Quality of Life Assessment in Pancreatic Cancer

  • D. Fitzsimmons
  • C. D. Johnson


Pancreatic cancer is well known to have a short duration of survival after diagnosis, and despite advances in treatment and therapies, little progress has been made regarding the outcome of prolonging quantity of life. Indeed, the majority of patients (80%) will receive palliative medical or surgical interventions aimed at control of symptoms only. Within this context of limited survival, quality of life assumes great importance. Clinicians should be concerned not only with advancing knowledge regarding the biophysical disease process but also with the consequences of illness on the well-being of their patients and how the patients cope with their illness, treatment and care. Such knowledge can only help to advance our understanding of pancreatic cancer.


Pancreatic Cancer Pancreatic Carcinoma Pancreatic Cancer Patient Life Assessment Advanced Pancreatic Cancer 
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  1. 1.
    Aaronson NK, Meyerowitz BE, Bard M et al. (1991) Quality of life research in oncology: past achievements and future priorities. Cancer 67:839–843.PubMedCrossRefGoogle Scholar
  2. 2.
    Aaronson NK, Cull A, Kaasa S, Sprangers MA (1994) The European Organisation for Research and Treatment of Cancer (EORTC) modular approach to quality of life assessment in oncology: an update. In: Spilker B (ed) Quality of life and pharmacoeconomics in clinical trials, 2nd edn. Raven Press, New York.Google Scholar
  3. 3.
    Ahlgren JD (1996) Chemotherapy for pancreatic carcinoma. Cancer 78:654–663.PubMedGoogle Scholar
  4. 4.
    Alter CL (1996) Palliative and supportive care of patients with pancreatic cancer. Semin Oncol 23:229–240.PubMedGoogle Scholar
  5. 5.
    Andersen JS, Burris HA, Casper E et al. (1994) Development of a new system for assessing clinical benefit for patients with advanced pancreatic cancer. Proc Am Soc Clin Oncol 13:461 (abstract).Google Scholar
  6. 6.
    Bakkevold KE, Kambestad B (1995) Palliation of pancreatic cancer. A prospective multicentre study. Eur J Surg Oncol 21:176–182.PubMedGoogle Scholar
  7. 7.
    Ballinger AB, McHugh M, Catnach SM, Alstead EM, Clark ML (1994) Symptom relief and quality of life after stenting for malignant bile duct obstruction. Gut 35:467–470.PubMedCrossRefGoogle Scholar
  8. 8.
    Ballinger AB, McHugh M, Catnach SM et al. (1994) Symptom relief and quality of life after stenting for malignant bile duct obstruction. Gut 35:476–470.CrossRefGoogle Scholar
  9. 9.
    Bloechle C, Izbicki JR, Knoefel WT et al. (1995) Quality-of-life in chronic-pancreatitis — results after duodenum-preserving resection of the head of the pancreas. Pancreas 11:77–85.PubMedCrossRefGoogle Scholar
  10. 10.
    Bowling A (1991) Measuring health: a review of quality of life measurement scales. Open University Press, Buckingham.Google Scholar
  11. 11.
    Bowling A (1991) Measuring disease. Open University Press, Buckingham.Google Scholar
  12. 12.
    Carter JP, Saxe GP, Newbold V, Peres CE, Campeau RJ, Bernal Green L (1993) Hypothesis: dietary management may improve survival from nutritionally linked cancers based on analysis of representative cases. J Am Coll Nutr 12:209–226.PubMedGoogle Scholar
  13. 13.
    Carter DC (1995) Clinical features and management of carcinoma of the pancreas. Br J Hosp Med 54:459–464.PubMedGoogle Scholar
  14. 14.
    Celia DF (1994) Quality of life: concepts and definitions. J Pain Symptom Management 9:186–192.CrossRefGoogle Scholar
  15. 15.
    De Wys WD (1986) Weightloss and nutritional abnormalities in cancer patients: incidence, severity and significance. In: Calman KC, Fearon KCH (eds) Nutritional support for the cancer patient. Bailliére Tindall, London.Google Scholar
  16. 16.
    Dunkel-Schatter C, Feinstein LG, Taylor SE, Falke RL (1991) Patterns of coping with cancer. Health Psychol 11:79–87.CrossRefGoogle Scholar
  17. 17.
