Adrenergic and Non-adrenergic Neural Control of the Arterial Wall

  • K. K. Dhital
  • G. Burnstock

Abstract

The availability of new and improved techniques in fluorescence histochemistry (particularly immunohistochemistry), electron microscopy, electrophysiology and pharmacology since the 1960s has led to a wealth of discoveries that have profoundly reshaped our understanding of the autonomic nervous system. There has also been a dramatic rise in the number of putative neurotransmitter substances, which show a marked overlap in their localization and function. These findings add new concepts and further complexity to autonomic neuroeffector mechanisms and demand a reappraisal of our definitions for subclassing these neurohumoral agents into neurotransmitters; neuromodulators and trophic factors.

Keywords

Histamine Peri Acetylcholine Statin Glucagon 

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References

  1. 1.
    Abráhám A (1981) Microscopic innervation of the heart and blood vessels in vertebrates including man. Pergamon Press, OxfordGoogle Scholar
  2. 2.
    Abrahams VC, Hilton SM (1958) Active muscle vasodilatation and its relation to the “fight and flight” reactions in the conscious animal. J Physiol (Lond) 140:16PGoogle Scholar
  3. 3.
    Adrian TE, Gu J, Allen JM et al. (1984) Neuropeptide Y in the male genital tract. Life Sci 35:2643–2648PubMedCrossRefGoogle Scholar
  4. 4.
    Ahlqvist RP (1948) A study of the adrenotropic receptors. Am J Physiol 153:586–600Google Scholar
  5. 5.
    Ajelis V, Björklund B, Falk B et al. (1979) Application of the aluminium formaldehyde (ALFA) histo- fluorescence method for demonstration of peripheral stores of catecholamines and indoleamines in freeze- dried paraffin embedded tissue, cryostat sections and whole mounts. Histochemistry 65:1–15PubMedCrossRefGoogle Scholar
  6. 6.
    Alafaci C, Cowen T, Crockard HA et al. (1985) The original distribution of noradrenergic and NPY-con- taining nerves in the cerebral blood vessels of the gerbil. J Cereb Blood Flow Metab 5 [Suppl 1]:S543-S544Google Scholar
  7. 7.
    Alafaci C, Cowen T, Crockard HA et al. (1986) Cerebral perivascular serotonergic fibres have a peripheral origin in the gerbil. Brain Res Bull 16:303–304PubMedCrossRefGoogle Scholar
  8. 8.
    Alafaci C, Cowen T, Crockard HA et al. (1986) Perivascular nerve types supplying cerebral blood vessels of the gerbil. Acta Physiol Scand 127 (Suppl 552):9–12Google Scholar
  9. 9.
    Allan G, Brook CD, Cambridge D et al. (1983) Enhanced responsiveness of vascular smooth muscle to vasoconstrictor agents after removal of endothelial cells. Br J Pharmacol 79:334PGoogle Scholar
  10. 10.
    Allen JM, Schon F, Todd N et al. (1984) Presence of neuropeptide Y in human circle of Willis and its possible role in cerebral vasospasm. Lancet II:550–552PubMedCrossRefGoogle Scholar
  11. 11.
    Allen JM, Gu J, Adrian TE et al. (1984) Neuropeptide Y in the guinea-pig biliary tract. Experientia 40:765–767PubMedCrossRefGoogle Scholar
  12. 12.
    Alm P, Alumets J, Brodin E et al. (1978) Peptidergic (substance P) nerves in the genitourinary tract. Neuroscience 3:419–425PubMedCrossRefGoogle Scholar
  13. 13.
    Alm P, Alumets R, Hakanson R et al. (1980) Origin and distribution of VIP (vasoactive intestinal polypeptide) nerves in the genito-urinary tract. Cell Tissue Res 205:337–347PubMedCrossRefGoogle Scholar
  14. 14.
    Altura BM (1981) Pharmacology of venules: some current concepts and clinical potential. J Cardiovasc Pharmacol 3:1413–1428PubMedCrossRefGoogle Scholar
  15. 15.
    Altura BM, Malaviy D, Reich CF et al. (1972) Effects of vasoactive agents on isolated human umbilical arteries and veins. Am J Physiol 222: 345–355PubMedGoogle Scholar
  16. 16.
    Amara SG, Jonas V, Rosenfeld MG et al. (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298:240–244PubMedCrossRefGoogle Scholar
  17. 17.
    Amenta F, Cavallotti C, Collier WL (1985) The adrenergic innervation of rat uterine tubes in old age: a fluorescence histochemical study. Arch Gerontol Geriatr 4:37–42PubMedCrossRefGoogle Scholar
  18. 18.
    Amenta F, De Rossi M, Mione MC et al. (1985) Characterization of [3H] 5-hydroxytryptamine uptake within rat cerebrovascular tree. Eur J Pharmacol 112:181–186PubMedCrossRefGoogle Scholar
  19. 19.
    Angus JA, Brazenor RM, Le Duc MA (1982) Verapil-A selective antagonist of constrictor substance in dog coronary artery: implications for variant angina. Clin Exp Pharmacol Physiol [Suppl 6]: 15–28Google Scholar
  20. 20.
    Appenzeller O, Dhital KK, Cowen T et al. (1984) The nerves to blood vessels supplying blood to nerves: the innervation of vasa nervorum. Brain Res 304:383–386PubMedCrossRefGoogle Scholar
  21. 21.
    Apperley E, Humphrey PPA, Levy GP (1976) Receptors for 5-hydroxytryptamine and noradrenaline in rabbit isolated ear artery and aorta. Br J Pharmacol 58:211–221PubMedGoogle Scholar
  22. 22.
    Armati-Gulson P, Burnstock G (1983) The development of adrenergic innervation in some human foetal blood vessels. J Auton Nerv Syst 7(2): 111–118PubMedCrossRefGoogle Scholar
  23. 23.
    Arneklo-Nobin B, Owman C (1985) Adrenergic and serotoninergic mechanisms in human hand arteries and veins studied by fluorescence histochemistry and in vitro pharmacology. Blood Vessels 22:1–12PubMedGoogle Scholar
  24. 24.
    Azanza MJ, Garin P (1986) The autonomic innervation of the rat diaphragm. Gen Pharmacol 17(1): 109–112PubMedCrossRefGoogle Scholar
  25. 25.
    Bannister R, Crowe R, Burnstock G (1981) Adrenergic innervation in autonomic failure. Neurology 31:1501–1506PubMedGoogle Scholar
  26. 26.
    Barajas L, Wang P (1975) Demonstration of acetylcholinesterase in the adrenergic nerves of the renal glomerular arterioles. J Ultrastruct Res 53:244–253PubMedCrossRefGoogle Scholar
  27. 27.
    Barja F, Mathison R (1982) Adrenergic and peptidergic (substance P and vasoactive intestinal polypeptide) innervation of the rat portal vein. Blood Vessels 19:263–272PubMedGoogle Scholar
  28. 28.
    Barja F, Huggel H, Mathison R (1982) Substance P nerve fibres in peripheral blood vessels. Neuroscience 7:S18Google Scholar
  29. 29.
    Barja F, Mathison R, Huggel H (1983) Substance P- containing nerve fibres in large peripheral blood vessels of the rat. Cell Tissue Res 229:411–422PubMedCrossRefGoogle Scholar
  30. 30.
    Barja F, Mathison R (1984) Sensory innervation of the rat portal vein and the hepatic artery. J Auton Nerv Sys 10:117–125CrossRefGoogle Scholar
  31. 31.
    Barnes PJ, Carstairs JR (1985) Autoradiographic localization of VIP receptors in guinea pig and human lung. Proc Br Pharmacol Soc 18–20 December, 128Google Scholar
  32. 32.
    Baumgarten HG (1972) Biogenic amines in the cyclo- stome and lower vertebrate brain. Prog Histochem Cytochem 4:1–90PubMedGoogle Scholar
  33. 33.
    Bell C (1974) Selective cholinergic denervation of the uterine artery in the guinea-pig. Experimentia 30:257258Google Scholar
  34. 34.
    Bérubé A, Marceau F, Drouin JN et al. (1978) The rabbit mesenteric vein: a specific bioassay for substance P. Can J Physiol Pharmacol 56:603–609PubMedCrossRefGoogle Scholar
  35. 35.
    Bevan JA, Su C (1973) Sympathetic mechanisms in blood vessels: nerve and muscle relationships. In: Elliot HW, George R, Okon R (eds) Annual review of pharmacology. 13:269–285Google Scholar
  36. 36.
    Bevan JA, Ljung B (1974) Longitudinal propagation of myogenic activity in rabbit arteries and in the rat portal vein. Acta Physiol Scand 90:703–751PubMedCrossRefGoogle Scholar
  37. 37.
    Bissette G, Manberg JW, Nemeroff CB et al. (1978) Neurotensin, a biologically active peptide. Life Sci 23(22):2173–2182PubMedCrossRefGoogle Scholar
  38. 38.
    Black JL, French RJ, Mylecharane EJ (1981) Receptor mechanisms for 5-hydroxytryptamine in rabbit arteries. Br J Pharmacol 74:619–626PubMedGoogle Scholar
  39. 39.
    Blackshear JL, Orlandi C, Garnic JD et al. (1985) Differential large and small vessel responses to serotonin in the dog hindlimb in vivo: role of the 5HT2 receptor. J Cardiovasc Pharmacol 7:42–49PubMedCrossRefGoogle Scholar
  40. 40.
    Blair DA, Glover WE, Roddie IC (1961) Vasomotor responses in the human arm during leg exercise. Circ Res 9:264–74Google Scholar
  41. 41.
    Bloom SR, Bryant MG, Polak JM et al. (1979) Vasoactive intestinal peptide-like immunoreactivity in salivary glands of the rat. J Physiol (Lond) 289:23PGoogle Scholar
  42. 42.
    Bloom SR, Edwards AV (1980) Vasoactive intestinal peptide in relation to atropine resistant vasodilatation in the submaxillary gland of the cat. J Physiol (Lond) 300:41–53Google Scholar
  43. 43.
    Boatman DL, Shaffer RA, Dixon RL (1965) Function of vascular smooth muscle and its sympathetic innervation in the newborn dog. J Clin Invest 44:241–246PubMedCrossRefGoogle Scholar
  44. 44.
    Boe J, Boe A-M, Simonsson B et al. (1980) In vitro affects on parasympathetic agonists and atropine on human segmental pulmonary arteries. Lung 157:65–70PubMedCrossRefGoogle Scholar
  45. 45.
    Borodulya AV, Pletchkova EC (1976) Cholinergic innervation of vessels of the base of the brain. Acta Anat (Basel) 96:135–147CrossRefGoogle Scholar
  46. 46.
    Brain SD, Williams TJ, Tippins JR et al. (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313:54–56PubMedCrossRefGoogle Scholar
  47. 47.
    Brain SD, Girgis S, MacIntyre I et al. (1985) Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. Br J Pharmacol 86:855–860PubMedGoogle Scholar
  48. 48.
    Brayden JE, Bevan JA (1985) Inhibition of cerebral neurovasodilatation by VIP-specific antiserum. J Cereb Blood Flow Metab 5 [Suppl 1]:S509Google Scholar
  49. 49.
    Brodin E, Alumets J, Hakanson R et al. (1981) Immu- noreactive substance P in the chicken gut: distribution, development and possible functional significance. Cell Tissue Res 216:455–469PubMedCrossRefGoogle Scholar
  50. 50.
    Brody MJ, Shaffer RA (1970) Distribution of vasodilator nerves in the canine hindlimb. Am J Physiol 218:470–474PubMedGoogle Scholar
  51. 51.
    Brownstein MJ, Saavedra JM, Axelrod J (1974) Coexistence of several putative neurotransmitters in single identified neurons of aplysia. Proc Natl Acad Sci USA 71:4662–4665PubMedCrossRefGoogle Scholar
  52. 52.
    Buchan AMJ, Polak JM, Pearse AGE (1980) Gut hormones in Salamandra salamandra. Cell Tissue Res 211:331–343PubMedCrossRefGoogle Scholar
  53. 53.
    Buchan AMJ, Polak JM, Bryant MG et al. (1981) Vasoactive intestinal polypeptide (VIP)-like immunoreactivity in anuran intestine. Cell Tissue Res 216:413–422PubMedCrossRefGoogle Scholar
  54. 54.
    Bucsics A, Saria A, Lembeck F (1961) Substance P in the adrenal gland: origin and species distribution. Neuropeptides 1:329CrossRefGoogle Scholar
  55. 55.
    Bülbring E, Burn JH (1935) The sympathetic dilator fibres in the muscles of the cat and dog. J Physiol (Lond) 83:483–501Google Scholar
  56. 56.
    Burcher E, Atterhög J-H, Pernow B et al. (1977) Cardiovascular effects of substance P: effects on the heart and regional blood flow in the dog. In: Von Euler US, Pernow B (eds) Substance P. Raven Press, New York, pp 261–268Google Scholar
  57. 57.
    Burnstock, G (1969) Evolution of the autonomic innervation of visceral and cardiovascular systems in vertebrates. Pharmacol Rev 21:247–324PubMedGoogle Scholar
  58. 58.
    Burnstock G (1970) Structure of smooth muscle and its innervation. In: Bülbring E, Brading A, Jones A, Tomita T (eds) Smooth muscle. Edward Arnold, London, pp 1–69Google Scholar
  59. 59.
    Burnstock G (1972) Purinergic nerves. Pharmacol Rev 24:509–581PubMedGoogle Scholar
  60. 60.
