Abstract
The term “B cell activation” describes processes by which small resting B cells, in G0 phase, are stimulated to divide and produce large amounts of secretory Ig molecules. If they are not activated, virgin B cells have a short life and memory B cells remain dormant.
Keywords
- Major Histocompatibility Complex
- Major Histocompatibility Complex Class
- Phorbol Ester
- Transferrin Receptor
- Immunol Today
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References
Alpert SD, Jonsen ME, Broff MD, Schneeberger E, Geha RS (1981) Macrophage T-cell interaction in man: handling of tetanus toxoid antigen by human monocytes. J Clin Immunol 1: 21–29
Baxter CS, Fish L, Ferguson TA, Michael J, Bash J (1982) Effects of tumor-promoting agents on cells of the murine immune system: inhibition of antibody synthesis and of macrophage-mediated tumor cell cytotoxicity In: Hecker E et al. (eds) Carcinogenesis, vol 7. Raven, New York, pp 637–642
Bergstedt-Lindqvist S, Sideras P, MacDonald HR, Severinson E (1984) Regulation of Ig class secretion by soluble products of certain T-cell lines. Immunol Rev 78: 25–50
Besancon F, Bourgeade MF, Testa U (1985) Inhibition of transferrin receptor expression by interferon-alpha in human lymphoblastoid cells and mitogen-induced lymphocytes. J Biol Chem 260: 13074–13080
Biozzi G, Mouton D, Stiffel C, Bouthillier Y (1984) A major role of the macrophage in quantitative genetic regulation of immunoresponsiveness and antiinfectious immunity. Adv Immunol 36: 189–234
Brochier J, Bona C, Ciorbaru R, Revillard J-P, Chedid L (1976) A human T-independent B lymphocyte mitogen extracted from Nocardia opaca. J Immunol 117: 1434–1439
Brock JH, de Sousa M (1986) Immunoregulation by iron-binding proteins. Immunol Today 7: 30–31
Bruszewski WB, Bruszewski JA, Tonnu H, Ferezy SL, O’Brien RL, Parker JW (1984) Early mitogen- induced metabolic events essential to proliferation of human T lymphocytes: dependence of specific events on the influence of adherent accessory cells. J Immunol 132: 2837–2843
Cambier JC, Monroe JG, Coggeshall KM, Ransom JT (1985) The biochemical basis of transmembrane signalling by B lymphocyte surface immunoglobulin. Immunol Today 6: 218–222
Chen W-H, Munoz J, Fudenberg HH, Tung E, Virella G (1981) Polyclonal activation of human peripheral blood B lymphocytes by formaldehyde-fixed Salmonella paratyphi B. J Exp Med 153: 365–374
Clark EA, Shu G, Ledbetter J A (1985) Role of the Bp35 cell surface polypeptide on human B-cell activation. Proc Natl Acad Sci USA 82: 1766–1770
Clement LT, Tedder TF (1985) Antibodies reactive with class I antigens of the major histocompatibility complex (MHC) inhibit B cell activation. Fed Proc 44: 974
Coggeshall KM, Cambier JC (1985) B cell activation VI. Effects of exogenous diglyceride and modulators of phospholipid metabolism suggest a central role for diacylglycerol generation in transmembrane signalling by mlg. J Immunol 134: 101–107
Cooper MD (1985) In: Melchers F, Potter M (eds) Mechanisms of B cell neoplasia 1985. Editiones Roche, Basle, p 55
Cooper MD, Kearney JF, Gathings WE, Lawton AR (1980) Effects of anti-Ig antibodies on the development and differentiation of B cells. Immunol Rev 52: 29–53
Corbel C, Melchers F (1984) The synergism of accessory cells and of soluble alpha-factors derived from them in the activation of B cells to proliferation. Immunol Rev 78: 51–74
Coutinho A, Pobor G, Petterson S et al. (1984) T cell-dependent B cell activation. Immunol Rev 78: 211–224
De Franco AL, Kung JT, Paul WE (1982) Regulation of growth and proliferation in B cell subpopulations. Immunol Rev 64: 161–182
del Guercio PD, Marcelletti JF, Katz DH (1986) B-cell lymphokines and activation of the immune system by internal structures. Immunol Today 7: 97–98
