Differential Diagnosis of Soft Tissue Calcification
Deposition of calcium salts is normally restricted to the skeleton. Ectopic or heterotopic calcification refers to calcium deposition in any other tissue, and these may be subdivided into the soft tissues and the viscera. The soft tissues include: skin, fat, skeletal muscle, cartilage, fibrous connective tissue, blood vessels, peripheral nerves and lymph nodes. Soft tissue calcification may occur either as amorphous masses or upon an ordered collagenous matrix as ectopic bone. This distinction is obvious histologically and can usually be made on a radiograph by the demonstration of trabeculation.
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