Abstract
Superficial bladder tumours (those not invading into muscle) represent by far the most common form of transitional cell carcinoma (TCC) (Koss 1975). They are usually papillary and of a low histological grade, although sessile tumours, which carry a somewhat worse prognosis, are not uncommon (deKernion and Skinner 1978).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alroy J, Teramura K, Miller AW, Pauli B, Gottesman JE, Flanagan M, Davidsohn I, Weinstein, RS (1978) Iso-antigens A, B, and H in urinary bladder carcinoma following radiotherapy. Cancer 41: 1739–1745
Althausen AF, Prout GR, Jr, Daly JJ (1976). Non-invasive papillary carcinoma of the bladder associated with carcinoma in situ. J Urol 116: 575–580
Ansfield F (1973) Treatment of tumours of the urinary tract. In: Ansfield F (ed) Chemotherapy of malignant neoplasms. Thomas, Springfield, 111, pp 289–290
Antonaci S, Piccinno A, Lucivero G (1981) Effect of BCG cell-mediated cytotoxicity in bladder cancer patients following surgical treatment. Tumori 67: 177–182
Asaki T, Matsumura Y, Takahashi T, Yoshimoto J, Kaneshige T, Fujita Y, Ohmori H (1980) The effects of intravesical instillation of thiotepa on the recurrence rate of bladder tumours. Acta Med Okayama 321: 43–49
Banks MD, Pontes JE, Izbicki RM, Pierce JM (1977) Topical instillation of doxorubicin hydrochloride in the treatment of recurring superficial transitional cell carcinoma of the bladder. J Urol 118: 757–760
Bean MA, Pees H, Fogh J, Grabstald H, Oettgen HF (1974) Cytotoxicity of lymphocytes from patients with cancer of the urinary bladder. Detection by 3H-proline microcytotoxicity test. Int J Cancer 14: 186–197
Bergman S, Javadpour N (1978) The cell surface antigens A, B, O(H) as an indicator of malignant potential in stage A bladder carcinoma: a preliminary report. J Urol 119: 49–51
Bergsma CJ, Leary FJ (1976) Total bladder necrosis following intravesical formalin. In: Proceedings of the Annual Meeting of the American Urological Association, North Central Section, Annual Meeting, Palm Beach, Florida, 1976
Billiau A (1981) The clinical value of interferon as antitumor agents. Eur J Cancer Clin Oncol 17: 949–967
Bloom ET, Brown DE (1980) Detection of antigenic differences and similarities between human transitional cell carcinoma cell lines using rabbit antisera. Urol Res 8: 5–13
Bloom ET, Ossorio RC, Brosman SA (1974) Cell mediated cytotoxicity against human bladder cancer. Int J Cancer 14: 326–332
Bogden AE, Cobb WR, LePage DJ (1982) An in vitro method for testing chemotherapeutic agents against first transplant generation human tumor xenografts. In: Fidler IJ, White RJ (eds) Design of models for testing cancer therapeutic agents. Van Nostrand Reinhold, New York, pp 175–184
Bonadonna G, Monfardini S, deLena M, Fossati-Bellani F, Baretta G (1972) Trials with Adriamycin. Results of 3 years study. In: Carter SK, DiMarcos A, Ghione M et al. (eds) International symposium on Adriamycin. Springer, Berlin Heidelberg New York, pp 139–152
Bowen JG (1978) Transitional cell carcinoma: circulation tumor antigen correlated with presence absence of tumor (leukocyte migration assay). Natl Cancer Inst Mongr 49: 245–247
Boxer RJ, Sofen H, Saxon A (1981) The detection of transitional cell bladder cancer antigen on established cell lines. Invest Urol 19: 70–74
Boyd PJR, Burnand KG (1974) Site of bladder tumor recurrence. Lancet II: 1290-1292
Bracken RB, Johnson DE, Von Eschenbach AC, Swanson DA, DeFuria D, Crooke S (1980) Role of intravesical Mitomycin C in the management of superficial bladder tumors. Urology 16: 11–15
Brosman S (1980) Immunotherapy in bladder cancer. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 166–170
Brosman S, Dorey F, Fahey J (1981) Intravesical BCG in superficial bladder cancer. In: Proceedings of the 7th Annual NBCP Investigator’s Workshop. Hershey, Pennsylvania, June 1981
Burnand KG, Boyd PJR, Mayo MF, Shuttleworth KED, Lloyd-Davies RW (1976) Single dose intravesical thiotepa as an adjuvant to cystodiathermy in the treatment of transitional cell carcinoma. Br J Urol 48: 55–59
Byar DP (1980) The Veterans Administration study of chemo prophylaxis for recurrent stage I bladder tumors: comparisons of placebo, pyridoxine and topical thiotepa. In: Pavone-Macaluso M, Smith PH, Edsmyr R (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 363–370