Earp HS, Austin KS, Buessow SC, Dy R, Gillespie GY (1984) Membranes from T and B lymphocytes have different patterns of tyrosine phosphorylation. Proc Natl Acad Sci USA 81: 2347–2351
Fauci AS (1983) Basic mechanisms of activation and immunoregulation of human B-lymphocyte responses. In: Fauci AS (moderator) Activation and regulation of human immune responses: implications in normal and disease states. Ann Intern Med 99: 61–75
Fauci AS, Ballieux RE (1982) Summary of workshop presentations and discussions. In: Fauci AS, Ballieux RE (eds) Human B-lymphocyte function: activation and immunoregulation. Raven, New York, pp 309–316
Forbes I J, Zalewski PD, Valente L (1982) Human B-lymphocyte maturation sequence revealed by TPA-induced differentiation of leukaemic cells. Immunobiology 163: 1–6
Forni L (1985) From the point of view of the B cell: considerations on B-cell activation. Scand J Immunol 22: 235–243
Frank MB, Watson J, Mochizuki D, Gillis S (1981) Biochemical and biologic characterisation of lymphocyte regulatory molecules VIII Purification of interleukin 2 from a human T cell leukemia. J Immunol 127: 2361–2365
Helderman JH, Strom TB (1978) Specific insulin binding site on T and B lymphocytes as a marker of cell activation. Nature 274: 62–63
Howard M, Paul WE (1983) Regulation of B-cell growth and differentiation by soluble factors. Ann Rev Immunol 1: 307–333
Howard M, Nakanishi K, Paul WE (1984) B cell growth and differentiation factors. Immunol Rev 78: 185–210
Imboden JB, Stobo JD (1985) Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ion from intracellular stores. J Exp Med 161: 446–456
Kehrl JH, Fauci AS (1983) Identification, purification, and characterisation of antigen-activated and antigen-specific human B lymphocytes. J Exp Med 157: 1692–1697
Kirchner H (1984) Interferons: a group of multiple lymphokines. Semin Immunopathol 7: 347–374
Kishi H, Miki Y, Kikutani H, Yamamura Y, Kishimoto T (1983) Sequential induction of phospholipid methylation and serine esterase activation in a B cell differentiation factor (BCDF)-stimulated human B cell line. J Immunol 131: 1961–1965
Klaus GGB, Chisholm P (1986) Does cyclosporine act in vivo as it does in vitro? Immunol Today 7: 101–103
Lanzavecchia A (1985) Antigen-specific interaction between T and B cells. Nature 314: 537–539
Mayer LF, Thompson C, Fu SM, Kunkel HG (1984) T cell factors regulating B cell activation and differentiation. Curr Top Microbiol Immunol 113: 77–85
Melchers F, Erdei A, Schulz T, Dierich MP (1985) Growth control of activated synchronized murine B cells by the C3d fragment of human complement. Nature 317: 264–267
Miedema F, Melief CJM (1985) T-cell regulation of human B-cell activation. A reappraisal of the role of interleukin 2. Immunol Today 6: 258–259
Miller RA, Gralow J (1984) The induction of Leu-1 antigen expression in human malignant and normal B cells by phorbol myristic acetate (PMA). J Immunol 133: 3408–3414
Mond JJ, Seghal E, Kung J, Finkelman FD (1981) Increased expression of I- region-associated antigen (1a) on B cells after cross-linking of surface immunoglobulin. J Immunol 127: 881–888
Monroe JG, Cambier JC (1983a) Level of mIa expression on mitogen-stimulated murine B lymphocytes is dependent on position in cell cycle. J Immunol 130: 626–631
Monroe JG, Cambier JC (1983b) B cell activation I. Anti-immunoglobulin-induced receptor cross-linking results in a decrease in the plasma membrane potential of murine B lymphocytes. J Exp Med 157: 2073–2086
Morrison DC, Rudbach JA (1981) Endotoxin-cell-membrane interactions leading to transmembrane signalling. In Inman FP (ed) Contemporary topics in molecular immunology, vol 8. Plenum, New York, pp 187–218
Muraguchi A, Kehrl JH, Butler JL, Fauci AS (1984) Regulation of human B-cell activation, proliferation and differentiation by soluble factors. J Clin Immunol 4: 337–347
Neckers LM (1984) Transferrin receptors regulate proliferation of normal and malignant B cells. Curr Top Microbiol Immunol 113: 62–68
