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Huntington’s Chorea pp 105–121Cite as

Genetics

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Abstract

Huntington’s description of the hereditary characteristics of this disease in his famous essay of 1872 was remarkably accurate. He described that “when either or both parents have shown manifestations of the disease, one or more of the offspring invariably suffer from the disease. It never skips a generation to again manifest itself in another. Once having yielded its claims it never regains them.” Huntington’s description based on his own empiric observations occurred only 6 years after Mendel’s classic paper. The interpretation of the familial aggregation of Huntington’s chorea in Mendelian terms, however, had to wait 36 years until Jelliffe (1908) drew attention to the fact that the mode of inheritance of this disease “shows a very close approximation to the results of Mendelian crossing”.

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Authors and Affiliations

  1. Division of Clinical Genetics, Children’s Hospital Medical Center, 300 Longwood Avenue, 02115, Boston, MA., USA

    Michael R. Hayden MB, ChB, PhD, DCH(SA)

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  1. Michael R. Hayden MB, ChB, PhD, DCH(SA)
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© 1981 Springer-Verlag Berlin Heidelberg

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Hayden, M.R. (1981). Genetics. In: Huntington’s Chorea. Springer, London. https://doi.org/10.1007/978-1-4471-1308-9_7

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  • DOI: https://doi.org/10.1007/978-1-4471-1308-9_7

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1310-2

  • Online ISBN: 978-1-4471-1308-9

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