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The Histology of Borderline Cancer pp 325–370Cite as

Lesions of the Digestive Tract

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Abstract

The digestive tract has, in the years under review, produced many more biopsies than, for example, the skeletal system or lymph nodes, but many fewer borderline problems. With an adequately representative biopsy, and excluding for the moment unusual individual lesions, problems in the digestive tract form fairly well-defined groups, none essentially different from those met in other systems. They are: (a) the squamous epithelial overgrowths of the oral cavity; (b) dysplasia or carcinoma in situ in oesophagus, stomach and large intestine; (c) the fibrotic pancreas; (d) the adenomatous polyps of, predominantly, the large intestine. A problem of a different order impinges only partly on histo-pathology, that of sampling, and for understandable technical reasons it is relatively common in the gastrointestinal tract.

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References

  • Abrams AM, Melrose RJ, Howell FV (1973) Necrotizing sialometaplasia. A disease simulating malignancy. Cancer 32: 130–135

    Article  PubMed  CAS  Google Scholar 

  • Ackerman LV (1948) Verrucous carcinoma of the oral cavity. Surgery 23: 670–678

    PubMed  CAS  Google Scholar 

  • Allen MS (1966) Hamartomatous inverted polyps of the rectum. Cancer 19: 257–265

    Article  PubMed  Google Scholar 

  • Appelman HD, Helwig EB (1977) Sarcomas of the stomach. Am J Clin Pathol 67: 2–10

    PubMed  CAS  Google Scholar 

  • Artinian B, Lough JO, Palmer JD (1971) Idiopathic ulcer of small bowel with pseudolympho-matous reaction. A clinicopathological study of six cases. Arch Pathol 91: 327–333

    PubMed  CAS  Google Scholar 

  • Azzopardi JG, Evans DJ (1971) Malignant lymphoma of parotid associated with Mikulicz disease (benign lymphoepithelial lesion). J Clin Pathol 24: 744–752

    Article  PubMed  CAS  Google Scholar 

  • Battifora H (1976) Spindle-cell carcinoma. Ultra-structural evidence of squamous origin and collagen production by the tumor cells. Cancer 37: 2275–2282

    Article  PubMed  CAS  Google Scholar 

  • Berg JW (1958) Histological aspects of the relation between gastric adenomatous polyps and gastric cancer. Cancer 11: 1149–1155

    Article  PubMed  CAS  Google Scholar 

  • Bernier JL, Bhaskar SN (1958) Lymphoepithelial lesions of salivary glands. Histogenesis and classification based on 186 cases. Cancer 11: 1156–1179

    Article  PubMed  CAS  Google Scholar 

  • Black MM, Freeman C, Mork T, Harvei S, Cutler SJ (1971) Prognostic significance of microscopic structure of gastric carcinomas and their regional lymph nodes. Cancer 27: 703–711

    Article  PubMed  CAS  Google Scholar 

  • Bolwell JS, James PD (1979) Peutz-Jeghers syndrome with pseudoinvasion of hamartomatous polyps and multiple epithelial neoplasms. Histopathol 3: 39–50

    Article  CAS  Google Scholar 

  • Brander WL, Needham PRG, Morgan AD (1974) Indolent mucoid carcinoma of stomach. J Clin Pathol 27: 536–541

    Article  PubMed  CAS  Google Scholar 

  • Britton DC, Thomson JPS (1979) Rectal endometriosis. J R Coll Surg Edinb 24: 30–33

    PubMed  CAS  Google Scholar 

  • Cawson RA (1969) Leukoplakia and oral cancer. Proc R Soc Med 62: 610–615

    PubMed  CAS  Google Scholar 

  • Cohn I (1976) Cancer of the pancreas. Detection and diagnosis. Cancer 37: 582–588

    Article  PubMed  Google Scholar 

  • Cooke BED (1975) Median rhomboid glossitis: Candidiasis and not a developmental anomaly. Br J Dermatol 93: 399–405

