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Pharmacological Treatment of Non-neurogenic Voiding Dysfunction

  • Chapter
The Pharmacology of the Urinary Tract

Part of the book series: Clinical Practice in Urology ((PRACTICE UROLOG))

Abstract

The lower urinary tract performs two functions: the storage and emptying of urine. The physiology of the cycle of micturition has been described by many qualified authors, each of whom has given his own particular concept of the neuroanatomy and neurophysiology of the smooth and striated muscular structures, the peripheral autonomic and somatic neural factors, and the spinal and supraspinal influences which are necessary for the normal micturition cycle. There are significant disagreements regarding the finer details of the relevant neuromorphology, neurophysiology and neuropharmacology. Perhaps the best example of this is the current controversy over the influence of the sympathetic nervous system on the physiology of micturition and the interrelationships, if any, of the parasympathetic and sympathetic influences on the smooth muscle of the urinary bladder and its outlet.

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References

  • Abel BJ, Jameson RM, Gibbon NOK, Krishnan KR (1974) The neuropathic urethra. Lancet II: 1229–1230

    Article  Google Scholar 

  • Abromowicz A (ed) (1978) Baclofen (Lioresal). Med Lett Drugs Ther 20: 43–44

    Google Scholar 

  • Allen TD (1977) The non-neurogenic neurogenic bladder. J Urol 117: 232–238

    PubMed  CAS  Google Scholar 

  • Andersen JT (1976) Detrusor hyperreflexia in benign infravesical obstruction: a cystometric study. J Urol 115: 532–534

    PubMed  CAS  Google Scholar 

  • Andersen JT, Walter S, Vejlsgaard R (1981) A clinical and bacteriological trial with DMSO in the treatment of severe detrusor hyperreflexia. Scand J Urol Nephrol [Suppl] 60: 63–65

    Google Scholar 

  • Anderson (1982) Evidence for a prostaglandin link in the purinergic activation of rabbit bladder smooth muscle. J Pharmacol Exp Ther 220: 347–352

    PubMed  CAS  Google Scholar 

  • Andersson K-E, Hustad S, Sjogren C (1980) Contribution of prostaglandins to the adenosine triphosphate induced contraction of rabbit urinary bladder. Br J Pharmacol 70: 443–452

    PubMed  CAS  Google Scholar 

  • Andersson K-E, Ek A, Hedlund H, Mattiasson A (1981) Effects of prazosin on isolated human urethra and in patients with lower motor neuron lesions. Invest Urol 19: 39–42

    PubMed  CAS  Google Scholar 

  • Atkins FL, Nicolosi GL (1979) Alpha adrenergic blocking activity of prazosin. Biochem Pharmacol 28: 1233–1237

    Article  PubMed  CAS  Google Scholar 

  • Awad SA, Downie JW, Kiruluta HG (1978) Alpha-adrenergic agents in urinary disorders of the proximal urethra. I. Sphincteric incontinence. Br J Urol 50: 332–335

    Article  PubMed  CAS  Google Scholar 

  • BaldessariniRJ (1980) Drugs and the treatment of psychiatric disorders. In: Gilman AG, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 391–447

    Google Scholar 

  • Barrett DM (1981) The effect of oral bethanechol chloride on voiding in female patients with excessive residual urine: a randomized double-blind study. J Urol 126: 640–642

    PubMed  CAS  Google Scholar 

  • Beisland HO, Fossberg E, Sander S (1981) On incompetent urethral closure mechanism: treatment with estriol and phenylpropanolamine. Scand J Urol Nephrol [Suppl] 60: 67–69

    Google Scholar 

  • Benson H, Epstein MD (1975) The placebo effect. JAMA 232: 1225–1226

    Article  PubMed  CAS  Google Scholar 

  • Benson GS, Sarshik SA, Raezer DM, Wein AJ (1977) Bladder muscle contractility: comparative effects and mechanisms of action of atropine, propantheline, flavoxate, and imipramine. Urology 9: 31–35

    Article  PubMed  CAS  Google Scholar 

  • Bigger JT, Giardina EGV, Perel JM, Kantor SJ, Glassman AH (1977) Cardiac anti-arrhythmic effect of imipramine hydrochloride. N Engl J Med 296: 206–208

    Article  PubMed  CAS  Google Scholar 

  • Birkasova M, Birkas, O, Flynn MJ, Cort JH (1978) Desmopressin in the management of nocturnal enuresis in children: a double-blind study. Pediatrics 62: 970–974

    PubMed  CAS  Google Scholar 

  • Blaivas JG, Labib KB, Michalik SJ, Zayed AAH (1980) Cystometric response to propantheline in detrusor hyperreflexia: therapeutic implications. J Urol 124: 259–262

    PubMed  CAS  Google Scholar 

  • Blaschke TF, Melmon KL (1980) Antihypertensive agents and drug therapy of hypertension. In: Gilman AG, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 793–818

    Google Scholar 

  • Bradley DV, Cazort RJ (1970) Relief of bladder spasm by flavoxate: a comparative study. J Clin Pharmacol 10: 65–68

    CAS  Google Scholar 

  • Briggs RS, Castleden CM, Asher MJ (1980) The effect of flavoxate on uninhibited detrusor contractions and urinary incontinence in the elderly. J Urol 123: 665–666

    PubMed  CAS  Google Scholar 

  • Bultitude MI, Hills NH, Shuttleworth KED (1976) Clinical and experimental studies on the action of prostaglandins and their synthesis inhibitors on detrusor muscle in vitro and in vivo. Br J Urol 48: 631–637

    Article  PubMed  CAS  Google Scholar 

  • Burgess CD, Turner P (1980) Cardiotoxicity of antidepressant drugs. Neuropharmacology 19: 1195–1199