Caldwell WL (1974) Carcinoma of the urinary bladder. JAMA 229: 1643
Caldwell WL (1976) Radiotherapy: definitive, integrated and palliative therapy. Urol Clin North Am 3: 129–148
Camacho F, Pinsky C, Kerr D, Whitmore W, Oettgen H (1980) Treatment of superficial bladder cancer with intravesical BCG. Proc Am Soc Clin Oncol 21: 359
Chasko SB, Keuhnelian JG, Gutowski WT, Gray AF (1980) Spindle cell cancer of the bladder during cyclophosphamide therapy for Wegener’s granulomatosis. Am J Surg Pathol 4: 191–196
Chodak GW, Straus FW, Schoenberg HW (1981) Simultaneous occurrence of transitional, squamous and adenocarcinoma of the bladder after 15 years of cyclophosphamide therapy. J Urol 125: 424–426
Chopin DK, Bubbers JE, deKernion JB, Fahey JL (1984) Tumor associated antigens (TA A) on human bladder cancer defined by monoclonal antibodies. In: Proceedings of 10th Annual NBCP Investigators’ Workshop, Sarasota, Florida, 4–7 January, 1984
Coates AS, Golovsky D, Freedman A (1981) Prolonged remission in recurrent bladder cancer after chemotherapy with cis-platinum. Med J Austr 1: 533–534
Cole P (1975) Lower urinary tract. In: Schottenfeld D (ed) Cancer epidemiology and prevention. Thomas, Springfield, 111, pp 233–262
Colleen S, Hellsten AE, Lindholm CE (1980) Intracavitary Epodyl for multiple, non-invasive, highly differentiated bladder tumors. Scan J Urol Nephrol 14: 43–45
Collste L, Berlin T, Gronberg-Ohman I, Von Garrelts B, Wijkstrom H (1980) Long-term intracavitary Epodyl in multiple or extensive papillary tumors of the urinary bladder. In: Pavone-Maculoso M, Smith PH, Edsmyr R (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 335–336
Confer D, Smith RB, Gillespie L (1977) Dramatic palliation for painful fixed bladder squamous cell carcinoma with 5-fluorouracil. J Urol 118: 483–484
Cooper PH, Waisman J, Johnston WH, Skinner DG (1973) Severe atypia of transitional epithelium and carcinoma of the urinary bladder. Cancer 31: 1055–1060
Cox CE, Cass AS, Boyce WH (1969) Bladder cancer: a 26 year review. J Urol 101: 550–558
Cummings KB, Shipley WU, Einstein AE et al. (1979) Current concepts in the management of patients with deeply invasive bladder carcinoma. Semin Oncol 6: 220–228
Daly JJ (1976) Carcinoma in situ of the urothelium. Urol Clin North Am 3: 87–105
D’Aoust JC, Archambautt WA, Merrin CE, Rosenbaum PF, Crook ST (1980) Analysis of toxicities associated with long-term administration of cis-platinum to patients with urogenital tumors. Proc Am Assoc Cancer Res 21: 355
Decenzo JM, Ledbetter GW (1976) The interaction of host immunocompetence and tumor aggressiveness in superficial bladder carcinoma. J Urol 115: 262–263
DeFuria MD, Bracken RB, Johnson DE, Soloway MS, Merrin CE, Morgan LR, Miller HC, Crooke ST (1980) Phase I-II study of Mitomycin C topical therapy for low grade, low stage transitional cell carcinoma of the bladder: an interim report. Cancer Treat Rep 64: 225–230
deKernion JB (1977) The chemotherapy of advanced bladder carcinoma. Cancer Res 37: 2771–2774
deKernion JB, Skinner DG (1978) Epidemiology, diagnosis and staging of bladder cancer. In: Skinner DG, deKernion JB (eds) Genitourinary cancer. Saunders, Philadelphia, pp 213–231
deKernion JB, Stewart BH, Yagoda A (1978) Treatment of advanced bladder cancer. In: Skinner DG, deKernion JB (eds) Genitourinary cancer. Saunders, Philadelphia, pp 284–294
Droller JJ (1980) Transitional cell carcinoma: an overview. Urol Clin North Am 7: 731–733
Duchek M (1980) Local treatment of uroepithelial bladder tumors with Adriamycin. In: Pavone- Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 323–326
Duchek M, Edsmyr F, Nasland I (1980) 5-Fluorouracil in the treatment of recurrent cancer of the urinary bladder. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 399–400
Durant JR (1980) Phase III adjuvant chemotherapy with cytoxan-Adriamycin-cw-platinum for resected transitional cell bladder carcinoma. In: Proceedings of the 6th NBCP Annual Meeting
Edsmyr F, Berlin T, Boman J, Duchek M, Esposti PL, Gustavson H, Wikstrom H (1980) Intravesical therapy with Adriamycin in patients with superficial bladder tumors. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 321–322
Edsmyr F, Andersson L, Esposti P (1984) Intravesical chemotherapy of carcinoma in situ in bladder cancer. Urology (Suppl) 23: 37–39