    Article  PubMed  CAS  Google Scholar 

  • Cornes JS, Wallace MH, Morson BC (1961) Benign lymphomas of the rectum and anal canal: A study of 100 cases. J Pathol Bacteriol 82: 371–382

    Article  PubMed  CAS  Google Scholar 

  • Crocker DW (1969) Smooth muscle tumors of the stomach. Ann Surg 170: 239–243

    Article  PubMed  CAS  Google Scholar 

  • Editorial (1976) When is a gastric ulcer really a cancer? Lancet I: 233–234

    Google Scholar 

  • Einhorn J, Wersäll J (1967) Incidence of oral carcinoma in patients with leukoplakia of the oral mucosa. Cancer 20: 2189–2193

    Article  PubMed  CAS  Google Scholar 

  • Eneroth C-M, Blanck C, Jakobsson PA (1968) Carcinoma in pleomorphic adenoma of the parotid gland. Acta Otolaryngol (Stockh) 66: 477–492

    Article  CAS  Google Scholar 

  • Eneroth C-M, Hjertman L, Moberger G (1970) Muco-spidermoid carcinoma of the palate. Acta Otolaryngol (Stockh) 70: 408–418

    Article  CAS  Google Scholar 

  • Eneroth C-M, Hjertman L, Moberger G, Söderberg G (1972) Muco epidermoid carcinomas of the salivary glands. With special reference to the possible existence of a benign variety. Acta Otolaryngol (Stockh) 73: 68–74

    Article  CAS  Google Scholar 

  • Enrile FT, Jesus PO de, Bakst AA, Baluyot R (1973) Pseudosarcoma of the esophagus (polypoid carcinoma of esophagus with pseudosarco-matous features). Cancer 31: 1197–1202

    Article  PubMed  CAS  Google Scholar 

  • Eras P, Winawer SJ (1969) Benign lymphoid hyperplasia of the stomach simulating gastric malignancy. Am J Dig Dis 14: 510–515

    Article  PubMed  CAS  Google Scholar 

  • Ferrari BT, O’Halloran RL, Longmire WP, Lewin KJ (1979) Atypical papillary hyperplasia of the pancreatic duct mimicking obstructing pancreatic carcinoma. N Engl J Med 301: 531–532

    Article  PubMed  CAS  Google Scholar 

  • Fevre DI, Green PHR, Barratt PJ, Nagy GS (1976) Review of five cases of early gastric carcinoma. Gut 17: 41–47

    Article  PubMed  CAS  Google Scholar 

  • Fonts EA, Greenlaw RH, Rush BF, Rovin S (1969) Verrucous squamous cell carcinoma of the oral cavity. Cancer 23: 152–160

    Article  PubMed  CAS  Google Scholar 

  • Friedman M, Nervi C, Casale C, Starace G, Arcangeli G, Page G, Ziparo E (1973) Significance of growth rates, cell kinetics and histology in the irradiation and chemotherapy of squamous cell carcinoma of the mouth. Cancer 31: 10–16

    Article  PubMed  CAS  Google Scholar 

  • Fu KK, Leibel SA, Levine ML, Friedlander LM, Boles R, Phillips TL (1977) Carcinoma of the major and minor salivary glands. Analysis of treatment results and sites and causes of failures. Cancer 40: 2882–2890

    Article  PubMed  CAS  Google Scholar 

  • Genre CF, Roth LM, Reed RJ (1971) “Benign” rectal carcinoids: A report of two patients with metastases to regional lymph nodes. Am J Clin Pathol 56: 750–757

    PubMed  CAS  Google Scholar 

  • George P, Brown C, Gilchrist J (1975) Operative biopsy of the pancreas. Br J Surg 62: 280–283

    Article  PubMed  CAS  Google Scholar 

  • Gerughty RM, Scofield HH, Brown FM, Hennigar GR (1969) Malignant mixed tumors of salivary gland origin. Cancer 24: 471–486

    Article  PubMed  CAS  Google Scholar 

  • Glover GW, Park WW (1971) Pharyngeal leiomyosarcoma. J Laryngol Otol 85: 1031–1038

