Abstract
Bone is a living tissue with properties of growth and renewal like most other types of tissue in the human organism. It has multiple functions among which support, weight-bearing and participation in calcium homeostasis are the most important. To understand these properties a certain knowledge of primary bone formation, postnatal growth (modelling) and the continuous renewal of adult bone throughout life (remodelling) (Frost 1969) is necessary. This Chapter deals with these subjects and with certain disorders involving bone tissue which may compromise its biomechanical and/or calcium homeostatic properties.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Charles P, Poser JW, Mosekilde L, Jensen FT (1985) Estimation of bone turnover evaluated by 47Ca kinetics: efficiency of serum bone gamma-carboxyglutamic acid-containing protein, serum alkaline phosphatase, and urinary hydroxyproline excretion. J Clin Invest 76:2254–2258
Charles P, Mosekilde L, Jensen FT (1986) Primary hyperparathyroidism: evaluated by 47Ca kinetics, calcium balance and serum bone Gla-protein. Eur J Clin Invest 16:277–283
Eriksen EF (1986) Normal and pathological remodeling of human trabecular bone: three-dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease. Endocr Rev 7:379–408
Eriksen EF, Gundersen HJG, Meisen F, Mosekilde L (1984a) Reconstruction of the formative site in iliac trabecular bone in 20 normal individuals employing a kinetic model for matrix and mineral apposition. Metab Bone Dis Rel Res 5:243–252
Eriksen EF, Meisen F, Mosekilde L (1984b) Reconstruction of the resorptive site in iliac trabecular bone: a kinetic model for bone resorption in 20 normal individuals. Metab Bone Dis Rel Res 5:235–242
Eriksen EF, Mosekilde L, Meisen F (1985) Trabecular bone remodeling and bone balance in hyperthyroidism. Bone 6:421–428
Eriksen EF, Mosekilde L, Meisen F (1986a) Kinetics of trabecular bone resorption and formation in hypothyroidism: evidence for a positive balance per remodeling cycle. Bone 7:101–108
Eriksen EF, Mosekilde L, Meisen F (1986b) Trabecular bone remodeling and balance in primary hyperparathyroidism. Bone 7:213–222
Frost HM (1969) Tetracycline-based histological analysis of bone remodeling. Calcif Tissue Res 3:211–237
Garn SM, Rohmann CG, Wagner B, Ascoli W (1967) Continuing bone growth throughout life: a general phenomenon. Am J Phys Anthropol 26:313–317
Jaworsky ZF (1971) Some morphologic and dynamic aspects of remodelling on the endostealcortical and trabecular surfaces. In: Menczel J, Harell A (eds) Calcified tissue: structural, functional and metabolic aspects. Academic Press, New York, pp 159–160
Kragstrup J, Gundersen HJG, Meisen F, Mosekilde L (1982) Estimation of the three-dimensional wall thickness of completed remodeling sites in iliac trabecular bone. Metab Bone Dis Rel Res 4:113–119
Meisen F, Mosekilde L (1977) Morphometric and dynamic studies of bone changes in hyperthyroidism. Acta Pathol Microbiol Scand [A] 85:141–150
Meisen F, Mosekilde L (1981) The role of bone biopsy in metabolic bone disease. Orthop Clin North Am 12:571–602
Meisen F, Nielsen HE (1977) Osteonecrosis following renal allotransplantation. Acta Pathol Microbiol Scand [A] 85:99–104
Mosekilde L, Christensen MS (1977) Decreased parathyroid function in hyperthyroidism: interrelationships between serum parathyroid hormone, calcium-phosphorus metabolism and thyroid function. Acta Endocrinol 84:566–575
Mosekilde L, Meisen F (1978a) Morphometric and dynamic studies of bone changes in hypothyroidism. Acta Pathol Microbiol Scand [A] 86:56–62
Mosekilde L, Meisen F (1978b) A tetracycline based histomorphometric evaluation of bone resorption and bone turnover in hyperthyroidism and hyperparathyroidism. Acta Med Scand 204:97–102
Mosekilde L, Mosekilde L (1986) Normal vertebral body size and compressive strength: relations to age and to vertebral and iliac trabecular bone compressive strength. Bone 7:207–212
Nielsen HE, Meisen F, Christensen MS (1980) Interrelationships between calcium-phosphorus metabolism, serum parathyroid hormone and bone histomorphometry in non-dialyzed and dialyzed patients with chronic renal failure. Mineral Electrolyte Metab 4:113–122
Nilsson P, Meisen F, Malmaeus J, Danielson BG, Mosekilde L (1985) Relationships between calcium and phosphorus homeostasis, parathyroid hormone levels, bone aluminium, and bone histomorphometry in patients on maintenance hemodialysis. Bone 6:21–27
Parfitt AM (1976) The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. 2. PTH and osteoblasts, the relationship between bone turnover and bone loss, and the state of bone in primary hyperparathyroidism. Metabolism 25:1033–1087
Parfitt AM (1982) The coupling of bone formation and bone resorption: a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis. Metab Bone Dis Rel Res 4:1–6
Parfitt AM (1984) Age related structural changes in trabecular and cortical bone. Cellular mechanisms and biomechanical consequences. Calcif Tissue Int 36:123–128
Talmage RV (1969) Calcium homeostasis-calcium transport and parathyroid action: the effects of parathyroid hormone on the movement of calcium between bone and fluid. Clin Orthop 67:210–224
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Melsen, F., Mosekilde, L. (1988). Calcified Tissues: Cellular Dynamics. In: Nordin, B.E.C. (eds) Calcium in Human Biology. ILSI Human Nutrition Reviews. Springer, London. https://doi.org/10.1007/978-1-4471-1437-6_8
Download citation
DOI: https://doi.org/10.1007/978-1-4471-1437-6_8
Publisher Name: Springer, London
Print ISBN: 978-1-4471-1439-0
Online ISBN: 978-1-4471-1437-6
eBook Packages: Springer Book Archive