Advertisement

Natural History

  • Michael R. Hayden

Abstract

A review of a disorder is incomplete without a discussion of its natural history, which is essentially a study of the behaviour of the disease process in a population. The two most important measurable points in the natural history are the age at onset and age at death. The duration of the disease is equal to the latter figure minus the former.

Keywords

Monozygotic Twin Juvenile Patient Moray Firth Great Genetic Similarity Monozygotic Twin Sister 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bachman D, Butler I, McKhann G (1977) The long term treatment of juvenile Huntington’s chorea with dipropylacetic acid. Neurology (Minncap) 27: 193 - 197Google Scholar
  2. Bell J (1934) Huntington’s chorea. In: Fisher RA (ed) The treasury of human inheritance, vol IV/1. CambridgeGoogle Scholar
  3. University Press, London, pp 1-77 Bickford JAR, Elisson RM (1953) High incidence of Huntington’s chorea in the Duchy of Cornwall. J Ment Sci 99: 291 - 294Google Scholar
  4. Bird TD, Omenn GS (1975) Monozygotic twins with Huntington’s chorea in a family expressing the rigid variant. Neurology 25: 1126 - 1129PubMedGoogle Scholar
  5. Bolt JM (1970) Huntington’s chorea in the West of Scotland. Br J Psychiatry 116: 259 - 270PubMedCrossRefGoogle Scholar
  6. Brackenridge CJ (1971) The relation of type of initial symptoms and line of transmission to ages at onset and death in Huntington’s disease. Clin Genet 2: 287 - 297PubMedCrossRefGoogle Scholar
  7. Brackenridge CJ (1973) Interrelations between some clinical factors in Huntington’s chorea. In: Barbeau A, Chase TN, Paulson GW (eds) Huntington’s chorea, 1872-1972. Raven Press, New York, pp 65 - 73Google Scholar
  8. Brackenridge CJ (1974) Effect of climatic temperature on the age of onset of Huntington’s chorea. J Neurol Neurosurg Psychiatry 37: 297 - 301PubMedCrossRefGoogle Scholar
  9. Brothers RCD (1964) Huntington’s chorea in Victoria and Tasmania. J Neurol Sci 1: 405 - 420CrossRefGoogle Scholar
  10. Cameron D, Venters GA (1967) Some problems in Huntington’s chorea. Scott Med J 12: 152 - 156PubMedGoogle Scholar
  11. Caro A (1977) Huntington’s chorea: a genetic problem in East Anglia. PhD thesis, University of East Anglia Davenport CB, Muncey EB (1916) Huntington’s chorea in relation to heredity and eugenics. Am J Insan 73: 195 - 222Google Scholar
  12. Dewhurst K, Oliver JE, Mcknight AL (1970) Socio-psychiatric consequences of Huntington’s disease. Br J Psychiatry 116: 255 - 258PubMedCrossRefGoogle Scholar
  13. Entres JL (1921) Zur Klinik und Vererbung der Huntingtonschen Chorea. Monographien aus dem Gesamtgebiete der Neurologie und Psychiatrie, Heft 27. Springer, BerlinGoogle Scholar
  14. Entres JL (1940) Der Erbvietstanz Huntingtonsche Chorea: erbbiologischer Teil. In: Gutt A (ed).Handbuch der Erbkrankheiten, vol III. Thieme, Leipzig, pp 243 - 262Google Scholar
  15. Hayden MR (1979) Huntington’s chorea in South Africa. PhD thesis, University of Cape TownGoogle Scholar
  16. Heathfield KWG (1967) Huntington’s chorea: investigation into prevalence of this disease in the area covered by the North East Metropolitan Hospital Board. Brain 90: 203 - 232PubMedCrossRefGoogle Scholar
  17. Husquinet H (1969) La choree de Huntington dans quatre provinces beiges. In: Rapports 67e session, Congrès de Psychiatrie et Neurologie de Langue Française. Masson et Cie, ParisGoogle Scholar
  18. Husquinet H, Frank G, Vrankx C (1973) Detection of future cases of Huntington’s chorea by the L-dopa load test: Experiment with 2 monozygotic twins. In: Barbeau A, Chase TN, Paulson GW (eds) Huntington’s chorea, 1872-1972. Raven Press, New York, pp 301 - 310Google Scholar
  19. Jelgersma HC (1957) Monozygotic twins with concordant Huntington’s chorea and discordant hemiplegia. Folio. Psychiatr Neerl 60: 50 - 52Google Scholar
  20. Jequier M (1945) La chorée de Huntington. Arch Julius Klaus Stift 20: 77 - 208Google Scholar
  21. Korenyi C, Whittier JR, Conchado D (1972) Stress in Huntington’s disease. Dis Nerv Syst 33: 339 - 344PubMedGoogle Scholar
  22. Lyon RL (1962) Huntington’s chorea in the Moray Firth area. Br Med J i: 1301 - 1306Google Scholar
