Abstract
The hallmark of diabetic nephropathy is glomerulosclerosis, the generalized microangiopathy seen in patients with diabetes mellitus. Diabetic nephropathy is probably responsible for 25% of cases of end-stage renal failure [149], and an increasing number of diabetics require either dialysis or transplantation [59]. Type I insulin-dependent diabetics generally have a more severe and rapidly progressive nephropathy than do type II initially insulin-independent diabetics [2,54,102]. Almost half of all type I diabetics develop nephropathy leading to uraemia after 10 to 30 years of overt diabetes mellitus [2,44,52,66,102,143,194]. Type II diabetics may also suffer renal damage and develop renal insufficiency, but mortality in this population is generally due to cardiovascular rather than renal disease [122]. The lesions of diabetic nephropathy occur early, preceding any clinical signs of frank nephropathy [45].
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Keywords
- Diabetic Nephropathy
- Glomerular Basement Membrane
- Renal Plasma Flow
- Strict Metabolic Control
- Nodular Glomerulosclerosis
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Bariéty, J. (1989). Diabetic Nephropathy. In: Camilleri, JP., Berry, C.L., Fiessinger, JN., Bariéty, J. (eds) Diseases of the Arterial Wall. Springer, London. https://doi.org/10.1007/978-1-4471-1464-2_24
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