    Article  PubMed  CAS  Google Scholar 

  • Byck R (1975) Drugs and the treatment of psychiatric disorders. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 5th edn. Macmillan, New York, pp 152–200

    Google Scholar 

  • Cameron MD (1966) Distigmine bromide (Ubretid) in the prevention of post-operative retention of urine. J Obstet Gynaecol Br Cwlth 73: 847–848

    Article  CAS  Google Scholar 

  • Cardozo DL, Stanton SL (1979) An objective comparison of the effects of parenterally administered drugs in patients suffering from detrusor instability. J Urol 122: 58–59

    PubMed  CAS  Google Scholar 

  • Cardozo LD, Stanton SL (1980) A comparison between bromocriptine and indomethacin in the treatment of detrusor instability. J Urol 123: 399–401

    PubMed  CAS  Google Scholar 

  • Cardozo LD, Stanton SL, Robinson H, Hole D (1980) Evaluation of flurbiprofen in detrusor instability. Br Med J 280: 281–282

    Article  PubMed  CAS  Google Scholar 

  • Castleden CM, George CF, Renwick AG, Asher MJ (1981) Imipramine - a possible alternative to current therapy for urinary incontinence in the elderly. J Urol 125: 318–320

    PubMed  CAS  Google Scholar 

  • Chan WY, Dawood MY, Fuchs F (1981) Prostaglandins in primary dysmenorrhea. Am J Med 70: 535–541

    Article  PubMed  CAS  Google Scholar 

  • Cole AT, Fried FA (1972) Favorable experiences with imipramine in the treatment of neurogenic bladder. J Urol 107: 44–45

    PubMed  CAS  Google Scholar 

  • Council on Scientific Affairs, AMA (1982) Dimethyl sulfoxide. JAMA 248: 1369–1371

    Article  Google Scholar 

  • Crews FT, Smith CB (1978) Presynaptic alpha receptor subsensitivity after long-term antidepressant treatment. Science 202: 322–324

    Article  PubMed  CAS  Google Scholar 

  • de Groat WC, Booth AM (1980) Physiology of the urinary bladder and urethra. Ann Int Med 92(2): 312–315

    Google Scholar 

  • de Groat WC, Saum WR (1972) Sympathetic inhibition of the urinary bladder and of pelvic ganglionic transmission in the cat. J Physiol (Lond) 220: 297–314

    Google Scholar 

  • de Groat WC, Saum WR (1976) Synaptic transmission in parasympathetic ganglia in the urinary bladder of the cat. J Physiol (Lond) 256: 137–158

    Google Scholar 

  • Delaere KPJ, Michiels HGE, Debruyne FMJ, Moonen WA (1977) Flavoxate hydrochloride in the treatment of detrusor instability. Urol Int 32: 377–381

    Article  PubMed  CAS  Google Scholar 

  • Delaere KPJ, Thomas CME, Moonen W A, Debruyne FMJ (1981) The value of intravesical prostaglandin E2 and F2α in women with abnormalities of bladder emptying. Br J Urol 53: 306–309

    Article  PubMed  CAS  Google Scholar 

  • Desmond AD, Bultitude MI, Hills NH, Shuttleworth KED (1980) Clinical experience with intravesical prostaglandin E2. A prospective study of 36 patients. Br J Urol 52: 357–366

    Article  PubMed  CAS  Google Scholar 

  • Dhattiwala AS (1976) The effect of imipramine on isolated innervated guinea-pig and rat urinary bladder preparations. J Pharm Pharmacol 28: 453–454

    Article  PubMed  CAS  Google Scholar 

  • Diokno AC, Koppenhoefer R (1976) Bethanechol chloride in neurogenic bladder dysfunction. Urology 8: 455–458

    Article  PubMed  CAS  Google Scholar 

  • Diokno AC, Lapides J (1972) Oxybutynin: a new drug with analgesic and anticholinergic properties. J Urol 108: 307–309

    PubMed  CAS  Google Scholar 

  • Diokno AC, Lapides J (1977) Action of oral and parenteral bethanechol on decompensated bladder. Urology 10: 23–24

    Article  PubMed  CAS  Google Scholar 

  • Diokno AC, Taub M (1975) Ephedrine in treatment of urinary incontinence. Urology 5: 624–625

    Article  PubMed  CAS  Google Scholar 

  • Diokno AC, Hyndman CW, Hardy DA, Lapides J (1972) Comparison of action of imipramine (Tofranil) and propantheline (Pro-Banthine) on detrusor contraction. J Urol 107: 42–43

    PubMed  CAS  Google Scholar 

  • Donker PJ, Van der Sluis C (1976) Action of beta adrenergic blocking agents on the urethral pressure profile. Urol Int 31: 6–12

    Article  PubMed  CAS  Google Scholar 

  • Downie JW, Twiddy DAS, Awad SA (1977) Antimuscarinic and noncompetitive antagonist properties of dicyclomine hydrochloride in isolated human and rabbit bladder muscle. J Pharmacol Exp Ther 201 : 662–668

    PubMed  CAS  Google Scholar 

  • Duncan GW, Shahani BT, Young RR (1976) An evaluation of baclofen treatment for certain symptoms in patients with spinal cord lesions. Neurology 26: 441–446

    PubMed  CAS  Google Scholar 

  • Ek A, Andersson K-E, Gullberg B, Ulmsten U (1978) The effects of long-term treatment with norephedrine on stress incontinence and urethral closure pressure profile. Scand J Urol Nephrol 12: 105–110

    Article  PubMed  CAS  Google Scholar 

  • Ekeland A, Sander S (1976) A urodynamic study of emepronium bromide in bladder dysfunction. Scand J Urol Nephrol 10: 195–199

