Urologic Applications of Regional Chemotherapy

  • John D. Maldazys
  • Jean B. deKernion
Part of the Clinical Practice in Urology book series (PRACTICE UROLOG)


Since its beginnings, the goal of cancer chemotherapy has been the selective destruction of cancer cells without systemic toxicity. The narrow margin between therapeutic and toxic doses with the presently available drugs has prevented this. The report by Klopp and co-workers in 1950 [20] of the injection of nitrogen mustard directly into the arterial supply of tumors raised hope that this goal would soon be realized. In the 1950s and 1960s enthusiasm for regional chemotherapy led clinicians to investigate its use against neoplasms of many cell types and organ sites. Ingenious methods were devised for drug administration in attempts to gain the maximum benefit.


Bladder Cancer Bladder Tumor Infusion Chemotherapy Regional Chemotherapy Infusion Catheter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ansfield FJ, Ramirez G, Skibba JL, Bryan GT, Davis HL, Wirtanen GW (1971) Intrahepatic arterial infusion with 5-fluorouracil. Cancer 28: 1147–1151PubMedCrossRefGoogle Scholar
  2. 2.
    Auersperg M, Us-Krasovec M (1970) In vivo sensitivity test for guided chemotherapy of malignant tumors. Proc Sixth Int Congr Chemother 2: 353–358Google Scholar
  3. 3.
    Austin WG, Monaco AP, Richardson GS, Baker WH, Shaw RS, Raker JW (1959) Treatment of malignant pelvic tumors by extracorporeal perfusion with chemotherapeutic agents. N Engl J Med 261: 1037–1045CrossRefGoogle Scholar
  4. 4.
    Blackshear PJ, Dorman FD, Blackshear PL, Varco RL, Buchwald H (1970) A permanently implantable self-recycling low flow constant rate multipurpose infusion pump of simple design. Surg Forum 21: 136–137PubMedGoogle Scholar
  5. 5.
    Brendler H, Leiter E, Edelman S (1967) Continuous intra-arterial perfusion of kidney tumors with cytotoxic agents prior to nephrectomy. In: King JS (ed) Renal neoplasia. Little, Brown and Company, BostonGoogle Scholar
  6. 6.
    Calvo DB, Patt YZ, Wallace S, Chuang VP, Benjamin RS, Pritchard JD, Hersh EM, Bodey GP, Mavligit GM (1980) Phase I-II trial of percutaneous intra-arterial cw-diamminedichloroplatinum ( II) for regionally confined malignancy. Cancer 45: 1278-1283Google Scholar
  7. 7.
    Chabner BA (1982) Pyrimidine antagonists. In: Chabner BA (ed) Pharmacologic principles of cancer treatment. W. B. Saunders, Philadelphia, pp 183–212Google Scholar
  8. 8.
    Clarkson B, Lawrence W (1961) Perfusion and infusion techniques in cancer chemotherapy. Med Clin North Am 45: 689–710PubMedGoogle Scholar
  9. 9.
    Cohen AM, Wood WC, Greenfield A, Waltman A, Dedrick C, Blackshear PJ (1980) Transbrachial hepatic artery chemotherapy using an implanted infusion pump. Dis Colon Rectum 23: 223–227PubMedCrossRefGoogle Scholar
  10. 10.
    Collins JM, Dedrick RL (1982) Pharmacokinetics of anticancer drugs. In: Chabner BA (ed) Pharmacologic principles of cancer treatment. W. B. Saunders, Philadelphia, pp 77–99Google Scholar
  11. 11.
    Eckman WW, Patlak CS, Fenstermacher JD (1974) A critical evaluation of the principles governing the advantages of intra-arterial perfusions. J Pharmacokinet Biopharm 2: 257–285PubMedCrossRefGoogle Scholar
  12. 12.
    Eilber FR, Mirra JJ, Grant TT, Weisenberger T, Morton DL (1980) Is amputation necessary for sarcomas? A seven-year experience with limb salvage. Ann Surg 192: 431–438PubMedCrossRefGoogle Scholar
  13. 13.