    Ebert M, Friess H, Beger HG, Büchler M (1994) Role of octreotide in the treatment of pancreatic cancer. Digestion 55 (Suppl 1):48–51.PubMedCrossRefGoogle Scholar
  18. 18.
    Fallowfield L (1990) Quality of life: the missing measurement in health care. Souvenir Press, London.Google Scholar
  19. 19.
    Faulkner A, Maguire P (1994) Talking to cancer patients and their families. Oxford Medical Publications, Oxford.Google Scholar
  20. 20.
    Fitzsimmons D (1998) Differences in perception of quality of life issues between health professionals and patients with pancreatic cancer. Psycho-Oncology (in press).Google Scholar
  21. 21.
    Gammon J (1991) Which way out of the crisis? Professional Nurse May:488–493.Google Scholar
  22. 22.
    Glaser BG and Strauss AL (1986) The discovery of grounded theory: strategies for qualitative research. Aldine, Chicago.Google Scholar
  23. 23.
    Glimelius B, Hoffman K, Graf W et al. (1995) Cost-effectiveness of palliative chemotherapy in advanced gastrointestinal cancer. Ann Oncol 6:267–274.PubMedGoogle Scholar
  24. 23a.
    Glimelius B, Hoffman K, Sjoden PO et al. (1996) Chemotherapy improves survival and quality-of-life in advanced pancreatic and biliary cancer. Ann Oncol 7:593–600.PubMedGoogle Scholar
  25. 24.
    Hopkins A (1992) Measures of quality of life and the uses to which such measures may be put. Royal College of Physicians, London.Google Scholar
  26. 25.
    Ishikawa O, Ohigashi H, Nakaizumi A et al. (1993) Surgical resection of potentially curable pancreatic cancer with improved preservation of endocrine function: further evaluation of intraoperative cytodiagnosis. Hepatogastroenterology 40:443–447.PubMedGoogle Scholar
  27. 26.
    Jaloweic A (1990) Issues in using multiple measures of quality of life. Semin Oncol Nursing 6:271–277.CrossRefGoogle Scholar
  28. 27.
    Karnofsky DA, Abelman WH, Craver LF et al. (1948) The use of nitrogen mustards in the palliative treatment of carcinoma. Cancer 1:634–656.CrossRefGoogle Scholar
  29. 28.
    Kawamata M, Ishitani K, Ishikawa K et al. (1996) Comparison between celiac plexus block and morphine treatment on quality of life in patients with pancreatic cancer pain. Pain 64:597–602.PubMedCrossRefGoogle Scholar
  30. 29.
    Kelsen DP, Portenoy RK, Thaler HT (1995) Pain and depression in patients with newly diagnosed pancreas cancer. J Clin Oncol 13:748–755.PubMedGoogle Scholar
  31. 30.
    Krech RL, Walsh D (1991) Symptoms of pancreatic cancer. J Pain Symptom Management 6:360–367.CrossRefGoogle Scholar
  32. 31.
    Lancet Editorial (1995) Quality of life and clinical trials. Lancet 346:1–2.Google Scholar
  33. 32.
    Lebovits AH and Lefkowitz M (1989) Pain management of pancreatic carcinoma: a review. Pain 36:1–11.PubMedCrossRefGoogle Scholar
  34. 33.
    Lebovits AH, Lefkowitz M (1988) Pain management of pancreatic carcinoma: a review. Pain: 36,1–11.CrossRefGoogle Scholar
  35. 34.
    Lionetto R, Pugliese V, Bruzzi P and Rosso R (1995) No standard treatment is available for advanced pancreatic cancer. Eur J Cancer 31A:882–887.PubMedCrossRefGoogle Scholar
  36. 35.
    Lionetto R, Pugliese V, Bruzzi P, Rosso R (1995) No standard treatment is available for advanced pancreatic cancer. Eur J Cancer 31A:882–887.PubMedCrossRefGoogle Scholar
  37. 36.
    Luman W, Cull A, Palmer KR (1996) Quality of life following endoscopic stenting for malignant biliary obstruction. Abstract Presented at the British Society of Gastroenterology, Brighton, March, 1996.Google Scholar
  38. 37.
    Maguire (1992) Improving the recognition and treatment of affective disorders in cancer patients. In: Granville-Grasson K (ed) Recent advances in psychiatry 7. Churchill Livingstone, Edinburgh.Google Scholar
  39. 38.
    Maguire P (1985) Barriers to psychological care of the dying. BMJ 291:1711–1713.PubMedCrossRefGoogle Scholar
  40. 39.
    McLaughlin S. (1994) Pancreatic cancer and diabetes. Diabetes Educ. 20, 20, 24, 26.Google Scholar