    Burnstock G (1975) Innervation of vascular smooth muscle: histochemistry and electron microscopy. In: Physiological and pharmacological control of blood pressure. Clin Exp Pharmacol Physiol [Suppl 2]:7–20Google Scholar
  61. 61.
    Burnstock G (1976) Do some nerve cells release more than one transmitter? Neuroscience 1:239–248PubMedCrossRefGoogle Scholar
  62. 62.
    Burnstock G (1977) Autonomic neuroeffector junctions - reflex vasodilatation of the skin. J Invest Dermatol 69:47–57PubMedCrossRefGoogle Scholar
  63. 63.
    Burnstock G (1978) A basis for distinguishing two types of purinergic receptors. In: Straub RW, Bolis L (eds) Cell membrane receptors for drugs and hormones: a multidisciplinary approach. Raven Press, New York, pp 107–118Google Scholar
  64. 64.
    Burnstock G (1979) The ultrastructure of autonomic cholinergic nerves and junctions. Prog Brain Res 49:3–21PubMedCrossRefGoogle Scholar
  65. 65.
    Burnstock G (1980) Cholinergic and purinergic regulation of blood vessels. In: Bohr DF, Somylo AP, Sparks HV (eds) Handbook of physiology, section 2: the cardiovascular system, vol II: vascular smooth muscle. American Physiological Society, Bethesda, pp 567–612Google Scholar
  66. 66.
    Burnstock G (1980) Neurotransmitters, cotransmitters, neuromodulators and trophic factors in the autonomic nervous system. In: Levi-Montalcini R (ed) Nerve cells, transmitters and behaviour. Elsevier, Amsterdam, pp 253–286Google Scholar
  67. 67.
    Burnstock G (1982) The co-transmitter hypothesis, with special reference to the storage and release of ATP with noradrenaline and acetylcholine. In: Cuello AC (ed) Cotransmission. Macmillan, London, pp 151–163Google Scholar
  68. 68.
    Burnstock G (1982) Neuropeptides as trophic factors. In: Bloom SR, Polak JM, Lindenlaub EFK (eds) Systemic role of regulatory peptides. Schattauer Verlag, Stuttgart, pp 423–441Google Scholar
  69. 69.
    Burnstock G (1983) Recent concepts of chemical communication between excitable cells. In: Osborne NN (ed) Dale’s principle and communication between neurones. Pergamon Press, Oxford, pp 7–35Google Scholar
  70. 70.
    Burnstock G (1985) Purinergic mechanisms broaden their sphere of influence. TINS 8(l):5–6Google Scholar
  71. 71.
    Burnstock G (1985) Neurohumoral control of blood vessels; some future directions. J Cardiovasc Pharmacol 7 [Suppl 3]:S137-S146PubMedCrossRefGoogle Scholar
  72. 72.
    Burnstock G (1985) Neurogenic control of cerebral circulation. Cephalagia [Suppl 2]:25–33Google Scholar
  73. 73.
    Burnstock G (1985) Nervous control of smooth muscle by transmitters, cotransmitters and modulators. Experimentia 41:869–874CrossRefGoogle Scholar
  74. 74.
    Burnstock G (1986) Purines as cotransmitters in adrenergic and cholinergic neurones. In: Hökfelt T et al. (eds) Coexistence of neuronal messengers: a new principle in chemical transmission. (Progress in brain research 68). Elsevier, Amsterdam, pp 193–203Google Scholar
  75. 75.
    Burnstock G, Prosser CL (1960) Conduction in smooth muscles: comparative electrical properties. Br J Pharmacol 43:180–189Google Scholar
  76. 76.
    Burnstock G, Robinson PM (1967) Localization of catecholamines and acetylcholinesterase in autonomic nerves. Circ Res 21 [Suppl 3]:43–55Google Scholar
  77. 77.
    Burnstock G, Iwayama T (1971) Fine structural identification of autonomic nerves and their relation to smooth muscle. Prog Brain Res 34:389–404CrossRefGoogle Scholar
  78. 78.
    Burnstock G, Costa M (1975) Adrenergic neurons. Chapman and Hall, LondonGoogle Scholar
  79. 79.
    Burnstock G, Crowe R, Wong HK (1979) Comparative pharmacological and histochemical evidence for purinergic inhibitory innervation of the portal vein of the rabbit, but not guinea-pig. Br J Pharmacol 65:377–388PubMedGoogle Scholar
  80. 80.
    Burnstock G, Chamley JM, Campbell GR (1980) The innervation of arteries. In: Schwartz CJ, Wethessen NT, Wolf S (eds) Structure and function of the circulation, vol. 1. Plenum Press, New York, pp 729–767Google Scholar
  81. 81.
    Burnstock G, Brown CM (1981) An introduction to purinergic receptors. In: Burnstock G (ed) Purinergic receptors. Chapman and Hall, London, pp 1–45CrossRefGoogle Scholar
  82. 82.
    Burnstock G, Griffith SG (1983) Neurohumoral control of the vasculature. In: Woolf N (eds) Biology and pathology of the vessel wall. Praeger, New York, pp 15–40Google Scholar
  83. 83.
    Burnstock G, Griffith SG (1983) Innervation of microvascular smooth muscle. Prog Appl Microcirc 3:19–39Google Scholar
  84. 84.
    Burnstock G, Griffith SG, Sneddon P (1984) Autonomic nerves in the precapillary vessel wall. J Cardiovass Pharmacol 6:S344-S353CrossRefGoogle Scholar
  85. 85.
    Burnstock G. Kennedy C (1985) Is there a basis for distinguishing two types of P2-purinoceptors? Gen Pharmacol 16(5):433–440PubMedCrossRefGoogle Scholar
  86. 86.
    Burnstock G, Kennedy C (1986) A dual function for ATP in the regulation of vascular tone: excitatory cotransmitter with noradrenaline from perivascular nerves and locally released inhibitory intravascular agent. Circ Res 58:319–330PubMedGoogle Scholar
  87. 87.
    Carpenter MB (1976) Human neuroanatomy, 7th edn. Williams and Wilkins, Baltimore, p 198Google Scholar
  88. 88.
    Carraway R, Leeman SE (1973) The isolation of a new hypotensive peptide, neurotensin from bovine hypothalami. J Biol Chem 248:6854–6861PubMedGoogle Scholar
  89. 89.
    Chan-Palay V (1976) Serotonin axons in the supra- and subependymal plexuses and in the leptomeninges; their roles in local alterations of cerebrospinal fluid and vasomotor activity. Brain Res 102:103–130PubMedCrossRefGoogle Scholar
  90. 90.
    Chan-Palay V (1977) Innervation of cerebral blood vessels by norepinephrine, indoleamine, substance P and neurotensin fibers and the leptominengeal indoleamine axons: their roles in vasomotor activity and local alterations of brain blood composition. In: Owman C, Edvinsson L (eds) Neurogenic control of brain circulation. Pergamon Press, Oxford, pp 39–53Google Scholar
  91. 91.
    Chang MM, Leeman SE, Niall HD (1971) Amino acid sequence of substance P. Nature New Biol 232:86PubMedCrossRefGoogle Scholar
  92. 92.
    Cherry PD, Furchgott RF, Zawadzki JV et al. (1982) Role of endothelial cells in relaxation of isolated arteries by bradykinin. Proc Natl Acad Sci USA 79:2106–10PubMedCrossRefGoogle Scholar
  93. 93.
    Chubb IW, Hodgson AJ, White GH (1980) Acetylcholinesterase hydrolyses substance P. Neuroscience 5:2065–2072PubMedCrossRefGoogle Scholar
  94. 94.
    Clague JR, Sternini C, Brecha NC (1985) Localization of calcitonon gene-related peptide-like immuno- reactivity in neurons of the rat gastrointestinal tract. Neurosci Lett 56:63–68PubMedCrossRefGoogle Scholar
  95. 95.
    Cocks TM, Angus JA (1983) Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Nature 305:627–630PubMedCrossRefGoogle Scholar
  96. 96.
    Cohen ML, Fuller RW, Wiley KS (1981) Evidence for 5-HT2 receptors mediating contraction in vascular smooth muscle. J Pharmacol Exp Therap 218:421–425Google Scholar
  97. 97.
    Cohen RA, Shepherd JT, Vanhoutte PM (1983) Prejunctional and postjunctional actions of endogenous norepinephrine at the sympathetic neuroeffector junction in canine coronary arteries. Circ Res 52:16–25PubMedGoogle Scholar
  98. 98.
    Corder R, Lowry PJ, Ramage AG et al. (1986) Comparison of the haemodynamic actions of neuropeptide Y, angiotensin II and noradrenaline, in anaesthetized cats. Eur J Pharmacol 121:25–30PubMedCrossRefGoogle Scholar
  99. 99.
    Costa M, Cuello AC, Furness JB et al. (1980) Distribution of enteric neurons showing immunoreactivity for substance P in the guinea-pig ileum. Neuroscience 5:323–331PubMedCrossRefGoogle Scholar
  100. 100.
    Costa M, Furness JB, Llewellyn-Smith IJ et al. (1981) Prejections of substance P-containing neurons within guinea-pig small intestine. Neuroscience 6:411–424PubMedCrossRefGoogle Scholar
  101. 101.
    Cottrell GA (1976) Does the giant cerebral neurone of Helix release two transmitters: ACh and serotonin? J Physiol (Lond) 259:44–45Google Scholar
  102. 102.
    Coughlin SR, Moskowitz MA, Antoniades HN et al. (1981) Serotonin receptor-mediated stimulation of bovine smooth muscle cell prostacyclin synthesis and its modulation by platelet-derived growth factor. Proc Natl Acad Sci USA 78:713–7138CrossRefGoogle Scholar
  103. 103.
    Cowen T, MacCormick DEM, Toff WD et al. (1982) The effect of surgical procedures on blood vessel innervation. A fluorescence histochemical study of degeneration and regrowth of perivascular adrenergic nerves. Blood Vessels 19:65–78PubMedGoogle Scholar
  104. 104.
    Cowen T, Haven AJ, Wen-Qin C et al. (1982) Development and ageing of perivascular adrenergic nerves in the rabbit. A quantitative fluorescence histochemical study using image analysis. J Auton Nerv Syst 5:317–336PubMedCrossRefGoogle Scholar
  105. 105.
    Cowen T, Haven AJ, Burnstock G (1985) Pontamine sky blue: a counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry. Histochemistry 82:205–208PubMedCrossRefGoogle Scholar
  106. 106.
    Cowen T, Alafaci C, Crockard HA et al. (1986) 5-HT- containing nerves to major cerebral arteries of the gerbil originate in the superior cervical ganglia. Brain Res 384:51–59PubMedCrossRefGoogle Scholar
  107. 107.
    Crowe R, Lincoln J, Blacklay PF et al. (1983) Vasoactive intestinal polypeptide-like immunoreactive nerves in diabetic penis. A comparison between strep- tozotocin-treated rats and man. Diabetes 32:1075–1077PubMedCrossRefGoogle Scholar
  108. 108.
    Cuello AC, Gamse R, Holzer P et al. (1981) Substance P-immunoreactive neurons following neonatal administration of capsaicin. Naunyn-Schmiedeberg’s Arch Pharmacol 315:185–194CrossRefGoogle Scholar
  109. 109.
    Cummings JP, Felten DL (1979) A raphe dendrite bundle in the rabbit medulla. J Comp Neurol 183:1–24PubMedCrossRefGoogle Scholar
  110. 110.
    Dahlof C, Dahlof P, Lundberg JM (1985) Neuropeptide Y (NPY): enhancement of blood pressure increase upon α-adrenoceptor activation and direct pressor effects in pithed rats. Eur J Pharmacol 109:289–292PubMedCrossRefGoogle Scholar
  111. 111.
    Dahlström A, Bööj S, Carlsson SS et al. (1981) Rapid accumulation and axonal transport of “cholinergic vesicles” in rat sciatic nerve, studied by immunohistochemistry. Acta Physiol Scand 111:217–219PubMedCrossRefGoogle Scholar
  112. 112.
    Dalsgaard C-J, Jonsson C-E, Hökfelt T et al. (1983) Localization of SP-immunoreactive fibres in the human digital skin. Experientia 39:1018–1020PubMedCrossRefGoogle Scholar
  113. 113.
    Daly I, De Burgh I, Hebb C (1966) Pulmonary and bronchial vascular systems. Edward Arnold, LondonGoogle Scholar
  114. 114.
    Da Prada M, Richards JG, Lorez HP (1978) Blood platelets and biogenic monoamines: biochemical, pharmacological and morphological studies. In: de Gaetano G, Garattini S (eds) Platelets: a multi-disciplinary approach. Raven Press, New York, pp 331–353Google Scholar
  115. 115.
    Dashwood M, Bagnall J (1982) An autoradiographic demonstration of prazosin binding to arterial vessels in the rat. Eur J Pharmacol 78:121–123PubMedCrossRefGoogle Scholar
  116. 116.
    Davies B (1983) Adrenergic receptors in autonomic failure. In: Bannister R (ed) Autonomic failure. A textbook of clinical disorders of the autonomic nervous system. Oxford University Press, Oxford, pp 174–200Google Scholar
  117. 117.
    De La Torre JC, Surgeon JW (1976) A methodological approach to rapid and sensitive monoamine histo- fluorescence using a modified glyoxylic acid technique: the SPG method. Histochemistry 49:81–93PubMedCrossRefGoogle Scholar
  118. 118.
