Skip to main content
SpringerLink
Log in
Book cover

Chemotherapy and Urological Malignancy pp 9–26Cite as

Cytotoxic Drugs and Hormonal Manipulations in the Management of Carcinoma of the Kidney

  • Chapter

Part of the book series: Clinical Practice in Urology ((PRACTICE UROLOG))

Abstract

The commonest renal tumor in adults is that arising from the cells of renal parenchyma. These cancers were described by Grawitz (1883), who named them hypernephromas upon the supposition that they might arise from nests of adrenal tissue in the kidney. The names ‘hypernephroma’ and ‘Grawitz tumor’ are obsolete, and renal carcinoma (or renal cell carcinoma) is the most appropriate term, since the tumors arise from the secretory cells of the renal tubular epithelium. Renal carcinoma is not a common disease; its incidence is about 7.5 cases per 100,000 population. In the United States there are about 7000 deaths from this tumor each year (American Cancer Society 1973): this represents 2.3% of male cancer deaths and 1.6% of cancer deaths in women.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alberto P, Senn HJ (1974) Hormonal therapy of renal carcinoma alone and in association with cytostatic drugs. Cancer 33:1226–1229

    Article  PubMed  CAS  Google Scholar 

  • Al-Sarraf M (1979) The clinical trial of tamoxifen in patients with advanced renal cell cancer. A Southwest Oncology Group study. Proc Am Soc Clin Oncol 20:378, C-360

    Google Scholar 

  • American Cancer Society (1973) Cancer facts and figures. New York: American Cancer Society

    Google Scholar 

  • Bloom HJG (1973) Hormone-induced and spontaneous regression of metastatic renal cancer. Cancer 32: 1066–1071

    Article  PubMed  CAS  Google Scholar 

  • Bonadonna G, Brusamolino E, Valagussa P, Rossi A, Brugnatelli L, Brambilla C, De Lena M, Tancini G, Bajetta E, Musumeci R, Veronesi U (1976) Combination chemotherapy as an adjuvant treatment in operable breast cancer. N Engl J Med 294:405–410

    Article  PubMed  CAS  Google Scholar 

  • Bukowski RM, Groppe C, Reimer R, Weick J, Hewlett JS (1979) Immunotherapy (IT)of metastatic renal cell carcinoma. Proc Am Soc Clin Oncol 20:402, C-457

    Google Scholar 

  • Carter RL (1968) The pathology of renal cancer. JAMA 204:221–222

    Article  PubMed  CAS  Google Scholar 

  • Carter SK, Wasserman TH (1975) The chemotherapy of urologic cancer. Cancer 36:729–747

    Article  PubMed  CAS  Google Scholar 

  • Cohen AJ, Li FP, Berg S, Marchetto DJ, Tsai S, Jacobs SC, Brown RS (1979) Hereditary renal-cell carcinoma associated with a chromosomal translocation. N Engl J Med 310:592–595

    Article  Google Scholar 

  • Concolino G, Marocchi A, Conti C, Tenaglia R, Di Silverio F, Bracci U (1978) Human renal cell carcinoma as a hormone-dependent tumor. Cancer Res 38:4340–4344

    PubMed  CAS  Google Scholar 

  • Currie VE, Kempin SJ, Sykes MP, Young CW (1979) Clinical studies of 2,4-diamino-5-(3’4’-dichlorophenyl)-6-methylpyrimidine (metoprine) with and without leucovorin. Proc Am Assoc Cancer Res 20:112,454

    Google Scholar 

  • Davis TE, Manalo FB (1978) Combination chemotherapy of advanced renal cell cancer with CCNU and vinblastine. Proc Am Soc Clin Oncol 19:316, C-39

    Google Scholar 

  • Everson TC, Cole WH (1966) Spontaneous regression of cancer. Saunders, Philadelphia London

    Google Scholar 

  • Faulconer RJ, Rosato FE, Wright GL, Schellhammer P (1978) Detection and isolation of antigens associated with renal cell carcinoma. Proc Am Soc Clin Oncol 19:308, C-8

    Google Scholar 

  • Fuks JZ, Van Echo DA, Aisner J, Kravitz S, Wiernik PH (1980) A Phase II trial of 4’-(9-acrindinyl-amino)-methanesulfon-m-anisidine (AMSA) in patients with renal cell carcinoma (RCC) and refractory small cell carcinoma of the lung (SCCL). Proc Am Soc Clin Oncol 21:477, C-622

    Google Scholar 

  • Ghose T, Tai J, Blair AH, Belitsky P, Aquino J, Norvell ST (1978) Antitumor antibodies as carriers of radionucleidesand cytotoxic drugs. Proc Am Assoc Cancer Res 19:236,942