    Article  PubMed  CAS  Google Scholar 

  • Goethals PL, Harrison EG, Devine KD (1963) Verrucous squamous carcinoma of the oral cavity. Am J Surg 106: 845–851

    Article  PubMed  CAS  Google Scholar 

  • Gravanis MB, Giansanti JS (1970) Malignant histopathologic counterpart of the benign lymphoepithelial lesion. Cancer 26: 1332–1342

    Article  PubMed  CAS  Google Scholar 

  • Greene FL (1974) Epithelial misplacement in adenomatous polyps of the colon and rectum. Cancer 33:206–217

    Article  PubMed  CAS  Google Scholar 

  • Harly TG, Elesha W (1968) Eosinophilic granuloma of the stomach (a report of three cases). Am Surg 34: 296–299

    Google Scholar 

  • Hay-Roe V, Hill RL, Civin WH (1960) An un-classifiable tumor of the esophagus. A case report. J Thorac Cardiovasc Surg 40: 107–113

    PubMed  CAS  Google Scholar 

  • Henry K, Farrer-Brown G (1977) Primary lymphomas of the gastrointestinal tract. I. Plasma cell tumours. Histopathol 1: 53–76

    Article  CAS  Google Scholar 

  • Hinton JM (1966) Risk of malignant change in ulcerative colitis. Gut 7: 427–432

    Article  PubMed  CAS  Google Scholar 

  • Hughes JH, Cruickshank AH (1969) Pseudosarcoma of the oesophagus. Br J Surg 56: 72–76

    Article  PubMed  CAS  Google Scholar 

  • Isaacson P, Attwood PRA (1979) Failure to demonstrate specificity of the morphological and histochemical changes in mucosa adjacent to colonic carcinoma (transitional mucosa). J Clin Pathol 32: 214–218

    Article  PubMed  CAS  Google Scholar 

  • Isaacson R, Weiland LH, Mcllrath DC (1974) Biopsy of the pancreas. Arch Surg 109: 227–230

    PubMed  CAS  Google Scholar 

  • Kanee B (1969) Oral florid papillomatosis complicated by verrucous squamous carcinoma. Treatment with methotrexate. Arch Dermatol 99: 196–202

    Article  PubMed  CAS  Google Scholar 

  • Klein H, Baumgartl E (1970) Eosinophiles Granulom des Rektums. Munch Med Wochenschr 112: 1141–1144

    PubMed  CAS  Google Scholar 

  • Kobayashi S, Proila JC, Kirsner JB (1970) Reactive lymphoreticular hyperplasia of the stomach. Arch Intern Med 125: 1030–1035

    Article  PubMed  CAS  Google Scholar 

  • Kozuka S, Sassa R, Taki T, Masamoto K, Nagasawa S, Saga S, Hasegawa K, Takeuchi M. (1979) Relation of pancreatic duct hyperplasia to carcinoma. Cancer 43: 1418–1428

    Article  PubMed  CAS  Google Scholar 

  • Kramer IRH (1975) Computer-aided analysis in diagnostic histopathology. Postgrad Med J 51: 690–694

    Article  PubMed  CAS  Google Scholar 

  • Kraus FT, Perez-Mesa C (1966) Verrucous carcinoma: Clinical and pathologic study of 105 cases involving oral cavity, larynx and genitalia. Cancer 19: 26–38

    Article  PubMed  CAS  Google Scholar 

  • Krolls SO, Trodahl JN, Boyers RC (1972) Salivary gland lesions in children. A survey of 430 cases. Cancer 30: 459–469

    Article  PubMed  CAS  Google Scholar 

  • Lane N (1957) Pseudosarcoma (polypoid sarcomalike masses) associated with squamous-cell carcinoma of the mouth, fauces, and larynx: Report of ten cases. Cancer 10: 19–41

    Article  PubMed  CAS  Google Scholar 

  • Lichtiger B, MacKay B, Tessmer CF (1970) Spindle-cell variant of squamous carcinoma. A light and electron microscopic study of 13 cases. Cancer 26: 1311–1320

