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Bladder Control: Role of Higher Levels of the Central Nervous System

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The Physiology of the Lower Urinary Tract

Abstract

During the last 150 years many investigators have attempted to study the central pathways which control micturition in humans and in animals; these results suggest that control over the bladder and sphincters is organized in different areas of the cortex and at various levels of the nervous system, the lowest of which is the spinal cord. The precise roles of many supraspinal sites in the regulation of the bladder are uncertain, and different workers interpret their results in different ways.

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References

  • Andersson O, Grillner S (1981) On the feedback control of the cat’s hindlimb during locomotion. In: Taylor A, Prochazka A (eds) Muscle receptors and movement. Macmillan, London, pp 427–431.

    Google Scholar 

  • Andrew J, Nathan PW (1964) Lesions of the anterior frontal lobes and disturbances of micturition and defaecation. Brain 87:233–262.

    PubMed  CAS  Google Scholar 

  • Appenzeller O (1982) The autonomic nervous system: an introduction to basic and clinical concepts, 3rd edn. Elsevier, New York, p 524.

    Google Scholar 

  • Bagshaw EV, Evans MH (1976) Measurement of current spread from microelectrodes when stimulating within the central nervous system. Exp Brain Res 25:391–100.

    PubMed  CAS  Google Scholar 

  • Barrington FJF (1921) The relation of the hind brain to micturition. Brain 44:23–53.

    Google Scholar 

  • Barris RW, Lehuman HR (1953) Bilateral anterior cingulate gyrus lesions. Syndrome of the anterior cingulate gyri. Neurology 3:44–52.

    PubMed  CAS  Google Scholar 

  • Bors E, Comarr AE (1971) Neurological urology. Karger, New York.

    Google Scholar 

  • Bradley WE (1984) Neurophysiology of the urinary bladder. In: Bradley, WE, Hald T (eds) The urinary bladder neurology and dynamics. Williams and Wilkins, Baltimore, pp 22–36.

    Google Scholar 

  • Bradley WE, Scott FB (1978) Physiology of the urinary bladder. In: Harrison JH, Gittes RF, Perlwitter AD, Stamey TA, Walsh PC (eds) Campbell’s urology, 4th edn. Saunders, Philadelphia, pp 87–124.

    Google Scholar 

  • Bradley WE, Teague CT (1968) Spinal cord organisation of micturition reflex afferents. Exp Neurol 22:504–516.

    PubMed  CAS  Google Scholar 

  • Bradley WE, Teague CT (1969) Cerebellar control of the urinary bladder. Exp Neurol 23:399–411.

    PubMed  CAS  Google Scholar 

  • Brodal A (1981) Neurological anatomy in relation to clinical medicine, 3rd edn. Oxford University Press, Oxford.

    Google Scholar 

  • Brutkowski S (1965) Functions of the prefrontal cortex in animals. Physiol Rev 45:721–746.

    PubMed  CAS  Google Scholar 

  • Cadden SW, Morrison JFB (1984) The effects of visceral distension on the activities of lumbar dorsal horn neurones in the rat. J Physiol 350:71P.

    Google Scholar 

  • Cadden SW, Morrison JFB (1987) Effects of visceral distension on the activities of neurones receiving cutaneous inputs in the rat lumbar dorsal horn: comparison with effects of remote noxious somatic stimuli. (Submitted to Brain Res).

    Google Scholar 

  • Carstens E (1982) Inhibition of spinal dorsal horn neuronal responses to noxious skin heating by medial hypothalamic stimulation in the cat. J Neurophysiol 48:808–822.

    PubMed  CAS  Google Scholar 

  • Chambers WW Jr (1947) Electrical stimulation of the interior of the cerebellum in the cat. Am J Anat 80:55–93.

    PubMed  Google Scholar 

  • de Groat WC (1971) Inhibition and excitation of sacral parasympathetic neurons by visceral and cutaneous stimuli in the cat. Brain Res 33:499–503.

    Google Scholar 

  • de Groat WC (1975) Nervous control of the urinary bladder of the cat. Brain Res 87:201–211.

