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Lesions of the Thyroid Gland

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The Histology of Borderline Cancer

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Abstract

The thyroid is unusual in having more, and histologically more sharply divisible, forms of cancer than most other monoepithelial organs or tissues such as, for example, breast or prostate. Classification into papillary, follicular, medullary and anaplastic types is now generally accepted, and many large series of cases thus subdivided have been published with analyses of clinical features, treatment and outcome. Two such, each particularly illustrative with their survival tables for the various forms of carcinoma, are those of Hainan (1966) and Woolner and his colleagues (1968). However, neither here nor in most other series is much consideration given to diagnostic borderline difficulties, whether the tissue in question is carcinomatous or not, and, if it is cancerous, of which type; for the subdivision is not always as easy to make as most texts would have us suppose.

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References

  • Ayala A, Sloane J, Wolma FJ (1968) Coexistent lymphoma, adenocarcinoma and struma lympho-matosa. JAMA 204: 829–831

    Article  PubMed  CAS  Google Scholar 

  • Block MA, Horn RC, Miller JM (1970) Hazards in the diagnosis and management of certain thyroid nodules in children. Am J Surg 120: 447–451

    Article  PubMed  CAS  Google Scholar 

  • Branson KM, Houston W (1949) Malignant disease of the thyroid gland. Lancet 2: 979–982

    Article  PubMed  CAS  Google Scholar 

  • Burke JS, Butler JJ, Fuller LM (1977) Malignant lymphomas of the thyroid. A clinical pathologic study of 35 patients including ultrastructural observations. Cancer 39: 1587–1602

    Article  PubMed  CAS  Google Scholar 

  • Butler JJ, Tulinius H, Ibanez ML, Ballantyne AJ, Clark RL (1967) Significance of thyroid tissue in lymph nodes associated with carcinoma of the head, neck or lung. Cancer 20: 103–112

    Article  PubMed  CAS  Google Scholar 

  • Byar DP, Green SB, Dor P, Williams ED, Colon J, van Gilse HA, Mayer M, Sylvester RJ, van Glabbeke M (1979) A prognostic index for thyroid carcinoma. A study of the E.O.R.T.C. thyroid cancer cooperative group. Europ J Cancer 15: 1033–1041

    CAS  Google Scholar 

  • Chong GC, Beahrs OH, Sizemore GW, Woolner LH (1975) Medullary carcinoma of the thyroid gland. Cancer 35: 695–704

    Article  PubMed  CAS  Google Scholar 

  • Cline RE, Shingleton WW (1968) Long-term results in the treatment of carcinoma of the thyroid. Am J Surg 115: 545–551

    Article  PubMed  CAS  Google Scholar 

  • Cureton RJR, Harland DHC, Hosford J, Pike C (1956) Reticulosarcoma in Hashimoto’s disease. Br J Surg 44: 561–566

    Article  Google Scholar 

  • Editorial (1971) The solitary thyroid nodule. Br Med J 2: 720–721

    Google Scholar 

  • Editorial (1973) The solitary thyroid nodule. Br Med J 4: 310–311

    Article  Google Scholar 

  • Editorial (1976) Thyroid cancer. Br Med J 1: 113–114

    Google Scholar 

  • Exelby PE, Frazell EL (1969) Carcinoma of the thyroid in children. Surg Clin North Am 49: 249–259

    PubMed  CAS  Google Scholar 

  • Glass HG, Waldron GW, Brown WG (1956) Coexistent sarcoma, adenocarcinoma, and Hashimoto’s disease in a thyroid gland. Cancer 9: 310–316

    Article  PubMed  CAS  Google Scholar 

  • Gordon PR, Huvos AG, Strong EW (1973) Medullary carcinoma of the thyroid gland: A clinico-pathologic study of 40 cases. Cancer 31: 915–924

    Article  PubMed  CAS  Google Scholar 

  • Greene R (1969) Treatment of thyroid cancer. Br Med J 4: 787–789

    Article  PubMed  CAS  Google Scholar 

  • Hainan KE (1966) Influence of age and sex on incidence and prognosis of thyroid cancer. Three hundred forty-four cases followed for ten years. Cancer 19: 1534–1536

    Article  Google Scholar 

  • Hazard JB, Hawk WA, Crile G (1959) Medullary (solid) carcinoma of the thyroid—a clinicopathologic entity. J Clin Endocrinol Metab 19: 152–161

    Article  PubMed  CAS  Google Scholar 

  • Heimann R, Vannineuse A, Sloover C de, Dor P (1978) Malignant lymphomas and undifferentiated small cell carcinoma of the thyroid: A clinicopathological review in the light of the Kiel classification for malignant lymphomas. Histo-pathol 2: 201–213