    Article  PubMed  CAS  Google Scholar 

  • Lim FE, Hartman AS, Tan EGC, Cady B, Meissner WA (1977) Factors in the prognosis of gastric lymphoma. Cancer 39: 1715–1720

    Article  PubMed  CAS  Google Scholar 

  • McDivitt RW (1974) “Early” large bowel cancer. A morphologist’s dilemma. Cancer 34: 904–908

    Article  PubMed  Google Scholar 

  • Martin HE, Howe ME (1938) Glossitis rhombica mediana. Ann Surg 107: 39–49

    Article  PubMed  CAS  Google Scholar 

  • Minielly JA, Harrison EG, Fontana RS, Payne WS (1967) Verrucous squamous cell carcinoma of the esophagus. Cancer 20: 2078–2087

    Article  PubMed  CAS  Google Scholar 

  • Morgan WS, Castleman B (1953) A clinicopatho-logic study of ‘Mikulicz’s disease’. Am J Pathol 29: 471–503

    PubMed  CAS  Google Scholar 

  • Morson BC (1966) Cancer in ulcerative colitis. Gut 7: 425–426

    Article  PubMed  CAS  Google Scholar 

  • Morson BC, Pang LSC (1967) Rectal biopsy as an aid to cancer control in ulcerative colitis. Gut 8: 423–434

    Article  PubMed  CAS  Google Scholar 

  • Muto T, Bussey HJR, Morson BC (1973) Pseudocarcinomatous invasion in adenomatous polyps of the colon and rectum. J Clin Pathol 26: 25–31

    Article  PubMed  CAS  Google Scholar 

  • Muto T, Bussey HJR, Morson BC (1975) The evolution of cancer of the colon and rectum. Cancer 36: 2251–2270

    Article  PubMed  CAS  Google Scholar 

  • Orloff MJ (1971) Carcinoid tumors of the rectum. Cancer 28: 175–180

    Article  PubMed  CAS  Google Scholar 

  • Park WW (1979) Letter to Editor. J Laryngol Otol 93: 103

    Article  Google Scholar 

  • Quan SHQ, Castro EB (1971) Papillary adenomas (villous tumors): A review of 215 cases. Dis Colon Rectum 14: 267–280

    Article  PubMed  CAS  Google Scholar 

  • Rafla S (1977) Malignant parotid tumors: Natural history and treatment. Cancer 40: 136–144

    Article  PubMed  CAS  Google Scholar 

  • Ranchod M, Kempson RL (1977) Smooth muscle tumors of the gastrointestinal tract and retroperi-toneum. A pathologic analysis of 100 cases. Cancer 39: 255–262

    Article  PubMed  CAS  Google Scholar 

  • Ransom HK (1953) Cancer of the stomach. Surg Gynecol Obstet 96: 275–287

    PubMed  CAS  Google Scholar 

  • Razzuk MA, Urschel HC, Race GJ, Nathan MJ, Paulson DL (1971) Pseudosarcoma of the esophagus. A case report. J Thorac Cardiovasc Surg 61: 650–653

    PubMed  CAS  Google Scholar 

  • Saltzstein SL (1969) Extranodal malignant lymphomas and pseudolymphomas. Pathol Annu 4: 159–184

    Google Scholar 

  • Sano R and others (1972) Review of five cases of early gastric carcinoma. Gut 17: 41–47

    Google Scholar 

  • Schultz NJ, Sanders RJ (1963) Evaluation of pancreatic biopsy. Ann Surg 158: 1053–1057

    Article  PubMed  CAS  Google Scholar 

  • Segal AW, Healy MJR, Cox AG, Williams I, Slavin G, Smithies A, Levi AJ (1975) Diagnosis of gastric cancer. Br Med J 2: 669–672

    Article  PubMed  CAS  Google Scholar 

  • Serlin O, Keehn RJ, Higgins GA, Harrower HW, Mendeloff GL (1977) Factors related to survival following resection for gastric carcinoma. Analysis of 903 cases. Cancer 40: 1318–1329

