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Trophoblast-Specific β1 Glycoprotein as an Indicator of Pregnancy and Neoplasia — A Review of Recent Clinical Studies

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Placental Proteins

Abstract

The measurements of placental proteins and embryo-specific antigens as tests of placental function, as means of detecting pregnancy or as tumour markers are presently under intensive investigation. Thus α-fetoprotein serves as a specific marker for chemically induced mouse hepatomas (ABELEV et al., 1963) and for human hepatocellular carcinoma (TATARINOV, 1963). Carcinoembryonic antigen is used as an indicator of colonic adenocarcinoma (GOLD and FREEDMANN, 1965). These proteins are present in normal adult serum at levels from 2-40 ng/ml (EGAN et al., 1972; MCINTIRE et al., 1975; RUOSLAHTI and SEPPÄLÄ, 1971). On the other hand placental proteins cannot usually be detected in the sera of normal non-pregnant adults even by sensitive radioimmunoassay techniques. Thus placental proteins are specific indicators of the presence of either pregnancy or cancer.

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Authors
  1. Y. S. Tatarinov
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Editors and Affiliations

  1. Department of Obstetrics and Gynaecology, University of Aberdeen, Royal Infirmary, Foresterhill, Aberdeen, AB9 2ZD, UK

    Arnold Klopper (Professor of Reproductive Endocrinology) (Professor of Reproductive Endocrinology)

  2. Joint Academic Unit of Obstetrics, Gynaecology, and Reproductive Physiology, The Medical College of St. Bartholomew’s Hospital, West Smithfield, London, EC1A 7BE, UK

    Timothy Chard (Professor of Reproductive Physiology) (Professor of Reproductive Physiology)

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Tatarinov, Y.S. (1979). Trophoblast-Specific β1 Glycoprotein as an Indicator of Pregnancy and Neoplasia — A Review of Recent Clinical Studies. In: Klopper, A., Chard, T. (eds) Placental Proteins. Springer, London. https://doi.org/10.1007/978-1-4471-1290-7_11

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  • DOI: https://doi.org/10.1007/978-1-4471-1290-7_11

  • Publisher Name: Springer, London

  • Print ISBN: 978-3-540-09406-7

  • Online ISBN: 978-1-4471-1290-7

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