    Delgado TJ, Brismar J, Svendgaard NA (1985) Subarachnoid haemorrhage in the rat: angiography and fluorescence microscopy of the major cerebral arteries. Stroke 16: 595–601PubMedCrossRefGoogle Scholar
  119. 119.
    Dey RD, Shannon WA, Said SI (1981) Localization of VIP-immunoreactive nerves in airways and pulmonary vessels of dogs, cats and human subjects. Cell Tissue Res 220:231–238PubMedGoogle Scholar
  120. 120.
    DeMey J, Burnstock G, Vanhoutte PM (1979) Modulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATP. Eur J Pharmacol 55:401–405CrossRefGoogle Scholar
  121. 121.
    DeMey JG, Vanhoutte PM (1981) Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J Physiol (Lond) 316:347–355Google Scholar
  122. 122.
    Dhall U, Cowen T, Haven AJ et al. (1986) Perivascular noradrenergic and peptidergic nerves show different patterns of changes during development and ageing in the guinea-pig. J Auton Nerv Syst 16:109–126PubMedCrossRefGoogle Scholar
  123. 123.
    Dhital KK, Lincoln J, Appenzeller O et al. (1986) Adrenergic innervation of vasa and nervi nervorum of optic, sciatic, vagus and sympathetic nerve trunks in normal and streptozotocin-diabetic rats. Brain Res 367:39–44PubMedCrossRefGoogle Scholar
  124. 124.
    Diani AR, Peterson T, Sawada GA et al. (1985) Elevated level of vasoactive intestinal peptide in the eye and urinary bladder of diabetic and prediabetic clinical hamsters. Diabetologia 28:302–307PubMedCrossRefGoogle Scholar
  125. 125.
    Di Carlo V (1977) Histochemical evidence for a serotonergic innervation of the microcirculation in the brain stem. In: Owman C, Edvinsson L (eds) Neurogenic control of the brain circulation. Pergamon Press, Oxford, pp 55–58Google Scholar
  126. 126.
    Di Carlo V (1981) Serotoninergic innervation of extrinsic brain stem blood vessels. Neurology 31:104Google Scholar
  127. 127.
    Di Carlo V (1984) Perivascular serotonergic neurons: somatodendritic contacts and axonic innervation of blood vessels. Neurosci Lett 51:295–302PubMedCrossRefGoogle Scholar
  128. 128.
    Di Carlo V (1984) Segmental serotoninergic innervation of spinal cord arterial circulation. Neurosci Lett 49:225–231PubMedCrossRefGoogle Scholar
  129. 129.
    Dolezel S, Gerova M, Gero J (1973) Sympathetic construction and monoaminergic innervation of large arteries. Folia Morphol (Praha) 21:364–366Google Scholar
  130. 130.
    Dolezel S, Gerova M, Gero J. (1974) Postnatal development of the sympathetic innervation in skeletal muscles of the dog. Physiol Bohemoslov 23:138–139Google Scholar
  131. 131.
    Drolet G, Gauthier P (1985) Peripheral and central mechanisms of the pressor response elicited by stimulation of the locus coeruleus in the rat. Can J Physiol Pharmacol 63:599–605PubMedCrossRefGoogle Scholar
  132. 132.
    Drury AN, Szent-Györgyi A (1929) The physiological activity of adenine compounds with special reference to their action upon the mammalian heart. J Physiol (Lond) 68:213–237Google Scholar
  133. 133.
    Duckies SP (1983) Age-related changes in adrenergic neuronal function of rabbit vascular smooth muscle. Neurobiol Aging 4:151–156CrossRefGoogle Scholar
  134. 134.
    Duckies SP. Said SI (1982) Vasoactive intestinal peptide as a neurotransmitter in the cerebral circulation. Eur J Pharmacol 78:371–374CrossRefGoogle Scholar
  135. 135.
    Duckies SP, Buck SM (1982) Substance P in the cerebral vasculature: depletion by capsaicin suggests a sensory role. Brain Res 245:171–174CrossRefGoogle Scholar
  136. 136.
    Duckies SP, Carter BJ, Williams CL (1985) Vascular adrenergic neuroeffector function does not decline in aged rats. Circ Res 56:109–116Google Scholar
  137. 137.
    Eckenstein F, Thoenen H (1982) Production of specific antisera and monoclonal antibodies to choline ace- tyltransferase: characterization and use for identification of cholinergic neurons. EMBO 1:363–368Google Scholar
  138. 138.
    Edvinsson L (1985) Characterization of the contractile effect of neuropeptide Y in feline cerebral arteries. Acta Physiol Scand 125:33–41PubMedCrossRefGoogle Scholar
  139. 139.
    Edvinsson L (1985) Functional role of perivascular peptides in the control of cerebral circulation. TINS 8(3): 126–131Google Scholar
  140. 140.
    Edvinsson L, Nielsen KC, Owman C et al. Sympathetic adrenergic influence on brain vessels as studied by changes in cerebral blood volume of mice. Eur Neurol 6:193–202Google Scholar
  141. 141.
    Edvinsson L, Nielsen KC, Owman C et al. (1972) Cholinergic mechanism in pial vessels. Histochemistry, electron microscopy and pharmacology. Z Zellforsch Mikrosk Anat 134:311–325PubMedCrossRefGoogle Scholar
  142. 142.
    Edvinsson L, Hardebo JC, Owman C (1978) Pharmacological analysis of 5-hydroxytryptamine receptors in isolated intracranial and extracranial vessels of cat and man. Circ Res 42:143–151PubMedGoogle Scholar
  143. 143.
    Edvinsson L, Fahrenkrug J, Hako J et al. (1980) VIP (vasoactive intestinal polypeptide)-containing nerves of intracranial arteries in mammals. Cell Tissue Res 208:135–142PubMedCrossRefGoogle Scholar
  144. 144.
    Edvinsson L, Uddman R (1981) Adrenergic, cholinergic and peptidergic nerve fibres in dura mater - involvement in headache? Cephalagia 1:175–179CrossRefGoogle Scholar
  145. 145.
    Edvinsson L, McCulloch J, Uddman R (1981) Substance P: immunohistochemical localization and effect upon cat pial arteries in vitro and in situ. J Physiol (Lond) 318:251–258Google Scholar
  146. 146.
    Edvinsson L, McCulloch J, Uddman R (1982) Feline cerebral veins and arteries: composition of autonomic innervation and vasomotor responses. J Physiol (Lond) 325:161–173Google Scholar
  147. 147.
    Edvinsson L, Uddman R (1982) Immunohistochemical localization and dilatory effect of substance P on human cerebral vessels. Brain Res 232:466–471PubMedCrossRefGoogle Scholar
  148. 148.
    Edvinsson L, Egund N, Owman CH et al. (1982) Reduced noradrenaline uptake and retention in cerebrovascular nerves associated with angiographically visible vasoconstriction following experimental subarachnoid hemorrhage in rabbits. Brain Res Bull 9:799–805PubMedCrossRefGoogle Scholar
  149. 149.
    Edvinsson L, Rosendal-Hegesen S, Uddman R (1983) Substance P: localization, concentration and release in cerebral arteries, choroid plexus and dura mater. Cell Tissue Res 234:1–7PubMedCrossRefGoogle Scholar
  150. 150.
    Edvinsson L, Degueurce A, Duverger D et al. (1983) Central serotonergic nerves project to the pial vessels of the brain. Nature 306:55–57PubMedCrossRefGoogle Scholar
  151. 151.
    Edvinsson L, Emson P, McCulloch J et al. (1983) Neuropeptide Y: cerebrovascular innervation and vasomotor effects in the cat. Neurosci Lett 43:79–84PubMedCrossRefGoogle Scholar
  152. 152.
    Edvinsson L, Emson P, McCulloch J et al. (1984) Neuropeptide Y: immunocytochemical localization to and effect upon feline pial arteries and veins in vitro and in situ. Acta Physiol Scand 122:155–163PubMedCrossRefGoogle Scholar
  153. 153.
    Edvinsson L, Ekblad E, Hakanson R et al. (1984) NPY- potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. Br J Pharmacol 83:519–525PubMedGoogle Scholar
  154. 154.
    Edvinsson L, Edman R, Ottoson A et al. (1985) Distribution, concentration and effects of neuropeptide-Y (NPY), substance P (SP) and vasoactive intestinal polypeptide (VIP) in human cerebral blood vessels. J Cereb Blood Flow Metab 5 [Suppl 1]:S545Google Scholar
  155. 155.
    Edvinsson L, McCulloch J, Sharkey J (1985) Vasomotor responses of cerebral arterioles in situ to putative dopamine receptor agonists. Br J Pharmacol 85:403–410PubMedGoogle Scholar
  156. 156.
    Edvinsson L, McCulloch J (1985) Distribution and vasomotor effects of peptide HI (PMI) in feline cerebral blood vessels in vitro and in situ. Regul Pept 10:345–356PubMedCrossRefGoogle Scholar
  157. 157.
    Ekblad E, Edvinsson L, Wahlestedt C et al. (1984) Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibres. Regul Pept 8:225–235PubMedCrossRefGoogle Scholar
  158. 158.
    Ekblad E, Rökaeus A, Hakanson R et al. (1985) Galanin nerve fibres in the rat gut: distribution, origin and projections. Neuroscience 16:355–363PubMedCrossRefGoogle Scholar
  159. 159.
    Eklund S, Fahrenkrug J, Jodal M et al. (1980) Vasoactive intestinal polypeptide, 5-hydroxytryptamine and reflex hyperaemia in the small intestine of the cat. J Physiol (London) 302:549–557Google Scholar
  160. 160.
    Eränko O, Eränko L (1971) Loss of histochemically demonstrable catecholamines and acetylcholinesterase from sympathetic nerve fibres of the pineal body of the rat after chemical sympathectomy with 6-hydroxy- dopamine. Histochem J 3:357–363PubMedCrossRefGoogle Scholar
  161. 161.
    Erspamer V, Melchiorri P, Sopranzi N (1972) The action of bombesin on the systemic arterial blood pressure of some experimental animals. Br J Pharmacol 45:442–450PubMedGoogle Scholar
  162. 162.
    Euler US von, Gaddum JH (1931) An unidentified depressor substance in certain tissue extracts. J Physiol (Lond) 72:74Google Scholar
  163. 163.
    Falck B, Hillarp NA, Thieme G et al. (1962) Fluorescence of catecholamines and related compounds condensed with formaldehyde. J Histochem Cytochem 10:348–354CrossRefGoogle Scholar
  164. 164.
    Falck B, Owman Ch (1965) A detailed methodological description of the fluorescence method for the cellular demonstration of biogenic monoamines. Acta Univ Lund Sect 27:1–23Google Scholar
  165. 165.
    Felten DL, Crutcher KA (1979) Neuronal-vascular relationships in the raphe nuclei, locus coeruleus, and substantia nigra in primates. Am J Anat 155:467–482PubMedCrossRefGoogle Scholar
  166. 166.
    Ferguson M, Bell C (1985) Substance P-immu- noreactive nerves in the rat kidney. Neurosci Lett 60:183–188PubMedCrossRefGoogle Scholar
  167. 167.
    Fisher LA, Kikkawa DO, Rivier JE et al. (1983) Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide. Nature 305:534–536PubMedCrossRefGoogle Scholar
  168. 168.
    Forssman BB, Hock D, Metz J (1982) Peptidergic innervation of the kidney. Neurosci Lett [Suppl] 10:S183Google Scholar
  169. 169.
    Forster C, Drew GM, Hilditch A et al. (1983) Dopamine receptors in human basilar arteries. Eur J Pharmacol 87:227–235PubMedCrossRefGoogle Scholar
  170. 170.
    Franco-Cereceda A, Dahlöf C, Lundberg JM (1985) Role of neuropeptide Y and calcitonin-gene related peptide (CGRP) in cardiac sympathetic and sensory control. Acta Physiol Scand [Suppl] 124:136CrossRefGoogle Scholar
  171. 171.
    Fraser RAR, Stein BM, Barrett RE et al. (1970) Noradrenergic mediation of experimental cerebrovascular spasm. Stroke 1:356–362PubMedCrossRefGoogle Scholar
  172. 172.
    Freund H, Ebeid AM, Fischer JE (1981) An increase in vasoactive intestinal peptide levels in canine endotoxin shock. Surg Gynecol Obstet 152:604–606PubMedGoogle Scholar
  173. 173.
    Fukuda M, Hosoki E, Ishida Y et al. (1985) Opioid receptor types on adrenergic nerve terminals of rabbit ear artery. Br J Pharmacol 86:539–545PubMedGoogle Scholar
  174. 174.
    Furchgott RF (1981) The requirement for endothelial cells in the relaxation of arteries by acetylcholine and some other vasodilators. Trends Pharmacol Sci 2:173–176CrossRefGoogle Scholar
  175. 175.
    Furchgott RF (1983) Role of endothelium in responses of vascular smooth muscle. Circ Res 53:557–573PubMedGoogle Scholar
  176. 176.
    Furness JB (1973) Arrangement of blood vessels and their relation with adrenergic nerves in the rat mesentery. J Anat 115:346–364Google Scholar
  177. 177.
    Furness JB, Costa M, Wilson AJ (1977) Water-stable fluorophores produced by reaction with aldehyde solution, for the histochemical localization of catecholand indole thylamine. Histochemistry 52:159–170PubMedCrossRefGoogle Scholar
  178. 178.
    Furness JB, Papka RE, Della NG et al. (1982) Substance P-like immunoreactivity in nerves associated with the vascular system of guinea-pigs. Neuroscience 7:447–459PubMedCrossRefGoogle Scholar
  179. 179.
