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Resection in Cancer: Lymph Node Dissection

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Pancreatic Disease

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Abstract

Radical resection of ductal carcinoma of the pancreas affords the only realistic chance of a cure. Though the disappointing results achieved to date in terms of overall long-term survival of resected patients still prompt many surgeons to refrain from surgical intervention (1), over the years there has been a progressive increase in resection rates, which have steadily risen from around 20% some 15 to 20 years ago to an average of 35% of cases observed today and which now even exceed 50% in some centres (2).

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References

  1. Gudjonson B (1995) Carcinoma of the pancreas: critical analysis of costs, results of resections and the need of standardized reporting. J Am Coll Surg 181:483–503

    Google Scholar 

  2. Biichler MW, Wagner M, Friess H (1996) Surgery for pancreatic cancer. In: Dervensis CG (ed) Advances in pancreatic disease. Georg Thieme Verlag, Stuttgart, pp.309–323

    Google Scholar 

  3. Bassi C, Falconi M, Zamboni G, Iacono C, Talamini G, Pederzoli P (1996) How should we go about staging cancer in the future? In: Beger HG et al. (eds), Cancer of the pancreas. Universitatsverlag Ulm, Germany, pp 125–131

    Google Scholar 

  4. Nagakawa T, Kobayashi H, Ueno K et al. (1993) The pattern of lymph node involvement in carcinoma of the head of the pancreas. Int J Pancreatol 13:15–22

    PubMed  CAS  Google Scholar 

  5. Delcore R, Rodriguez FJ, Forster J, Hermreck AS, Thomas JH (1996) Significance of lymph node metastases in patients with pancreatic cancer undergoing curative resection. Am J Surg 172:463–469

    Article  PubMed  CAS  Google Scholar 

  6. Ishikawa O (1993) What constitutes curative pancreatectomy for adenocarcinoma of the pancreas? Hepatogastroenterology 40:414–417

    PubMed  CAS  Google Scholar 

  7. Cubilla AL, Fitzgerald PJ (1980) Surgical pathology of tumors of exocrine pancreas. In: Moossa AR (ed) Tumors of the pancreas. Williams & Wilkins, Baltimore pp 159–193

    Google Scholar 

  8. Nagakawa T, Kobayashi H, Ueno K, Ohta T, Kayahara, Miyazaki I (1994) Clinical study on lymphatic flow to the paraaortic lymph nodes in carcinoma of the head of the pancreas. Cancer 73:1155–1162

    Article  PubMed  CAS  Google Scholar 

  9. Yamamoto M, Saitoh Y (1996) Does lymph node dissection prolong survival? In: Beger HG et al. (eds) Cancer of the pancreas. Universitatsverlag Ulm, Germany, pp 409–418

    Google Scholar 

  10. Kockerling F, Kessler H, Hermanek P, Gall FP (1996) The role of lymph node dissection in the treatment of ductal carcinoma of the pancreas. In: Beger HG et al. (eds) Cancer of the pancreas. Universitatsverlag Ulm, Germany, pp 403–408

    Google Scholar 

  11. Isikawa O, Ohhigashi K, Sasaky J et al. (1988) Praticai usefulness of lymphatic and connective tissue clearance for the carcinoma of the pancreas head. Ann Surg 208:215–220

    Article  Google Scholar 

  12. Nagai H, Kuroda A, Morioka Y (1986) Lymphatic and local spread of T1 and T2 pancreatic cancer. Ann Surg 80:65–71

    Article  Google Scholar 

  13. Gall FP, Kessler H, Hermanek P (1991) Surgical treatment of ductal pancreatic carcinoma. Eur J Surg Oncol 17:173–181

    PubMed  CAS  Google Scholar 

  14. Bassi C, Falconi M, Talamini G et al. (1995) Prospective study of the detection and treatment of small tumours of the head of the pancreas. J Hepat Bil Pancr Surg 2:347–351

    Article  Google Scholar 

  15. Japan Pancreas Society (1996) Classification of pancreatic carcinoma (English edn). Kanehara, Tokyo

    Google Scholar 

  16. Yamamoto M, Ohashi O, Ishida H, Kamigaki T, Onoyama H, Saitoh Y (1994) Relationship between survival and cancer extension. Int J Pancreatol 16:118–120.

