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Normal and Abnormal Testicular Development and Descent (Testicular Maldescent, Malignancy, Cancer Therapy and Fertility)

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Abstract

Testicular maldescent is a risk factor for testicular cancer and for infertility and is more prevalent in men presenting with fertility problems. Cancer therapy may result in infertility. Sometimes testicular malignancy is first detected because cancerous cells are identified in the seminology laboratory (Howard et al. 1989).

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References

  • Backhouse KM (1966) The natural history of testicular descent and maldescent. Proc R Soc Med 59:357–360

    PubMed  CAS  Google Scholar 

  • Bartone FF, Huseman CA, Maizels M, Firlit CF (1984) Pitfalls in using human chorionic gonadotrophin Stimulation test to diagnose anorchia. J Urol 132:563–567

    PubMed  CAS  Google Scholar 

  • Batata MA, Whitmore WF, Cun FC, Hilaris BS, Loh J, Grabstald H, Golbey R. (1980) Cryptorchidism and testicular cancer. J Urol 124:382–387

    PubMed  CAS  Google Scholar 

  • Berthelsen JG (1984) Sperm counts and serum follicle-stimulating hormone levels before and after radiotherapy and chemotherapy in men with testicular germ cell cancer. Fertil Steril 41:281–286

    PubMed  CAS  Google Scholar 

  • Bramswig JH, Schellong G, Nieschlag E (1983) Pituitary-gonadal function following therapy of testicular relapse in boys with acute lymphoblastic leukaemia. Klin Padiat 195:176–180

    Article  CAS  Google Scholar 

  • Brown LM, Pottern LM, Hoover RN (1987) Testicular cancer in young men: search for cause of epidemic increase. J Epidemiol Community Health 41:349–354

    Article  PubMed  CAS  Google Scholar 

  • Byrne J, Mulvihill JJ, Myers MH et al. (1987) Effect of treatment on fertility in long-term survivors of childhood or adolescent cancer. N Engl J Med 317:1315–1321

    Article  PubMed  CAS  Google Scholar 

  • Calamara JC, Morgenfeld MC, Mancini RE, Vilar O (1978) Biochemical changes of the human semen produced by chlorambucil, testosterone propionate and human chorionic gonadotrophin administration. Andrologia 11:43–50

    Article  Google Scholar 

  • Campbell HE (1959) The incidence of malignant growth of the undescended testis. A reply and re-evaluation. J Urol 81:663–668

    PubMed  CAS  Google Scholar 

  • Chapman RM (1982) Effect of cytotoxic therapy on sexuality and gonadal function. Semin Oncol 9:84–94

    PubMed  CAS  Google Scholar 

  • Chilvers C, Pike MC, Foreman D, Fogelman K, Wadsworth MEJ (1984) Apparent doubling of frequency of undescended testes in England and Wales in 1962–81. Lancet ii:330–332

    Article  Google Scholar 

  • Conway AJ, Boylan LM, Howe C, Ross G, Haridelsman DJ (1988) Randomized clinical trial of testosterone replacement therapy in hypogonadal men. Int J Androl 11:247–267

    Article  PubMed  CAS  Google Scholar 

  • Cour-Palais IJ (1966) Spontaneous descent of the testicle. Lancet i:1403–1405

    Article  Google Scholar 

  • Drasga RE, Einhorn LH, Williams SD, Patel DN, Stevens EU (1983) Fertility after chemotherapy for testicular cancer. J Clin Oncol 1:179–212

    PubMed  CAS  Google Scholar 

  • Etteldorf JN, West CD, Pitcock JA, Williams DL (1976) Gonadal function, testicular histology cyclophosphamide therapy in patients with nephrotic syndrome. J Paediat 88:206–212

    Article  CAS  Google Scholar 

  • Everson DP, Arlin Z, Welt S, Claps ML, Melamed MR (1984) Male reproductive capacity may recover following treatment with the L-10 protocol for acute lymphocytic leukaemia. Cancer 53:30–36

    Article  Google Scholar 

  • Fallon B, Kennedy TJ (1985) Long-term follow-up of fertility in cryptorchid patients. Urology 25:502

    Article  PubMed  CAS  Google Scholar 

  • Fossa SD, Almaas B, Jetre V, Bjerkedal T (1986) Paternity after irradiation for testicular cancer. Acta Radiol Oncol 25:33–36

    Article  PubMed  CAS  Google Scholar 

  • Fossa SD, Klepp O, Norman N (1988) Lack of gonadal potential by medroxyprogesterone acetate-induced transient medical castration during chemotherapy for testicular cancer. Br J Oncol 62: 449–453