    PubMed  Google Scholar 

  • de Groat WC (1976) Mechanisms underlying the recurrent inhibition in the sacral parasympathetic outflow to the urinary bladder. J Physiol 257:503–514.

    PubMed  Google Scholar 

  • de Groat WC (1986) Spinal cord projections and neuropeptides in visceral afferent neurons. In: Cervero F, Morrison JFB (eds) Visceral sensation. Elsevier, Amsterdam, pp 165–187 (Progress in brain research, vol 67).

    Google Scholar 

  • de Groat WC, Lalley PM (1972) Reflex firing in the lumbar sympathetic outflow to activation of vesical afferent fibres. J Physiol 226:289–309.

    PubMed  Google Scholar 

  • de Groat WC, Ryall RW (1968) Recurrent inhibition in sacral parasympathetic pathways to the bladder. J Physiol 196:579–591.

    PubMed  Google Scholar 

  • de Groat WC, Ryall RW (1969) Reflexes to the sacral parasympathetic neurones concerned with micturition in the cat. J Physiol 200:87–108.

    PubMed  Google Scholar 

  • de Groat WC, Saum WR (1972) Sympathetic inhibition of the urinary bladder and of pelvic ganglionic transmission in the cat. J Physiol 220:297–314.

    PubMed  Google Scholar 

  • de Groat WC, Saum WR (1976) Synaptic transmission in parasympathetic ganglia in the urinary bladder in the cat. J Physiol 256:137–158.

    Google Scholar 

  • de Groat WC, Theobald RJ (1976) Reflex activation of sympathetic pathways to vesical smooth muscle and parasympathetic ganglia by electrical stimulation of vesical afferents. J Physiol 259:223–238.

    PubMed  Google Scholar 

  • de Groat WC, Douglas JW, Glass J, Simonds W, Weimer B, Werner P (1975) Changes in somato-vesical reflexes during postnatal development in the kitten. Brain Res 94:150–154.

    Google Scholar 

  • de Groat WC, Nadelhaft I, Milne RJ, Booth AM, Morgan C, Thor K (1981) Organisation of the sacral parasympathetic reflex pathways to the urinary bladder and large intestine. J Auton Nerv Syst 3:135–160.

    PubMed  Google Scholar 

  • de Groat WC, Booth AM, Milne RJ, Roppolo JR (1982) Parasympathetic preganglionic neurons in the sacral spinal cord. J Auton Nerv Syst 5:23–43.

    PubMed  Google Scholar 

  • de Groat WC, Kawatani M, Hisamitsu T, Lowe I, Morgan C, Roppolo J, Booth AM, Nadelhaft I, Kuo D, Thor K (1983) The role of neuropeptides in the sacral autonomic reflex pathways of the cat. J Auton Nerv Syst 7:339–350.

    PubMed  Google Scholar 

  • Dembowsky K, Lackner K, Czachurski J, Seller H (1981) Tonic catecholaminergic inhibition of the spinal somato-sym- pathetic reflexes originating in the ventrolateral medulla oblongata. J Auton Nerv Syst 3:277–290.

    PubMed  CAS  Google Scholar 

  • Edvardsen P, Ursin T (1968) Micturition thresholds in cats with amygdala lesions. Exp Neurol 21:495–501.

    PubMed  CAS  Google Scholar 

  • Elam W, Thoren P, Svensson TH (1986) Locus coeruleus neurones and sympathetic nerves: activation by visceral afferents. Brain Res 375: 117–125.

    PubMed  CAS  Google Scholar 

  • Enoch DM, Kerr FWL (1967a) Hypothalamic vasopressor and vesicopressor pathways. I. Functional studies. Arch Neurol (Chicago) 16:290–306.

    CAS  Google Scholar 

  • Enoch DM, Kerr FWL (1967b) Hypothalamic vasopressor and vesicopressor pathways. II. Anatomic study of their course and connections. Arch Neurol (Chicago) 16:307–320.

    CAS  Google Scholar 

  • Evans MH, McPherson A (1959) The effects of distension of the bladder on somatic reflexes in the cat. J Physiol 146:438–458.