    Google Scholar 

  17. Lillemoe KD (1995) Current management of pancreatic carcinoma. Ann Surg 221:133–148

    Article  PubMed  CAS  Google Scholar 

  18. Yeo CJ, Cameron JL, Lillemoe KD et al. (1995) Pancreaticoduodenectomy for cancer of the head of the pancreas. Ann Surg 221:721–733

    Article  PubMed  CAS  Google Scholar 

  19. Ceuterick M, Gelin M, Rickaert F et al. (1989) Pancreaticoduodenal resection for pancreatic or periampullary tumours: a ten-year experience. Hepatogastroenterology 36:467–473

    PubMed  CAS  Google Scholar 

  20. Cameron JL, Pitt HA, Yeo CJ, Lillemoe KD, Kaufmann HS, Coleman J (1993) One hundred and forty five consecutive pancreaticoduodenectomies without mortality. Ann Surg 217:430–438

    Article  PubMed  CAS  Google Scholar 

  21. Tsuchiya R, Harada N, Tsunoda T, Miyamoto T, Ura K (1988) Long-term survivors after operation on carcinoma of the pancreas. Int J Pancreatol 3:491–496

    CAS  Google Scholar 

  22. Camenron JL, Crist DW, Sitzmann JV et al. (1991) Factors influencing survival after pancreaticoduodenectomy for pancreatic cancer. Am J Surg 161:120–125

    Article  Google Scholar 

  23. Kawarada Y, Yanagisawa K, Isaji S, Mizumoto R (1994) The prevalence of pancreatic cancer lymph node metastasis in Japan and pancreatic cancer categories. Int J Pancreatol 16:101–104

    Google Scholar 

  24. Hagiwara K (1990) Experimental and clinicopathological studies on lymphatic flow of the pancreas. Igaku Kenkiu 52:61–85

    Google Scholar 

  25. Nagai H (1987) Involvement of paraaortic lymph nodes by pancreatic cancer and its lymphatic flow. Jpn J Surg 88:308–317

    CAS  Google Scholar 

  26. Nitecki SS, Sarr MG, Colby TV, van Heerden JA (1995) Long-term survival after resection for ductal adenocarcinoma of the pancreas. Is it really improving? Ann Surg 221:59–66

    Article  PubMed  CAS  Google Scholar 

  27. Geer RJ, Brennam MF. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg 165:68–73

    Google Scholar 

  28. Klempnauer J, Ridder GJ, Bektas H, Pichlmayr R (1995) Surgery for exocrine pancreatic cancer: who are the five and ten year survivors? Oncology 52:353–359

    Article  PubMed  CAS  Google Scholar 

  29. Allema JH, Reinders ME, van Gulik TM et al. (1995) Prognostic factor for survival after pancreaticoduodenectomy for patients with carcinoma of the pancreatic head region. Cancer 75:2069–2076

    Article  PubMed  CAS  Google Scholar 

  30. Staley CA, Lee JE, Cleary KR et al (1996) Preoperative chemoradiation, pancreaticoduodenectomy and intraoperative radiation therapy for adenocarcinoma of the pancreatic head. Am J Surg 171:118–125

    Article  PubMed  CAS  Google Scholar 

  31. Fortner JG, Klimstra DS, Senie RT, Maclean BJ (1996) Tumor size is the primary prognosticator for pancreatic cancer after regional pancreatectomy. Ann Surg 223:147–143