    Ensminger W, Niederhuber J, Dakhil S, Thrall J, Wheeler R (1981) Totally implanted drug delivery system for hepatic arterial chemotherapy. Cancer Treat Rep 65: 393–400PubMedGoogle Scholar
  14. 14.
    Fortuny IE, Theologides A, Kennedy BJ (1975) Hepatic arterial infusion for liver metastases from lung cancer: comparison of mitomycin C (NSC-26980) and 5-fluorouracil (NSC-19893). Cancer Chemother Rep 59: 401–404PubMedGoogle Scholar
  15. 15.
    Goldman ML, Bilbao MK, Rosch J, Dotter CT (1975) Complications of indwelling chemotherapy catheters. Cancer 36: 1983–1990PubMedCrossRefGoogle Scholar
  16. 16.
    Hurley JD, Wall T, Worman LW, Schulte WJ (1961) Experiences with pelvic perfusion for carcinoma. Arch Surg 83: 127–137Google Scholar
  17. 17.
    Jacobs SC, Lawson RK (1982) Pathologic effects of pre-cystectomy therapy with combination intra-arterial doxorubicin and local bladder hyperthermia for bladder cancer. J Urol 127: 43–47PubMedGoogle Scholar
  18. 18.
    Kaplan WD, D’Orsi CJ, Ensminger WD, Smith EH, Levin DC (1978) Intra-arterial radionuclide infusion: a new technique to assess chemotherapy perfusion patterns. Cancer Treat Rep 62: 699–703PubMedGoogle Scholar
  19. 19.
    Kato T, Nemoto R, Mori H, Takahashi M, Tamakawa Y (1981) Transcatheter arterial chemoem-bolization of renal cell carcinoma with microencapsulated mitomycin C. J Urol 125: 19–24PubMedGoogle Scholar
  20. 20.
    Klopp CT, Alford TC, Bateman J, Berry GN, Winship T (1950) Fractionated intra-arterial cancer chemotherapy with methyl bis amine hydrochloride: a preliminary report. Ann Surg 132: 811–832PubMedCrossRefGoogle Scholar
  21. 21.
    Kraybill WG, Harrison M, Sasaki T, Fletcher WS (1977) Regional intra-arterial infusion of adriamycin in the treatment of cancer. Surg Gynecol Obstet 144: 335–338PubMedGoogle Scholar
  22. 22.
    Levi J A, Aroney RS, Dalley DN (1980) Combination chemotherapy with cyclophosphamide, doxorubicin and bleomycin for metastatic transitional cell carcinoma of the urinary bladder. Cancer Treat Rep 64: 1011–1013PubMedGoogle Scholar
  23. 23.
    Logothetis CJ, Samuels ML, Wallace S, Chuang V, Trindade A, Grant C, Haynie TP, Johnson DE (1982) Management of pelvic complications of malignant urothelial tumors with combined intra-arterial and IV chemotherapy. Cancer Treat Rep 66: 1501–1507PubMedGoogle Scholar
  24. 24.
    Maki DG, McCormick RD, Uman SJ, Wirtanen GW (1979) Septic endarteritis due to intraarterial catheters for cancer chemotherapy. Cancer 44: 1228–1240PubMedCrossRefGoogle Scholar
  25. 25.
    Nakazono M, Iwata S (1981) Pre-operative intra-arterial chemotherapy for bladder cancer. Urol Res 9: 289–295PubMedCrossRefGoogle Scholar
  26. 26.
    Nevin JE, Hoffman AA (1975) Use of arterial infusion of 5-fluorouracil either alone or in combination with supervoltage radiation as a treatment for carcinoma of the prostate and bladder. Am J Surg 130: 544–549PubMedCrossRefGoogle Scholar
  27. 27.
    Nevin JE, Melnick I, Baggerly JT, Easley CA, Landes R (1974) Advanced carcinoma of bladder: treatment using hypogastric artery infusion with 5-fluorouracil, either as a single agent or in combination with bleomycin or adriamycin and supervoltage radiation. J Urol 112: 752–758PubMedGoogle Scholar
  28. 28.
    Nevin JE, Melnick I, Baggerly JT, Esteves J, Landes R, Easley CA (1974) Arterial infusion of 5-fluorouracil as a treatment for carcinoma of the prostate. J Urol 112: 114–119PubMedGoogle Scholar
  29. 29.
    Ogata J, Migita N, Nakamura T (1973) Treatment of carcinoma of the bladder by infusion of the anticancer agent (mitomycin C) via the internal iliac artery. J Urol 110: 667–670PubMedGoogle Scholar