    PubMed  CAS  Google Scholar 

  • Ekman G, Andersson K-E, Rud T, Ulmsten U (1980) A double blind crossover study of the effects of terodiline in women with unstable bladder. Acta Pharmacol Toxicol 46 [Suppl] 1: 39–43

    Google Scholar 

  • Fingl E, Woodbury DM, (1975) General principles. In: Goodman L, Gilman A (eds) The pharmacological basis of therapeutics, 5th edn. Macmillan, New York, pp 1–46

    Google Scholar 

  • Finkbeiner AE, Welch LT, Bissada NK (1978) Uropharmacology. IX. Direct acting smooth muscle stimulants and depressants. Urology 12: 231–235

    Article  PubMed  CAS  Google Scholar 

  • Fischer CP, Diokno A, Lapides J (1978) The anticholinergic effects of dicyclomine hydrochloride in uninhibited neurogenic bladder dysfunction. J Urol 120: 328–329

    PubMed  CAS  Google Scholar 

  • Forman A, Andersson K-E, Henriksson L, Rud T, Ulmsten U (1978) Effects of nifedipine on the smooth muscle of the human urinary tract in-vitro and in-vivo. Acta Pharmacol Toxicol 43: 111–118

    Article  CAS  Google Scholar 

  • Fossberg E, Beisland HO, Sander S (1981) Sensory urgency in females: treatment with phenylpropanolamine. Eur Urol 7: 157–160

    PubMed  CAS  Google Scholar 

  • Fowler JE Jr (1981) Prospective study of intravesical dimethyl sulfoxide in the treatment of suspected early interstitial cystitis. Urology 18: 21–26

    Article  PubMed  Google Scholar 

  • Fox S, Krnjević K, Morris ME, Puil E, Werman R (1978) Action of baclofen on mammalian synaptic transmission. Neuroscience 3: 495–515

    Article  PubMed  CAS  Google Scholar 

  • Franz DN (1975) Drugs for Parkinson’s disease: centrally acting muscle relaxants. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 5th edn. Macmillan, New York, pp 227–244

    Google Scholar 

  • Fredericks CM, Green RL, Anderson GF (1978) Comparative in-vitro effects of imipramine, oxybutynin and flavoxate on rabbit detrusor. Urology 12: 487–491

    Article  PubMed  CAS  Google Scholar 

  • Gibaldi M, Grundhofer B (1975) Biopharmaceutic influences on the anticholinergic effects of propantheline. Clin Pharmacol Ther 18: 457–461

    PubMed  CAS  Google Scholar 

  • Gibbon NOK (1965) Urinary incontinence in disorders of the nervous system. Br J Urol 37: 624–632

    Article  PubMed  CAS  Google Scholar 

  • Gleason DM, Reilly RJ, Bottaccini MR, PierceMJ (1974) The urethral continence zone and its relation to stress incontinence. J Urol 112: 81–88

    PubMed  CAS  Google Scholar 

  • Gosling JA, Dixon JS, Critchley HOD, Thompson S-A (1981) A comparative study of the human external sphincter and periurethral levator ani muscles. Br J Urol 53: 35–41

    Article  PubMed  CAS  Google Scholar 

  • Graham RM, Pettinger WA (1979) Prazosin. N Engl J Med 300: 232–236

    Article  CAS  Google Scholar 

  • Hachen HJ, Krocker V (1977) Clinical and laboratory assessment of the efficacy of baclofen on urethral sphincter spasticity in patients with traumatic paraplegia. Eur Urol 3: 237–240

    PubMed  CAS  Google Scholar 

  • Hackler RH, Broecker BH, Klein FA, Brady SM (1980) A clinical experience with dantrolene sodium for external urinary sphincter hypertonicity in spinal cord injured patients. J Urol 124: 78–81

    PubMed  CAS  Google Scholar 

  • Harris JD, Benson GS (1980) Effect of dantrolene sodium on canine bladder contractility. Urology 16: 229–231

    Article  PubMed  CAS  Google Scholar 

  • Hartviksen K (1966) Discussion. Acta Neurol Scand 42 [Suppl] 20: 180

    Google Scholar 

  • Hebjørn S, Walter S (1978) Treatment of female incontinence with emepronium bromide. Urologia Int 33: 120–129

    Article  Google Scholar 

  • Hebjørn S (1977) Treatment of detrusor hyperreflexia in multiple sclerosis. Urol Int 32: 209–217

    Article  PubMed  Google Scholar 

  • Hebjørn S, Andersen JT, Walter S, Dam AM (1976) Detrusor hyperreflexia. Scand J Urol Nephrol 10: 103–109

    Article  PubMed  Google Scholar 

  • Hilton P, Stanton SL (1982) The use of desmopressin (DDA VP) in nocturnal urinary frequency in the female. Br J Urol 54: 252–255

    Article  PubMed  CAS  Google Scholar 

  • Hinman F (1974) Urinary tract damage in children who wet. Pediatrics 54: 142–150

    Google Scholar 

  • Hinman F Jn (1980) Syndromes of vesical incoordination. Urol Clin N Am 7: 311–319

    Google Scholar 

  • Hodgson BJ, Dumas S, Bolling DR, Heesch CM (1978) Effect of estrogen on sensitivity of rabbit bladder and urethra to phenylephrine. Invest Urol 16: 67–69

    PubMed  CAS  Google Scholar 

  • Hollister LE (1978) Tricyclic antidepressants. N Engl J Med 299: 1106–1109

    Article  PubMed  CAS  Google Scholar 

  • Holmberg E, Waldeck B (1980) On the possible role of potassium ions in the action of terbutaline on skeletal muscle contractions. Acta Pharmacol Toxicol 46: 141–149

