Abstract
Current theories relating to the genesis of atherosclerosis assign an important role to smooth-muscle cells. The first stages of this disease consist of a thickening of the intima caused by the proliferation of smooth-muscle cells which have migrated from the media towards the intima [60,61]. According to certain investigators, this stimulation of the growth of smooth-muscle cells, which are usually quiescent in normal arteries, could be explained either by a mutation conferring a selective advantage on a single cell which could then divide upon stimulation [2] or by injury to the intimal barrier causing the smooth-muscle cells to be exposed to circulating serum factors [60], and, in particular, to platelet-derived growth factors which seems to be the principal mitogenic agent for smooth-muscle cells [6,62].
Keywords
- Hyaluronic Acid
- Thelial Cell
- Aortic Smooth Muscle Cell
- Bovine Aortic Endothelial Cell
- Arterial Smooth Muscle Cell
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Breton, M., Picard, J. (1989). Effects of “Ageing” on Arterial Cells in Vitro. In: Camilleri, JP., Berry, C.L., Fiessinger, JN., Bariéty, J. (eds) Diseases of the Arterial Wall. Springer, London. https://doi.org/10.1007/978-1-4471-1464-2_5
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DOI: https://doi.org/10.1007/978-1-4471-1464-2_5
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