    CAS  Google Scholar 

  • Gilhooly PE, Meyers F, Lattimer JK (1984) Fertility prospects for children with cryptorchidism. Am J Dis Child 138:940–943

    PubMed  CAS  Google Scholar 

  • Gill WB, Schumacher GFB, Bibbo M (1976) Structural and functional abnormalities in the sex organs of male offspring of mothers treated with diethylstilboestrol (DES). J Reprod Med 16:147

    PubMed  CAS  Google Scholar 

  • Glode LM, Robinson J, Gould SF (1981) Protection from cyclophosphamide-induced testicular damage with an analogue of gonadotropin-releasing hormone. Lancet ii:1132–1134

    Article  Google Scholar 

  • Gould SF, Pavell D, Nett T, Glode LM (1983) A rat model for chemotherapy-produced male infertility. Arch Androl 11:141–150

    Article  PubMed  CAS  Google Scholar 

  • Griffiths J (1893) Structural changes in the testicle of the dog when it is placed within the abdominal cavity. J Anat Physiol 26:482

    Google Scholar 

  • Hahn EW, Feingold SM, Simpson L, Batata M (1982) Recovery from azoospermia induced by low dose radiation in seminoma patients. Cancer 50:337–340

    Article  PubMed  CAS  Google Scholar 

  • Handelsman DJ, Conway AJ, Donnelly PE, Turtle JR (1980) Azoospermia after iodine-131 treatment for thyroid carcinoma. Br Med J 281:1527

    Article  PubMed  CAS  Google Scholar 

  • Hargreave TB (1986) Carcinoma-in-situ of the tests. Leading article. Br Med J 293:1389–1390

    Article  CAS  Google Scholar 

  • Hargreave TB (1988) Laparoscopy for the urologist. In: Hargreave TB Practical urological endoscopy. Blackwell Scientific Publications, Oxford, pp 206–211

    Google Scholar 

  • Hargreave TB, Elton RA, Webb JA, Busuttil A, Chisholm GD (1984) Maldescended testes and fertility: a review of 68 cases. Br J Urol 56:734–739

    Article  PubMed  CAS  Google Scholar 

  • Henderson BE, Benton B, Jeng J, Ya MC, Pike MC (1979) Risk factors for cancer of testis in young men. Int J Cancer 23:598–602

    Article  PubMed  CAS  Google Scholar 

  • Hohl RJ, Schilsky RL (1989) Non-malignant complications of therapy for Hodgkin’s Disease. Haematol Oncol Clin North Am 3:331–343

    CAS  Google Scholar 

  • Holmes GE, Holmes FF (1978) Pregnancy outcome of patients treated for Hodgkin’s disease. Cancer 41:1317–1322

    Article  PubMed  CAS  Google Scholar 

  • Howard GCW, Hargreave TB, McIntyre MA (1989) Case report: carcinoma-in-situ of the testis diagnosed in semen cytology. Clin Radiol 40:323–324

    Article  PubMed  CAS  Google Scholar 

  • Hunter J (1762) Observations on the state of the testes in the foetus and on the hernia congenita. In: William Hunter, Medical Commentaries 1762; Part 1

    Google Scholar 

  • Hutson JM (1985) Hypothesis, A biphasic model for the hormonal control of testicular descent. Lancet ii: 419–420

    Article  Google Scholar 

  • Hutson JM, Shaw G, Wai SO, Short RV, Renfree MB (1988) Mullerian inhibiting substance production and testicular migration and descent in the pouch of a marsupial. Development 104:549–556

    PubMed  CAS  Google Scholar 

  • Johnson DH, Hainsworth JD, Linde RB, Greco FA (1984) Testicular function forming combination chemotherapy with cis-platin, vinblastine and bleomycin. Med Pediat Oncol 12:233–238

    Article  CAS  Google Scholar 

  • Kaempfer SH, Wiley FMCK, Hoffman DJ, Rhodes EA (1985) Fertility considerations and procreative alternatives in cancer care. Semin Oncol Nursing 1:25–34

    Article  CAS  Google Scholar 

  • Kreuser ED, Harsch U, Hetzel WD, Schreml W (1986) Chronic gonadal toxicity in patients with testicular cancer after chemotherapy. Eur J Cancer Clin Oncol 22:289–3294

    Article  PubMed  CAS  Google Scholar 

  • Lentz RD, Bergstein J, Steffes MW, Brown DR, Prem K, Michael AF, Vernier RL (1977) Post-puberal evaluation of gonadal function following cyclophosphamide therapy before and during puberty. J Pediat 91:385–394

    Article  PubMed  CAS  Google Scholar 

  • Levitt SB, Kogan SJ, Engal RM, Weiss RM, Martin DC, Ehrlich RM (1978) The impalpable testes, a rational approach to management. J Urol 120:515–520

    PubMed  CAS  Google Scholar 

  • Lipshultz LI, Camino-Torres R, Greenspan CS, Snyder PJ (1976) Testicular function after orchiopexy for unilateral undescended testes, N Engl J Med 295:15–18.