    Article  CAS  Google Scholar 

  • Husted S, Andersson K-E, Sommer L, Østergaard JR (1980) Anticholinergic and calcium antagonistic effects of terodiline in rabbit urinary bladder. Acta Pharmacol Toxicol 46 [Suppl] 1: 20–30

    Article  CAS  Google Scholar 

  • Innes IR, Nickerson M (1975) Atropine, scopolamine, and related antimuscarinic drugs. In: Goodman L, Gilman A (eds) The pharmacological basis of therapeutics, 5th edn. Macmillan, New York, pp 514–532

    Google Scholar 

  • Jensen D Jr (1981) Pharmacological studies of the uninhibited neurogenic bladder. Acta Neurol Scand 64: 175–195

    Article  PubMed  Google Scholar 

  • Johns A, Tasker JJ, Johnson CE, Theman MA, Paton DM (1976) The mechanism of action of dicyclomine hydrochloride on rabbit detrusor muscle and vas deferens. Arch Int Pharmacodyn 224: 109–113

    PubMed  CAS  Google Scholar 

  • Johnston JH, Farkas A (1975) Congenital neuropathic bladder: practicalities and possibilities of conservational management. Urology 5: 719–727

    Article  PubMed  CAS  Google Scholar 

  • Jonas D, Linzbach P, Weber W (1979a) The use of midodrin in the treatment of ejaculation disorders following retroperitoneal lymphadenectomy. Eur Urol 5: 184–187

    PubMed  CAS  Google Scholar 

  • Jonas U, Petri E, Kissal J (1979b) The effect of flavoxate on hyperactive detrusor muscle. Eur Urol 5: 106–108

    PubMed  CAS  Google Scholar 

  • Jones RF, Burke D, Marosszeky JE, Gillies JD (1970) A new agent for the control of spasticity. J Neurol Neurosurg Psychiatry 33: 464–468

    Article  PubMed  CAS  Google Scholar 

  • Kaneko S, Minami K, Yachiku S, Kurita T (1980) Bladder neck dysfunction. The effect of the alpha adrenergic blocking agent phentolamine on bladder neck dysfunction and a fluorescent histochemical study of bladder neck smooth muscle. Invest Urol 18: 212–218

    PubMed  CAS  Google Scholar 

  • Kedia KR, Persky L (1981) Effect of phenoxybenzamine (Dibenzyline) on sexual function in man. Urology 18: 620–622

    Article  PubMed  CAS  Google Scholar 

  • Khanna OP (1976) Disorders of micturition: neuropharmacologic basis and results of drug therapy. Urology 8: 316–328

    Article  PubMed  CAS  Google Scholar 

  • Khanna OP, DiGregorio GJ, Barbieri EJ, McMichael RF, Ruch E (1979) In-vitro study of antispasmodic effects of dicyclomine hydrochloride on vesicourethral smooth muscle of guinea pig and rabbit. Urology 13: 457–462

    Article  PubMed  CAS  Google Scholar 

  • Khanila OP, Barbieri EJ, McMichael RF (1981) The effects of adrenergic agonists and antagonists on vesicourethral smooth muscle of rabbit. J Pharmacol Exp Ther 216: 95–100

    Google Scholar 

  • Kiesswetter H, Hennrich F, Englisch M (1983) Clinical and urodynamic assessment of pharmacologic therapy of stress incontinence. Urol Int 38: 58–63

    Article  PubMed  CAS  Google Scholar 

  • Kilbinger H, Weihrauch TR (1982) Drugs increasing gastrointestinal motility. Pharmacology 25: 61–72

    Article  PubMed  CAS  Google Scholar 

  • Kleeman FJ (1970) The physiology of the internal urinary sphincter. J Urol 104: 549–554

    PubMed  CAS  Google Scholar 

  • Koelle GB (1975) Parasympathomimetic agents. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 5th edn. Macmillan, New York, pp 467–476

    Google Scholar 

  • Kohler FP, Morales PA (1968) Cystometric evaluation of flavoxate hydrochloride in normal and neurogenic bladders. J Urol 100: 729–730

    PubMed  CAS  Google Scholar 

  • Korczyn AD, Kish I (1979) The mechanism of imipramine in enuresis nocturna. Clin Exp Pharmacol Physiol 6: 31–35

    Article  PubMed  CAS  Google Scholar 

  • Kosman ME (1978) Evaluation of a new antidiuretic agent, desmopressin acetate (DDA VP). JAMA 240: 1896–1897

    Article  PubMed  CAS  Google Scholar 

  • Krane RJ, Olsson CA (1973a) Phenoxybenzamine in neurogenic bladder dysfunction. I. A theory of micturition. J Urol 110: 650–652

    PubMed  CAS  Google Scholar 

  • Krane RJ, Olsson CA (1973b) Phenoxybenzamine in neurogenic bladder dysfunction. II. Clinical considerations. J Urol 110: 653–656

    PubMed  CAS  Google Scholar 

  • Krier J, Thor KB, De Groat WC (1979) Effects of clonidine on the lumbar sympathetic pathways to the large intestine and urinary bladder of the cat. Eur J Pharmacol 59: 47–53

    Article  PubMed  CAS  Google Scholar 

  • Kunin SA, Limbert DJ, Platzker ACG, McGinley J (1970) The efficacy of imipramine in the management of enuresis. J Urol 104: 612–615

    PubMed  CAS  Google Scholar 

  • Lapides J (1964) Urecholine regimen for rehabilitating the atonic bladder. J Urol 91: 658–659

    PubMed  CAS  Google Scholar 

  • Lapides J (1974) Neurogenic bladder: principles of treatment. Urol Clin N Am 1: 81–97