    Article  PubMed  CAS  Google Scholar 

  • Sharma MP, Gregg JA, Loewenstein MS, McCabe RP, Zamcheck N (1976) Carcinoembryonic antigen (CEA) activity in pancreatic juice of patients with pancreatic carcinoma and pancreatitis. Cancer 38: 2457–2461

    Article  PubMed  CAS  Google Scholar 

  • Sherwin RP, Strong MS, Vaughan CW (1963) Polypoid and junctional squamous cell carcinoma of the tongue and larynx with spindle cell carcinoma (“pseudosarcoma”). Cancer 16: 51–60

    Article  PubMed  CAS  Google Scholar 

  • Shields TW, Eilert JB, Battifora H (1972) Pseudosarcoma of the oesophagus. Thorax 27: 472–479

    Article  PubMed  CAS  Google Scholar 

  • Silverberg SG (1970) “Juvenile” retention polyps of the colon and rectum. Am J Dig Dis 15: 617–625

    Article  PubMed  CAS  Google Scholar 

  • Soga J, Tazawa K (1971) Pathologic analysis of carcinoids. Histologic re-evaluation of 62 cases. Cancer 28: 990–998

    Article  PubMed  CAS  Google Scholar 

  • Soga J, Saito K, Suzuki N, Sakai T (1970) Plasma cell granuloma of the stomach. A report of a case and review of the literature. Cancer 25: 618–625

    Article  PubMed  CAS  Google Scholar 

  • Soga J, Tazawa K, Aizawa O, Wada K, Tuto T (1971) Argentaffin cell adenocarcinoma of the stomach: An atypical carcinoid? Cancer 28: 999–1003

    Article  PubMed  CAS  Google Scholar 

  • Spiro RH, Huvos AG, Strong EW (1975) Cancer of the parotid gland. A clinicopathologic study of 288 primary cases. Am J Surg 130: 452–459

    Article  PubMed  CAS  Google Scholar 

  • Stout AP, Lattes R (1957) Tumors of the Esophagus. Atlas of tumor pathology, sect 5, fasc 20. Armed Forces Institute of Pathology, Washington, D.C.

    Google Scholar 

  • Tomasulo J (1971) Gastric polyps. Histologic types and their relationship to gastric carcinoma. Cancer 27: 1346–1355

    Article  PubMed  CAS  Google Scholar 

  • Waterfall WE, Somers S, Desa DJ (1978) Benign oesophageal papillomatosis. A case report with a review of the literature. J Clin Pathol 31: 111–115

    Article  PubMed  CAS  Google Scholar 

  • Warkel RL, Cooper PH, Helwig EB (1978) Ade-nocarcinoid, a mucin-producing carcinoid tumor of the appendix. A study of 39 cases. Cancer 42: 2781–2793

    Article  PubMed  CAS  Google Scholar 

  • Warner TFCS (1979) Iodine-131 and malignancy. Lancet I: 38

    Article  Google Scholar 

  • Woyke S, Domagala W, Olszewski W, Korabeic M (1974) Pseudosarcoma of the skin. An electron microscopic study and comparison with the fine structure of the spindle-cell variant of squamous carcinoma. Cancer 33: 970–980

    Article  PubMed  CAS  Google Scholar 

  • Zakariai YM, Quan SHQ, Hajdu SI (1975) Carcinoid tumors of the gastrointestinal tract. Cancer 35: 588–591

    Article  PubMed  CAS  Google Scholar 

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  1. University Department of Pathology, Ninewells Hospital, Dundee, Scotland, UK

    W. Wallace Park MD (Edin.), FRCPath.

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  1. W. Wallace Park MD (Edin.), FRCPath.
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© 1980 Springer-Verlag Berlin · Heidelberg

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Park, W.W. (1980). Lesions of the Digestive Tract. In: The Histology of Borderline Cancer. Springer, London. https://doi.org/10.1007/978-1-4471-1295-2_8

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  • DOI: https://doi.org/10.1007/978-1-4471-1295-2_8

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