Ek A, Colleen S (1980) Treatment of multiple non-invasive bladder tumours with intravesical Epodyl. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 337–342
Elliott AY, Dombrovski S, Fraley EE (1978) Transitional cell carcinoma: fluorescent antibody binding to tumor cells. Natl Cancer Inst Mongr 49: 23
England HR, Molland EA, Oliver RT, Blandy JP (1980) Flat carcinoma in situ of the bladder treated by systemic cyclophosphamide—a preliminary report. In: Pavone-Macaluso J, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 371–376
Esquivel EL, Mackenzie AR, Whitmore WF (1965) Treatment of bladder tumors by instillation of thiotepa, Actinomycin D, or 5-fluorouracil. Invest Urol 2: 381
Fair WR (1974) Formalin in the treatment of massive bladder hemorrhage. Urology 3: 573 - 577
Fetter TB, Bogaev JH, McCuskey B, Seres JL (1959) Carcinoma of the bladder: sites of metastases. J Urol 81: 746–748
Fidler IJ (1982) The role of host factors and tumor heterogeneity in the testing of therapeutic agents. In: Fidler IJ, White RJ (eds) Design of models for testing cancer therapeutic agents. Van Nostrand Reinhold, New York, pp 239–247
Field AK, Tytell AA, Lampson GP, Hilleman MR (1967) Inducers of interferon and h st resistance. II. Multistranded synthetic polyneucleotide complexes. Proc Natl Acad Sci USA 58: 1004–1010
Fradet Y, Cordon-Cardo C, Whitmore WF, Old LJ (1984) Definition of human bladder tumor subsets with monoclonal antibodies to tumor associated antigens. In: Proceedings of the 10th Annual NBCP Investigators Workshop. Sarasota, Florida, 4-7 January, 1984, p 37
Frei E, Luce JK, Middleman E (1972) Clinical trials of Adriamycin. In: Carter SK, DiMarco A, Ghione A et al. (eds) International symposium on Adriamycin. Springer, Berlin Heidelberg New York, pp 153–164
Friedell GH (1976) Carcinoma, carcinoma in situ and “early lesions” of the uterine cervix and urinary bladder: introduction and definitions. Cancer Res 36: 2482
Gad-el Mawla N, Muggia PM, Hamza MR, El-Morsi B, Sherif M, Mansour MA, Khafagy M, El Sebai IT (1978) Chemotherapeutic management of carcinoma of the bilharzial bladder. A Phase II trial with hexamethylmelamine and VM-26. Cancer Treat Rep 62: 993–996
Gammelgaard PA, Morgensen P, Lindbeck F (1980) Bladder instillation of Adriamycin in multiple recurrent noninvasive papillomatous bladder tumours. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 329–331
Garnick B, Scade D, Israel M, Maxwell B, Richie JP (1984) Intravesical doxorubicin for prophylaxis in management of recurrent superficial bladder carcinoma. J Urol 131: 43–46
Gavrell GJ, Lewis RW, Meehan WL, LeBlanc GA (1978) Intravesical thiotepa in the immediate postoperative period in patients with recurrent transitional cell carcinoma of the bladder. J Urol 120: 410–411
Ghoneim MA, and Awaad HK (1980) Results of treatment in carcinoma of the bilharzial bladder. J Urol 123: 850–852
Gonwa TA, Corbett WT, Schey HM, Buckalew VM (1980) Analgesic-associated nephropathy and transitional cell carcinoma of the urinary tract. Ann Intern Med 93: 249–252
Gozzo JJ, Cronin WJ, O’Brien P, Monaco AP (1980) Detection of tumor associated antigens in the urine of patients with bladder cancer. J Urol 125: 804–807
Glucksman MA (1980) Bladder carcinoma after cyclophosphamide therapy. (Letter to the Editor). Urology 16: 553
Green DF, Robinson MRG, Glashan R, Newling D, Dalesio O, Smith PH (1984) Does intravesical chemotherapy prevent invasive bladder cancer? J Urol 131: 33–35
Grossman HB (1983) Hybridoma antibodies reactive with human bladder carcinoma cell surface antigens. J Urol 130: 610–615
Hakala TR, Lange PH, Castro AB, Elliott A, Fraley EE (1974) Antibody induction of lymphocyte mediated cytoxicity against human transitional cell carcinomas of the gentitourinary tract. Cancer 34: 1929–1934
Hall RR (1980a) Intravesical hyperthermia for transitional cell carcinoma of the bladder. In: Pavone- Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 267–270
Hall RR (1980b) Methotrexate therapy for multiple T1 category bladder carcinoma. In: Pavone- Macaluso M, Smith PH, Edsymr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 337–380
Hall RR, Turner AG (1980) Methotrexate treatment for advanced bladder cancer. A review after 6 years. Br J Urol 52: 403