    CAS  Google Scholar 

  • Lapides J, Dodson A Jr (1953) Observations on effect of methantheline bromide in urological disturbances. Arch Surg 66: 1–9

    CAS  Google Scholar 

  • Lapides J, Friend CR, Ajemian EP, Sonda LP (1963) Comparison of action of oral and parenteral bethanechol chloride upon the urinary bladder. Invest Urol 1: 94–97

    PubMed  CAS  Google Scholar 

  • Larsen J-J, Mortensen S (1978) Effect of ritodrine on the bladder capacity in unanaesthetized pigs. Acta Pharmacol Toxicol 43: 405–408

    Article  CAS  Google Scholar 

  • Lee LW (1949) The clinical use of urecholine in dysfunctions of the bladder. J Urol 62: 300–307

    PubMed  CAS  Google Scholar 

  • Levin RM, Shofer FS, Wein AJ (1980) Cholinergic, adrenergic and purinergic response of sequential strips of rabbit urinary bladder. J Pharmacol Exp Ther 212: 536–540

    PubMed  CAS  Google Scholar 

  • Levin RM, Jacobowitz D, Wein AJ (1981) Autonomic innervation of rabbit urinary bladder following estrogen administration. Urology 17: 449–453

    Article  PubMed  CAS  Google Scholar 

  • Levin RM, Staskin D, Wein AJ (1982) The muscarinic cholinergic binding kinetics of the human urinary bladder. Neurol Urodynamics 1: 221–225

    Article  CAS  Google Scholar 

  • Leyson FJ, Martin BF, Sporer A (1980) Baclofen in the treatment of detrusor-sphincter dyssynergia in spinal cord injury patients. J Urol 124: 82–84

    PubMed  CAS  Google Scholar 

  • Lish PM, Labudde JA, Peters EL, Robbins SI (1965) Oxybutynin: a musculotropic antispasmodic drug with moderate anticholinergic action. Arch Int Pharmacodyn 156: 467–488

    PubMed  CAS  Google Scholar 

  • MacGregor RJ, Diokno AC (1981) The alpha adrenergic blocking action of prazosin hydrochloride on the canine urethra. Invest Urol 18: 426–429

    PubMed  CAS  Google Scholar 

  • McGuire E (1979) Urethral sphincter mechanisms. Urol Clin N Am 6: 39–49

    CAS  Google Scholar 

  • McGuire EJ, Lytton B, Pepe V, Kohorn EI (1976) Stress urinary incontinence. Obstet Gynecol 47: 255–264

    PubMed  CAS  Google Scholar 

  • McNally C (1982) Smith-Kline Company. Personal communication (letter)

    Google Scholar 

  • Mahony DT, Laferte RO, Mahoney JE (1973) Observations on sphincter augmenting effect of imipramine in children with urinary incontinence. Urology 1: 317–323

    Article  PubMed  CAS  Google Scholar 

  • MÃ¥nsson W, Sundin T, Gullberg B (1980) Evaluation of a synthetic vasopressin analogue for treatment of nocturia in benign prostatic hypertrophy. Scand J Urol Nephrol 14: 139–141

    Article  PubMed  Google Scholar 

  • Medical Letter (1980) Dimethyl sulfoxide (DMSO). Med Lett 22: 94–95

    Google Scholar 

  • Merrill DC, Rotta J (1974) A clinical evaluation of detrusor denervation supersensitivity using air cystometry. J Urol 111: 27–30

    PubMed  CAS  Google Scholar 

  • Meyhoff HH, Nordling J (1981) Different cystometric types of deficient micturition reflex control in female urinary incontinence with special reference to the effect of parasympatholytic treatment. Br J Urol 53: 129–133

    Article  PubMed  CAS  Google Scholar 

  • Milner G, Hills NF (1968) A double-blind assessment of antidepressants in the treatment of 212 enuretic patients. Med J Aust I: 943–947

    Google Scholar 

  • Mirakhur R, Dundee J (1980) Comparison of the effects of atropine and glycopyrrolate on various end organs. J R Soc Med 73: 727–730

    PubMed  CAS  Google Scholar 

  • Mirakhur RK, Dundee JW, Jones CJ (1978) Evaluation of the anticholinergic actions of glycopyrronium bromide. Br J Clin PharmacoI5: 77–81

    CAS  Google Scholar 

  • Moisey CU, Stephenson TP, Brendler CB (1980) The urodynamic and subjective results of treatment of detrusor instability with oxybutynin chloride. Br J Urol 52: 472–475

    Article  PubMed  CAS  Google Scholar 

  • Moncada S, Flower R, Vane J (1980) Prostaglandins, prostacyclin, and thromboxane A2. In: Gilman AG, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 668–681

    Google Scholar 

  • Montague DK, Stewart BH (1979) Urethral pressure profiles before and after Ornade administration in patients with stress urinary incontinence. J Urol 122: 198–199

    PubMed  CAS  Google Scholar 

  • Muller J, Schulze S (1980) Imipramine cardiotoxicity: an electrocardiographic and hemodynamic study in rabbits. Acta Pharmacol Toxicol 46: 191–199

    Article  CAS  Google Scholar 

  • Murdock MM, Sax D, Krane RJ (1976) Use of dantrolene sodium in external sphincter spasm. Urology 8: 133–137

    Article  PubMed  CAS  Google Scholar 

  • Nanninga JB, Kaplan P, Lal S (1977) Effect of phentolamine on perineal muscle EMG activity in paraplegia. Br J Urol 49: 537–539

    Article  PubMed  CAS  Google Scholar 

  • Noack CH (1964) Enuresis nocturna: a long-term study of 44 children treated with imipramine hydrochloride (Tofranil) and other drugs. Med J Aust I: 191–194