    PubMed  CAS  Google Scholar 

  • Fields HL, Basbaum AI (1978) Brainstem control of spinal pain-transmission neurones. Annu Rev Physiol 40:217–248.

    PubMed  CAS  Google Scholar 

  • Floyd K, McMahon SB, Morrison JFB (1982) Inhibitory interactions between colonic and vesical afferents in the micturition reflex of the cat. J Physiol 322:45–52.

    PubMed  CAS  Google Scholar 

  • Giesler GJ, Liebeskind JC (1976) Inhibition of visceral pain by electrical stimulation of the periaqueductal gray matter. Pain 2:43–48.

    PubMed  Google Scholar 

  • Gilbey MP, Coote JH, Macleod VH, Peterson DF (1981) Inhibition of sympathetic activity by stimulating in the raphe nuclei and the role of 5-hydroxytryptamine in this effect. Brain Res 226:131–142.

    PubMed  CAS  Google Scholar 

  • Gjone R (1966) Excitatory and inhibitory bladder responses to stimulation of ‘limbic’, diencephalic and mesencephalic structures in the cat. Acta Physiol Scand 66:91–102.

    PubMed  CAS  Google Scholar 

  • Gjone R, Setekleiv J (1963) Excitatory and inhibitory responses to stimulation of the cerebral corteßf in the cat. Acta Physiol Scand 59: 337–349.

    PubMed  CAS  Google Scholar 

  • Hammond DL, Proudfit HK (1980) Effects of locus coeruleus lesions on morphine-induced antinociception. Brain Res 188:79–91.

    PubMed  CAS  Google Scholar 

  • Henneman E, Olson CB (1965) Relations between structure and function in design of skeletal muscles. J Neurophysiol 28:581–598.

    PubMed  CAS  Google Scholar 

  • Hess WR (1947) Vegetative Funktionen und Zwischenhirn. Helv Physiol Pharmacol Acta Suppl IV: 1–65.

    Google Scholar 

  • Hess WR, Brügger M (1943a) Das subkortikale Zentrum der affektiven Abwehrreaktion. Helv Physiol Pharmacol Acta 1:511–532.

    Google Scholar 

  • Hess WR, Brügger M (1943b) Der Mitkions- und der Defäk- tionsakt als Erfolg zentraler Reisung. Helv Physiol Pharmacol Acta 1:533–547.

    Google Scholar 

  • Jänig W (1983) The autonomic nervous system. In: Schmidt RF, Thews G (eds) Human physiology. Springer, Berlin Heidelberg New York, pp 111–144.

    Google Scholar 

  • Kabat H, Magoun HW, Ranson SW (1936) Reaction of the bladder to stimulation of points in the forebrain and midbrain. J Comp Neurol 63:211–239.

    Google Scholar 

  • Kandel ER, Schwartz JH (1981) Principles of neural science. Arnold, London Karplus JP, Kreidl A (1909) Gehirn und Sympathicus. I. Zwis- chenhirnbasis und Halssympathicus. Arch Physiol (Bonn) 129:138–144.

    Google Scholar 

  • Koikegami H, Dodo T, Mochida Y, Takahashi H (1957) Stimulation experiments on the amygdaloid nuclear complex and related structures. Effects upon renal volume, urinary secretion, movements of the urinary bladder, blood pressure and respiratory movements. Folia Psychiatr Neurol Jpn 11:157–206.

    PubMed  CAS  Google Scholar 

  • Kremer WF (1947) Autonomic and somatic reactions induced by stimulation of the cingulate gyrus in dogs. J Neurophysiol 10:371–379.

    PubMed  CAS  Google Scholar 

  • Kuru M (1965) Nervous control of micturition. Physiol Rev 45:425–494.

    PubMed  CAS  Google Scholar 

  • Kuru M, Ozaki H, Kurati T (1961) Effect of simultaneous simulations of the bulbar vesico-constrictor and vesico-relaxer centers. J Comp Neurol 116:195–208.

    PubMed  CAS  Google Scholar 

  • Kuru M, Koyama Y, Ozaki H (1963) Part of the brainstem controlling the tone of the external urethral sphincter. Proc Jpn Acad 39:530–533.