Nossal GJV, Pike BL (1984) A reappraisal of “T-independent” antigens. II. Studies on single, hapten-specific B cells from neonatal CBA/H or CBA/N mice fail to support classification into TI-1 and TI-2 categories. J Immunol 132: 1696–1701
Opitz H-G, Opitz U, Lemke H, Hewlett G, Schreml W, Flad H-D (1977) The role of fetal calf serum in the primary immune response in vitro. J Exp Med 145: 1029–1038
Oppenheim J J, Kovacs EJ, Matsushima K, Durum SK (1986) There is more than one interleukin 1. Immunol Today 7: 45–56
Persson UCI, Lennart LG, Hammarstrom LLG, Smith CIE (1977) Macrophages are required for the dextran-sulfate induced activation of B lymphocytes. J Immunol 119: 1138–1144
Persson UCI, Hammarstrom U, Moller G, Smith CIE (1978) The role of adherent cells in B and T lymphocyte activation. Immunol Rev 40: 79–101
Pick E, Keisari Y, Bromberg Y, Freund M, Yabukowski A (1982) Effect of tumor promoters in immunological systems — the macrophage as a target cell for the action of phorbol esters. In: Hecker E et al. (eds) Carcinogenesis, vol 7. Raven, New York, pp 625–634
Provvedini DM, Tsoukas CD, Deftos LJ, Manolagas SC (1983) 1,25-dihydroxyvitamin D3 receptors in human leukocytes. Science 221: 1181–1183
Resch K, Ferber E (1977) Phospholipid metabolism of stimulated lymphocytes. Effects of phytohe-magglutinin, concanavalin A and an anti-immunoglobulin serum. Eur J Biochem 27: 153–161
Robèrt K-H, Einhorn S, Juliusson G, Östlund L, Biberfeld P (1985) Interferon induces proliferation and differentiation in primary chronic lymphocytic leukaemia cells. Clin Exp Immunol 62: 530–534
Ròsen A, Gergely M, Jondal M, Klein G, Britton S (1977) Polyclonal Ig production after Epstein-Barr virus infection of human lymphocytes in vitro. Nature 267: 52–54
Rosenberg SA, Lipsky PE (1981) The role of monocytes in pokeweed mitogen-stimulated human B cell activation: separate requirements for intact monocytes and a soluble monocyte factor. J Immunol 126: 1341–1345
Rosenberg SA, Lipsky PE (1982) The role of monocytes in human B-cell activation In: Fauci AS, Ballieux RE (eds) Human B-lymphocyte function: activation and immunoregulation. Raven, New York, pp 263–287
Scouros MA, Bohleber-Matza M, Murphy SG (1983) Kinetics of protein A activation of mononuclear cells from patients with chronic lymphocytic leukemia I. CLL B-cells are not intrinsically unresponsive to staphylococcal protein A. Leuk Res 7: 703–712
Sidman CL, Unanue ER (1978) Control of proliferation and differentiation in B lymphocytes by anti-Ig antibodies and a serum-derived cofactor. Proc Natl Acad Sci USA 75: 2401–2405
Sidman CL, Paige CJ, Schreier MH (1984) B cell maturation factor (BMF): a lymphokine or family of lymphokines promoting the maturation of B lymphocytes. J Immunol 132: 209–222
Sieckmann DG, Asofsky R, Mosier DE et al. (1978) Activation of mouse lymphocytes by anti-immunoglobulin. I. Parameters of the proliferative response. J Exp Med 147: 814–829
Sugawara I, Ishizaka S (1983) The degree of monocyte participation in human B- and T-cell activation by phorbol myristate acetate. Clin Immunol Immunopathol 26: 299–308
Touw I, Lowenberg B (1985) Interleukin 2 stimulates chronic lymphocytic leukemia colony formation in vitro. Blood 66: 237–240
Webb DR (1983) The biochemistry of antigen-specific T-cell factors. Ann Rev Immunol 1: 428–438
Wedner HJ (1984) Biochemical events associated with lymphocyte activation. Surv Immunol Res 3: 295–303
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Forbes, I.J., Leong, A.SY. (1987). B Cell Activation. In: Essential Oncology of the Lymphocyte. Springer, London. https://doi.org/10.1007/978-1-4471-1467-3_12
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DOI: https://doi.org/10.1007/978-1-4471-1467-3_12
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