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Tumor Markers in Prostatic Disease

  • Chapter
Adenocarcinoma of the Prostate

Part of the book series: Clinical Practice in Urology ((PRACTICE UROLOG))

Abstract

One of the current problems in the diagnosis of prostatic cancer is that there is no procedure which can detect early localized disease curable by surgery and that truly localized cancers can only be detected by rectal examination in 10%–20% of patients. Another problem is the variability of the natural history of the disease. Clinically, some tumors remain localized for long periods, producing few, if any symptoms or signs, and others disseminate widely before symptoms are manifested. Due to this, numerous grading systems, as well as highly sophisticated cytometric systems, have been introduced to correlate the morphologic parameters of the cancer cells with their biologic characteristics, such as growth rate and metastatic potential. In addition, various biochemical or immunochemical markers have been researched in the past, and some of the molecular markers of prostatic cancer have found a place in the clinical laboratory (Benson and Coffey 1983; Whitmore 1984).

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Authors
  1. A. W. Bruce
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  2. B. K. Choe
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Editors and Affiliations

  1. Division of Urology, University of Toronto, Toronto General Hospital, Suite 14-205, The Eaton Wing, 200 Elizabeth Street, Toronto, Ontario, Canada, M5G 2C4

    Andrew W. Bruce FRCS, FRCS(C) (Professor and Chairman) (Professor and Chairman)

  2. Division of Urology, University of Toronto, Toronto General Hospital, Suite 14-209, The Eaton Wing, 200 Elizabeth Street, Toronto, Ontario, Canada, M5G 9Z9

    John Trachtenberg MD, FRCS(C) (Associate Professor, Career Scientist) (Associate Professor, Career Scientist)

  3. Ministry of Health, Province of Ontario, Canada

    John Trachtenberg MD, FRCS(C) (Associate Professor, Career Scientist) (Associate Professor, Career Scientist)

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© 1987 Springer-Verlag Berlin Heidelberg

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Bruce, A.W., Choe, B.K. (1987). Tumor Markers in Prostatic Disease. In: Bruce, A.W., Trachtenberg, J. (eds) Adenocarcinoma of the Prostate. Clinical Practice in Urology. Springer, London. https://doi.org/10.1007/978-1-4471-1398-0_3

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  • DOI: https://doi.org/10.1007/978-1-4471-1398-0_3

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1400-0

  • Online ISBN: 978-1-4471-1398-0

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