    Google Scholar 

  • Glick J, Wein A, Negendank W, Harris D, Brodovsky H, Padavic K, Torri S (1979) Tamoxifen in metastatic prostate and renal cancer. Proc Am Soc Clin Oncol 20:311, C-81

    Google Scholar 

  • Grawitz P (1883) Die sogenannten Lipomas der Niere. Virchow Arch [Pathol Anat] 93:39–63

    Article  Google Scholar 

  • Hahn RG (1977) Megace, VP-16, Cytoxan and galactitol. Phase II treatment trials in advanced renal cell cancer. Proc Am Soc Clin Oncol 18:332, C-262

    Google Scholar 

  • Hahn RG, Temkin NR, Savlov ED, Perlia C, Wampler GL, Horton J, Marsh J, Carbone PP (1978) Phase II study of vinblastine, methyl-CCNU, and medroxyprogesterone in advanced renal cell cancer. Cancer Treat Rep 62:1093–1095

    PubMed  CAS  Google Scholar 

  • Hrushesky WJ (1977) What’s old and new in advanced renal cell carcinoma. Proc Am Soc Clin Oncol 18: 318, C-206

    Google Scholar 

  • Ishmael DR, Bottomley R, Geyer J (1980) Effect of nephrectomy on eventual response to chemotherapy in renal cell carcinoma. Proc Am Soc Clin Oncol 21:429, C-439

    Google Scholar 

  • Ishmael DR, Bottomley RH, Hoge AF (1976) Treatment of renal cell adenocarcinoma (hypernephroma) with Depo-Provera and combination chemoimmunotherapy. Proc Am Soc Clin Oncol 17:265, C-113

    Google Scholar 

  • Ishmael DR, Burpo LJ, Bottomley RH (1978) Combined therapy of advanced hypernephroma with medroxyprogesterone, BCG, adriamycin and vincristine. Proc Am Soc Clin Oncol 19:407, C-403

    Google Scholar 

  • Katakkar SB, Franks CR (1978) Chemo-hormonal therapy for metastatic renal cell carcinoma with adriamycin, hydroxyurea, vinblastine, and medroxyprogesterone acetate. Cancer Treat Rep 62: 1379–1380

    PubMed  CAS  Google Scholar 

  • Kato T, Nemoto R, Mori H, Kumagai I (1979) Microencapsulated mitomycin-C therapy in renal cell carcinoma. Lancet II: 479–480

    Article  Google Scholar 

  • Kirkman H (1959) Estrogen-induced tumors of the kidney in the Syrian hamster. Natl Cancer Inst Mongr 1: 1–37

    CAS  Google Scholar 

  • Kirulata G, Morales A, Lott S (1975) Response of renal adenocarcinoma to cyclophosphamide. Urology 6: 557–558

    Article  Google Scholar 

  • Knight WA, Livingston RB, Fabian C, Costanzi J (1979) Methyl-glyoxal bis-guanylhydrazone (methyl-GAG, MGBG) in advanced human malignancy. Proc Am Soc Clin Oncol 20:319, C-115

    Google Scholar 

  • Knight WA, Livingston RB, Fabian C, Costanzi J (1980) Methyl-glyoxal bis-guanulhydrazone (methyl-GAG, MGBG) in advanced renal carcinoma. Proc Am Soc Clin Oncol 21: 367, C-190

    Google Scholar 

  • Kradjian JM, Bennington JL (1964) Renal carcinoma recurrent 31 years after nephrectomy. Arch Surg 90:192–195

    Google Scholar 

  • Levi J A, Dalley D, Aroney R (1980) A comparative trial of the combination vinblastine (V), methotrexate (A) and bleomycin (B) with and without tamoxifen (T) for metastatic renal cell carcinoma (RCC). Proc Am Soc Clin Oncol 21:426, C-425

    Google Scholar 

  • Li JJ, Li SA, Gonzales R(1979) Specific hormone binding in human renal carcinoma and kidney. Proc Am Assoc Cancer Res 20: 273, 1107

    Google Scholar 

  • Lokich JL, Harrison JH (1975) Renal cell carcinoma: natural history and chemotherapeutic experience. J Urol 114: 371–374

    PubMed  CAS  Google Scholar 

  • Luderer RC, Opipari MI, Perrotta AL (1978) Treatment of metastatic renal cell carcinoma: Review of experience and world literature. Journal of the American Osteopathic Association 77: 590–603

    PubMed  CAS  Google Scholar 

  • McPherson TA, Tan YH (1979) Phase I study of human fibroblast interferon (FI) in human malignancy. Proc Am Soc Clin Oncol 20:378, C-361

    Google Scholar 

  • Middleton RG (1967) Surgery for metastatic renal cell carcinoma. J Urol 97:973–977