    Furness JB, Costa M, Eckenstein F (1983) Neurones localized with antibodies against choline ace- tyltransferase in the enteric nervous system. Neurosci Lett 40:105–109PubMedCrossRefGoogle Scholar
  180. 180.
    Furness JB, Costa M, Keast JR (1984) Choline ace- tyltransferase and peptide immunoreactivity of sub- mucous neurons in the small intestine of the guinea- pig. Cell Tissue Res 237:329–336PubMedCrossRefGoogle Scholar
  181. 181.
    Furness JB, Costa M, Papka RE et al. (1984) Neuropeptides contained in peripheral cardiovascular nerves. Clin Exp Hypertens [A] 6 (12):91–106CrossRefGoogle Scholar
  182. 182.
    Furness JB, Costa M, Gibbins IL et al. (1985) Neuro- chemically similar myenteric and submucous neurons directly traced to the mucosa of the small intestine. Cell Tissue Res 241:155–163PubMedCrossRefGoogle Scholar
  183. 183.
    Gabella G (1976) Structure of the autonomic nervous system. Chapman and Hall, LondonCrossRefGoogle Scholar
  184. 184.
    Gaddum JH, Picarelli ZP (1957) Two kinds of tryp- tamine receptor. Br J Pharmacol 12:323–328Google Scholar
  185. 185.
    Gamse R, Leeman SE, Holzer P et al. (1981) Differential aspects of capsaicin on the content of somatostatin, substance P and neurotensin in the nervous system of the rat. Naunyn Schmiedebergs Arch Pharmacol 317:140PubMedCrossRefGoogle Scholar
  186. 186.
    Gaudin-Chazel G, Portalier P, Barrit MC et al. (1982) Serotonin-like immunoreactivity in paraffin sections of the nodose ganglia of the cat. Neurosci Lett 33:169–172CrossRefGoogle Scholar
  187. 187.
    Gautret B, Schmidt H (1985) Central and peripheral sites for cardiovascular actions of Dynorphin- (1–13) in rats. Eur J Pharmacol 111:263–266PubMedCrossRefGoogle Scholar
  188. 188.
    Gazelius B, Olgart L (1980) Vasodilatation in the dental pulp produced by electrical stimulation of the inferior olveolar nerve in the cat. Acta Physiol Scand 108:181–186PubMedCrossRefGoogle Scholar
  189. 189.
    Gazelius B, Edwall B, Lundberg J et al. (1985) Calcitonin gene-related peptide (CGRP), a potent vasodilator related to sensory nerves in the cat. Acta Physiol Scand [Suppl] 124:134Google Scholar
  190. 190.
    Geffen LB, Livett DB, Rush RA (1969) Immunohistochemical localization of protein components of catecholamine storage vesicles. J Physiol (Lond) 204:593–605Google Scholar
  191. 191.
    Geller RG, Govier WC, Pisano JJ et al. (1970) The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals. Br J Pharmacol 40:605–616PubMedGoogle Scholar
  192. 192.
    Gibbins IL, Brayden JE, Bevan JA (1984) Perivascular nerves with immunoreactivity to vasoactive intestinal polypeptide in cephalic arteries of the cat: distribution, possible origins and functional implications. Neuroscience 13:1327–1346PubMedCrossRefGoogle Scholar
  193. 193.
    Gibbins IL, Morris J-L, Furness JB et al. (1985) Neuropeptide Y and dynorphin in noradrenergic neurons and substance P in presumptive cholinergic neurons innervating the guinea-pig iris. Proc Aust Physiol Pharmacol Soc 16(2):91PGoogle Scholar
  194. 194.
    Gibbins IL, Furness JB, Costa M et al. (1985) Colocalization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous vascular and visceral sensory neurons of guinea-pigs. Neurosci Lett 57:125–130PubMedCrossRefGoogle Scholar
  195. 195.
    Gibson SJ, Polak JM, Bloom SR et al. (1984) Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species. J Neurosci 4:3101–3111PubMedGoogle Scholar
  196. 196.
    Glover WE (1985) Increased sensitivity of rabbit ear artery to noradrenaline following perivascular nerve stimulation may be a response to neuropeptide Y released as cotransmitter. Clin Exp Pharmacol Physiol 12:227–230PubMedCrossRefGoogle Scholar
  197. 197.
    Gokhale SD, Gulati OD, Kelkar LV et al. (1966) Effects of some drugs on human umbilical artery in vitro. Br J Pharmacol 27:332–346Google Scholar
  198. 198.
    Goldberg LI, Kohli JD (1981) Specific dopamine receptors in vascular smooth muscle. In: Vanhoutte PM, Leussen I (eds) Vasodilatation. Raven Press, New York, pp 131–140Google Scholar
  199. 199.
    Gräb W, Jenssen S, Rein N (1929) Die leberals Blutdepot. Klin Wochschr 8:1539–1548CrossRefGoogle Scholar
  200. 200.
    Greenwald SE, Lever MJ, MacIntyre I et al. (1985) Human calcitonin gene-related peptide is a potent vasodilator in the pig coronary circulation. Proc Br Pharmacol Soc (Abstracts) 1985, 18–20Google Scholar
  201. 201.
    Greenway CV, Lawson AE (1966) The effects of adrenaline and noradrenaline on venous return and regional blood flow in the anaesthetised cat with special reference to intestinal blood flow. J Physiol (Lond) 186:579–595Google Scholar
  202. 202.
    Griffith SG, Lincoln J, Burnstock G (1982) Serotonin as a neurotransmitter in cerebral arteries. Brain Res 247:388–392PubMedCrossRefGoogle Scholar
  203. 203.
    Griffith SG, Burnstock G (1983) Serotoninergic neurons in human fetal intestine: an immu- nohistochemical study. Gastroenterology 85:929–937PubMedGoogle Scholar
  204. 204.
    Griffith SG, Burnstock G (1983) Immunohistochemical demonstration of serotonin in nerves supplying human cerebral and mesenteric blood-vessels: some speculations about their involvement in vascular disorders. Lancet I:561–562PubMedCrossRefGoogle Scholar
  205. 205.
    Grigor’eva TA (1962) The innervation of blood vessels. Pergamon Press, New YorkGoogle Scholar
  206. 206.
    Gu J, Huang WM, Blank M et al. (1983) Measurement of VIP and origin of its innervation in the rat urinary bladder. Regul Pept 6(3):305CrossRefGoogle Scholar
  207. 207.
    Gu J, Polak JM, Allen JM, et al. (1984) High concentrations of a novel peptide, Neuropeptide Y, in the innervation of mouse and rat heart. J Histochem Cytochem 32:467–472PubMedCrossRefGoogle Scholar
  208. 208.
    Hallberg D, Pernow B (1975) Effect of substance P on various vascular beds in the dog. Acta Physiol Scand 93:277–285PubMedCrossRefGoogle Scholar
  209. 209.
    Hanko J, Hardebo JE, Owman Ch (1981) Effects of various neuropeptides on cerebral blood flow. J Cereb Blood Flow Metab 1:S346-S347Google Scholar
  210. 210.
    Hanko JH, Tornebrandt K, Hardebo JE et al. (1985) Neuropeptide Y induces and modulates vasoconstriction in intracranial and peripheral vessels of animals and man. J Cereb Blood Flow Metab 5 [Suppl 1]:S511Google Scholar
  211. 211.
    Hanko J, Hardebo JE, Kahrström J et al. (1985) Calcitonin gene-related peptide is present in mammalian cerebrovascular nerve fibres and dilates pial and peripheral arteries. Neurosci Lett 57:91–95PubMedCrossRefGoogle Scholar
  212. 212.
    Hanko J, Sundler F, Hardebo JE et al. (1985) Dilatation of pial and peripheral arteries by calcitonin gene- related peptides. J Cereb Blood Flow Metab 5 [Suppl 1]:S507Google Scholar
  213. 213.
    Hanley MR, Benton HP, Lightman SL et al. (1984) A vasopressin-like peptide in the mammalian sympathetic nervous system. Nature 309:258–261PubMedCrossRefGoogle Scholar
  214. 214.
    Häppölä O, Pä värinta H, Soinila S et al. (1986) Pre- and postnatal development of 5-hydroxytryptamine- immunoreactive cells in the superior cervical ganglion of the rat. J Auton Nerv Syst 15:21–31PubMedCrossRefGoogle Scholar
  215. 215.
    Hara H, Hamill GS, Jacobowitz DM (1985) Origin of cholinergic nerves to the rat major cerebral arteries: coexistence with vasoactive intestinal polypeptide. Brain Res Bull 14:179–188PubMedCrossRefGoogle Scholar
  216. 216.
    Hardebo JE, Hanko J, Kährström J et al. (1985) Endothelium-dependent relaxation in cerebral arteries. J Cereb Flood Flow Metab 5 [Suppl 1]:S533Google Scholar
  217. 217.
    Head RJ, Stitzel RE, Delaland IS et al (1977) Effect of chronic denervation on activities of monoamineoxidase and catechol-O-methyl transferase and on contents of noradrenaline and adenosine-triphosphate in rabbit ear artery. Blood Vessels 14:229–239PubMedGoogle Scholar
  218. 218.
    Hedge GA, Huffman LF, Grunditz T et al. (1984) Immunocytochemical studies of the peptidergic innervation of the thyroid gland in the Brattleboro rat. Endocrinology 115:2071–2076PubMedCrossRefGoogle Scholar
  219. 219.
    Helke CJ, O’Donohue TL, Jacobowitz DM (1980) Substance P as a baro- and chemoreceptor afferent neurotransmitter: immunocytochemical and neurochemical evidence in the rat. Peptides 1:1–9PubMedCrossRefGoogle Scholar
  220. 220.
    Hellstrand P, Järhult J (1980) Effects of nine different gastrointestinal polypeptides on vascular smooth muscle in vitro. Acta Physiol Scand 110:89–94PubMedCrossRefGoogle Scholar
  221. 221.
    Hellstrand P, Fahrenkrug J, Uddman R et al. (1985) Role of vasoactive intestinal polypeptide (VIP) in the neurogenic vasodilatation of the portal vein in the rabbit. Regul Pept 12:309–316PubMedCrossRefGoogle Scholar
  222. 222.
    Hendry SHC, Jones EG, Beinfeld MC (1983) Chole- cystokinin-immunoreactive neurons in rat and monkey cerebral cortex make symmetric synapses and have intimate associations with blood vessels. Proc Natl Acad Sci USA 80:2400–2404PubMedCrossRefGoogle Scholar
  223. 223.
    Hill CE, Hirst GDS, Van Helden DF (1983) Development of sympathetic innervation to proximal and distal arteries of the rat mesentery. J Physiol (Lond) 338:129–147Google Scholar
  224. 224.
    Hillarp N-A (1946) Structure of the synapse and the peripheral innervation apparatus of the autonomic nervous system. Acta Anat [Suppl 4]: 1–153Google Scholar
  225. 225.
    Hirst GDS, Neild TO (1980) Evidence for two populations of excitatory receptors for noradrenaline on arteriolar smooth muscle. Nature 283:767–768PubMedCrossRefGoogle Scholar
  226. 226.
    Hogaboom GK, O’Donnell JP, Fedan JS (1980) Purinergic receptors: photoaffinity analog of adenosine triphosphate is a specific adenosine triphosphate antagonist. Science 208:1273–1275PubMedCrossRefGoogle Scholar
  227. 227.
    Hökfelt T, Kellerth J-O, Nilsson G et al. (1975) Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Brain Res 100:235–252PubMedCrossRefGoogle Scholar
  228. 228.
    Hökfelt T, Johansson O, Kellerth J-O (1977) Immunohistochemical distribution of substance P. In: Von Euler, US, Pernow B (eds) Substance P. Raven Press, New York, pp 117–145Google Scholar
  229. 229.
    Hökfelt T, Lundberg JM, Schultzberg M et al. (1981) Immunohistochemical evidence for a local VIP-ergic neuron system in the adrenal gland of the rat. Actas Physiol Scand 113:575–576CrossRefGoogle Scholar
  230. 230.
    Holmgren S, Vaillant C, Dimaline R (1982) VIP-, substance P-, gastrin/CCK-, bombesin-, somatostatin- and glucagon-like immunoreactivities in the gut of the rainbow trout, Salmo gairdneń. Cell Tissue Res 223:141–153PubMedCrossRefGoogle Scholar
  231. 231.
    Holton P (1959) The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol (Lond) 145:494–504Google Scholar
  232. 232.
    Holzer P, Gamse R, Lembeck F (1980) Distribution of substance P in the rat gastrointestinal tract - lack of effect of capsaicin pretreatment. Eur J Pharmacol 61:303PubMedCrossRefGoogle Scholar
  233. 233.
    Holzer P, Ducsics A, Lembeck F (1982) Distribution of capsaicin-sensitive nerve fibres containing immuno- reactive substance P in cutaneous and visceral tissues of the rat. Neurosci Lett 31:253PubMedCrossRefGoogle Scholar
  234. 234.
    Honig CR, Frierson JL (1976) Neurons intrinsic to arterioles initiate postcontraction vasodilation. Am J Physiol 230:493–507PubMedGoogle Scholar
  235. 235.
    Honma S (1970) Presence of monoaminergic neurons in the spinal cord and intestine of the Lamprey, Lampetra japonica. Arch Histol Jpn 32:383–393PubMedGoogle Scholar
  236. 236.