    CAS  Google Scholar 

  • Heitz P, Moser H, Staub JJ (1976) A study of 573 thyroid tumors and 161 autopsy cases observed over a thirty-year period. Cancer 37: 2329–2337

    Article  PubMed  CAS  Google Scholar 

  • Hill CS, Ibanez ML, Samaan NA, Ahearn MJ, Clark RL (1973) Medullary (solid) carcinoma of the thyroid gland: An analysis of the M. D. Anderson Hospital experience with patients and this tumor, its special features, and its histogenesis. Medicine (Baltimore) 52: 141–171

    Google Scholar 

  • Hirabayashi RN, Lindsay S (1965) The relation of thyroid carcinoma and chronic thyroiditis. Surg Gynecol Obstet 121: 243–252

    PubMed  CAS  Google Scholar 

  • Ibanez ML, Russell WO, Albores-Saavedra J, Lampertico P, White EC, Clark RL (1966) Thyroid carcinoma—biologic behavior and mortality. Postmortem findings in 42 cases, including 27 in which the disease was fatal. Cancer 19: 1039–1052

    Article  PubMed  CAS  Google Scholar 

  • Iida F, Yonekura M, Miyakawa M (1969) Study of intraglandular dissemination of thyroid cancer. Cancer 24: 764–771

    Article  PubMed  CAS  Google Scholar 

  • Kendall LW, Condon RE (1969) Prediction of malignancy in solitary thyroid nodules. Lancet 1: 1071–1073

    Article  PubMed  CAS  Google Scholar 

  • Klinck GH, Winship T (1959) Psammoma bodies and thyroid cancer. Cancer 12: 656–662

    Article  PubMed  CAS  Google Scholar 

  • Lennert K, Mohri N, Stein H, Kaiserling E (1975) The histopathology of malignant lymphoma. Br J Haematol 31: suppl 193–203

    Article  Google Scholar 

  • Lennert K, Stein H, Kaiserling E (1975a) Cytological and functional criteria for the classification of malignant lymphomata. Br J Cancer 31: suppl II 29–43

    Google Scholar 

  • Lindsay S, Dailey ME (1955) Malignant lymphoma of the thyroid gland and its relation to Hashimoto disease: A clinical and pathologic study of 8 patients. J Clin Endocrinol Metab 15: 1332–1353

    Article  PubMed  CAS  Google Scholar 

  • Lukes RJ, Collins RD (1975) New approaches to the classification of the lymphomata. Br J Cancer 31: suppl II 1–28

    Google Scholar 

  • Meissner WA, Warren S (1969) Tumors of the thyroid gland. Atlas of tumor pathology, 2nd ser, fasc 4. Armed Forces Institute of Pathology, Washington, D.C.

    Google Scholar 

  • Melvin KEW, Tashjian AH, Miller HH (1972) Studies in familial (medullary) thyroid carcinoma. Recent Prog Horm Res 28: 399–460

    PubMed  CAS  Google Scholar 

  • Meyer JS, Steinberg LS (1969) Microscopically benign thyroid follicles in cervical lymph nodes. Serial section study of lymph node inclusions and entire thyroid gland in 5 cases. Cancer 24: 302–311

    Article  PubMed  CAS  Google Scholar 

  • Nishiyama RH, Dunn EL, Thompson NW (1972) Anaplastic spindle-cell and giant-cell tumors of the thyroid gland. Cancer 30: 113–127

    Article  PubMed  CAS  Google Scholar 

  • Noguchi S, Noguchi A, Murakami N (1970) Papillary carcinoma of the thyroid. I. Developing pattern of metastasis. Cancer 26: 1053–1060

    Article  PubMed  CAS  Google Scholar 

  • Noguchi S, Noguchi A, Murakami N (1970a) Papillary carcinoma of the thyroid. II. Value of prophylactic lymph node excision. Cancer 26: 1061–1064

    Article  PubMed  CAS  Google Scholar 

  • Normann T, Johannessen JV, Gautvik KM, Olsen BR, Brennhovd JO (1976) Medullary carcinoma of the thyroid: Diagnostic problems. Cancer 38: 366–377

    Article  PubMed  CAS  Google Scholar 

  • Otani S (1972) Papillary adenomatous tumors of aberrant thyroid in cervical lymph nodes. Mt Sinai J Med NY 39: 70–75

    CAS  Google Scholar 

  • Park WW, Lees JC (1955) The histology of cancer of the thyroid. Cancer 8: 320–335

    Article  PubMed  CAS  Google Scholar 

  • Rappaport H (1966) Atlas of tumor pathology, sect III, fasc 8. Tumors of the hematopoietic system. Armed Forces Institute of Pathology, Washington, D.C.