    PubMed  CAS  Google Scholar 

  • Miller CF, Blom J (1980) Adjuvant chemotherapy of renal cell carcinoma using a combination of bleomycin (BLM) and lomustine (CCNU). Proc Am Soc Clin Oncol 21:362, C-171

    Google Scholar 

  • Mittelman A, Albert DJ, Murphy GP (1973) Lomustine treatment of metastatic renal cell carcinoma. JAMA 225: 32–35

    Article  PubMed  CAS  Google Scholar 

  • Papac R, Luikhart S, Kirkwood J (1980) High-dose tamoxifen in patients with advanced renal cell cancer and malignant melanoma. Proc Am Soc Clin Oncol 21: 358, C-155

    Google Scholar 

  • Papac RJ, Ross AS, Levy A (1977) Renal cell carcinoma: analysis of 31 cases with assessment of endocrine therapy. Am J Med Sci 274: 281–289

    Article  PubMed  CAS  Google Scholar 

  • Prager MD, Peters PC, Baechtel FS, Brown G (1980) Specific immunotherapy of metastatic human renal cell carcinoma: preliminary results. Proc Am Assoc Cancer Res 21:213,856

    Google Scholar 

  • Price LA, Goldie JH, Hill BT (1975) Methodichlorophen as anti-tumour drug. Br Med J i: 20–21

    Article  Google Scholar 

  • Prout GR (1973) The kidney and ureter. In: Holland JF, Frei E (eds) Cancer medicine. Lea & Febiger, Philadelphia, pp 1655–1669

    Google Scholar 

  • Ramming KP, deKernion JB (1977) Immune RNA therapy for renal cell carcinoma: Survival and immunologic monitoring. Ann Surg 186:459–466

    Article  PubMed  CAS  Google Scholar 

  • Ramming KP, Gupta RK, deKernion JB (1977) Detection of antibodies to tumor associated antigens in patients with hypernephroma. Proc Amer Soc Clin Oncol 18:319, C-211

    Google Scholar 

  • Ramming KP, Gupta RK, deKernion JB (1979) Induction of antibody to human renal cell cancer in vivo by injections of xenogeneic immune RNA. Proc Am Assoc Cancer Res 20:215, 872

    Google Scholar 

  • Robson CJ, Churchill BM, Anderson W (1969) The results of radical nephrectomy for renal cell carcinoma. J Urol 101:297–301

    PubMed  CAS  Google Scholar 

  • Rodriguez LH, Johnson DE (1978) Clinical trial of cisplatinum (NSC 119875) in metastatic renal cell carcinoma. Urology 11:344–346

    Article  PubMed  CAS  Google Scholar 

  • Samuels ML, Sullivan P, Howe CD (1968) Medroxyprogesterone acetate in the treatment of renal cell carcinoma (hypernephroma). Cancer 22:525–532

    Article  PubMed  CAS  Google Scholar 

  • Spiers ASD, Allar M (1979) Beneficial effects of concurrent androgen treatment during cytotoxic chemotherapy. Proc Am Soc Clin Oncol 20:295, C-8

    Google Scholar 

  • Talley RW (1973) Chemotherapy of adenocarcinoma of the kidney. Cancer 32: 1062–1065

    Article  PubMed  CAS  Google Scholar 

  • Todd RF, Garnick MB, Canellos GP (1980) Chemotherapy of advanced renal adenocarcinoma with methyl-glyoxal-bis-guanylhydrazone (methyl-GAG). Proc Am Soc Clin Oncol 21:340, C-85

    Google Scholar 

  • Wagle DG, Murphy GP (1971) Hormonal therapy in advanced renal cell carcinoma. Cancer 28:318–321

    Article  PubMed  CAS  Google Scholar 

  • Wajsman Z, Beckley S, Madajewucz S, Dragone N (1980) High-dose cyclophosphamide (CPM) in metastatic renal cell cancer. Proc Am Soc Clin Oncol 21: 423, C-413

    Google Scholar 

  • Woodruff MW, Wagle D, Gailani SD, Jones R (1967) The current status of chemotherapy for advanced renal carcinoma. J Urol 97: 611–618

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. A. S. D. Spiers
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Oncology, The Albany Medical College, Albany, New York, 12208, USA

    A. S. D. Spiers MB, BS, MD(Melb.), PhD, FRCPE, FRACP, FACP (Professor of Medicine) (Professor of Medicine)

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Spiers, A.S.D. (1982). Cytotoxic Drugs and Hormonal Manipulations in the Management of Carcinoma of the Kidney. In: Spiers, A.S.D. (eds) Chemotherapy and Urological Malignancy. Clinical Practice in Urology. Springer, London. https://doi.org/10.1007/978-1-4471-1332-4_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-1332-4_2

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1334-8

  • Online ISBN: 978-1-4471-1332-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation