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Hormone Receptors in Prostatic Cancer

  • Chapter
Book cover Adenocarcinoma of the Prostate

Part of the book series: Clinical Practice in Urology ((PRACTICE UROLOG))

Abstract

During the last decade, the clinical use of steroid hormone receptor assays has become an accepted part of the management of a number of diseases of hormone target organs. In breast cancer, and to a lesser extent in endometrial cancer, the concentrations of receptors for estrogen and progestin in the malignant tissue are regarded as prognostic factors in early disease, and as predictive factors for the value of endocrine treatment for patients with advanced disease (Knight et al. 1980; McGuire and Clark 1983). In acute lymphocytic leukemia, the cellular concentration of glucocorticoid receptors appears to be an indicator of prognosis and response to glucocorticoid therapy (Costlow et al. 1982). The assay of androgen receptor (AR) in cultured genital skin fibroblasts can assist in the diagnosis and selection of treatment of benign conditions such as androgen resistance syndromes (Bardin and Wright 1980). It is therefore somewhat disappointing that studies of the application of AR assays to the management of prostatic carcinoma, which is known to be an androgen-sensitive disease in the majority of cases, have met with very limited success. Some of the reasons for this are inherent in the nature of the disease and are discussed below. Nevertheless, the research involved in the development of these assays, together with that into related areas of the biochemistry of human and animal prostatic tissue, has added much to our knowledge of the basic mechanisms involved in the control of prostatic growth.

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Authors
  1. B. G. Mobbs
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  2. J. G. Connolly
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Editors and Affiliations

  1. Division of Urology, University of Toronto, Toronto General Hospital, Suite 14-205, The Eaton Wing, 200 Elizabeth Street, Toronto, Ontario, Canada, M5G 2C4

    Andrew W. Bruce FRCS, FRCS(C) (Professor and Chairman) (Professor and Chairman)

  2. Division of Urology, University of Toronto, Toronto General Hospital, Suite 14-209, The Eaton Wing, 200 Elizabeth Street, Toronto, Ontario, Canada, M5G 9Z9

    John Trachtenberg MD, FRCS(C) (Associate Professor, Career Scientist) (Associate Professor, Career Scientist)

  3. Ministry of Health, Province of Ontario, Canada

    John Trachtenberg MD, FRCS(C) (Associate Professor, Career Scientist) (Associate Professor, Career Scientist)

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© 1987 Springer-Verlag Berlin Heidelberg

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Mobbs, B.G., Connolly, J.G. (1987). Hormone Receptors in Prostatic Cancer. In: Bruce, A.W., Trachtenberg, J. (eds) Adenocarcinoma of the Prostate. Clinical Practice in Urology. Springer, London. https://doi.org/10.1007/978-1-4471-1398-0_4

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  • DOI: https://doi.org/10.1007/978-1-4471-1398-0_4

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  • Print ISBN: 978-1-4471-1400-0

  • Online ISBN: 978-1-4471-1398-0

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