    Google Scholar 

  • Rose RG, Kelsey MP, Russell WO, Ibanez ML, White EC, Clark RL (1963) Follow-up study of thyroid cancer treated by unilateral lobectomy. Am J Surg 106: 494–500

    Article  PubMed  CAS  Google Scholar 

  • Russell WO, Ibanez ML, Clark RL, White EC (1963) Thyroid carcinoma. Classification, intraglandular dissemination, and clinicopathological study based upon whole organ sections of 80 glands. Cancer 16: 1425–1460

    Article  PubMed  CAS  Google Scholar 

  • Russell MA, Gilbert EF, Jaeschke WF (1975) Prognostic features of thyroid cancer. A long-term followup of 68 cases. Cancer 36: 553–559

    Article  PubMed  CAS  Google Scholar 

  • Sampson RJ, Oka H, Key CR, Buncher CR, Iijima S (1970a) Metastases from occult thyroid carcinoma. An autopsy study from Hiroshima and Nagasaki, Japan. Cancer 25: 803–811

    Article  PubMed  CAS  Google Scholar 

  • Saxén E, Franssila K, Bjarnason O, Norman T, Ringertz N (1978) Observer variation in histologic classification of thyroid cancer. Acta Pathol Microbiol Scand [A] 86: 483–486

    Google Scholar 

  • Saxén EA, Franssila K, Hakama M (1969) Effect of histological typing of Registry material on the results of epidemiological comparisons in thyroid cancer. In: Hedinger E (ed) Thyroid cancer, UICC Monograph ser, vol 12. Springer, Berlin Heidelberg New York, pp 58–103

    Google Scholar 

  • Silliphant WM, Klinck GH, Levitin MS (1964) Thyroid carcinoma and death. A clinicopatho-logical study of 193 autopsies. Cancer 17: 513–525

    Article  PubMed  CAS  Google Scholar 

  • Silverberg SG, Vidone RA (1966) Adenoma and carcinoma of the thyroid. Cancer 19: 1053–1062

    Article  PubMed  CAS  Google Scholar 

  • Silverberg SG, Hutter RVP, Foote FW (1970) Fatal carcinoma of the thyroid: Histology, metastases, and causes of death. Cancer 25: 792–802

    Article  PubMed  CAS  Google Scholar 

  • Stoffel E (1910) Lokales amyloid der Schilddrüse. Virchows Arch [Pathol Anat] 201: 245–251

    Article  Google Scholar 

  • Tawes RL, Delorimier AA (1968) Thyroid carcinoma during youth. J Pediatr Surg 3: 210–218

    Article  PubMed  CAS  Google Scholar 

  • Taylor S (1969) Carcinoma of the thyroid gland. J R Coll Surg Edinb 14: 183–192

    PubMed  CAS  Google Scholar 

  • Taylor S (1969a) The solitary thyroid nodule. J R Coll Surg Edinb 14: 267–271

    PubMed  CAS  Google Scholar 

  • Tollefsen HR, De Cosse JJ, Hutter RVP (1964) Papillary carcinoma of the thyroid. A clinical and pathological study of 70 fatal cases. Cancer 17: 1035–1044

    Article  PubMed  CAS  Google Scholar 

  • Wade JSH (1975) The aetiology and diagnosis of malignant tumours of the thyroid gland. Br J Surg 62: 760–764

    Article  PubMed  CAS  Google Scholar 

  • Ward R (1944) Malignant goiter. Surgery 16: 783–803

    Google Scholar 

  • Winship T (1967) Management of patients with cancer of the thyroid. Cancer 20: 1815–1818

    Article  PubMed  CAS  Google Scholar 

  • Woolner LB, McConahey WM, Beahrs OH, Black BM (1966) Primary malignant lymphoma of the thyroid. Review of forty-six cases. Am J Surg 111: 502–523

    Article  PubMed  CAS  Google Scholar 

  • Woolner LB, Beahrs OH, Black BM, McConahey WM, Keating FR (1968) Thyroid carcinoma: General considerations and follow-up data on 1181 cases. In: Young S, Inman DR (eds) Symposium of thyroid neoplasia. Academic Press, London, pp 51–77

    Google Scholar 

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Authors and Affiliations

  1. University Department of Pathology, Ninewells Hospital, Dundee, Scotland, UK

    W. Wallace Park MD (Edin.), FRCPath.

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  1. W. Wallace Park MD (Edin.), FRCPath.
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© 1980 Springer-Verlag Berlin · Heidelberg

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Park, W.W. (1980). Lesions of the Thyroid Gland. In: The Histology of Borderline Cancer. Springer, London. https://doi.org/10.1007/978-1-4471-1295-2_3

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  • DOI: https://doi.org/10.1007/978-1-4471-1295-2_3

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1297-6

  • Online ISBN: 978-1-4471-1295-2

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