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“Quality of Life” Assessment in Multiple Sclerosis Clinical Trials: Current Status and Strategies for Improving Multiple Sclerosis Clinical Trial Design

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Multiple Sclerosis

Abstract

Sometime in the future, a multiple sclerosis (MS) patient comes to see the neurologist. Neurologist: “Well, your MRI looks great!” Patient: “That’s wonderful doc, because my life is falling apart, I feel lousy and that medication you gave me made me sicker than my MS did”. This situation is mirrored in clinical trials in which statistical imperatives dictate that outcomes be narrowly defined, often in terms of a single primary outcome measure. Although this strategy may help to avoid the type of error that occurs when so many outcomes are examined, it is problematic because a broad spectrum of other clinically relevant outcomes may be discounted.

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Authors
  1. Nicholas G. LaRocca
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  2. Paul G. Ritvo
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  3. Deborah M. Miller
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  4. Jill S. Fischer
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  5. Howard Andrews
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  6. Donald W. Paty
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Editor information

Editors and Affiliations

  1. The UCSF/Mount Zion Multiple Sclerosis Center, University of California at San Francisco, 1600 Divisadero Street, 94115, San Francisco, CA, USA

    Donald E. Goodkin MD

  2. Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195-5244, Cleveland, OH, USA

    Richard A. Rudick MD

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© 1996 Springer-Verlag London Limited

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LaRocca, N.G., Ritvo, P.G., Miller, D.M., Fischer, J.S., Andrews, H., Paty, D.W. (1996). “Quality of Life” Assessment in Multiple Sclerosis Clinical Trials: Current Status and Strategies for Improving Multiple Sclerosis Clinical Trial Design. In: Goodkin, D.E., Rudick, R.A. (eds) Multiple Sclerosis. Springer, London. https://doi.org/10.1007/978-1-4471-1271-6_7

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  • DOI: https://doi.org/10.1007/978-1-4471-1271-6_7

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-033-0

  • Online ISBN: 978-1-4471-1271-6

  • eBook Packages: Springer Book Archive

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