Cellular Calcium: Action of Hormones

  • R. H. Wasserman
Part of the ILSI Human Nutrition Reviews book series (ILSI HUMAN)


An appreciation of the indispensability of the calcium ion in physiological systems began with the experiments of Sydney Ringer, who, in the 1880s, noted that calcium was required to maintain the contractility of the frog heart, essential to the development of fertilized eggs and tadpoles and important in cell adhesion (Campbell 1983). Subsequent studies by Locke, Loeb, Loewi and others in the early 1900s demonstrated that calcium was required for the action of hormones such as adrenaline. That calcium was necessary for the survival of cells in culture and for the maintenance of colonies of cells in tissues and organs became known in later years. More recently, it has become widely recognized that the actions of various hormones and other agonists involve changes in intracellular calcium levels.


Adenylate Cyclase Phosphatidic Acid Phorbol Ester Phosphatidic Acid Intracellular Store 
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  • R. H. Wasserman

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