    Google Scholar 

  • Nordling J, Meyhoff HH, Christensen NJ (1979) Effects of clonidine (Catapresan) on urethral pressure. Invest Urol 16: 289–291

    PubMed  CAS  Google Scholar 

  • Norlén L, Sundin T, Waagstein F (1978) Beta-adrenoceptor stimulation of the human urinary bladder in-vivo. Acta Pharmacol Toxicol 43 [Suppl II]: 26–30

    Article  Google Scholar 

  • Öbrink A, Bunne G (1978) The effect of alpha adrenergic stimulation in stress incontinence. Scand J Urol Nephrol 12: 205–208

    Article  PubMed  Google Scholar 

  • Olsson CA, Siroky MB, Krane RJ (1977) The phentolamine test in neurogenic bladder dysfunction. J Urol 117: 481–485

    PubMed  CAS  Google Scholar 

  • Olsson OAT, Swanberg E, Svedinger I, Waldeck B (1979) Effects of p-adrenoceptor agonists on airway smooth muscle and on slow-contracting skeletal muscle: in-vitro and in-vivo results compared. Acta Pharmacol Toxicol 44: 272–276

    Article  CAS  Google Scholar 

  • Olubadewo JO (1980) The effect of imipramine on rat detrusor muscle contractility. Arch Int Pharmacodyn 245: 84–94

    PubMed  CAS  Google Scholar 

  • Palmer JH, Worth PH, Exton-Smith AN (1981) Flunarizine: a once daily therapy for urinary incontinence. Lancet III: 279–281

    Article  Google Scholar 

  • Paulson DF (1978) Oxybutynin chloride in control of post-transurethral vesical pain and spasm. Urology 11: 237–238

    Article  PubMed  CAS  Google Scholar 

  • Pederson E, Grynderup V (1966) Clinical pharmacology of the neurogenic bladder. Acta Neurol Scand (Suppl) 42: 111

    Article  Google Scholar 

  • Perera GLS, Ritch AES, Hall MRP (1982) The lack of effect of intramuscular emepronium bromide for urinary incontinence. Br J Urol 54: 259–260

    Article  PubMed  CAS  Google Scholar 

  • Perlberg S, Caine M (1982) Adrenergic response of bladder muscle in prostatic obstruction. Urology 20: 524–527

    Article  PubMed  CAS  Google Scholar 

  • Petersen KE, Andersen OO, Hansen T (1974) Mode of action and relative value of imipramine and similar drugs in the treatment of nocturnal enuresis. Eur J Clin Pharmacol 7: 187–194

    Article  PubMed  CAS  Google Scholar 

  • Petti TA, Law W (1981) Abrupt cessation of high dose imipramine therapy treatment in children. JAMA 246: 768–769

    Article  PubMed  CAS  Google Scholar 

  • Philp NH, Thomas DG (1980) The effect of distigmine bromide on voiding in male paraplegic patients with reflex micturition. Br J Urol 52: 492–496

    Article  PubMed  CAS  Google Scholar 

  • Philp NH, Thomas DG, Clarke SJ (1980) Drug effects on the voiding cystometrogram: a comparison of oral bethanechol and carbachol. Br J Urol 52: 484–487

    Article  PubMed  CAS  Google Scholar 

  • Raezer DM, Wein AJ, Jacobowitz D, Corriere IN Jr (1973) Autonomic innervation of canine urinary bladder: cholinergic and adrenergic contributions and interaction of sympathetic and parasympathetic nervous systems in bladder function. Urology 2: 211–221

    Article  Google Scholar 

  • Raezer DM, Benson GS, Wein AJ, Duckett JW Jr (1977) The functional approach to the management of the pediatric neuropathic bladder. A clinical study. J Urol 117: 649–654

    PubMed  CAS  Google Scholar 

  • Ramsden PD, Hindmarsh JR, Price DA, Yeates WK, Bowditch JDP (1982) DDAVP for adult enuresis - a preliminary report. Br J Urol 54: 256–258

    Article  PubMed  CAS  Google Scholar 

  • Rashbaum M, Mandelbaum CC (1948) Non-operative treatment of urinary incontinence in women. Am J Obstet Gynecol 56: 777–780

    PubMed  CAS  Google Scholar 

  • Raz S, Caine M (1972) Adrenergic receptors in the female canine urethra. Invest Urol 9: 319–323

    PubMed  CAS  Google Scholar 

  • Raz S, Smith RB (1976) External sphincter spasticity syndrome in female patients. J Urol 115: 443–446

    PubMed  CAS  Google Scholar 

  • Raz S, Zeigler M, Caine (1973) The role of female hormones in stress incontinence. In: Proceedings of the 16th Congress of the Societe International d’Urologie, Amsterdam, vol 2. Doin, Paris, pp 397–402

    Google Scholar 

  • Raz S, Kaufman JJ, Ellison GW, Mayers LW (1977) Methyldopa in treatment of neurogenic bladder disorders. Urology 9: 188–190

    Article  PubMed  CAS  Google Scholar 

  • Rees DLP, Ransley PG (1980) Eskornade in the treatment of diurnal incontinence in children. Br J Urol 52: 476–479

    Article  PubMed  CAS  Google Scholar 

  • Rees DLP, Whitfield HN, Islam AKMS, Doyle PT, Mayo ME, Wickham JEA (1976) Urodynamic findings in adult females with frequency and dysuria. Br J Urol 47: 853–860

    Article  Google Scholar 

  • Richelson E (1983) Antimuscarinic and other receptor blocking properties of antidepressants. Mayo Clin Proc 58: 40–46