Hamburger AW, Salmon SE (1977) Primary bioassay of human tumor stem cells. Science 197: 461–463
Hanna N (1981) Preparation of tumor cells for in vivo drug sensitivity testing. In: Proceedings of the UCLA Department of Microbiology and Immunology Workshop No 33, Los Angeles, California, 14–15 May, 1981
Hanna N (1982) Nude mice as recipients for syngeneic, allogeneic and xenogeneic neoplasms. In: Fidler IJ, White RJ (eds) Design of models for testing cancer therapeutic agents. Van Nostrand Reinhold, New York, pp 165–174
Herberman RB (1980) Summary—augmentation of NK activity. In: Herberman RB (ed) Natural cell mediated immunity against tumors. New York, Academic, pp 707–719
Herr HW (1980) Diamminedichloride platinum II in the treatment of advanced bladder cancer. J Urol 123: 853–855
Herr HW, Bean MA, Whitmore WF (1978) Mixed leukocyte culture reactivity of lymph node cells regional to transitional cell carcinoma of the bladder. Natl Cancer Inst Monogr 49: 177–181
Herr HW, Pinsky CM, Whitmore WF, Oettgen HF, Melamed MR (1983) Intravesical BCG therapy of superficial bladder tumors. In: Proceedings of the 78th Annual Meeting of the American Urological Association, Las Vegas, Nevada, 19 April, 1983
Hewitt CW, Shultz SM, Cole J, Miller JB, Martin DC (1982) Identification of bladder-cancer associated antigens by two dimensional gel immuno-electrophoresis. In: Proceedings of the 77th Annual Meeting of the American Urological Association, Kansas City, Missouri, 1982
Higby DJ (1980) Chemotherapeutic management of bladder cancer. In: Aisner J, Chang P (eds) Cancer treatment research. Developments in oncology series, vol 2. Martinus Nijhoff, The Hague, pp 142–152
Hollinshead AC (1978) Preliminary studies of sera and urine from patients with bladder cancer. Natl Cancer Inst Monogr 49: 193–198
Hollister D, Coleman M (1980) Hematologic effects of intravesical thiotepa for bladder carcinoma. JAMA 244: 2065–2067
Howe GR, Burch JO, Miller AD, Cook GM, Esteves J, Morrison B, Gordon P, Chambers LW, Fodor G, insor GM (1980) Tobacco use, occupation, coffee, various nutrients, and bladder cancer. J Natl Cancer Inst 64: 701–713
Ikic D, Maricic Z, Oresic V, Rode B, Nola P, Smudj K, Knezevic M, Jusic D, Soos E (1981) Application of human leukocyte interferon in patients with urinary bladder papillomatosis, breast cancer and melanoma. Lancet I: 1022–1024
Jacobi GH, Kurth KH, Klipper KF, Hohenfellner R (1979) On the biological behavior of T1 transitional cell tumor of the urinary bladder and initial results of the prophylactic use of topical Adriamycin under controlled and randomized conditions. In: Diagnosis and treatment of superficial bladder tumors. Motedison, Stockholm, pp 83–94
Jacobs SE, Lawson RK (1982) Pathological effects of precystectomy therapy with combination of doxorubicin hydrochloride and local bladder hyperthermia for bladder cancer. J Urol 127: 43–47
Jakse G, Hofstadter F (1981) ABH antigenicity of in situ carcinoma of the urinary bladder during intracavity treatment with doxorubicin hydrochloride. Urol Res 9: 153–159
Jakse G, Hofstadter F, Marberger H (1981) Intracavitary doxorubicin hydrochloride therapy for carcinoma in situ of the bladder. J Urol 125: 185–190
Jewett HJ, Strong GH (1946) Infiltrating carcinoma of the bladder. Relation of depth of penetration of the bladder wall to incidence of local extension and metastases. J Urol 55: 366–372
Jones WA, Gibbons RP, Correa RJ, Cummings KB, Mason JT (1980) Primary adenocarcinoma of the bladder. Urology 15: 119–122
Kedia KR, Gibbons C, Persky L (1981) The management of advanced bladder carcinoma. J Urol 125: 655–658
Kemeny N, Yagoda A, Wang Y, Field K, Wrobleski H, Whitmore W (1981) Randomized trial of standard therapy with or without poly I:C in patients with superficial bladder cancer. Cancer 48: 2154–2157
Koontz WW (1979) Intravesical chemotherapy and chemoprevention of superficial, low grade, low stage bladder carcinoma. Semin Oncol 6: 217–219
Koontz WW, Prout GR Jr, Smith W, Frable WJ, Minnis JE (1981) The use of intravesical thiotepa in the management of non-invasive carcinoma of the bladder. J Urol 125: 307–312
Koontz WW, Heney N, Schmidt JD, Soloway M, Penick GD, Ahmed S, Prout G (1983) The ablative effect of intravesical Mitomycin C for thiotepa failures. In: Proceedings of the 78th Annual Meeting of the American Urological Association, Las Vegas, Nevada, 19 April, 1983
