Tissue Characterisation by NMR

  • Margaret A. Foster

Abstract

Nuclear magnetic resonance has been used in the examination of tissues almost since the discovery of the phenomenon by Bloch and independently by Purcell in 1946. It is often asserted (but was not published) that the earliest NMR study in vivo was performed by Bloch who placed his finger into the NMR probe and obtained a proton signal from the digit. In vitro tissue studies were occasionally reported during the 1950s and 1960s, e.g. Odeblad et al. (1956), Bratton et al. (1965). It was, however, the reports of Damadian and his co-workers in the early 1970s (e.g. Damadian 1971), describing differences in proton relaxation times between normal and pathological tissues, which initiated the great surge of interest in the application of NMR to biological and medical studies. These studies have culminated in the widespread use of NMR spectroscopy and especially of imaging which we see today.

Keywords

Manganese Coherence Sarcoma Gall Macromolecule 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bachus R, Koenig H, Lenz G, Deimling M, Reinhardt ER (1985) Tissue differentiation in MRI by means of pattern recognition. Proceedings of the 4th Meeting of the Society of Magnetic Resonance in Medicine. SMRM, Berkeley, CA, pp 18–19.Google Scholar
  2. Bielke G, Bruckner A, Meindl S, Seelen van W, Higer HP, Pfannenstiel P, Meves M (1985) A method for a multiparametric tissue characterisation in NMR-imaging. Proceedings of the 4th Meeting of the Society of Magnetic Resonance in Medicine. SMRM, Berkeley, CA, pp 22–23.Google Scholar
  3. Bloch F, Hansen WW, Packard M (1946) The nuclear induction experiment. Phys Review 70: 474–485.CrossRefGoogle Scholar
  4. Bottomley PA, Foster TH, Argersinger RE, Pfiefer LM (1974) A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1–100 MHz: Dependence on tissue type, NMR frequency, temperature, species, excision and age. Med Phys 11: 425–448.CrossRefGoogle Scholar
  5. Bratton CB, Hopkins AL, Weinberg JW (1965) Nuclear magnetic resonance studies of living muscle. Science 147: 738–741.PubMedCrossRefGoogle Scholar
  6. Damadian R (1971) Tumour detection by nuclear magnetic resonance. Science 171: 1151–1153.PubMedCrossRefGoogle Scholar
  7. Farrar TC, Becker ED (1971) Pulse and Fourier transform NMR. Academic Press, New York.Google Scholar
  8. Odeblad E, Bahr BN, Lindstrom E (1956) Proton magnetic resonance of human red blood cells in heavy water exchange experiments. Arch Biochem Biophys 63: 221–225.PubMedCrossRefGoogle Scholar
  9. Purcell EM, Torrey HC, Pound RV (1946) Resonance absorption by nuclear magnetic moments in a solid. Phys Review 69: 37–43.CrossRefGoogle Scholar
  10. Wehrli FW, MacFall JR, Glover GH, Grigsby N (1984) The dependence of nuclear magnetic resonance image contrast on intrinsic and pulse sequence timing parameters. Magnetic Resonance Imaging 2: 3–16.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Margaret A. Foster

There are no affiliations available

Personalised recommendations