    PubMed  CAS  Google Scholar 

  • Richter JE, Castell DO (1982) Gastroesophageal reflux. Ann Int Med 97: 93–103

    PubMed  CAS  Google Scholar 

  • Ritch AES, George CF, Castleden CM, Hall MRP (1977) A second look at emepronium bromide in urinary incontinence. Lancet 1: 504–506

    Article  PubMed  CAS  Google Scholar 

  • Robinson AG (1976) DDA VP in the treatment of central diabetes insipidus. N Engl J Med 294: 507–511

    Article  PubMed  CAS  Google Scholar 

  • Rohner TJ, Hannigan JD, Sanford EJ (1978) Altered in-vitro adrenergic responses of dog detrusor muscle after chronic bladder outlet obstruction. Urology 11: 357–361

    Article  PubMed  CAS  Google Scholar 

  • Ron M, Shapiro A, Caine M (1980) The action of bromocriptine on human detrusor muscle. Urol Res 8: 207–209

    Article  PubMed  CAS  Google Scholar 

  • Rosenbaum AH, Maruta T, Richelson E (1979) Drugs that alter mood. Tricyclic agents and monoamine oxidase inhibitors. Mayo Clin Proc 54: 335–344

    PubMed  CAS  Google Scholar 

  • Rossier AB, Fam BA, Lee IY, Sarkarati M, Evans DA (1982) Role of striated and smooth muscle components in the urethral pressure profile in traumatic neurogenic bladders: a neuropharmacological and urodynamic study. Preliminary report. J Urol 128: 529–535

    PubMed  CAS  Google Scholar 

  • Roussan MS, Abramson AS, Levine SA, Feibel A (1975) Bladder training: its role in evaluating the effect of an antispasticity drug on voiding in patients with neurogenic bladder. Arch Phys Med Rehabil 56: 463–468

    PubMed  CAS  Google Scholar 

  • Rud T (1980a) The effects of estrogens and gestagens on the urethral pressure profile in urinary continent and stress incontinent women. Acta Obstet Gynecol Scand 59: 265–270

    Article  PubMed  CAS  Google Scholar 

  • Rud T (1980b) Urethral pressure profile in continent women from childhood to old age. Acta Obstet Gynecol Scand 59: 331–335

    Article  PubMed  CAS  Google Scholar 

  • Rud T, Andersson K-E, Boye N, Ulmsten U (1980) Terodiline inhibition of human bladder contraction. Effects in vitro and in women with unstable bladder. Acta Pharmacol Toxicol 46 [Suppl] 1: 31–38

    Article  Google Scholar 

  • Salmon UJ, Walter RI, Geist SH (1941) The use of estrogen in the treatment of dysuria and incontinence in post-menopausal women. Am J Obstet Gynecol 42: 845–851

    Google Scholar 

  • Schreiter F, Fuchs P, Stockamp K (1976) Estrogenic sensitivity of alpha receptors in the urethral musculature. Urol Int 31: 13–19

    Article  PubMed  CAS  Google Scholar 

  • Sjögren C, Andersson K-E (1979) Effects of cholinoceptor blocking drugs, adrenoceptor stimulants and calcium antagonists on the transmurally stimulated guinea pig urinary bladder in-vitro and in-vivo. Acta Pharmacol Toxicol 44: 228–234

    Article  Google Scholar 

  • Smey P, King LR, Firlit CF (1980) Dysfunctional voiding in children secondary to internal sphincter dyssynergia: treatment with phenoxybenzamine. Urologic Clin N Am 7: 337–347

    CAS  Google Scholar 

  • Sonda LP, Gershon C, Diokno AC, Lapides J (1979) Further observations on the cystometric and uroflowmetric effects of bethanechol chloride on the human bladder. J Urol 122: 775–777

    PubMed  CAS  Google Scholar 

  • Sporer A, Leyson JFJ, Martin BF (1978) Effects of bethanechol chloride on the external urethral sphincter in spinal cord injury patients. J Urol 120: 62–66

    PubMed  CAS  Google Scholar 

  • Spyraki C, Fibiger HC (1980) Functional evidence for subsensitivity of noradrenergic α-2 receptors after chronic desipramine treatment. Life Sci 27: 1863–1867

    Article  PubMed  CAS  Google Scholar 

  • Stanton SL (1973) A comparison of emepronium bromide and flavoxate hydrochloride in the treatment of urinary incontinence. J Urol 110: 529–532

    PubMed  CAS  Google Scholar 

  • Stanton SL (1978) Diseases of the urinary system. Drugs acting on the bladder and urethra. Br Med J 1: 1607–1608

    Article  PubMed  CAS  Google Scholar 

  • Starr I, Ferguson LK (1940) Beta methylcholine urethane. Its action in various normal and abnormal conditions, especially postoperative urinary retention. Am J Med Sci 200: 372–385

    Article  Google Scholar 

  • Stewart BH, Shirley SW (1976) Further experience with intravesical DMSO in the treatment of interstitial cystitis. J Urol 116: 36–38

    PubMed  CAS  Google Scholar 

  • Stewart BH, Banowsky LHW, Montague DK (1976) Stress incontinence: conservative therapy with sympathomimetic drugs. J Urol 115: 558–559

    PubMed  CAS  Google Scholar 

  • Stockamp K (1975) Treatment with phenoxybenzamine of upper urinary tract complications caused by intravesical obstruction. J Urol 113: 128–131

    PubMed  CAS  Google Scholar 

  • Stockamp K, Schreiter F (1975) Alpha adrenolytic treatment of the congenital neuropathic bladder. Urol Int 30: 33

    Article  PubMed  CAS  Google Scholar 

  • Tulloch AGS, Creed KE (1979) A comparison between propantheline and imipramine on bladder and salivary gland function. Br J Urol 51: 359–362