    Article  PubMed  CAS  Google Scholar 

  32. Trede M, Chir B, Schwall G, Saeger HD (1990) Survival after pancreatoduodenectomy. Ann Surg 211:447 458

    Google Scholar 

  33. Nagakawa T, Konishi I, Ohta T et al. (1991) The results and problems of extensive radical surgery for carcinoma of the head of the pancreas. Jpn J Surg 21:262–267

    Article  PubMed  CAS  Google Scholar 

  34. Osaki H (1994) Modern surgical treatment of pancreatic cancer. Int J Pancreatol 16:121–129

    Google Scholar 

  35. Henne-Bruns D, Kremer B, Meyer-Pannwitt U, Schroder VS (1993) Partial duodeno-pancreatectomy with radical lymphoadenectomy in patients with pancreatic and periampullary carcinomas: initial results. HepatoGastroenterology 40:145–149

    PubMed  CAS  Google Scholar 

  36. Tsunoda T, Ura K, Eto T, Matsumoto T, Tsuchiya R (1991) UICC and Japanese stage classification for carcinoma of the pancreas. Int J Pancreatol 8:205–214

    CAS  Google Scholar 

  37. Zerbi A, Balzano GP, Bottura R, Di Carlo V (1994) Reliability of pancreatic cancer classifications. Int J Pancreatol 15:13–18

    PubMed  CAS  Google Scholar 

  38. Bassi C, Butturini G, Falconi M et al. (1996) Prognosis of pancreatic carcinoma: why are differences to be found between European and Japanese patients? In: Dervenis CG (ed) Advances in pancreatic diseases. Georg Thieme Verlag, Stuttgart, pp 303–308

    Google Scholar 

  39. Yeo CJ, Cameron JL (1994) Arguments against radical (extended) resection for adenocarcinoma of the pancreas. Adv Surg 27:273–284

    PubMed  CAS  Google Scholar 

  40. Satake K, Nishimaki H, Yokomatsu H et al. (1992) Surgical curability and prognosis for standard versus extended resections for T1 carcinoma of the pancreas. Surg Gynecol Obstet 175:259–265

    PubMed  CAS  Google Scholar 

  41. Pedrazzoli S, Di Carlo V, Dionigi R and the Lymphadenectomy Study Group (1998). Traditional versus extended lymphadenectomy associated with pancreatoduodenectomy in surgical treatment of pancreatic head cancer. Multicenter prospective randomized trial. Ann Surg (in press)

    Google Scholar 

  42. Sperti C, Pasquali C, Piccoli A, Pedrazzoli S (1996) Survival after resection for ductal adenocarcinoma of the pancreas. Br J Surg 83:625–631

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. C. Bassi
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  2. M. Falconi
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  3. S. Pedrazzoli
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  4. C. Pasquali
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  5. P. Pederzoli
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Editor information

Editors and Affiliations

  1. Southampton General Hospital, University Surgical Unit, Tremona Road, SO1 6HU, Southampton, UK

    C. D. Johnson MChir, FRCS (Senior Lecturer and Honorary Consultant Surgeon, Faculty of Medicine) (Senior Lecturer and Honorary Consultant Surgeon, Faculty of Medicine)

  2. Surgical Unit, Royal Infirmary, 16 Alexandra Parade, G4 OSF, Glasgow, UK

    C. W. Imrie ChB, FRCS (Consultant Surgeon) (Consultant Surgeon)

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© 1999 Springer-Verlag London Limited

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Bassi, C., Falconi, M., Pedrazzoli, S., Pasquali, C., Pederzoli, P. (1999). Resection in Cancer: Lymph Node Dissection. In: Johnson, C.D., Imrie, C.W. (eds) Pancreatic Disease. Springer, London. https://doi.org/10.1007/978-1-4471-0801-6_36

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  • DOI: https://doi.org/10.1007/978-1-4471-0801-6_36

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1205-1

  • Online ISBN: 978-1-4471-0801-6

  • eBook Packages: Springer Book Archive

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