor, and Ty lymphocytes. J Immunol 129: 1775–1781
Silberberg I, Thorbecke GJ, Baer RL et al. (1975) Antigen-bearing Langerhans cells in skin dermal lymphatics and in lymph nodes. Cell Immunol 25: 137–151
Simpkins H, Kiprof DD, Davis JL et al. (1985) T cell chronic lymphocytic leukemia with lymphocytes of unusual immunologic phenotype and function. Blood 65: 127–133
Singh AK, Lewis P, Wetherley-Mein G (1984) Heterogeneity of T-lymphocytic chronic lymphatic leukemia. Scand J Haematol 32: 195–206
Slease RB, Pitha JV, Eichner ER (1984) Adult T-cell leukemia: clinical and immunologic characterization of a nonendemic case. Am J Clin Pathol 82: 495–501
Stein H, Mason DY, Gerdes J et al. (1981) Immunohistology of B-cell lymphomas. In: Knapp W (ed) Leukemia markers. Academic, London, pp 99–108
Stingl G, Wolff K (1982) Origin and function of Langerhans cells and their role in disease. In: Goos M, Christophers E (eds) Lymphoproliferative diseases of the skin. Springer, Berlin Heidelberg New York, pp 34–40
Stutman O (1977) Two main features of T cell development: thymus traffic and postthymic maturation. Contemp Top Immunobiol 7: 1–46
Su I-J, Shih L-Y, Kadin ME et al. (1985) Pathologic and immunologic characterization of malignant lymphoma in Taiwan with special reference to retro virus-associated adult T-cell lymphoma/leuke- mia. Am J Clin Pathol 84: 715–723
Suchi T, Tajima K (1979) Peripheral T-cell malignancy as a problem in lymphoma classification. Jpn J Clin Oncol 9 (suppl): 443–450
Tajima K, Tominagas S, Kuroishi T et al. (1979) Geographical features and epidemiological approach to endemic T-cell leukemia/lymphoma in Japan. Jpn J Clin Oncol 9 (suppl): 495–504
Takatsuki K, Uchiyama T, Sagawa K, Yodoi J (1976) Adult T-cell leukemia (in Japanese). Jpn J Clin Hematol 17: 416–427
Takatsuki K, Uchiyama T, Sagawa K, Yodoi J (1977) Adult T-cell leukemia in Japan. In: Seno S, Tkaku F, Irino S (eds) Topics in haematology. Excerpta Medica, Amsterdam, pp 73–77
Tatsumi E, Takiguchi Y, Domae N et al. (1980) Suppressive activity of some leukemic T cells from adult patients in Japan. Clin Immunol Immunopathol 15: 190–199
Thien SL, Catovsky D, Oscier D et al. (1982) T-chronic lymphocytic leukaemia presenting as primary hypogammaglobulinemia — evidence of a proliferation of T suppressor cells. Clin Exp Immunol 47: 670–676
Thiers BH (1982) Controversies in mycosis fungoides. J Am Acad Dermatol 7: 1–16
Thiers BH, Maize JC, Spicer SS, Cantor AB (1984) The effect of ageing and chronic sun exposure on human Langerhans cell populations. J Invest Dermatol 82: 223–226
Thomas JA, Janossy G, Graham-Brown RAC, Kung PC, Goldstein G (1982) The relationship of T lymphocyte subsets and la-like antigen positive non-lymphoid elements in early stages of cutaneous T-cell lymphoma J Invest Dermatol 78: 169–176
Thomas LB, Rappaport H (1975) Mycosis fungoides and its relationship to other malignant lymphomas. In: Rebuck JW, Berard CW, Abell MR (eds) International Academy of Pathology monograph. The reticuloendothelial system. Williams and Wilkins, Baltimore, pp 243–261
Tidman N, Janossy G, Broder M et al. (1981) Delineation of human thymocyte differentiaton pathways utilizing double-staining techniques with monoclonal antibodies. Clin Exp Immunol 45: 457–467
Tjernlund U (1978) Epidermal expression of Langerhans cells in mycosis fungoides. Arch Dermatol Res 261: 81–86
Tsukimoto I, Wong KY, Lampkin BC (1976) Surface markers and prognostic factors in acute lymphoblastic leukemia. N Engl J Med 294: 245–248
Tubbs RR, Fishleder A, Weiss RA et al. (1983) Immunohistologic cellular phenotypes of lymphoproliferative disorders. Comprehensive evaluation of 564 cases including 257 non-Hodgkin’s lymphomas classified by the International Working Formulation. Am J Pathol 113: 207–221
