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The Vascular Wall and Hormonal Control of Vasomotor Function

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Diseases of the Arterial Wall

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Abstract

The simplest concept of hormonal control of vascular tone would be that circulating vasoconstrictor and vasodilator factors act directly upon the smooth-muscle cells of the media after they have crossed or circumvented the endothelial cells and the fibroconnective matrix of the intima, without undergoing modification. It is, however, known that more complex biochemical processes take place in the vascular wall or on its surface and that the endothelium plays a major role in the hormonal modulation of vasomotor function, having the enzymatic equipment necessary for activating angiotensin I to become the vasoconstricting angiotensin II and for inactivating the vasodilator bradykinin. Pharmacologically, the endothelium has characterizable receptors for histamine and serotonin. It takes up vasoactive adenylated nucleotides and noradrenaline, and metabolizes certain vasoactive prostaglandins.

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  1. F. Alhenc-Gelas
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  2. P. Corvol
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Editors and Affiliations

  1. Service d’Anatomie Pathologique et Unité de Recherche sur la Pathologie Rénale et Vasculaire, INSERM U28, Paris, France

    Jean-Pierre Camilleri (Professeur) (Professeur)

  2. Department of Morbid Anatomy, Institute of Pathology, The London Hospital, Whitechapel, London, E1 1BB, UK

    Colin L. Berry (Professor) (Professor)

  3. Service de Médecine Interne et de Pathologie Vasculaire, Hôpital Broussais, Paris, France

    Jean-Noël Fiessinger (Professeur) (Professeur)

  4. Service de Néphrologie et Unité de Recherche sur la Pathologie Rénale et Vasculaire, INSERM U28, Hôpital Broussais, Paris, France

    Jean Bariéty (Professeur) (Professeur)

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Alhenc-Gelas, F., Corvol, P. (1989). The Vascular Wall and Hormonal Control of Vasomotor Function. In: Camilleri, JP., Berry, C.L., Fiessinger, JN., Bariéty, J. (eds) Diseases of the Arterial Wall. Springer, London. https://doi.org/10.1007/978-1-4471-1464-2_9

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  • DOI: https://doi.org/10.1007/978-1-4471-1464-2_9

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