Mediators in Acute Lung Injury: The Whole Body Inflammatory Response Hypothesis
A wide variety of extrapulmonary events such as major sepsis, burns, fat embolism, multiple trauma and pancreatitis may initiate an acute lung injury with the development of the adult respiratory distress syndrome (ARDS) (Anon. 1985). This same phenomenon, though usually in a much less severe form, has been observed in the controlled therapeutic situations of haemodialysis (Craddock et al. 1977), cardiopulmonary bypass (Westaby 1983) and nylon fibre leucapheresis (Nusbacher et al. 1978) where blood traverses a number of allegedly biocompatible foreign surfaces.
KeywordsCardiopulmonary Bypass Acute Lung Injury Chronic Granulomatous Disease Adult Respiratory Distress Syndrome Human Neutrophil Elastase
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