    Humphrey PPA, Feniuk W, Watts AD (1983) Prejunctional effects of 5-hydroxytryptamine on noradrenergic nerves in the cardiovascular system. Fed Proc 42:218–222PubMedGoogle Scholar
  237. 237.
    Iijima T (1977) A histochemical study of the innervation of cerebral blood vessels in the turtle. J Comp Neurol 176:307–314PubMedCrossRefGoogle Scholar
  238. 238.
    Iijima T, Wasano T (1980) A histochemical and ultra- structural study of serotonin-containing nerves in cerebral blood vessels of the lamprey. Anat Rec 198:671–680PubMedCrossRefGoogle Scholar
  239. 239.
    Itakura T, Okuno T, Nakakita K et al. (1984) A light and electron microscopic immunohistochemical study of vasoactive intestinal polypeptide- and substance P- containing nerve fibres along the cerebral blood vessels: Comparison with aminergic and cholinergic nerve fibres. J Cereb Blood Flow Metab 4:407–414PubMedCrossRefGoogle Scholar
  240. 240.
    Itakura T, Yokote H, Kumura H et al. (1985) 5- Hydroxytryptamine innervation of vessels in the rat cerebral cortex. Immunohistochemical findings and hydrogen clearance study of CBF. J Neurosurg 62:42–47PubMedCrossRefGoogle Scholar
  241. 241.
    Hakura T, Nakai K, Nakakita K et al. (1985) Autoradiographic demonstration of adrenergic receptors in cerebral blood vessels. J of Cereb Blood Flow Metab 5 [Suppl 1]:S495Google Scholar
  242. 242.
    Järhult J, Hellstrand P, Sundler F (1980) Immunohistochemical localization and vascular effects of vasoactive intestinal polypeptide in skeletal muscle of the cat. Cell Tissue Res 207:55–64PubMedCrossRefGoogle Scholar
  243. 243.
    Järhult J, Fahrenkrug J, Hellstrand P et al. (1982) VIP (vasoactive intestinal polypeptide)-immunoreactive innervation of the portal vein. Cell Tissue Res 221:617–625PubMedCrossRefGoogle Scholar
  244. 244.
    Jessen KR, Saffrey MJ, Van Noorden S et al. (1980) Immunohistochemical studies of the enteric nervous system in tissue culture and in situ: localization of vasoactive intestinal polypeptide (VIP), substance P and enkephalin immunoreactive nerves in the guinea- pig gut. Neuroscience 5:1717–1735PubMedCrossRefGoogle Scholar
  245. 245.
    Jójárt I, Joó F, Siklós L, László FA (1984) Immunoelectronhistochemical evidence for innervation of brain microvessels bu vasopressin-immunoreactive neurons in the rat. Neurosci Lett 51:259–264PubMedCrossRefGoogle Scholar
  246. 246.
    Kai-Kai MA, Ken P (1985) Localization of 5-hydro- zytryptamine to neurons and endoneurial mast cells in rat sensory ganglia. J Neurocytol 14:63–78PubMedCrossRefGoogle Scholar
  247. 247.
    Kalkman HO, Boddeke HWGM, Doods HN et al. (1981) Hypotensive activity of serotonin receptor agonists in rats is related to their affinity for 5-HT, receptors. Eur J Pharmacol 91:155–156CrossRefGoogle Scholar
  248. 248.
    Kamilkawa Y, Cline JR, Su C (1980) Diminished purinergic modulation of the vascular adrenergic neu- trotransmission in spontaneously hypertensive rats. Eur J Pharmacol 66:347–353CrossRefGoogle Scholar
  249. 249.
    Kapadia SE, de Lanerolle NC (1984) Immunohistochemical and electron microscopic demonstration of vascular innervation in the mammalian brain stem. Brain Res 292:33–39PubMedCrossRefGoogle Scholar
  250. 250.
    Karenkan K-S, Chao LP (1981) Localization of choline acetyltransferase at neuromuscular junctions. Muscle Nerve 4:91–93CrossRefGoogle Scholar
  251. 251.
    Karnovsky MJ, Roots L (1964) A “direct coloring” thiocholine method for Cholinesterase. J Histochem Cytochem 12:219–221PubMedCrossRefGoogle Scholar
  252. 252.
    Kása P, Mann SP, Hebb C (1970) Localization of choline acetyltransferase. Nature 226:812–814PubMedCrossRefGoogle Scholar
  253. 253.
    Kasakov L, Burnstock G (1983) The use of the slowly degradable analog, α-ß -methylene ATP, to produce desensitisation of the P2-purinoceptor: effect on non- adrenergic, noncholinergic responses of the guinea-pig urinary bladder. Eur J Pharmacol 86:291–294CrossRefGoogle Scholar
  254. 254.
    Katsuragi T, Su C (1980) Purine release from vascular adrenergic nerves by high potassium and a calcium ionophore A-23187. J Pharmacol Exp Ther 215:685–690PubMedGoogle Scholar
  255. 255.
    Katsuragi T, SU C (1982) Augmentation by theophylline of (3H) purine release from vascular adrenergic nerves: evidence for presynaptic autoinhibition. J Pharmacol Exp Ther 220:152–156PubMedGoogle Scholar
  256. 256.
    Katz B (1966) Nerve, muscle and synapse. McGraw- Hill, New YorkGoogle Scholar
  257. 257.
    Kennedy C, Burnstock G (1985) Evidence for two types of P2-purinoceptors in the longitudinal muscle of the rabbit portal vein. Eur J Pharmacol 111:49–56PubMedCrossRefGoogle Scholar
  258. 258.
    Kennedy C, Delbro D, Burnstock G (1985) P2-Puri- noceptors mediate both vasodilation (via the endothelium) and vasoconstriction of the isolated rat femoral artery. Eur J Pharamcol 107:161–168CrossRefGoogle Scholar
  259. 259.
    Kilborn MJ, Potter EK, McCloskey DI (1985) Neuromodulation of the cardiac vagus: comparison of neuropeptide Y and related peptides. Regul Pept 12:155–161PubMedCrossRefGoogle Scholar
  260. 260.
    Kobayashi S, Tsukahara S, Sugita K et al. (1981) Adrenergic and cholinergic innervation of rat cerebral arteries. Histochem 70:129–138CrossRefGoogle Scholar
  261. 261.
    Kobayashi S, Kyoshima K, Olschowka JA et al. (1983) Vasoactive intestinal polypeptide immunoreactive and cholinergic nerves in the whole mount preparation of the major cerebral arteries of the rat. Histochemistry 79:377–381PubMedCrossRefGoogle Scholar
  262. 262.
    Kobayashi H, Wada A, Izumi F et al. (1985) Alpha- adrenergic receptors in cerebral microvessels of nor- motensive and hypertensive rats. Circ Res 56:402–409PubMedGoogle Scholar
  263. 263.
    Koelle GB, Friedenwald JS (1949) A histochemical method for localizing Cholinesterase activity. Proc Soc Exp Biol Med 70:617–622PubMedGoogle Scholar
  264. 264.
    Kubo T, Su C (1983) Effects of adenosine on [3H] norepinephrine release from perfused mesenteric arteries of SHR and renal hypertensive rats. Eur J Pharmacol 87:349–352PubMedCrossRefGoogle Scholar
  265. 265.
    Kügelen IV, Starke K (1985) Noradrenaline and adenosine triphosphate as co-transmitters of neurogenic vasoconstriction in rabbit mesenteric artery. J Physiol (Lond) 367:435–455Google Scholar
  266. 266.
    Lagnado MLJ, Crowe R, Lincoln J et al. (1988) A reduction of nerves containing vasoactive intestinal polypeptide and serotonin, but not neuropeptide Y and noradrenaline in cerebral blood vessel of the 8 week streptozotocin-induced diabetic rat. Blood Vessels (in press)Google Scholar
  267. 267.
    Lamotte CC, Johns DR, de Lanerolle NC (1982) Immunohistochemical evidence of indolamine neurons in Monkey spinal cord. J Comp Neurol 206:359–370PubMedCrossRefGoogle Scholar
  268. 268.
    Lands AM, Arnold A, McAuliff JP et al. (1967) Differentiation of receptor systems activated by sympathomimetic amines. Nature 214:597–598PubMedCrossRefGoogle Scholar
  269. 269.
    Langer SZ (1974) Presynaptic regulation of the release of catecholamines. Pharmacol Rev 23:1793–1800Google Scholar
  270. 270.
    Larsson L-I, Fahrenkrug J, Schaffalitzky de Muckadell O et al. (1976) Localization of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons. Proc Natl Acad Sci USA 73:3197–3200PubMedCrossRefGoogle Scholar
  271. 271.
    Larsson L-I, Edvinsson L, Fahrenkrug J et al. (1976) Immunohistochemical localization of a vasoactive polypeptide (VIP) in cerebrovascular nerves. Brain Res 113:400–404PubMedCrossRefGoogle Scholar
  272. 272.
    Larsson L-I, Fahrenkrug J, Schaffalitzky de Muckadell O (1977) Occurrence of nerves containing vasoactive intestinal polypeptide immunoreactivity in the male genital tract. Life Sci 21:503–508PubMedCrossRefGoogle Scholar
  273. 273.
    Larsson L-I, Fahrenkrug J, Schaffalitzky de Muckadell O (1977) Vasoactive intestinal polypeptide occurs in nerves of the female genitourinary tract. Science 197:1374–1375PubMedCrossRefGoogle Scholar
  274. 274.
    Lechin F, Van der Dijs B, Lechin E et al. (1978) The dopaminergic and noradrenergic blockades: a new treatment for headache. Headache 18: 69–74PubMedCrossRefGoogle Scholar
  275. 275.
    Lee TJ-F, Saito A (1984) Altered cerebral vessel innervation in the spontaneously hypertensive rat. Circ Res 55:393–403Google Scholar
  276. 276.
    Lee TJ-F, Saito A, Berezin I (1984) Vasoactive intestinal polypeptide-like substance: the potential transmitter for cerebral circulation. Science 224:898–901PubMedCrossRefGoogle Scholar
  277. 277.
    Lee Y, Takami K, Kawai Y et al. (1985) Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P. Neuroscience 15:1227–1237PubMedCrossRefGoogle Scholar
  278. 278.
    Lembeck F, Holzer P (1979) Substance P as neurogenic mediator of antidromic vasocilation and neurogenic plasma extravasation. Naunyn Schmiedebergs Arch Pharmacol 310:175PubMedCrossRefGoogle Scholar
  279. 279.
    Lembeck F, Donnerer J, Bartho L (1982) Inhibition of neurogenic vasodilatation and plasma extravasation by substance P antagonists, somatostatin and (D-METZ, PRO5) enkephalinamide. Eur J Pharmacol 85:171–176PubMedCrossRefGoogle Scholar
  280. 280.
    Levitt B, Westfall DP (1982) Factors influencing the release of purines and norepinephrine in the rabbit portal vein. Blood Vessels 19:30–40PubMedGoogle Scholar
  281. 281.
    Liang CC (1975) A possible sympathetic cholinergic mechanism in the renal reflex elicited by stimulation of abdominal viscera in the dog. Clin Exp Pharmacol Physiol 2:103–117PubMedCrossRefGoogle Scholar
  282. 282.
    Lindvall O, Björklund A (1974) The glyoxylic acid fluorescence histochemical method: a detailed account of the methodology for the visualization of central catecholamine neurons. Histochemistry 39:97–127PubMedCrossRefGoogle Scholar
  283. 283.
    Lindvall M, Alumets J, Edvinsson L et al. (1978) Peptidergic (VIP) nerves in the mammalian choroid plexus. Neurosci Lett 9:77–82PubMedCrossRefGoogle Scholar
  284. 284.
    Liu-Chen LY, Mayberg M, Moskowitz MA (1983) Immunohistochemical evidence for a substance P-con- taining trigemino-vascular pathway to pial arteries in cats. Brain Res 268:162–166PubMedCrossRefGoogle Scholar
  285. 285.
    Liu-Chen LY, Gillespie SA, Norregaard TV et al. (1984) Cholecystokinin-8 (CCK8) immunoreactivity in cerebral arteries and pia arachnoid and the effect of unilateral trigeminal ganglionectomy. Fed Proc 43:304Google Scholar
  286. 286.
    Lobato RD, Marin J, Salaices M et al. (1980) Effect of experimental subarachnoid hemorrhage on the adrenergic innervation of cerebral arteries. J Neurosurg 53:477–479PubMedCrossRefGoogle Scholar
  287. 287.
    Londos C, Cooper DMF, Wolff J (1980) Subclasses of external adenosine receptors. Proc Natl Acad Sci USA 77:2551–2554PubMedCrossRefGoogle Scholar
  288. 288.
    Low PA, Walsh JC, Huang CY et al. (1975) The sympathetic nervous system in alcoholic neuropathy. A clinical and pathological study. Brain 98:357–364PubMedCrossRefGoogle Scholar
  289. 289.
    Lundberg JM (1981) Evidence for coexistence of vasoactive intestinal polypeptide (VIP) and acetylcholine in neurons of cat exocrine glands: morphological, biochemical and functional studies. Acta Physiol Scand [Suppl 496]: 1–57Google Scholar
  290. 290.
    Lundberg J, Ljung B, Stage D et al. (1976) Postnatal autogenic development of the adrenergic innervation pattern in rat portal vein: a histochemical study. Cell Tissue Res 172:15–27PubMedCrossRefGoogle Scholar
  291. 291.