    Google Scholar 

  • Langworthy OR, Kolb LC (1933) The encephalic control of tone in musculature of the urinary bladder. Brain 56:371–382.

    Google Scholar 

  • Langworthy OR, Hesser FH (1936) An experimental study of micturition released from cerebral control. Am J Physiol 115:694–700.

    Google Scholar 

  • Lewin RJ, Dillard GV, Porter RW (1967) Extrapyramidal inhibition of the urinary bladder. Brain Res 4:301–307.

    PubMed  CAS  Google Scholar 

  • Lichternstein R (1912) Uber die zentrale Blaseninnervation, ein Beitrag zur Physiologie des Zwischenhirnes. Wien Klin Wochenschr 25:1248–1249.

    Google Scholar 

  • Light AR (1985) The spinal terminations of single, physiologically characterised axons originating in the ponto- medullary raphe of the cat. J Comp Neurol 234:536–548.

    PubMed  CAS  Google Scholar 

  • Loewy AD (1982) Descending pathways to sympathetic preganglionic neurones. In: Kuypers HGJM, Martin GF (eds) Descending pathways to the spinal cord. Elsevier, Amsterdam, pp 267–277 (Progress in brain research, vol 57).

    Google Scholar 

  • Lumb BM (1986) Brainstem control of visceral afferent pathways in the spinal cord. In: Cervero F, Morrison JFB (eds) Visceral sensation. Elsevier, Amsterdam, pp 279–293 (Progress in brain research, vol 67).

    Google Scholar 

  • Lumb BM, Morrison JFB (1984) Convergence of visceral and somatic information on to identified reticulo- and raphe- spinal neurones in the rat. J Physiol 357:33P.

    Google Scholar 

  • Mackel R (1979) Segmental and descending control of the external urethral and anal sphincters in the cat. J Physiol 294:105–122.

    PubMed  CAS  Google Scholar 

  • Maggi CA, Santicioli P, Borsini F, Giuliani S, Meli A (1986) The role of capsaicin-sensitive innervation of the rat urinary bladder in the activation of micturition reflex. Naunyn- Schmiedebergs Arch Pharmacol 332:276–283.

    PubMed  CAS  Google Scholar 

  • Magoun HW, Ranson SW, Hetherington A (1938) Descending connections from the hypothalamus. Arch Neurol Psychiatry 39:1127–1149.

    Google Scholar 

  • Martner J (1975) Influences on the defaecation and micturition reflexes by the cerebellar fastigial nucleus. Acta Physiol Scand 94:95–104.

    PubMed  CAS  Google Scholar 

  • Matsumoto H (1957) On the autonomic control of superior colliculus and limbic area to the bladder and rectum. Wakayama Igaku 8:65–80.

    Google Scholar 

  • Matthews PBC (1986) Observations on the automatic gain compensation of reflex gain on varying the pre-existing level of motor discharge in man. J Physiol 374:73–90.

    PubMed  CAS  Google Scholar 

  • McMahon SB (1986) Sensory-motor integration in urinary bladder function. In: Cervero F, Morrison JFB (eds) Visceral sensation. Elsevier, Amsterdam, pp 245–253.

    Google Scholar 

  • McMahon SB, Morrison JFB (1982a) Spinal neurones with long projections activated from the abdominal viscera of the cat. J Physiol 332:1–20.

    Google Scholar 

  • McMahon SB, Morrison JFB (1982b) Two groups of spinal interneurones that respond to stimulation of the abdominal viscera of the cat. J Physiol 332:21–34.

    Google Scholar 

  • McMahon SB, Morrison JFB (1982c) Factors that determine the excitability of parasympathetic reflexes to the bladder. J Physiol 332:35–43.

    Google Scholar 

  • McMahon SB, Spillane Kathy (1982) Brainstem influences on the parasympathetic supply to the urinary bladder of the cat. Brain Res 234:237–249.

    PubMed  CAS  Google Scholar 

  • McMahon SB, Morrison JFB, Spillane Kathy (1982) An electrophysiological study of somatic and visceral convergence in the reflex control of the external sphincters. J Physiol 328:379- 387.