Uchiyama T, Yodoi J, Sagawa K et al. (1977) Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood 50: 481–492
Uchiyama T, Sagawa K, Takatsuki K, Uchino H (1978) Effect of adult T-cell leukemia cells on pokeweed mitogen-induced normal B-cell differentiation. Clin Immunol Immunopathol 10: 24–34
Uchiyama T, Broder S, Bonnard GD, Waldmann T (1980) Immunoregulatory functions of cultured human T lymphocytes. Trans Assoc Am Physicians 93: 251–262
Van de Griend RJ, De Bruin HG, Rümke HC et al. (1982) Isolation and partial characterisation of a novel subset of human T lymphocytes defined by monoclonal antibodies. Immunology 47: 317–320
van der Loo EM, van Muijen GNP, van Vloten WA, Beens W, Scheffer E, Meijer CJ (1979) C-type virus like particles specifically localised in Langerhans cells and related cells of skin and lymph nodes of patients with mucosis fungoides and Sézary’s syndrome. A morphological and biochemical study. Virchows Arch [Cell Pathol] 31: 193–203
van der Loo EM, van Vloten W, Cornelisse CJ, Scheffer E, Meijer CJ (1981) The relevance of morphometry in the differential diagnosis of cutaneous T cell lymphomas. Br J Dermatol 104: 257–269
Van Scott EJ, Haynes HA (1971) Cutaneous lymphomas. In: Fitzpatrick TB, Arndt KA, Clark WH et al. (eds) McGraw-Hill, New York, pp 556–559
Waldmann TA, Greene WC, Sarin PS et al. (1984) Functional and phenotypic comparison of human T cell leukemia/lymphoma virus positive adult T cell leukemia with human T cell leukemia/lymphoma virus negative Sézary leukemia and their distinction using anti-Tac. Monoclonal antibody identifying the human receptor for T cell growth factor. J Clin Invest 73: 1711–1718
Waldron JA, Leech JH, Glick AD, Flexner JM, Collins RD (1977) Malignant lymphoma of peripheral T lymphocyte origin: immunologic pathologic and clinical features in 6 patients. Cancer 40: 1604–1617
Wassermann J, Bieberfeld G, Baral E, Blomgren H, Thyresson N, Brehmer-Andersson E (1980) Suppressor T cells in mycosis fungoides and socalled pre-mycotic eruptions. Acta Derm Venereol (Stockh) 60: 139–143
Watanabe S, Nakajima T, Shimosato Y et al. (1979) T-cell malignancies: subclassification and interrelationships. Jpn J Clin Oncol 9 (suppl): 423–442
Watanabe S, Shimosato Y, Shimoyama M (1981) Lymphoma and leukemia of T lymphocytes. In: Sommers SC, Rosen PP (eds) Pathology Annual Monograph. Appleton Century Crofts, New York, pp 155–203
Weinberg DS, Pinkus GS (1981) Non-Hodgkin’s lymphoma of large multilobated cell type. A clinicopathologic study of ten cases. Am J Clin Pathol 76: 190–196
Weinstein HJ, Vance ZB, Jaffe N, Buell D, Cassady JR, Nathan DG (1979) Improved prognosis for patients with mediastinal lymphoblastic lymphoma. Blood 53: 687–694
Weiss LM, Wood GS, Dorfman RF (1985a) T-cell signet-ring cell lymphoma. A histologic, ultrastructural and immunohistochemical study of 2 cases. Am J Surg Pathol 9: 273–280
Weiss LM, Crabtree GS, Rouse RV, Warnke RA (1985b) Morphologic and immunologic characterization of 50 peripheral T-cell lymphomas. Am J Pathol 118: 316–324
Whang-Peng J, Bunn P Jr, Knutsen T et al. (1979) Cytogenetic abnormalities in patients with cutaneous T-cell lymphomas. Cancer Treat Rep 63: 575–580
Wieczorek R, Burke JS, Knowles DM II (1985) Leu-Ml antigen expression in T-cell neoplasia. Am J Pathol 121: 374–380
Wood GS, Burke JS, Horning S, Doggett RS, Levey R, Warnke RA (1983) The immunologic and clinicopathologic heterogeneity of cutaneous lymphomas other than mycosis fungoides. Blood 62: 464–472
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Forbes, I.J., Leong, A.SY. (1987). T Cell Leukaemias and Lymphomas. In: Essential Oncology of the Lymphocyte. Springer, London. https://doi.org/10.1007/978-1-4471-1467-3_19
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