  30. 30.
    Pinedo HM, Kenis Y (1977) Chemotherapy of advanced soft tissue sarcoma in adults. Cancer Treat Rev 4: 67–86PubMedCrossRefGoogle Scholar
  31. 31.
    Plasse T. Ohnuma T, Bruckner H, Chamberlain K, Moss T, Holland JE (1982) Portable infusion pumps in ambulatory cancer therapy. Cancer 50: 27–31Google Scholar
  32. 32.
    Sagiyama K, Uozumi J, Aoki K, Baba T (1983) Efficacy of “two-route chemotherapy” using intraarterial cisplatin and IV sodium thiosulfate, its antidote, in rat bladder tumor. Cancer Treat Rep 67: 567–572PubMedGoogle Scholar
  33. 33.
    Samuels ML, Moran ME, Johnson DE, Bracken RB (1979) CISCA combination chemotherapy for metastatic carcinoma of the bladder. In: Johnson DE, Samuels ML (eds) Cancer of the genitourinary tract. Raven Press, New York, pp 101–106Google Scholar
  34. 34.
    Schulman CC, Struyven J, Bredael JJ, Delcour A (1983) Intraarterial chemotherapy of infiltrative bladder tumors. Proc Am Urol Assoc, Abstr #348, p 178Google Scholar
  35. 35.
    Seldinger SI (1953) Catheter replacement of the needle in percutaneous arteriography. Acta Rad Stockh. 39: 368-376, 1953Google Scholar
  36. 36.
    Stewart DJ, Benjamin RS, Zimmerman S, Caprioli RM, Wallace S, Chuang V, Calvo D, Samuels M, Bonura J, Loo TL (1983) Clinical pharmacology of intra-arterial cw-diamminedichloroplatinum ( II ). Cancer Res 43: 917-920Google Scholar
  37. 37.
    Sullivan RD (1962) Continuous arterial infusion cancer chemotherapy. Surg Clin North Am 42: 365–379PubMedGoogle Scholar
  38. 38.
    Sullivan RD, Watkins E, Oberfield RA, Khazei AM (1967) Current status of protracted arterial infusion cancer chemotherapy for the treatment of solid tumors. Surg Clin North Am 47: 769–784PubMedGoogle Scholar
  39. 39.
    Thomson KR, Goldin AR (1979) Angiographic techniques in interventional radiology. Rad Clin North Am 17: 375–391Google Scholar
  40. 40.
    Turner AG (1981) Methotrexate in advanced bladder cancer. Cancer Treat Rep 65 (Suppl 1): 183–186PubMedGoogle Scholar
  41. 41.
    Vogl SE, Kaplan BH (1979) Chemotherapy of advanced head and neck cancer with methotrexate, bleomycin and cw-diamminedichloroplatinum II in an effective outpatient schedule. Cancer 44: 26–31PubMedCrossRefGoogle Scholar
  42. 42.
    Wallace S, Chuang VP, Samuels M, Johnson D (1982) Transcatheter intra-arterial infusion of chemotherapy in advanced bladder cancer. Cancer 49: 640–645PubMedCrossRefGoogle Scholar
  43. 43.
    Watkins E, Hering AC, Luna R, Adams HD (1960) The use of intravascular balloon catheters for isolation of the pelvic vascular bed during pump-oxygenator perfusion of cancer chemotherapeutic agents. Surg Gynecol Obstet 111: 464–468PubMedGoogle Scholar
  44. 44.
    Wiley AL, Wirtanen GW, Joo P, Ansfield EJ, Ramirez G, Davis HL, Vermund H (1975) Clinical and theoretical aspects of the treatment of surgically unresectable retroperitoneal malignancy with combined intra-arterial actinomycin-D and radiotherapy. Cancer 36: 107–122PubMedCrossRefGoogle Scholar
  45. 45.
    Wirtanen GW (1973) Percutaneous transbrachial artery infusion catheter techniques. AJR 117: 696–700Google Scholar
  46. 46.
    Zwelling LA, Kohn KW (1982) Platinum complexes. In: Chabner BA (ed) Pharmacologic principles of cancer treatment. W. B. Saunders, Philadelphia, pp 309–339Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • John D. Maldazys
  • Jean B. deKernion

There are no affiliations available

Personalised recommendations