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Mechanical Factors in the Pathogenesis, Localization and Evolution of Atherosclerotic Plaques

  • Chapter
Diseases of the Arterial Wall

Abstract

Mechanical stresses associated with blood flow and pressure have been associated with the pathogenesis of atherosclerosis in the human arterial tree. Observations that plaques tend to occur preferentially in relation to branch ostia, bifurcations and bends of the major arteries have led to hypotheses that alterations in flow which occur at transitions in geometric configuration potentiate the development of intimal lesions. The proposed fluid dynamic localizing features include increases in flow velocity [38,199] and wall shear stress [67], low flow velocity and reduced wall shear stress [25,66,219], flow separation [64,134,172] and departures from uniform unidirectional laminar flow such as turbulence [58,94,206] and variations in flow direction and velocity [46,68,123,185]. Regions of branching and curvature are associated also with alterations in the distribution of mural tensile stresses.

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Authors
  1. S. Glagov
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  2. C. K. Zarins
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  3. D. P. Giddens
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  4. D. N. Ku
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Editors and Affiliations

  1. Service d’Anatomie Pathologique et Unité de Recherche sur la Pathologie Rénale et Vasculaire, INSERM U28, Paris, France

    Jean-Pierre Camilleri (Professeur) (Professeur)

  2. Department of Morbid Anatomy, Institute of Pathology, The London Hospital, Whitechapel, London, E1 1BB, UK

    Colin L. Berry (Professor) (Professor)

  3. Service de Médecine Interne et de Pathologie Vasculaire, Hôpital Broussais, Paris, France

    Jean-Noël Fiessinger (Professeur) (Professeur)

  4. Service de Néphrologie et Unité de Recherche sur la Pathologie Rénale et Vasculaire, INSERM U28, Hôpital Broussais, Paris, France

    Jean Bariéty (Professeur) (Professeur)

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Glagov, S., Zarins, C.K., Giddens, D.P., Ku, D.N. (1989). Mechanical Factors in the Pathogenesis, Localization and Evolution of Atherosclerotic Plaques. In: Camilleri, JP., Berry, C.L., Fiessinger, JN., Bariéty, J. (eds) Diseases of the Arterial Wall. Springer, London. https://doi.org/10.1007/978-1-4471-1464-2_15

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