    Article  PubMed  CAS  Google Scholar 

  • Lipshultz L (1976) Cryptorchidism in the the subfertile male. Fertil Steril 27:609

    PubMed  CAS  Google Scholar 

  • Longo DL, Young RC, Wesley M, Hubbard SM, Duffey PL, Jaffe ES, Devita VT (1986) Twenty years of MOPP therapy for Hodgkin’s disease. J Clin Oncol 4:1295–1306

    PubMed  CAS  Google Scholar 

  • Lushbaugh CC, Casarett GW (1976) The effects of gonadal irradiation in clinical radiation therapy: a review. Cancer 27:1111–1120

    Article  Google Scholar 

  • Mauch PM, Weinstein H, Botrick L, Belli J, Cassady JR (1983) An evaluation of long-term survival and treatment complications in children with Hodgkin’s disease. Cancer 51:925–952

    Article  PubMed  CAS  Google Scholar 

  • Marshall WA, Tanner JM (1970) Variations in the pattern of pubertal changes in boys. Arch Dis Child 45:13–23

    Article  PubMed  CAS  Google Scholar 

  • Marshall WA, Tanner JM (1974) Puberty. In: Davis JA, Dobbing J (eds) Scientific foundations of paediatrics. Heinemann Medical, London, pp 124–151

    Google Scholar 

  • Maxted W, Baker R, McCrystal H, Fitzgerald E (1965) Complete masculinization of the external genitalia in congenital adrenocortical hyuperplasia. Presentation of two cases. J Urol 94:266–270

    PubMed  CAS  Google Scholar 

  • OPCS (Office of Population Census and Surveys) (1990) Cancer statistics: registrations, England and Wales 1985. HMSO, London

    Google Scholar 

  • Papadopoulos I (1991) LHRH analogues do not protect the germinal epithelium duiring chemotherapy: an experimental animal investigation. Urol Res 19:31–34

    Article  PubMed  CAS  Google Scholar 

  • Pike MC, Chilvers C, Peckham MJ (1986) Effect of age at orchiopexy on risk of testicular cancer. Lancet i:1246–1248

    Article  Google Scholar 

  • Rajfer J, Handelsman DJ, Swerdloff RS, Hurwotz R, Kaplan H, Vandergast T, Ehrlich RM. (1986) Hormonal therapy in cryptorchidism. N Engl J Med 314:466

    Article  PubMed  CAS  Google Scholar 

  • Raynaud A (1958) L’appareil gubernaculaire du fetus de souris et ces modifications experimentales. Bull Soc Zool 83:340.

    Google Scholar 

  • Richardson DW, Short RV (1978) Fertility in adolescence. Time of onset of sperm production in boys. J Biosoc Sci (Suppl) 5:15–25

    Google Scholar 

  • Rorth M, Grigor KM, Gwicerman A, Dawgaard G, Skakkebeak EDS (1986) Carcinoma-in-situ and testis cancer; biology and treatment. Proceedings of a workshop on testis cancer held in Copenhagen. Blackwell Scientific Publications, Oxford

    Google Scholar 

  • Rowley MJ, Leach DR, Warner GA, Heller CG (1974) Effect of graded doses of ionising radiation on the human testis. Radiat Res 59:665–678

    Article  PubMed  CAS  Google Scholar 

  • Schilsky RL (1989) Infertility in patients with testicular cancer: testis, tumour or treatment? J Natl Cancer Inst 81:1204

    Article  PubMed  CAS  Google Scholar 

  • Scorer CG (1964) The descent of the testis. Arch Dis Child 39:605–609

    Article  PubMed  CAS  Google Scholar 

  • Scott LS, Young D (1962) Varicocele. Fertil Steril 13:325

    PubMed  CAS  Google Scholar 

  • Scott LS (1961) Unilateral cryptorchidism: subsequent effects on fertility. J Reprod Fertil 2:54

    Article  PubMed  CAS  Google Scholar 

  • Senturia YD Peckham CS (1990) Children fathered by men treated with chemotherapy for testicular cancer. Eur J Cancer 26:429