    Lundberg JM, Hökfelt T, Schultzberg M et al. (1979) Occurrence of vasoactive intestinal polypeptide (VIP)- like immunoreactivity in certain cholinergic neurons of the cat: evidence from combined immunohistochem- istry and acetylcholinesterase staining. Neuroscience. 4:1539–1559PubMedCrossRefGoogle Scholar
  292. 292.
    Lundberg JM, Hökfelt T, Fahrenkrug J et al. (1979) Peptides in the cat carotid body (glomus caroticum): VIP-, enkephalin-, and substance P-like immunoreactivity. Acta Physiol Scand 107:279–281PubMedCrossRefGoogle Scholar
  293. 293.
    Lundberg JM, Hökfelt T, Änggärd et al. (1980) Peripheral peptide neurons: distribution, axonal transport, and some aspects on possible function. In: Costa E, Trabucchi M (eds) Advances in biochemical psychopharmacology, vol 22. Neural peptides and neuronal communication. Raven Press, New York, pp 25–36Google Scholar
  294. 294.
    Lundberg JM, Änggärd A, Fahrenkrug J et al. (1980) Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: functional significance of coexisting transmitters for vasodilation and secretion. Proc Natl Acad Sci USA 77:1651–1655PubMedCrossRefGoogle Scholar
  295. 295.
    Lundberg JM, Hökfelt T, Änggärd A et al. (1980) Peripheral peptide neurons: distribution, axonal transport, and some aspects on possible function. In: Costa E, Trabucchi M (eds) Advances in biochemical psychopharmacology, vol 22. Neural peptides and neuronal communication. Raven Press, New York, pp 25–36Google Scholar
  296. 296.
    Lundberg JM, Hökfelt T, Änggärd A et al. (1980) Coexistence of an avian pancreatic polypeptide (APP) immunoreactive substance and catecholamines in some peripheral and central neurons. Acta Physiol Scand 110:107–109PubMedCrossRefGoogle Scholar
  297. 297.
    Lundberg JM, Änggärd A, Emson P et al. (1981) Vasoactive intestinal polypeptide and cholinergic mechanisms in cat nasal mucosa: studies on choline acetyltransferase and release of vasoactive intestinal polypeptide. Proc Natl Acad Sci USA 78:5255–5259PubMedCrossRefGoogle Scholar
  298. 298.
    Lundberg JM, Terenius L, Hökfelt T et al. (1982) Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol Scand 116:477–480PubMedCrossRefGoogle Scholar
  299. 299.
    Lundberg JM, Änggärd A, Fahrenkrug J (1982) VIP as a mediator of hexamethonium-sensitive, atropine- resistant vasodilation in the cat tongue. Acta Physiol Scand 116:387–392PubMedCrossRefGoogle Scholar
  300. 300.
    Lundberg JM, Tatemoto K (1982) Pancreatic polypeptide family (APP, BPP, NPY and NPY) in relation to sympathetic vasoconstriction resistant to α-adreno- ceptor blockade. Acta Physiol Scand 116:393–402PubMedCrossRefGoogle Scholar
  301. 301.
    Lundberg JM, Saria A (1982) Vagal substance P nerves involved in control of vascular permeability and smooth muscle tone in trachea and bronchi. Br J Pharmacol 77:441PGoogle Scholar
  302. 302.
    Lundberg JM, Terenius L, Hökfelt T et al. (1983) High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci Lett 42:167–172PubMedCrossRefGoogle Scholar
  303. 303.
    Lundberg JM, Fahrenkrug J, Larsson O et al. (1984) Corelease of vasoactive intestinal polypeptide and peptide histidine isolencine in relation to atropine- resistant vasodilatation in cat submandibular salivary gland. Neurosci Lett 52:37–42PubMedCrossRefGoogle Scholar
  304. 304.
    Lundberg JM, Änggärd A, Pernow J et al. (1985) Neuropeptide Y-, substance P- and VIP-immunoreactive nerves in cat spleen in relation to autonomic vascular and volume control. Cell Tissue Res 239:9–18PubMedCrossRefGoogle Scholar
  305. 305.
    Lundberg JM, Saria A, Franco-Cerceda A et al. (1985) Differential effects of reserpine and 6-hydroxydopa- mine on neuropeptide Y (NPY) and noradrenaline in peripheral neurons. Naunyn Schmiedebergs Arch Pharmacol 328:331–340PubMedCrossRefGoogle Scholar
  306. 306.
    Lundberg JM, Franco-Cereceda A, Hua X et al. (1985) Coexistence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin. Eur J Pharmacol 108:315–319PubMedCrossRefGoogle Scholar
  307. 307.
    Lundvall J, Järhult J (1976) Beta-adrenergic dilator component of the sympathetic vascular response in skeletal muscle. Acta Physiol Scand 96:180–192PubMedCrossRefGoogle Scholar
  308. 308.
    Mabe Y, Tatemoto K, Huidobro-Turo JP (1985) Neuropeptide Y- induced pressor responses: Activation of a non-adrenergic mechanism, potentiation by reserpine and blockade by nifedipine. Eur J Pharmacol 116:33–39PubMedCrossRefGoogle Scholar
  309. 309.
    Malm L, Sundler F, Uddman R (1980) Effects of vasoactive intestinal polypeptide on resistance and capacitance vessels in the nasal mucosa. Acta Otolaryngol (Stockh) 90:304–308CrossRefGoogle Scholar
  310. 310.
    Matsuyama T, Shiosaka S, Matsumoto M et al. (1983) Overall distribution of vasoactive intestinal polypeptide-containing nerves on the wall of cerebral arteries: an immunohistochemical study using whole- mounts. Neuroscience 10:89–96PubMedCrossRefGoogle Scholar
  311. 311.
    Matsuyama T, Matsumoto M, Shiosaka S et al. (1984) dual innervation of substance P-containing neuron system in the wall of the cerebral arteries. Brain Res 322:144–147PubMedCrossRefGoogle Scholar
  312. 312.
    Matsuyama T, Matsumoto M, Shiosaka S et al. (1984) Serotonergic and peptidergic innervation of the cerebral arteries: an immunohistochemical and electron microscopic study. Neurosci Lett [Suppl 17]:S118Google Scholar
  313. 313.
    Mattiason A, Ekblad E, Sundler F et al. (1985) Origin and distribution of neuropeptide Y-, vasoactive intestinal polypeptide- and substance P- containing nerve fibres in the urinary bladder of the rat. Cell Tissue Res 239:141–146CrossRefGoogle Scholar
  314. 314.
    McCulloch J (1983) Peptides and the microregulation of blood flow in the brain. Nature 304:120PubMedCrossRefGoogle Scholar
  315. 315.
    McCulloch J (1984) Role of dopamine in interactions among cerebral function, metabolism and blood flow. In: MacKenzie ET et al. (eds) Neurotransmitters and the cerebral circulation. (LERS Monograph, vol 2) Raven Press, New York, pp 137–155Google Scholar
  316. 316.
    McCulloch J (1984) Perivascular nerve fibres and the cerebral circulation. TINS 7(5): 135–138Google Scholar
  317. 317.
    McCulloch J, Edvinsson L (1980) The effects of vasoactive intestinal polypeptide upon pial arteriolar calibre, cerebral blood flow, cerebral oxygen consumption and the electroencephalogram. Am J Physiol 238:H449–456PubMedGoogle Scholar
  318. 318.
    McGrath JC (1982) Evidence for more than one type of postjunctional α-adrenoceptor. Biochem Pharmacol 31:467–484PubMedCrossRefGoogle Scholar
  319. 319.
    McGrath JC (1983) The variety of vascular α-adre- noceptors. TIPS 4:14–18Google Scholar
  320. 320.
    McKenna OC, Angelakos ET (1968) Acetylcholinesterase-containing nerve fibres in the canine kidney. Circ Res 23:645–651PubMedGoogle Scholar
  321. 321.
    Melander T, Hökfelt T, Rökaeus A et al. (1985) Distribution of galanin-like immunoreactivity in the gastro-intestinal tract of several mammalian species; Cell Tissue Res 239:253–270PubMedCrossRefGoogle Scholar
  322. 322.
    Meldrum LA, Burnstock G (1983) Evidence that ATP acts as a cotransmitter with noradrenaline in sympathetic nerves supplying the guinea-pig vas deferens. Eur J Pharmacol 92:161–163PubMedCrossRefGoogle Scholar
  323. 323.
    Mellander S, Johansson B (1968) Control of resistance, exchange and capacitance junctions in the peripheral circulation. Pharmacol Rev 20:117–196PubMedGoogle Scholar
  324. 324.
    Mellander S, Andersson P-O, Afzelius L-E et al. (1981) Neural beta-adrenergic dilation of the facial vein in man. Possible mechanism in emotional blushing. Acta Physiol Scand 114:393–399CrossRefGoogle Scholar
  325. 325.
    Morris JL, Gibbins IL, Furness JB et al. (1985) Colocalization of neuropeptide Y, vasoactive intestinal polypeptide and dynorphin in non-noradrenergic axons of the guinea-pigs uterine artery. Neurosci Lett 62:31–37PubMedCrossRefGoogle Scholar
  326. 326.
    Moritoki H, Su I (1981) Potentiating effects of 5- hydroxytryptamine and histamine on nerve stimulation induced contractions of the rabbit mesenteric artery. Arch Int Pharmacodyn Ther 252(2): 186–195PubMedGoogle Scholar
  327. 327.
    Moskowitz MA (1984) The neurobiology of vascular head pain. Ann Neurol 16:157–168PubMedCrossRefGoogle Scholar
  328. 328.
    Moskowitz MA, Liebmann JE, Reinhard JF et al. (1979) Raphe origin of serotonin-containing neurons within choroid plexus of the cat. Brain Res 169:590–594PubMedCrossRefGoogle Scholar
  329. 329.
    Moskowitz MA, Norregaard TV, Liu-Chen L-Y et al. (1984) VIP, CCK, and met-enkephalin in pia arachnoid and cerebral arteries after unilateral lesion of cat trigeminal ganglia. Abstr Soc Neurosci 13:576Google Scholar
  330. 330.
    Mott JC (1961) The stability of the cardiovascular system. In: Wolstenholme GEW, O’Connor M (eds): Somatic stability in the newly born. A Ciba Foundation symposium. Little Brown, Boston, pp 192–214Google Scholar
  331. 331.
    Mulderry PK, Ghatei MA, Rodrigo J et al. (1985) Calcitronin gene-related peptide in cardiovascular tissues of the rat. Neuroscience 14:947–954PubMedCrossRefGoogle Scholar
  332. 332.
    Muramatsu I, Fujiwara M, Mivra A et al. (1981) Possible involvement of adenine nucleotides in sympathetic neuroeffector mechanisms of dog basilar artery. J Pharmacol Exp Ther 216:401–409PubMedGoogle Scholar
  333. 333.
    Myers HZ, Axhwnk EA, Honig CR (1975) Ganglion cells in arterioles of skeletal muscles role in sympathetic vasodilation. Am J Physiol 229:126–138PubMedGoogle Scholar
  334. 334.
    Nagy JI, LaBella LA, Buss M (1984) Immuno- histochemistry of adenosine deaminase: implications for adenosine neurotransmission. Science 224:166–168PubMedCrossRefGoogle Scholar
  335. 335.
    Nagy JI, Buss M, LaBella LA, Daddona PE (1984) Immunohistochemical localization of adenosine deaminase in primary afferent neurons of the rat. Neurosci Lett 48:133–138PubMedCrossRefGoogle Scholar
  336. 336.
    Napoleone P, Sancesario G, Amenta F (1982) 5- Hydroxytryptophan uptake in the indoleaminergic nerve fibres within rat cerebrovascular tree. Neurosci Lett 28:57–60PubMedCrossRefGoogle Scholar
  337. 337.
    Napoleone P, Sancesario G, Amenta F (1982) Indoleaminergic innervation of rat choroid plexus: a fluorescence histochemical study. Neurosci Lett 34:143–147PubMedCrossRefGoogle Scholar
  338. 338.
    Nilsson SFE, Bill A (1985) Effects of facial nerve stimulation, VIP and PHI on ocular blood flow. Acta Physiol Scand 124 [Suppl 542]: 132Google Scholar
  339. 339.
    Norregaard TV, Moskowitz MA (1985) Substance P and the sensory innervation of intracranial and extracranial feline cephalic arteries. Implications for vascular pain mechanisms in man. Brain 108:517–533PubMedCrossRefGoogle Scholar
  340. 340.
    Oleson S-P (1985) A calcium-dependent reversible permeability increase in microvessels in frog brain, induced by serotonin. J Physiol (Lond) 361:103–113Google Scholar
  341. 341.
    Olgart L, Hökfelt T, Nillson G et al. (1977) Localization of substance P-like immunoreactivity in nerves in the tooth pulp. Pain 4:153–159PubMedCrossRefGoogle Scholar
  342. 342.
    Osias MB, Siegel NJ, Chaudry IH et al. (1977) Post- ischemic renal failure: accelerated recovery with adenosine triphosphate magnesium chloride infusion. Arch Surg 112:729–731PubMedGoogle Scholar
  343. 343.
    Olson L, Alund M, Norberg K-A (1976) Fluorescence microscopical demonstration of a population of gastrointestinal nerve fibres with a selective affinity for quina- crine. Cell Tissue Res 171:407–423PubMedCrossRefGoogle Scholar
  344. 344.
    Osborne LW, Silva DG (1970) Histological, acetylcholinesterase and fluorescence histochemical studies on the atrial ganglia of the monkey heart. Exp Neurol 27:497–511PubMedCrossRefGoogle Scholar
  345. 345.
