The Distinction Between Benign and Malignant Adrenocortical Tumours causing Cushing’s and/or the Adrenogenital Syndromes: Structural and Functional Criteria
One of the principal problems facing the diagnostic histopathologist is the differentiation of benign from malignant adrenocortical neoplasms. Such a prognostic problem is not unique to the adrenal but is common to all endocrine tumours. From the foregoing account, it is clear that many of the classical histological criteria of malignancy such as capsular and vascular invasion and prominent mitotic activity are not present, or are not prominent, in adrenocortical tumours causing hypercorticalism and which were subsequently shown to be carcinomas by their ability to metastasise. In this section we will describe and discuss some alternative approaches to assist reaching a more precise distinction of benign from malignant based on in vitro functional assessments of such lesions and their relationship to tumour structure.
KeywordsAdrenocortical Carcinoma Adrenocortical Tumour Steroid Profile Compact Cell Basement Membrane Material
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