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Bronchoalveolar Mast Cells and Asthma pp 43–53Cite as

Hyperosmolar Histamine Release from Human Lung Mast Cells: Its Relevance to Exercise-Induced Asthma

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Part of the book series: The Bloomsbury Series in Clinical Science ((BLOOMSBURY))

Abstract

Sir John Floyer (1698) was the first to remark that “all violent exercise makes the asthmatic to breathe short”. After an initial bronchodilation which persists for the duration of the exercise, breathlessness increases as the asthmatic bronchoconstricts reaching peak in severity at 3–5 min (Herxheimer 1946). The severity of the post-exercise bronchoconstriction increases with increasing duration and work load to reach a maximum after 6–8 min of exercise at 70% of maximum oxygen uptake (Silverman and Anderson 1972). Prolonging the duration of exercise or repeating the exercise within 3 h (the refractory period) results in a reduction in the severity of post-exercise bronchoconstriction (Godfrey et al. 1973; Edmunds et al. 1978).

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Authors and Affiliations

  1. Department of Immunology, The Middlesex Hospital Medical School, London, W1, UK

    Kevin Charles Flint BA, MB.BChir, MRCP (Barry Nicholson Hudspith, Chartered Biologist, MIBiol)

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  1. Kevin Charles Flint BA, MB.BChir, MRCP
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© 1987 Springer-Verlag Berlin Heidelberg

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Flint, K.C. (1987). Hyperosmolar Histamine Release from Human Lung Mast Cells: Its Relevance to Exercise-Induced Asthma. In: Bronchoalveolar Mast Cells and Asthma. The Bloomsbury Series in Clinical Science. Springer, London. https://doi.org/10.1007/978-1-4471-1458-1_5

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  • DOI: https://doi.org/10.1007/978-1-4471-1458-1_5

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1460-4

  • Online ISBN: 978-1-4471-1458-1

  • eBook Packages: Springer Book Archive

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