  23. Marx R (1971) Huntington’s disease in Minnesota. PhD thesis, University of Minnesota Mattsson B ( 1974 ) Clinical, genetic and pharmacological studies in Huntington’s chorea. UMEA UniversityGoogle Scholar
  24. Medical Dissertations 7. UMEA, Sweden, pp 21-51 Minski L, Guttmann E (1938) Huntington’s chorea: a study of 34 families. J Ment Sci 84: 21 - 96Google Scholar
  25. Myrianthopoulos N, Rowley P (1960) Monozygotic twins concordant for Huntington’s disease. Neurology 10: 506 - 511PubMedGoogle Scholar
  26. Oepen H (1973) Discordant features of monozygotic twin sisters with Huntington’s chorea. In: Barbeau A, Chase TN, Paulson GW (eds) Huntington’s chorea, 1872-1972. Raven Press, New York, pp 199 - 201Google Scholar
  27. Oliver JE (1970) Huntington’s chorea in Northamptonshire. Br J Psychiatry 166: 241 - 253CrossRefGoogle Scholar
  28. Orbeck AL, Quelprud T (1954) Setesdalsrykka (chorea progressiva hereditaria). Nor Videnskap Acad Sehr 1: 1 - 125Google Scholar
  29. Panse F (1942) Die Erbchorea: eine klinische-genetische Studie. Samml Psychiatr Neurol Einzeldarst 18. Thieme, LeipzigGoogle Scholar
  30. Parker N (1958) Observations on Huntington’s chorea based on a Queensland survey. Med J Aust. 1: 251 - 259Google Scholar
  31. Perrine GA, Goodman RM (1966) A family study of Huntington’s chorea with unusual manifestations. Ann Intern Med 64: 507 - 574Google Scholar
  32. Petit H (1969) Rapports 67e session, Congrès de Psychiatrie et Neurologie de Langue Française, Brussels. Masson, ParisGoogle Scholar
  33. Reed TE, Chandler JH, Hughes EM, Davidson RT (1958) Huntington’s chorea in Michigan: demography and genetics. Am J Hum Genet 10: 201 - 225PubMedGoogle Scholar
  34. RosanofF A, Handy L (1935) Huntington’s chorea in twins. Arch Neurol 33: 839 - 841Google Scholar
  35. Rosenthal C (1927) Zur Symptomatologie und früh-Diagnostik der Huntingtonsche Krankheit. Z Gesamte Neurol Psychiatr 3: 254 - 269CrossRefGoogle Scholar
  36. Russell JW (1894) Two cases of hereditary chorea ocurring in twins. Birmingham Med Rev 35: 31 - 33Google Scholar
  37. Schioltz-Christensen E (1969) Chorea Huntington and epilepsy in monozygotic twins. Eur Neurol 2: 250 - 255CrossRefGoogle Scholar
  38. Scoones T (1980) Huntington’s chorea. Office of Health Economics Publication 67. OHE, London, p7 Shokeir MH (1975) Investigations on Huntington’s disease in the Canadian prairies. II. Fecundity and fitness. Clin Genet 7: 349 - 353Google Scholar
  39. Sjogren T (1936) Vererbungsmedizinische Untersuchungen über Huntingtons Chorea in einer schwedische Bauernpopulation. Z Menschl Vererb-Konstit-Lehre 19: 131 - 165Google Scholar
  40. Spengler M (1956) Verschlimmerung von Chorea Huntington in der Gravidität. Schweiz Med Wochenschr 86: 931 - 932PubMedGoogle Scholar
  41. Spillane J, Phillips R (1937) Huntington’s chorea in South Wales. Q J Med 6: 403 - 423Google Scholar
  42. Stevens DL (1973) The heterozygote frequency for Huntington’s chorea. In: Barbeau A, Chase TN, Paulson GW (eds) Huntington’s chorea, 1872-1972. Raven Press, New York, pp 191 - 198Google Scholar
  43. Stevens DL (1976) Huntington’s chorea, a demographic, genetic and clinical study. MD thesis, University of London, pp 1 - 338Google Scholar
  44. Vogel F, Motulsky A (1979) In: Human genetics: problems and approaches. Springer, Berlin, Heidelberg, New York, pp 595 - 596Google Scholar
  45. Wallace DC (1972) Huntington’s chorea in Queensland: a not uncommon disease. Med J Aust 2: 1275 - 1277Google Scholar
  46. Wendt GG (1960) Praktische Erfahrungen bei der Sammlung aller Falle von Huntingtonscher Chorea. In: Die spontane und induzierte Mutationsrate bei Versuchstieren und beim Menschen, Strahlenschutz Vol 17. Gersbach, München, pp 1 - 36Google Scholar
  47. Wendt GG, Drohm D (1972) Fortschritte der allgemeinen und klinischen Humangenetik: vol IV, Die Huntingtonsche Chorea. Thieme, Stuttgart Wendt GG, Londzettel I, Unterreiner I (1959) Erkrankungsalter bei der Huntingtonscher Chorea. Acta Genet (Basel) 9: 18 - 32Google Scholar
  48. Zolliker A (1949) Die Chorea Huntington in der Schweiz. Schweiz Arch Neurol Psychiatr 64: 448 - 457Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • Michael R. Hayden
    • 1
  1. 1.Division of Clinical GeneticsChildren’s Hospital Medical CenterBostonUSA

Personalised recommendations