Hemophilic Synovitis

  • Holger Pettersson
  • Marvin S. Gilbert


A number of hemophilic patients will develop a persistent synovitis with swelling of a joint, and this condition appears to be inflammatory rather than hemorrhagic. This represents a poorly understood clinical syndrome. The natural history of such swelling is variable in that it may persist for months or years, may progress rapidly into a classic hemophilic arthropathy, or at times may clear spontaneously. It may be difficult to differentiate synovitis from recurrent bleeding, and at times there seems to be a close relationship between them. These two conditions represent what König (1892) referred to as the second-stage of hemophilic arthropathy. Because of the clinical importance of this condition, it will be described in some detail in this chapter.


Recurrent Bleeding Severe Hemophilia Soft Tissue Change Hemophilic Patient Patellofemoral Compartment 
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  1. Ahlberg Å (1973) Radioactive gold in treatment of chronic synovial effusion in haemophilia. In: Ala F, Denson KWE (eds) Haemophilia. Excerpta Medica, Amsterdam.Google Scholar
  2. Arnold WD, Hilgartner MW (1977) Hemophilic arthropathy: Current concepts of pathogenesis and management. J Bone Joint Surg [Am] 59: 287–305.Google Scholar
  3. Fernandez-Pallazi F, de Bosch NB (1983) Radioactive synoviorthesis in hemophilic hemarthrosis. Follow-up of fifty cases. The XVth World Federation of Hemophilia Congress, Stockholm, Sweden.Google Scholar
  4. Gilbert MS (1977) Musculoskeletal manifestation of hemophilia. Mt Sinai J Med 44: 339–358.PubMedGoogle Scholar
  5. König F (1892) Die Gelenkerkrankungen bei Blutern mit besonderer Berücksichtigung der Diagnose. Klin Vorträge NF 36: 233. Translated in Clin Orthop 52: 5–11, 1967.CrossRefGoogle Scholar
  6. Risse JC, Menkes C, Allain JP, Witvoet J (1973) Synoviorthesis in the treatment of chronic haemophilic arthropathy: A preliminary report. In: Ala F, Denson KWE (eds) Haemophilia. Excerpta Medica, Amsterdam.Google Scholar
  7. Schreiber RR (1975) Musculoskeletal system—radiologic findings. In: Brinkhous KM, Hemker HC (eds) Handbook of Hemophilia. Excerpta Medica, Amsterdam, pp 333–370.Google Scholar
  8. Storti E, Traldi E, Tosatti E, Davoli G (1970) Synovectomy in hemophilia: A new therapeutic approach and efficient technique of hemostasis. Gazetta Sanitaria 14: 11–17.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Holger Pettersson
    • 1
    • 2
  • Marvin S. Gilbert
    • 3
  1. 1.University of LundSweden
  2. 2.Division for Skeletal Radiology, Department of RadiologyUniversity HospitalLundSweden
  3. 3.Department of Orthopedics, Mt. Sinai School of MedicineCity University of New YorkUSA

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