Koss LG (1975) Tumors of the urinary bladder. In: Koss (ed) Atlas of tumor pathology, fascicle 11, 2nd ser. Armed Forces Institute of Pathology, Washington DC
Koss LG (1979) Tumors of the urinary tract and prostate. In: Koss LG (ed) Diagnostic cytology and its histological basis, 3rd edn. Lippincott, Philadelphia, p 684
Kramer SA, Bredael J, Croker BP, Paulson DF, Glenn JF (1979) Primary non-urachal adenocarcinoma of the bladder. J Urol 121: 278–281
Kurth KH, Tunn U, Ay R, Debruyne F, dePauw M, Sylvester R, Tenkate FW (1983) Phase II chemotherapy with Adriamycin or ethoglucid (Epodyl) for resected Ta and T1 papillary carcinoma of the bladder. In: Proceedings of the 78th Annual Meeting of the American Urological Association, Las Vegas, Nevada, 19 April, 1983
Lamm DL, Thor DE, Winters WD, Stogdill VO, Radwin H (1981) BCG immunotherapy of bladder cancer: inhibition of tumor recurrence and associated immune responses. Cancer 48: 82–86
Lange PH, Limas C, Fraley EE (1978) Tissue blood-group antigens and prognosis in low stage transitional cell carcinoma of the bladder. J Urol 119: 52–55
Larsen J (1980) Inactivation of Epodyl in aluminium foil cups as a cause of ineffective treatment of non-invasive bladder tumors. Scan J Urol Nephrol 14: 239–242
Lieber MM, Kovach JS (1981) Soft agar clonogenic assay for primary human renal carcinoma: in vitro chemotherapeutic drug sensitivity testing. In: Proceedings of the 76th Annual Meeting of the American Urological Association, Boston, Maryland, 1981
Lindholm CE, Mattson W, Langeland P, Gunning I (1980) 5-Fluorouracil and Adriamycin in locally recurrent and/or metastatic bladder cancer. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 391–394
Logothetis CT (1981) CISCA chemotherapy for bladder cancer. Cancer Bull 33: 79–80
Malling N, Sorensen SS (1980) Adjuvant thiotepa in the treatment of bladder papillomata. A prospective randomized experiment ( Abstr ). Ugeskr Laeger 142: 1678–1679
Martinez-Piñeiro JA (1980) Introduction to immunology and immunotherapy of bladder tumors. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 131–134
Matsumoto K, Kakizoe T, Mikuriya S, Tanaka T, Kondo I, Umegaki Y (1981) Clinical evaluation of intraoperative radiotherapy for carcinoma of the urinary bladder. Cancer 47: 509–513
Melloni D, Pavone-Macaluso M (1980) Intravesical treatment of superficial urinary bladder tumors with Adriamycin. In: Pavone-Macaluso M, Smith PH, Esmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 317–320
Merrin CE (1979) Treatment of genitourinary tumors with cis-dichlorodiammineplatinum (II): experience in 250 patients. Cancer Treat Rep 63: 1570–1584
Merrin CE, Cartagena R, Wajsman Z, Baumgartner G, Murphy GP (1975) Chemotherapy of bladder carcinoma with cyclophosphamide and Adriamycin. J Urol 114: 884–887
Messing EM, Bubbers JE, Whitmore KE, deKernion JB, Fahey JL (1984) Murine hybridoma antibodies to human transitional cell carcinoma. J Urol (in press)
Middleman E, Luce J, Frei E (1971) Clinical trials with Adriamycin. Cancer 28: 844–850
Mishima T, Oda K, Murata S, Ooe H, Mori Y, Takahashi T (1975) Mitomycin C bladder instillation therapy for bladder tumors. J Urol 114: 217–219
Mohiuddin M, Strong GH, Mulholland SG (1982) Combined pre and postoperative adjuvant radiotherapy for bladder cancer. Urology 19: 135–138
Moore G, Bross ID, Ausman R, Nadler S, Jones R, Slack N, Reimm A (1963) Effects of 5-fluorouracil in 389 patients with cancer. Cancer Chemother Rep 27: 67–69
Montesano R, Devron C, Kuroki T, Saint Vincent L, Handleman S, Sanford KK, Defeo D, Weinstein IB (1977) Test for malignant transformation of rat liver cells in culture: cytology, growth in soft agar, and production of plasminogen activator. J Natl Cancer Inst 59: 1651–1658
Morales A (1980) Treatment of carcinoma in situ of the bladder with BCG: Phase II trial. Cancer Immunol Immunother 9: 69–72
Morales A, Ersil A (1979) Prophylaxis of recurrent bladder cancer with Bacillus-Calmette-Guerin in cancer of the genitourinary tract. In: Johnson DE, Samuels ML (eds) Proceedings of the University of Texas Systems Cancer Center M D Anderson Hospital and Tumor Institute, 23rd Annual Conference in Cancer, Houston, Texas, November 1978. Raven, New York, p 121