    PubMed  CAS  Google Scholar 

  • McPherson A (1966) The effects of somatic stimuli on the bladder of the cat. J Physiol 185:185–204.

    PubMed  CAS  Google Scholar 

  • Milhorn HT (1966) The application of control theory to physiological systems. Saunders, Philadelphia, p 376.

    Google Scholar 

  • Morrison JFB (1982) The neural control of the bladder. In: Bloom SR, Polak JM, Lindenlaub E (eds) Systemic role of regulatory peptides. Schattauer, Stuttgart, pp 381–396.

    Google Scholar 

  • Morrison JFB, Spillane K (1981) The inhibitory influence of raphe stimulation on vesical parasympathetic reflexes in the cat. J Physiol 317:84P.

    Google Scholar 

  • Morrison JFB, Spillane Kathy (1986) Neuropharmacological studies on descending inhibitory controls over the micturition reflex. J Auton Nerv Syst (suppl):393–397.

    Google Scholar 

  • Mukai K (1959) Experimental studies on the bladder contraction point in gyrus cinguli and projection fibres from this point. Osaka Daigaku Igaku Zasshi 11:1645–1653.

    Google Scholar 

  • Mundy AR (1984) Clinical physiology of the bladder, urethra and pelvic floor. In: Mundy AR, Stephenson TP, Wein AJ (eds) Urodynamics, principles, practice and application. Churchill Livingstone, Edinburgh, pp 14–25.

    Google Scholar 

  • Mundy AR, Blaivas JG (1984) Nontraumatic neurological disorders. In: Mundy AR, Stephenson TP, Wein AJ (eds) Urodynamics, principles, practice and application. Churchill Livingstone, Edinburgh, pp 278–287.

    Google Scholar 

  • Nathan PW (1976) The central nervous connections of the bladder. In: Williams DI, Chisholm GD (eds) Scientific foundations of urology, vol II. Heinemann, London, pp 51–58.

    Google Scholar 

  • Nishiyama K (1959) Experimental studies on the bladder responses following electrical stimulation of the hypothalamus and its descending pathways. Osaka Daiguka Igaku Zasshi 11:4801–4808.

    Google Scholar 

  • Newsom Davis J, Sears T (1970) The proprioceptive control of the intercostal muscles during their voluntary activation. J Physiol 209:711–738.

    Google Scholar 

  • Pfeifer B (1919) Ãœber corticale Blasenstörungen und deren Lokalisation bei Hirnverletzten. Z Neurol Psychiatry 46:223–284.

    Google Scholar 

  • Porter RW (1967) A pallidal response to detrusor contraction. Brain Res 4:381–383.

    PubMed  CAS  Google Scholar 

  • Porter RW, Pazo JH, Dillard GV (1971) Triphasic brain stem response to detrusor contraction. Brain Res 35:119–126.

    PubMed  CAS  Google Scholar 

  • Ranson SW, Kabat H, Magoun HW (1935) Autonomic responses to electrical stimulation of hypothalamus preoptic region and septum. Arch Neurol Psychiatry 33:474–477.

    Google Scholar 

  • Ruch TC (1965) The urinary bladder. In: Ruch TC, Patton HD (eds) Physiology and biophysics. Saunders, Philadelphia, pp 1010–1021.

    Google Scholar 

  • Saper CB, Loewy AD, Swanson LW, Cowan WM (1976) Direct hypothalamo-autonomic connections. Brain Res 117:305–312.

    PubMed  CAS  Google Scholar 

  • Sato A, Sato Y, Schmidt RF (1980) Reflex bladder activity induced by electrical stimulation of hind limb somatic afferents in the cat. J Auton Nerv Syst 1:229–24.

    PubMed  CAS  Google Scholar 

  • Satoh K, Tohyama M, Tetsuro S, Yamamoto K, Shimizu N (1978a) Descending projection of the nucleus tegmentalis laterodorsalis to the spinal cord; studied by the horseradish peroxidase method following 6-hydroxy-dopa administration. Neurosci Lett 8:9–15.