    Owman C, Edvinsson L, Hardebo JE et al. (1977) Immunohistochemical demonstration of actin and myosin in brain capillaries. Acta Neurol Scand 56 [Suppl 64]:384–385Google Scholar
  346. 346.
    Page IH (1954) Serotonin (5-hydroxytryptamine) Physiol Rev 34:563–588PubMedGoogle Scholar
  347. 347.
    Papka RE, Furness JB, Della NG et al. (1981) Depletion by capsaicin of substance P-immu- noreactivity and acetylcholinesterase activity from nerve fibres in the guinea pig heart. Neurosci Lett 27:47–54PubMedCrossRefGoogle Scholar
  348. 348.
    Papka RE, Cotton JP, Traurig HH (1985) Comparative distribution of neuropeptide tyrosine-vasoactive intestinal polypeptide-, substance P- immunoreactive, acetylcholinesterase-positive and noradrenergic nerves in the reproductive tract of the female rat. Cell Tissue Res 242:475–490PubMedCrossRefGoogle Scholar
  349. 349.
    Parnavelas JG, Kelly W, Burnstock G (1985) Ultra- structural localization of choline acetyltransferase in vascular endothelial cells in rat brain. Nature 316:724–725PubMedCrossRefGoogle Scholar
  350. 350.
    Paton DM (1981) Presynaptic neuromodulation mediated by purinergic receptors. In: Burnstock G (ed) Purinergic receptors. Chapman and Hall, London, pp 199–219 (Receptors and recognition, series B, vol 12)CrossRefGoogle Scholar
  351. 351.
    Paton WDM, Vizi ES (1969) The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea-pig ileum longitudinal muscle strip. Br J Pharmacol 35:10–18PubMedGoogle Scholar
  352. 352.
    Pegram BL, Bevan RD, Bevan JA (1976) Facial vein of the rabbit: neurogenic vasodilation mediated by ß- adrenergic receptors. Circ Res 39:854–860PubMedGoogle Scholar
  353. 353.
    Peng JH, Kimura H, McGreer PL et al. (1981) Anticholine acetyltransferase fragments antigen binding (Fab) for immunohistochemistry. Neurosci Lett 21:281–285PubMedCrossRefGoogle Scholar
  354. 354.
    Peroutka SJ, Snyder SH (1979) Multiple serotonin receptors: differential binding of [3H]5-hydroxy- tryptamine, [3H]lysergic acid diethylamide and [3H]spir- peridol. Mol Pharmacol 16:687–699PubMedGoogle Scholar
  355. 355.
    Polak JM, Bloom SR (1980) Peripheral localization of regulatory peptides as a clue to their function. J Histochem Cytochem 28:918–924PubMedCrossRefGoogle Scholar
  356. 356.
    Puroy RE, Huributt DE, Rains LA (1981) Receptors for 5-hydroxytryptamine in rabbit isolated ear artery and aorta. Blood Vessels 18:16–27Google Scholar
  357. 357.
    Quirion R, Rioux F, St Pierre S et al. (1979) Increased sensitivity to neurotensin in fasted rats. Life Sci 25:1969–1973PubMedCrossRefGoogle Scholar
  358. 358.
    Rapport MM, Green AA, Page I (1948) Serum vasoconstrictor (serotonin). IV. Isolation and characterization. J Biol Chem 176:1243–1251PubMedGoogle Scholar
  359. 359.
    Reinecke M, Weihe E, Forsmann WG (1980) Substance P- immunoreactive nerve fibres in the heart. Neurosci Letts 20:265–269CrossRefGoogle Scholar
  360. 360.
    Reinecke M, Schlüter P, Yanaihara N et al. (1981) VIP immunoreactivity in enteric nerves and endocrine cells of the vertebrate gut. Peptides 2 (Suppl. 2): 149–156PubMedCrossRefGoogle Scholar
  361. 361.
    Reinecke M, Weihe E, Carraway RE et al. (1982) Localization of neurotensin immunoreactive nerve fibres in the guinea-pig heart: evidence derived by immunohistochemistry, radioimmunoassay and chromatography. Neuroscience 7:1785–1795PubMedCrossRefGoogle Scholar
  362. 362.
    Reinecke M, Vallance C, Weihe E et al. (1982) Neuropeptide (substance P, neurotensin) immunoreactive nerve fibres in the heart of higher vertebrates. Neurosci Lett [Suppl] 10:S403Google Scholar
  363. 363.
    Reinhard JF, Koskowitz MA, Elspas S et al. (1978) Serotoninergic innervation of rat and bovine parenchymal brain blood vessels: biochemical and pharmacological studies. Neurosci Abstr 4:451Google Scholar
  364. 364.
    Reinhard JF, Liebmann JE, Schlosberg AJ et al. (1979) Serotonin neurons project to small blood vessels in the brain. Science 206:85–87PubMedCrossRefGoogle Scholar
  365. 365.
    Rennels ML, Nelson E (1975) Capillary innervation in the mammalian central nervous system: an electron microscopic demonstration. Am J Anat 144:233–241PubMedCrossRefGoogle Scholar
  366. 366.
    Rennels ML, Fujimoto K, Nelson E (1979) Capillary innervation in the hypothalamus: a fluorescence histochemical and electron microscopic study. Acta Neurol Scand 60 [Suppl 72]:92–93Google Scholar
  367. 367.
    Rennels ML, Gregory TF, Fujimoto K (1983) Innervation of capillaries by local neurons in the cat hypothalamus: a light microscopic study with horseradish peroxidase. J Cereb Blood Flow Metab 3:535–542PubMedCrossRefGoogle Scholar
  368. 368.
    Riphagen CL, Pittman Q (1985) Cardiovascular responses to intrathecal administration of arginine vasopression in rats. Regul Pept 10:293–298PubMedCrossRefGoogle Scholar
  369. 369.
    Richardson BP, Engels G, Donatsch P et al. (1985) Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature 316:126–131PubMedCrossRefGoogle Scholar
  370. 370.
    Roddie IC, Shepherd JT, Whelan RF (1957) Contribution of constrictor and dilator nerves to skin vasodilatation during body heating. J Physiol (Lond) 136:489Google Scholar
  371. 371.
    Rodrigo J, Polak JM, Terenghi G et al. (1985) Calcitonin gene-related peptide (CGRP)-immunoreactive sensory and motor nerves of the mammalian palate. Histochemistry 82:67–74PubMedCrossRefGoogle Scholar
  372. 372.
    Rose GA, Moulds RFW (1979) Pharmacological comparison of isolated human cerebral and digital arteries. Stroke 10:736–741PubMedCrossRefGoogle Scholar
  373. 373.
    Rosenfeld MG, Mermod J-J, Amara SG et al. (1983) Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304:129–135PubMedCrossRefGoogle Scholar
  374. 374.
    Rossel S, Olgart L, Gazelius B (1981) Inhibition of antidromic and substance P-induced vasodilation by a substance P-antagonist. Acta Physiol Scand 111:381–382CrossRefGoogle Scholar
  375. 375.
    Rowan RA, Bevan JA (1982) Distribution of adrenergic synaptic cleft width in vascular and non-vascular smooth muscle. In: Bevan JA (ed) Vascular neuroeffector mechanisms IV. Proceedings of the 4th international symposium on vascular neuroeffector mechanisms, Kyoto, Japan. Raven Press, New YorkGoogle Scholar
  376. 376.
    Rubenstein AE, Rudansky MC, Yahr MD (1983) Autonomic failure due to amyloid. In: Bannister R (ed) Autonomic failure. A textbook of clinical disorders of the autonomic nervous system. Oxford University Press, Oxford, pp 574–595Google Scholar
  377. 377.
    Ryan ML, Clark KE, Brody MJ (1974) Neurogenic and mechanical control of canine uterine vascular resistance. Am J Physiol 227:547–555PubMedGoogle Scholar
  378. 378.
    Saba H, Cowen T, Haven AJ et al. (1984) Reduction in noradrenergic perivascular nerve density in the left and right cerebral arteries of old rabbits. J Cereb Blood Flow Metab 4:284–289PubMedCrossRefGoogle Scholar
  379. 379.
    Saffrey MJ, Polak JM, Burnstock G (1982) Distribution of vasoactive intestinal polypeptide-, substance P, enkephalin- and neurotensin-like immunoreactive nerves in the chicken gut during development. Neuroscience 7:279–293PubMedCrossRefGoogle Scholar
  380. 380.
    Said SI, Mutt V (1970) Polypeptide with broad biological activity: isolation from small intestines. Science 169:1217–1218PubMedCrossRefGoogle Scholar
  381. 381.
    Santer RM (1982) Fluorescence histochemical observations on the adrenergic innervation of the cardiovascular system in the aged rat. Brain Res Bull 9:667–672PubMedCrossRefGoogle Scholar
  382. 382.
    Saria A, Martling C-R, Dalsgaard C-J et al. (1985) Evidence for substance P-immunoreactive spinal affer- ents that mediate bronchoconstriction. Acta Physiol Scand 125:407–414PubMedCrossRefGoogle Scholar
  383. 383.
    Scatton B, Duverger D, L’Heureux R et al. (1985) Neurochemical studies on the nature of the serotoninergic innervation of the cerebral circulation of the cerebral circulation. J Cereb Blood Flow Metab 5 [Suppl 1]:S527Google Scholar
  384. 384.
    Schmidt M, Imbs J-L, Schwartz J (1981) The vascular dopamine receptor: a review. J Pharmacol 12:355–382PubMedGoogle Scholar
  385. 385.
    Schon F, Ghatei MA, Allen JM et al. (1985) The effect of sympathectomy on calcitonin gene related peptide levels in the rat trigeminovascular system. Brain Res 348:197–200PubMedCrossRefGoogle Scholar
  386. 386.
    Schon F, Allen JM, Yeats JC et al. (1985) Neuropeptide Y innervation of the rodent pineal gland and cerebral blood vessels. Neurosci Lett 57:65–71PubMedCrossRefGoogle Scholar
  387. 387.
    Schultzberg M, Hökfelt T, Nilsson G et al. (1980) Distribution of peptide- and catecholamine-containing neurons in the gastro-intestinal tract of rat and guinea- pig: immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine β-hydroxylase, Neuroscience 5:689–744PubMedCrossRefGoogle Scholar
  388. 388.
    Scott TM, Foote J, Galway G (1984) Changes in the catecholaminergic innervation of jejunal arteries following induction of diabetes with streptozotocin. J Anat 139:738Google Scholar
  389. 389.
    Shibata S, Hattori K, Sakurai I, Mori I et al. (1971) Adrenergic innervation and cocaine-induced potentiation of adrenergic responses of aortic strips from young and old rabbits. J Pharmacol Exp Ther 177:621–632PubMedGoogle Scholar
  390. 390.
    Sikri KL, Hoyes AD, Barber P et al. (1981) Substance P-like immunoreactivity in the intramural nerve plexuses of the guinea-pig ureter: a light and electron microscopical study. J Anat 133:425–442PubMedGoogle Scholar
  391. 391.
    Skok VI (1973) Physiology of autonomic ganglia. Igaku Shoin, TokyoGoogle Scholar
  392. 392.
    Sneddon P, Burnstock G (1984) Inhibition of excitatory junction potentials in guinea-pig vas deferens by α, ß- methylene-ATP: further evidence for ATP and noradrenaline as cotransmitters. Eur J Pharmacol 100:85–90PubMedCrossRefGoogle Scholar
  393. 393.
    Sneddon P, Burnstock G (1984) Do we need γ-receptors? TIPS 5:264–265Google Scholar
  394. 394.
    Sneddon P, Burnstock G (1984) ATP as a co-transmitter in rat tail artery. Eur J Pharmacol 106:149–152PubMedCrossRefGoogle Scholar
  395. 395.
    Sternini C, Brecha N (1985) Distribution and colocalization of neuropeptide Y- and tyrosine hydroxylaselike immunoreactivity in the guinea-pig heart. Cell Tissue Res 241:93–102PubMedCrossRefGoogle Scholar
  396. 396.
    Stjernquist M, Hakanson R, Leander S et al. (1983) Immunohistochemical localization of substance P, vasoactive intestinal polypeptide and gastrin-releasing peptide in vas deferens and seminal vesicle, and the effect of these and eight other neuropeptides on resting tension and neurally evoked contractile activity. Regul Pept 7:67–86PubMedCrossRefGoogle Scholar
  397. 397.
    Stone RA, Laties AM, Brecha NC (1982) Substance P- like immunoreactive nerves in the anterior segment of the rabbit, cat and monkey eye. Neuroscience 7:2459–2468PubMedCrossRefGoogle Scholar
  398. 398.
    Story DF, Allen GS, Glover AB et al. (1975) Modulation of adrenergic transmission by acetylcholine. Clin Exp Pharmacol Physiol [Suppl 2]:27–33Google Scholar
  399. 399.
    Ström C, Lundberg J, Ahlman H et al. (1981) On the VIP-ergic innervation of the uterotubal junction. Acta Physiol Scand 11:213–215CrossRefGoogle Scholar
  400. 400.
    Su C (1975) Neurogenic release of purine compounds in blood vessels. J Pharmacol Exp Ther 195:159–166PubMedGoogle Scholar
  401. 401.
    Su C (1978) Modes of vasoconstrictor and vasodilator neurotransmission. Blood Vessels 15:183–189PubMedGoogle Scholar
  402. 402.