Morales A, Ottenhof P, Emerson L (1981) Treatment of residual non-infiltrating bladder cancer with Bacillus Calmette-Güerin. J Urol 125: 649–651
Moriyama N, Ito K (1980) Light and electron microscopic changes in bladder tumor cells after intravesical instillation and hyperthermic vesical irrigation of Bleomycin (Abstr). Nippon, Hinyokika Gakkai Zasshi 71: 1371–1380
Morrison AS, Buring JE, Verhouk WG, Aoki K, Leck I, Ohno Y, Obata K (1984) International study of smoking and bladder cancer. J Urol 131: 650–654
Murphy WM, Soloway MS, Crabtree WM (1981) The morphologic effects of Mitomycin C in mammalian urinary bladder. Cancer 47: 2567–2574
Nagata K (1980) Studies on the absorption of anticancer agents through the bladder—basis of instillation therapy—III. Urinary excretion and vesical tissue concentration of instilled Adriamycin in patients with bladder cancer (Abstr). Hinyokika Kiyo 26: 983–988
Nakajima K, Hisazumi H, Uchibayashi T, Naito K, Misaki T, Kuroda K, Miyazaki K, Fujita Y, Taya T, Kameda K (1980) A combination therapy of hyperthermia and Bleomycin for bladder cancer ( Abstr ). Hinokika Kiyo 26: 1153–1161
Natale RB, Yagoda A, Watson RC, Whitmore WF, Blumenreich M, Braun DW (1981) Methotrexate: an active drug in bladder cancer. Cancer 47: 1246–1250
Needles B, Blumenreich M, Yagoda A, Sogani P, Whitmore WF (1981) Intravesical cis-platinum for superficial bladder cancer. Proc Am Assoc Cancer Res 22: 158, 625
Nevin JE, Melnick I, Baggerly JT, Hoffman A, Landes RR, Easley C (1973) The continuous arterial infusion of 5-fluorouracil as a therapeutic adjunct in the treatment of carcinoma of the bladder and prostate. Cancer 31: 138–144
Nielsen HV, Thybo E (1979) Epodyl treatment of bladder tumors. Scan J Urol Nephrol 13: 59–63
Ogata J, Migita N, Nakamura T (1973) Treatment of carcinoma of the bladder by infusion of the anticancer agent ( Mitomycin C) via the internal iliac artery. J Urol 110: 667–670
Ogawa H, Onodera Y, Watanabe M, Higaki Y, Yoshida H, Imamura K, Sugiyama Y (1980) Clinical effect of intravesical instillation with carboquone and cystosine arabinoside on superficial bladder tumors ( Abstr ). Hinyokika Kiyo 26: 1437–1448
Okada K, Gon H, Nogaki J, Niimura T, Saito T, Amagai T, Yamamoto T, Kiyotaki S, Sato Y, Ogawa N, Morita H, Kitajima K, Kishimoto T (1980) Hyperthermic treatment for bladder tumors. Urokinase combination therapy ( Abstr ). Nishinippon Hinyokika 42: 967–971
Oliver RTD (1980) The place of chemotherapy in the treatment of patients with invasive carcinoma of the bladder. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 381–385
Peterson LT, Paulson DF, Bonar RA (1974) Response of human urothelium to chemical carcinogens in vitro. J Urol 111: 154–159
Pontes JE, Dhawbwala CB, Pierce JM (1984) Intravesical Adriamycin therapy for bladder cancer—long-term results. Urology (Suppl). 23: 35–36
Prout GR Jr, Bross ID, Slack NH, Ausman RK (1968) Carcinoma of the bladder. 5-Fluorouracil and the critical role of a placebo: a cooperative group report. I. Cancer 22: 926–931
Prout GR Jr, Griffen, PP, Nocks BN, DeFuria MD, Daly JJ (1982) Intravesical therapy of low stage bladder carcinoma with Mitomycin C: comparison of results in untreated and previously treated patients. J Urol 127: 1096–1098
Prout GR, Koontz WW, Coombs LJ, Hawkins IR, Friedell GH (1983) Long-term fate of 90 patients with superficial bladder cancer randomly assigned to receive or not receive thiotepa. J Urol 130: 677–680
Richards B (1980) Adjuvant chemotherapy following primary irradiation in T3 tumors, and other topics in urological oncology. In: Pavone Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 395–397
Richie JP, Blute RD, Waisman J (1980) Immunologic indications of prognosis in bladder cancer. The importance of cell surface antigens. J Urol 123: 22–24
Riddle PR (1973) The management of superficial bladder tumors with intravesical Epodyl. Br J Urol 45: 84–87
Riddle PR, Wallace DM (1971) Intracavitary chemotherapy for multiple non-invasive bladder tumors. Br J Urol 43: 181–184
Robinson MGR, Shelty MB, Richards B, Bastaple J, Glashan RW, Smith PH (1977) Intravesical Epodyl in the management of bladder tumors. Combined experience of the Yorkshire Urological Cancer Group. J Urol 118: 972–973
Sadoughi H, Rubenstone A, Misna J, Davidsohn I (1980) The cell surface antigens of bladder washing specimens in patients with bladder tumor. A new approach. J Urol 123: 19–21
