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Quantitative 99mTc Diphosphonate Uptake Measurements

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Bone Scanning in Clinical Practice

Abstract

The isotope bone scan, using technetium-99m (99mTc) diphosphonate, is essentially a visual display of skeletal function. 99mTc diphosphonate is adsorbed onto any metabolically active bone with an intact blood supply. Uptake of 99mTc diphosphonate is believed to be primarily related to new bone formation; however, as bone formation and resorption are coupled, this uptake reflects skeletal metabolism. Any increase in bone turnover, whether focal or diffuse, will result in an increase in 99mTc diphosphonate uptake. Thus measurement of this uptake by bone provides a sensitive and objective means of quantifying skeletal metabolism (Holmes 1978).

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  1. M. L. Smith
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Editors and Affiliations

  1. Department of Nuclear Medicine, Guy’s Hospital, St. Thomas Street, London, SE1 9RT, UK

    Ignac Fogelman BSc, MD, MRCP (Consultant Physician) (Consultant Physician)

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© 1987 Springer-Verlag Berlin Heidelberg

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Smith, M.L. (1987). Quantitative 99mTc Diphosphonate Uptake Measurements. In: Fogelman, I. (eds) Bone Scanning in Clinical Practice. Springer, London. https://doi.org/10.1007/978-1-4471-1407-9_16

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  • DOI: https://doi.org/10.1007/978-1-4471-1407-9_16

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1409-3

  • Online ISBN: 978-1-4471-1407-9

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