    Article  PubMed  CAS  Google Scholar 

  • Shalet SM (1982) Abnormalities of growth and gonadal function in children treated for malignant disease: a review. J R Soc Med 5:641–647

    Google Scholar 

  • Sharpe L, Black RJ, Muir CS, Warner J, Clarke JA (1993) Trends in cancer of the testis in Scotland 1961–1990. Scot Office Home Health Dep Health Bull 51:255–268

    Google Scholar 

  • Sharpe RM (1992) Are environmental chemicals a threat to male fertility? Chem Ind Feb:88–92

    Google Scholar 

  • Short RV (1976) The evolution of human reproduction. Proc R Soc Lond 195:3–24

    Article  PubMed  CAS  Google Scholar 

  • Slanina J, Musshoff K, Rahner T, Stiasny T (1977) Long-term effects in irradiated patients with Hodgkins disease. Int J Radiat Oncol Biol Physiol 2:1–19

    Article  CAS  Google Scholar 

  • Stone JM, Cruikshank DG, Sandeman TF, Mathews JP (1991) Laterality, maldescent, trauma and other clinical factors in epidemiology of cancer of testis. Br J Cancer 64:132–138

    Article  PubMed  CAS  Google Scholar 

  • Stoter G, Koopman A, Vendrik CP et al. (1989) Ten-year survival and late sequalae in testicular cancer patients treated with cisplatin, vinblastine and bleomycin. J Clin Oncol 7:1099–1104

    PubMed  CAS  Google Scholar 

  • Swerdlow AJ, Huttly SRA, Smith PG (1987) Testicular cancer and antecedant diseases. Br J Cancer 55:97–103

    Article  PubMed  CAS  Google Scholar 

  • Tabbara KF (1983) Chlormbucil in Behcet’s disease. A reappraisal. Opthalmology 90:906–908

    CAS  Google Scholar 

  • Thorsland RW, Paulsen CA (1972) Proceedings of the national symposium on natural and manmade radiation in space. NASA document TMX 2440:229–232

    Google Scholar 

  • Turner WR (1992) Congenital genito-urinary anomalies secondary to maternal drug use. In: Roos SN (ed) Urology annual 1992, vol 6. Norton, New York, pp 299–311

    Google Scholar 

  • Viviani S, Santoro A, Ragni G, Bonfante V, Bestetti O, Bonadonna G (1985) Gonadal toxicity after combination chemotherapy for Hodgkin’s disease comparative results of MOPP vs ABVD. Eur J Cancer Clin Oncol 21:601–605

    Article  PubMed  CAS  Google Scholar 

  • Waxman J, Terry Y, Wrigley P, Malpas J, Rees L, Besser GM, Lister T (1982) Gonadal function in Hodgkin’s disease; long-term follow-up of chemotherapy. Br Med J 285:1612

    Article  CAS  Google Scholar 

  • Waxman J, Terry Y, Rees LH, Lister TA (1983) Gonadal function in men treated for acute leukaemia. Br Med J 287:1093–1094

    Article  CAS  Google Scholar 

  • West AB, Butler MR, Fitzpatrick J, O’Brien A (1985) Testicular tumours in subfertile men: report of 4 cases with implications for management of patients presenting with infertility. J Urol 133:107–109

    PubMed  CAS  Google Scholar 

  • Westenfelder M (1984) Maldescensus testis, risk for malignant degeneration. In: Kelami A, Pryor JP (eds) Progress in reproductive biology and medicine, vol 10. In Operative Andrology 2. Karger, Basel, pp 56–65

    Google Scholar 

  • Whitaker RH (1975) Orchidopexy and orchiectomy. Br J Hosp Med 14:282–294.

    Google Scholar 

  • WHO (1991) Report and recommendations of a WHO inter-nation workshop, impact of the environment on reproductive health. Danish Med Bull 38:425–426

    Google Scholar 

  • Wojciechowski K (1977) Long-term results of undescended testicle operative treatment. Prog Pediat Surg 10:296–304

    PubMed  CAS  Google Scholar 

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© 1994 Springer-Verlag London Limited

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Howard, G.C.W., Hargreave, T.B. (1994). Normal and Abnormal Testicular Development and Descent (Testicular Maldescent, Malignancy, Cancer Therapy and Fertility). In: Hargreave, T.B. (eds) Male Infertility. Springer, London. https://doi.org/10.1007/978-1-4471-1029-3_10

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  • DOI: https://doi.org/10.1007/978-1-4471-1029-3_10

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