  41. 40.
    McLeod RS. Taylor BR. O’Connor BI et al. (1995) Quality of life, nutritional status, and gastrointestinal hormone profile following the Whipple procedure. Am J Surg 169:179–85PubMedCrossRefGoogle Scholar
  42. 41.
    Moore H (1996) Activity of gemcitibine in patients with advanced pancreatic carcinoma. Cancer 78:633–638.PubMedGoogle Scholar
  43. 42.
    Newman, I, McDowell C (1992) A guide to rating scales and questionnaires. Oxford University Press, Oxford.Google Scholar
  44. 43.
    Niezgoda HE, Pater JL (1993) A validation study of the domains of the core EORTC quality of life questionnaire. Qual Life Res 2:129–148.CrossRefGoogle Scholar
  45. 44.
    Ottery F (1996) Supportive nutritional management of the patient with pancreatic cancer. Oncology 10:26–32.PubMedGoogle Scholar
  46. 45.
    Palmer KR, Kerr M, Knowles G, Cull A et al. (1994) Chemotherapy prolongs survival in inoperable pancreatic carcinoma. Br J Surg 81:882–885.PubMedCrossRefGoogle Scholar
  47. 46.
    Passik SD and Breitbart WS (1996) Depression in patients with pancreatic carcinoma. Diagnostic and treatment issues. Cancer 78:615–626.PubMedGoogle Scholar
  48. 47.
    Portenoy RK (1991) Pain and quality of life: clinical issues and implications for research. In: Tchelmedigion NS and Cella DF (eds) Quality of life in oncology: practice and research. New York.Google Scholar
  49. 48.
    Ringdal GI, Ringdal K (1993) Testing the EORTC quality of life questionnaire on cancer patients with heterogeneous diagnoses. Qual Life Res 2:129–140.PubMedCrossRefGoogle Scholar
  50. 49.
    Schumate CR, Baron TH (1996) Palliative procedures for pancreatic cancer: when and which one? South Med J 89:27–32.CrossRefGoogle Scholar
  51. 50.
    Schoeman MN, Huibregtse K (1995) Pancreatic and ampullary carcinoma. [Review.] Gastro-intest Endosc Clin North Am 5(1):217–236.Google Scholar
  52. 51.
    Singh SM, Reber HA (1989) Surgical palliation for pancreatic cancer. Surg Clin North Am 69:599–611.PubMedGoogle Scholar
  53. 52.
    Slevin ML (1992) Quality of life: philosophical question or clinical reality? Br Med J 305:466–469.CrossRefGoogle Scholar
  54. 53.
    Strauss A, Corbin J (1990) Basics of qualitative research: grounded theory procedures and techniques. Sage, New York.Google Scholar
  55. 54.
    Sugarbaker PH, Barosky I, Rosenberg SA, Gianola FJ (1982) Quality of life assessment of patients in extremity sarcoma clinical trials. Surgery 91:17–23.PubMedGoogle Scholar
  56. 55.
    Tamura K, Kin S, Nagami H et al. (1992) Heterotopic autotransplantation of the distal pancreas segment after total pancreatectomy for cancer of the head of the pancreas. Pancreas 7:664–671.PubMedCrossRefGoogle Scholar
  57. 56.
    Taylor OM, Benson EA, McMahon MJ. 1993. Clinical trial of tamoxifen in patients with irresectable pancreatic adenocarcinomavThe Yorkshire Gastrointestinal Tumour Group. Br J Surg 80:384–386.PubMedCrossRefGoogle Scholar
  58. 57.
    Trede M, Carter DC (1987) Surgery of the pancreas. Churchill Livingstone, Edinburgh.Google Scholar
  59. 58.
    Watanapa P, Williamson RCN (1992) Surgical palliation for pancreatic cancer: developments during the past two decades. Br J Surg 79:8–20.PubMedCrossRefGoogle Scholar
  60. 59.
    Webster S, Johnson CD (1994) Quality of life in pancreatic cancer. Fourth-year medical student study-in-depth project. University of Southampton (unpublished).Google Scholar
  61. 60.
    Yasue M, Sakamoto J, Morimoto T et al. (1995) Evaluation of the effect of pancreatic resection in advanced pancreatic cancer with special reference using hospital-free survival as a measure of quality of life. Jpn J Clin Oncol 25:37–45.PubMedGoogle Scholar

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© Springer-Verlag London Limited 1999

Authors and Affiliations

  • D. Fitzsimmons
  • C. D. Johnson

There are no affiliations available

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