    Article  PubMed  CAS  Google Scholar 

  • Turner-Warwick R (1979) A urodynamic review of bladder outlet obstruction in the male and its clinical implications. Urol Clin N Am 6: 171–192

    Google Scholar 

  • Turner-Warwick R, Whiteside CG, Worth PHL, Milroy EJG, Bates CP (1973) A urodynamic view of the clinical problems associated with bladder neck dysfunction and its treatment by endoscopic incision and transtrigonal posterior prostatectomy. Br J Urol 45: 44–59

    PubMed  CAS  Google Scholar 

  • Ulmsten U, Andersson K-E, Persson CGA (1977) Diagnostic and therapeutic aspects of urge urinary incontinence in women. Urol Int 32: 88–96

    Article  PubMed  CAS  Google Scholar 

  • Ursillo RC (1967) Rationale for drug therapy in bladder dysfunction. In: Boyarsky S (ed) The neurogenic bladder. Williams & Wilkins, Baltimore, pp 187–190

    Google Scholar 

  • Vaidyanathan S, Rao MS, Bapna BC, Chary KSN, Palaniswamy R (1980) Beta adrenergic activity in human proximal urethra: a study with terbutaline. J Urol 124: 869–871

    PubMed  CAS  Google Scholar 

  • Veith RC, Raskind MA, Caldwell JH, Barnes RF, Gumbrecht G, Ritchie JL (1982) Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease. N Engl J Med 306: 954–959

    Article  PubMed  CAS  Google Scholar 

  • Walter S, Hansen J, Hansen L, Maegaard E, Meyhoff HH, Nordling J (1982) Urinary incontinence in old age. A controlled clinical trial of emepronium bromide. Br J Urol 54: 249–251

    Article  PubMed  CAS  Google Scholar 

  • Wein AJ (1979) Pharmacologic approaches to the management of neurogenic bladder dysfunction. Journal of Continuing Education in Urology 18(5): 17–34

    Google Scholar 

  • Wein AJ (1980) Pharmacology of the bladder and urethra. In: Stanton SL, Tanagho EA (eds) Surgery of female incontinence. Springer-Verlag, Berlin Heidelberg New York, pp 185–199

    Google Scholar 

  • Wein AJ (1981) Classification of neurogenic voiding dysfunction. J Urol 125: 605–609

    PubMed  CAS  Google Scholar 

  • Wein AJ, Raezer DM (1979) Physiology of micturition. In: Krane R, Siroky M (eds) Clinical neurology. Little, Brown & Co., Boston, pp 1–33

    Google Scholar 

  • Wein AJ, Hanno PM, Dixon DO, Raezer DM, Benson GS (1978) The effect of oral bethanechol chloride on the cystometrogram of the normal adult male. J Urol 120: 330–331

    PubMed  CAS  Google Scholar 

  • Wein AJ, Benson GS, Jacobowitz D (1979) Lack of evidence for adrenergic innervation of the external urethral sphincter. J Urol 121: 324–326

    PubMed  CAS  Google Scholar 

  • Wein AJ, Raezer DM, Malloy TR (1980a) Failure of the bethanechol supersensitivity test to predict improved voiding after subcutaneous bethanechol administration. J Urol 123: 202–203

    PubMed  CAS  Google Scholar 

  • Wein AJ, Malloy TR, Shofer F, Raezer DM (1980b) The effects of bethanechol chloride on urodynamic parameters in normal women and in women with significant residual urine volumes. J Urol 124: 397–399

    PubMed  CAS  Google Scholar 

  • Weiner N (1980a) Atropine, scopolamine and related antimuscarinic drugs. In: Gilman AG, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 120–137

    Google Scholar 

  • Weiner N (1980b) Norepinephrine, epinephrine and the sympathomimetic amines. In: Gilman AG, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 138–175

    Google Scholar 

  • Weiner N (1980c) Drugs that inhibit adrenergic nerves and block adrenergic receptors. In: Gilman AG, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 176–210

    Google Scholar 

  • Weinshilboum RM (1980) Antihypertensive drugs that alter adrenergic function. Mayo Clin Proc 55: 390–402

    PubMed  CAS  Google Scholar 

  • Whitfield HN, Doyle PT, Mayo ME, Poopalasingham N (1976) The effect of adrenergic blocking drugs on outflow resistance. Br J Urol 47: 823–827

    Article  Google Scholar 

  • Woodhead DM, Hall TC, Snodgrass WT (1967) An effective control of benign enuresis. J Urol 97: 98–100

    PubMed  CAS  Google Scholar 

  • Yalla SV, Blunt KJ, Fam BA, Constantinople NL, Gittes RF (1977) Detrusor-urethral sphincter dyssynergia. J Urol 118: 1026–1029

    PubMed  CAS  Google Scholar 

  • Ziegler MG, Lake CR, Williams AC, Teychenne PF, Shoulson I, Steinsland O (1979) Bromocriptine inhibits norepinephrine release. Clin Pharmacol Ther 25: 137–142

    PubMed  CAS  Google Scholar 

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  1. Alan J. Wein
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  1. Hebrew University, Jerusalem, Israel

    Marco Caine MS, FRCS, FACS (Professor of Urology, Director) (Professor of Urology, Director)

  2. Department of Urology, Hadassah University Hospital, Jerusalem, Israel

    Marco Caine MS, FRCS, FACS (Professor of Urology, Director) (Professor of Urology, Director)

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Wein, A.J. (1984). Pharmacological Treatment of Non-neurogenic Voiding Dysfunction. In: Caine, M. (eds) The Pharmacology of the Urinary Tract. Clinical Practice in Urology. Springer, London. https://doi.org/10.1007/978-1-4471-1359-1_7

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