    Su C (1981) Purinergic receptors in blood vessels. In: Burnstock G (ed) Purinergic receptors. Chapman and Hall, London, pp 93–117 (Receptors and recognition, series B, vol 12)CrossRefGoogle Scholar
  403. 403.
    Su C, Duckies SP, Florence V (1977) Uptake of 3H- norepinephrine in rabbit mesenteric blood vessels. Blood Vessels 14:65–76PubMedGoogle Scholar
  404. 404.
    Su C, Bevan JA, Assali NS et al. (1977) Development of neuroeffector mechanisms in the carotid artery of the fetal lamb. Blood Vessels 14:12–24PubMedGoogle Scholar
  405. 405.
    Sundler F, Alumets J, Brodin E (1977) Perivascular substance P-immunoreactive nerves in tracheobronchial tissue. In: Von Euler US, Pernow B (eds) Substance P. Raven Press, New York, pp 271–273Google Scholar
  406. 406.
    Sundler F, Alumets J, Hakanson R et al. (1977) VIP innervation of the gallbladder. Gastroenterology 72:1375–1377PubMedGoogle Scholar
  407. 407.
    Sundler F, Moghimzadeh E, Hakanson R et al. (1983) Nerve fibres in the gut and pancreas of the rat displaying neuropeptide-Y immunoreactivity. Intrinsic and extrinsic origin. Cel Tissue Res 230:487–193CrossRefGoogle Scholar
  408. 408.
    Svendgaard N-A, Edvinsson L, Olin T et al. (1977) On the pathophysiology of cerebral vasospasm: transmitter changes in perivascular sympathetic nerves, and increased pial artery sensitivity to norepinephrine and serotonin. In: Owman C, Edvinsson (eds) Neurogenic control of brain circulation. Proceedings of international symposium, Wenner-Gren. Pergamon Press, Oxford, pp 143–152Google Scholar
  409. 409.
    Taché Y, Gonion M, Lauffenberger M et al. (1984) Inhibition of gastric acid secretion by intrathecal injection of calcitonin gene-related peptide in rats. Life Sci 35:871–878PubMedCrossRefGoogle Scholar
  410. 410.
    Tagawa T, Ando K, Wasano T et al. (1979) A histochemical study of the innervation of cerebral blood vessels in the bullfrog. J Comp Neurol 183:25–32PubMedCrossRefGoogle Scholar
  411. 411.
    Takami K, Kawai Y, Shiosaka S et al. (1985) Immunohistochemical evidence for the coexistence of calcitonin gene-related peptide and choline acetyltransferase-like immunoreactivity in neurons of the rat hypoglossal facial and ambiguous nuclei. Brain Res 328:386–389PubMedCrossRefGoogle Scholar
  412. 412.
    Tatemoto K, Carlquist M, Mutt V (1982) Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296:659–660PubMedCrossRefGoogle Scholar
  413. 413.
    Terenghi G, Polak JM, Proberg L et al. (1982) Mapping, quantitative distribution and origin of substance P- and VIP-containing nerves in the uvea of guinea-pig eye. Histochemistry 75:399–417PubMedCrossRefGoogle Scholar
  414. 414.
    Terenghi G, Polak JM, Ghatei MA et al. (1985) Distribution and origin of calcitonin gene-related peptide (CGRP) immunoreactivity in the sensory innervation of the mammalian eye. J Comp Neurol 233:506–516PubMedCrossRefGoogle Scholar
  415. 415.
    Terenghi G, Polak JM, Rodrigo J et al. (1986) Calcitonin gene-related peptide-immunoreactive nerves in the tongue, epiglottis and pharynx of the rat: occurrence, distribution and origin. Brain Res 365:1–14PubMedCrossRefGoogle Scholar
  416. 416.
    Toda N, Fujita Y (1973) Responsiveness of isolated cerebral and peripheral arteries to serotonin, norepinephrine and transmural electrical stimulation. Circ Res 33:98–104PubMedGoogle Scholar
  417. 417.
    Toda N (1976) Influence of dopamine and noradrenaline on isolated cerebral arteries of the dog. Br J Pharmacol 58:121PubMedGoogle Scholar
  418. 418.
    Tonoue T, Hata H, Ohnishi T et al. (1985) Somatostatin and GABA correlate with cervical autonomic nerve activity. Regul Pept 10:299–307PubMedCrossRefGoogle Scholar
  419. 419.
    Tuor UI, Kelly P, Edvinsson L et al. (1985) Neuro peptide Y and the regulation of local cerebral blood flow. A quantitative autoradiographic study. J Cereb Blood Flow Metab 5 [Suppl 1]:S513Google Scholar
  420. 420.
    Uddman R, Alumets J, Densert O et al. (1978) Occurrence and distribution of VIP nerves in the nasal mucosa and tracheobronchial wall. Acta Otolaryngol (Stockh) 86:443–448Google Scholar
  421. 421.
    Uddman R, Alumets J, Edvinsson L et al. (1978) Peptidergic (VIP) innervation of the oesophagus. Gastroenterology 75:5–8PubMedGoogle Scholar
  422. 422.
    Uddman R, Sundler F (1979) Vasoactive intestinal polypeptide nerves in human upper respiratory tract. Otol Rhinol Laryngol 41:221–226Google Scholar
  423. 423.
    Uddman R, Alumets J, Densert O et al. (1979) Innervation of the feline eustachian tube. Ann Otol Rhinol Laryngol 88:557–561PubMedGoogle Scholar
  424. 424.
    Uddman R, Malm L, Sundler F (1980) The origin of vasoactive intestinal polypeptide (VIP) nerves in the feline nasal mucosa. Acta Otolaryngol (Stockh) 89:152–156CrossRefGoogle Scholar
  425. 425.
    Uddman R, Björlin G, Möller B et al. (1980) Occurrence of VIP nerves in mammalian dental pulps. Acta Odontol Scand 38:325–328PubMedCrossRefGoogle Scholar
  426. 426.
    Uddman R, Fahrenkrug J, Malm L et al. (1980) Neuronal VIP in salivary glands: distribution and release. Acta Physiol Scand 110:31–38PubMedCrossRefGoogle Scholar
  427. 427.
    Uddman R, Alumets J, Ehinger B et al. (1980) Vasoactive intestinal peptide nerves in ocular and orbital structures of the cat. Invest Ophthalmol Vis Sei 19:878–885Google Scholar
  428. 428.
    Uddman R, Alumets J, Hakanson R et al. (1980) Vasoactive intestinal peptide (VIP) occurs in nerves of the pineal gland. Experientia 36:1119–1120PubMedCrossRefGoogle Scholar
  429. 429.
    Uddman R, Edvinsson L, Sundler F (1981) Perivascular substance P: occurrence and distribution in mammalian pial vessels. J Cereb Blood Flow Metab 1:227–232PubMedCrossRefGoogle Scholar
  430. 430.
    Uddman R, Alumets J, Edvinsson L et al. (1981) VIP nerve fibres around peripheral blood vessels. Acta Physiol Scand 112:65–70PubMedCrossRefGoogle Scholar
  431. 431.
    Uddman R, Edvinsson L, Hakanson R et al. (1982) Immunohistochemical demonstration of APP (avian pancreatic polypeptide) - immunoreactive nerve fibres around cerebral blood vessels. Brain Res Bull 9:715–718PubMedCrossRefGoogle Scholar
  432. 432.
    Uddman R, Edvinsson L, Malm L (1982) Perivascular nerves in the feline carotid rete. Cell Tissue Res 226:301–308PubMedCrossRefGoogle Scholar
  433. 433.
    Uddman R, Ninoyu O, Sundler F (1982) Adrenergic and peptidergic innervation of cochlear blood vessels. Arch Otol Rhinol Laryngol 236:7–14CrossRefGoogle Scholar
  434. 434.
    Uddman R, Edvinsson L, Owman C et al. (1983) Nerve fibres containing gastrin-releasing peptide around pial vessels. J Cereb Blood Flow Metab 3:386–390PubMedCrossRefGoogle Scholar
  435. 435.
    Uddman R, Sundler F, Emson P (1984) Occurrence and distribution of neuropeptide-Y-immunoreactive nerves in the respiratory tract and middle ear. Cell Tissue Res 237:321–327PubMedCrossRefGoogle Scholar
  436. 436.
    Uddman R, Edvinsson L, Ekman R et al. (1985) Innervation of the feline cerebral vasculature by nerve fibres containing calcitonin gene-related peptide: trigeminal origin and co-existence with substance P. Neurosci Lett 62:131–136PubMedCrossRefGoogle Scholar
  437. 437.
    Uddman R, Ekblad E, Edvinsson L et al. (1985) Neuropeptide Y-like immunoreactivity in perivascular nerve fibres of the guinea-pig. Regul Pept 10:243–257PubMedCrossRefGoogle Scholar
  438. 138.
    Uvnäs B (1966) Cholinergic vasodilator nerves. Fed Proc 25:1613–1622Google Scholar
  439. 139.
    Vaalasti A, Linnoila I, Hervonen A (1980) Immunohistochemical demonstration of VIP, [Met5]- and [Leu5]-enkephalin immunoreactive nerve fibres in the human prostate and vesicles. Histochemistry 66:89–98PubMedCrossRefGoogle Scholar
  440. 440.
    Van Calker D, Muller M, Hamprecht B (1979) Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells. J Neurochem 33:999–1005PubMedCrossRefGoogle Scholar
  441. 441.
    Vanhoutte PM (1974) Inhibition of acetylcholine of adrenergic neurotransmission in vascular smooth muscle. Circ Res 34:317–326PubMedGoogle Scholar
  442. 442.
    Vanhoutte PM, Cohen RA, Van Nueten JM (1984) Serotonin and arterial vessels. J Cardiovasc Pharmacol 6:S421-S428PubMedCrossRefGoogle Scholar
  443. 443.
    Van Neuten JM, Janssen PAJ, De Ridder W et al. (1982) Interaction between 5-hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit: effect of ketanserin (R41468). Eur J Pharmacol 77:281–287CrossRefGoogle Scholar
  444. 444.
    Verrecchia C, Hamel E, Sercombe R et al. (1985) Constriction of cerebral arteries to noradrenaline is modulated by the endothelium. J Cereb Blood Flow Metab 5 [Suppl 1]:S549Google Scholar
  445. 445.
    Vizi ES (1979) Presynaptic modulation of neurochemical transmission. Prog Neurobiol 12:181–290PubMedCrossRefGoogle Scholar
  446. 446.
    Wall PD, Fitzgerald M (1982) If substance P fails to fulfill the criteria as a neurotransmitter in somatosensory efferents, what might be its function? In: Ciba Found Symp 91:249–266PubMedGoogle Scholar
  447. 447.
    Wharton J, Polak JM, Bryant MG et al. (1979) Vasoactive intestinal polypeptide (VIP)-like immunoreactivity in salivary glands. Life Sci 25:273–280PubMedCrossRefGoogle Scholar
  448. 448.
    Wharton J, Polak JM, Bloom SR et al. (1979) Substance P-like immunoreactive nerves in mammalian lung. Invest Cell Pathol 2:3PubMedGoogle Scholar
  449. 449.
    Wharton J, Polak JM, Pearse AGE et al. (1980) Enkephalin-, VIP- and substance P-like immunoreactivity in the carotid body. Nature 284:269–271PubMedCrossRefGoogle Scholar
  450. 450.
    Wharton J, Polak JM, Probert L et al. (1981) Peptide containing nerves in the ureter of the guinea-pig and cat. Neuroscience 6:969–982PubMedCrossRefGoogle Scholar
  451. 451.
    Wharton J, Polak JM, McGregor GP et al. (1981) The distribution of substance P-like immunoreactive nerves in the guinea-pig heart. Neuroscience 6:2193–2204PubMedCrossRefGoogle Scholar
  452. 452.
    Willis E, Ottesen B, Wagner G et al. (1981) Vasoactive intestinal polypeptide (VIP) as a possible neurotransmitter involved in penile erection. Acta Physiol Scand 113:545–547PubMedCrossRefGoogle Scholar
  453. 453.
    Winquist RJ, Bevan JA (1981) Relation location of alpha- and beta-adrenoceptors to site of release of sympathetic transmitter in rabbit facial vein. Circ Res 49:486–491PubMedGoogle Scholar
  454. 454.
    Woods JR, Dandavino A, Murayama K et al. (1977) Autonomic control of cardiovascular functions during neonatal development and in adult sheep. Circ Res 40:401–407PubMedGoogle Scholar
  455. 455.
    Yamamoto K, Matsuyama T, Shiosaka S et al. (1983) Overall distribution of substance P-containing nerves in the wall of cerebral arteries of the guinea pig and its origins. J Comp Neurol 215:421–426PubMedCrossRefGoogle Scholar
  456. 456.
    Zaidi M, Bevis PJR, Girgis SI et al. (1985) Circulating CGRP comes from the perivascular nerves. Eur J Pharmacol 117:283–284PubMedCrossRefGoogle Scholar
  457. 457.
    Zawadzki JV, Furchgott RF, Cherry P (1981) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by substance P. Fed Proc 40:689Google Scholar
  458. 458.
    Zerbe RL, Feverstein G (1985) Cardiovascular effects of centrally administered vasopressin in conscious and anaesthetised rats. Neuropeptides 6:471–484PubMedCrossRefGoogle Scholar
  459. 459.
    Zhang SQ, Terenghi G, Unger WG et al. (1984) Changes in substance P- and neuropeptide Y-immu- noreactive fibres in rat and guinea-pig irides following unilateral sympathectomy. Exp Eye Res 39:365–372PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • K. K. Dhital
  • G. Burnstock

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