Nuclear magnetic resonance has been used in the examination of tissues almost since the discovery of the phenomenon by Bloch and independently by Purcell in 1946. It is often asserted (but was not published) that the earliest NMR study in vivo was performed by Bloch who placed his finger into the NMR probe and obtained a proton signal from the digit. In vitro tissue studies were occasionally reported during the 1950s and 1960s, e.g. Odeblad et al. (1956), Bratton et al. (1965). It was, however, the reports of Damadian and his co-workers in the early 1970s (e.g. Damadian 1971), describing differences in proton relaxation times between normal and pathological tissues, which initiated the great surge of interest in the application of NMR to biological and medical studies. These studies have culminated in the widespread use of NMR spectroscopy and especially of imaging which we see today.
KeywordsManganese Coherence Sarcoma Gall Macromolecule
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