Sakamoto S, Ogata J, Ikegami K, Maeda H (1980) Chemotherapy for bladder cancer with neocarzinostatin: evaluation of systemic administration. Eur J Cancer 16: 103–113
Samuels ML, Logothetis C, Trindate A, Johnson DE (1980) Cytoxan, Adriamycin and cis-platinum ( CISCA) in metastatic bladder cancer. Proc Am Assoc Cancer Res 21: 137
Sandberg AA (1980) Tumors of the urinary tract. In: Sandberg A A (ed) The chromosomes in human cancer and leukemia. Elsevier North Holland, New York, pp 503–511
Sarna G (1979) Principles of chemotherapy. In: Skinner DG, deKernion JB (eds) Genitourinary cancer. Saunders, Philadelphia, pp 14–39
Schulman CC (1980) Adjuvant therapy of T1 bladder carcinoma: preliminary results of an EORTC randomized study. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 347–354
Schulman CC, Denis LJ, Wauters E (1980) Intravesical cis-platinum in bladder tumors: toxicity study. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) bladder tumors and other topics in urological oncology. Plenum, New York, pp 355–359
Schwartz S, Yagoda A, Natale RB, Watson RC, Whitmore WF, Lesser M (1983) Phase II trial of sequentially administered cis-platinum, cyclophosphamide and doxorubicin for urothelial tract tumors. J Urol 130: 681–684
Shin SI, Freedman VH, Risser R, Pollack R (1975) Tumorigenicity of virus transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. Proc Natl Acad Sci USA 72: 4435
Skinner DG, Kaufman JJ (1978) Management of invasive and high grade bladder cancer. In: Skinner DG, deKernion JB (eds) Genitourinary cancer. Saunders, Philadelphia, p 268
Smalley RU, Bartolucci AA, Hemstreet G, Hester M (1981) A Phase II evaluation of a 3 drug combination of cyclophosphamide, doxorubicin and 5-fluorouracil and of 5-fluorouracil in patients with advanced bladder carcinoma or stage D prostatic carcinoma. J Urol 125: 191–195
Smith PH (1980) The aims and activities of the EORTC Urological Group. In: Pavone-Macaluso M, Smith PH, Edsmyr F (eds) Bladder tumors and other topics in urological oncology. Plenum, New York, pp 35–40
Soloway MS (1978) Cis-diamminedichloroplatinum (II) (DDP) in advanced bladder cancer. J Urol 120: 716–719
Soloway MS (1980) Rationale for intensive intravesical chemotherapy for superficial bladder cancer. J Urol 123: 461–466
Soloway MS (1982) Editorial comment. J Urol 127: 1098
Soloway MS (1984) Editorial comment. J Urol 131: 49
Soloway MS, Murphy WM, deFuria MD, Crooke S, Finebaum P (1981a) The effect of Mitomycin C on superficial bladder cancer. J Urol 125: 646–648
Soloway MS, Ikard M, Ford K (1981b). Cis-diamminedichloroplatinum ( II) in locally advanced and metastatic urothelial cancer. Cancer 47: 476–480
Stanisic TH, Buick RN, Salmon SE (1980a) Soft agar methylcellulose assay for human bladder carcinoma. In: Salmon SE (ed) Cloning of human tumor cells. Alan R Liss, New York, pp 75–84
Stanisic TH, Buick RN, Trent JM, Fry SE, Salmon SE (1980b) In vitro clonal assay for bladder cancer: the biological potential of urothelium and determination of in vitro sensitivity to cytotoxic agents. Surg Forum 31: 585–587
Stober U, Peter HH (1980) BCG immunotherapy for prevention of relapse in patients with bladder cancer? ( Abstr ). Therapiewoche 30: 6067–6070
Storm FK (1982) Hyperthermia in cancer therapy. In: Proceedings of UCLA Interdepartmental Conference—New advances in oncology, Los Angeles, California, 4 March 1982
Studer UE, Biedermann C, Chollet C, Karrer P, Kraft H, Toggenburg, Vonbank F (1984) Prevention of recurrent superficial bladder tumors by oral etretinate. Preliminary results of randomized, double-blind multicenter trial in Switzerland. J Urol 131: 47’49
Sullivan RD (1962) Intraarterial methotrexate therapy: the dose, duration and route of administration of methotrexate in clinical cancer chemotherapy. In: Porter R, Wiltshaw E (eds) First symposium on methotrexate in the treatment of cancer. Wright, Bristol, pp 50–55
Summers JL, Falor WH, Ward R (1981) A ten year analysis of chromosomes in non-invasive papillary carcinoma of the bladder. J Urol 125: 424–426
Summers JL, Coon JS, Ward RM, Falor WH, Miller AW, Weinstein RS (1983) Prognosis in carcinoma of the urinary bladder based upon tissue group ABH and Thomsen-Friedenreich antigen status and karotype of the initial tumor. Cancer Res 43: 934–939