    PubMed  CAS  Google Scholar 

  • Satoh K, Shimizu N, Tohyama M, Maeda T (1978b) Localisation of the micturition reflex at dorsolateral pontine tegmentum of the rat. Neurosci Lett 8:27–33.

    PubMed  CAS  Google Scholar 

  • Sherrington CS (1892) Notes on the arrangement of some motor fibres in the lumbo-sacral plexus. J Physiol 13:621–772.

    PubMed  CAS  Google Scholar 

  • Skyltety FM (1959) Relation of periaqueductal grey matter to stomach and bladder motility. Neurology 9: 190–198.

    Google Scholar 

  • Spillane Kathy (1982) Brainstem influences on pelvic parasympathetic reflexes. PhD Thesis, University of Leeds.

    Google Scholar 

  • Takebayashi H, Kobai Y, Ushida A, Matsumoto H, Yoshioka T, Arimoto K, Shimizu K, Matsuda A, Kawashima A, Yinya Y, Fujita I, Maeshima S (1957) Superior colliculus, playing roles in the optokinetic and neurovegetative mechanism. Wakayama Med Rep 4:1–12.

    Google Scholar 

  • Tang PC (1955) Levels of brainstem and diencephalon controlling micturition reflex. J Neurophysiol 18:583–595.

    PubMed  CAS  Google Scholar 

  • Tang PC, Ruch TC (1956) Localisation of brainstem and diencephalic areas controlling the micturition reflex. J Comp Neurol 106:213–245.

    PubMed  Google Scholar 

  • Terzian H, Ore GD (1955) Syndrome of Kluver and Bucy. Reproduced in man by bilateral removal of the temporal lobes. Neurology 5:373–380.

    PubMed  CAS  Google Scholar 

  • Wang SC, Ranson SW (1939a) Autonomic responses to stimulation of the lower brainstem. J Comp Neurol 71:437–455.

    Google Scholar 

  • Wang SC, Ranson SW (1939b) Descending pathways from the hypothalamus to the medulla and spinal cord. Observations on blood pressure and bladder responses. J Comp Neurol 71:457–472.

    Google Scholar 

  • West DC, Wolstencroft JH (1977) Location and conduction velocity of raphe-spinal neurones in nucleus raphe magnus and raphe pallidus in the cat. Neurosci Lett 5:147–151.

    PubMed  CAS  Google Scholar 

  • West DC, Wolstencroft JH (1982) Descending inhibition of the flexor withdrawal reflexes in the decerebrate cat. J Physiol 327:60P.

    Google Scholar 

  • Westlund KN, Coulter JD (1980) Descending projections of the locus coeruleus and subcoeruleus/medial parabrachial nuclei in the monkey: axonal transport studies and dopamines- hydroxylase immunocytochemistry. Brain Res Rev 2:235–264.

    CAS  Google Scholar 

  • Wolstencroft JH, West DC (1982) Functional characteristics of raphespinal and other projections from nucleus raphe magnus. In: Sjolund B, Bjorklund A (eds) Brain stem control of spinal mechanisms. Elsevier, Amsterdam, pp 359–380.

    Google Scholar 

  • Yamamoto S, Araki K (1962) Intra-abdominal pressure response to medullary stimulation in cats. Exp Neurol 5:110–119.

    PubMed  CAS  Google Scholar 

  • Yamamoto S, Araki K, Kikuchi M (1961) Abdominal musclereflexes of pelvic origin in cats. Exp Neurol 4:345–357.

    PubMed  CAS  Google Scholar 

  • Yamamoto S, Araki K, Kikuchi M (1962) Electromyographic study of reflex activity in abdominal wall muscles and diaphragm following pelvic afferent excitation in cats. Tohoku J Exp Med 75:375–383.

    PubMed  CAS  Google Scholar 

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Morrison, J.F.B. (1987). Bladder Control: Role of Higher Levels of the Central Nervous System. In: Torrens, M., Morrison, J.F.B. (eds) The Physiology of the Lower Urinary Tract. Springer, London. https://doi.org/10.1007/978-1-4471-1449-9_8

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