Tannock IF (1978) Cell kinetics and chemotherapy. A critical review. Cancer Treat Rep 62: 1117–1133
Tannock IF (1981) Selection of chemotherapeutic agents. In: Proceedings of the 7th Annual NBCP Investigators’ Workshop. Hershey, Pennsylvania, June 1981
Turner AG, Hendry WF, Williams GB, Bloom HJG (1977) The treatment of advanced bladder cancer with methotrexate. Br J Urol 46: 431–438
Utz DC, DeWeerd JH (1978) The management of low grade low stage carcinoma of the bladder. In: Skinner DG, deKernion JB (eds) Genitourinary cancer. Saunders, Philadelphia, pp 256–268
Utz DC, Farrow GM (1980) Management of carcinoma in situ of the bladder: the case for surgical management. Urol Clin North Am 7: 533–541
Utz DC, Hanna KA, Farrow GM (1970) The plight of the patient with carcinoma in situ of the bladder. J Urol 103: 160–164
Uyama T (1980) Intravesical instillation of Adriamycin combined with low-dose irradiation for superficial bladder cancer. Urology 15: 584–587
Uyama T, Nakamura S, Yamamoto A, Moriwaki S (1980) Treatment of advanced bladder cancer by intraarterial infusion of Adriamycin ( Abstr ). G an To Kagaku Ryoho 7: 1964–1970
van der Werf-Messing B (1978) Cancer of the urinary bladder treated by interstitial radium implant. Int J Radiol Oncol Biol Phys 45: 373–378
van der Werf-Messing B, Hop WCJ (1981) Carcinoma of the urinary bladder (category T1NXM0) Chemotherapy of Bladder Cancer treated either by radium implant or by transurethral resection only. Int J Radiol Oncol Biol Phys 7: 299–303
Veenema RJ (1978) Editorial comment. J Urol 120: 1411
Veenema RJ, Dean AL, Roberts M, Fingerhut B, Chowhury RK, Tarassoly H (1962) Bladder carcinoma treated by direct instillation of thiotepa. J Urol 88: 60–63
von Hoff DD, Harris GJ, Johnson G, Glaubiger D (1980) Initial experience with the human tumor stem cell assay system: potential and problems. In: Salmon SE (ed) Cloning of human tumor stem cells. Alan R Liss, New York, pp 113–124
Weinstein RS, Alroy J, Farrow GM, Miller AW, Davidsohn I (1979) Blood group isoantigen deletion in carcinoma in situ of the human bladder. Cancer 43: 661–668
Whitmore WF (1980) Integrated irradiation and cystectomy for bladder cancer. Br J Urol 52: 1
Whitmore WF, Batata MA, Ghoneim MS, Grabstald H, Unal A (1977) Radical cystectomy with or without prior irradiation for the treatment of bladder cancer. J Urol 118: 184–187
Williams SD, Einhorn LH, Donohue JP (1979) Cis-platinum combination chemotherapy of bladder cancer. Cancer Clin Trials 2: 335 - 338
Wilson WL (1960) Chemotherapy of human solid tumors with 5-fluorouracil. Cancer 13: 1230–1239
Winters WD, Lamm DL (1981) Antibody responses to Bacillus-Calmette-Guerin during immu¬notherapy in bladder cancer patients. Cancer Res 41: 2672–2676
Wright GL, Starling JJ, Sieg SM (1981) Monoclonal antibodies to tumor associated antigens in human prostate and bladder cancer. Fed Proc 40 (II): 995
Yagoda A (1977) Future implications of Phase 2 chemotherapy trials in 95 patients with measurable advanced bladder cancer. Cancer Res 37: 2775–2780
Yagoda A (1981) Chemotherapy of advanced bladder cancer. In: Conolly JG (ed) Carcinoma of the bladder. Raven Press, New York, pp 251–260
Yagoda A, Watson RC, Whitmore WF (1980) Phase II trial of methotrexate in urinary bladder cancer. Proc Am Assoc Cancer Res 21: 427
Young AK, Hammond B, Middleton AW (1979) The prognostic value of cell-surface antigens in low grade non-invasive transitional cell carcinoma of the bladder. J Urol 122: 462–464
Young CW (1971) Interferon inducers in cancer. Med Clin North Am 55: 721–728
Zincke H, Utz DC, Taylor WF, Myers RP, Leary FJ (1983) Influence of thiotepa and doxorubicin instillation at the time of transurethral surgical treatment of bladder cancer on tumor recurrence: a prospective, randomized, double-blind, controlled trial. J Urol 129: 505–509
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Messing, E., deKernion, J.B. (1985). Chemotherapy of Bladder Cancer. In: Zingg, E.J., Wallace, D.M.A. (eds) Bladder Cancer. Clinical Practice in Urology. Springer, London. https://doi.org/10.1007/978-1-4471-1362-1_10
Download citation
DOI: https://doi.org/10.1007/978-1-4471-1362-1_10
Publisher Name: Springer, London
Print ISBN: 978-1-4471-1364-5
Online ISBN: 978-1-4471-1362-1
eBook Packages: Springer Book Archive