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Metalloproteinases and Stromal Biology in Cancer

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Pancreatic Disease

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Abstract

The normal extracellular matrix (ECM) comprises the basement membrane and interstitial stroma and functions as a supportive framework for parenchymal cells and a physical barrier which regulates the entry of cells into the tissue (35). The integrity of the ECM is carefully controlled but may be disrupted during tissue remodelling or various pathological situations including healing, inflammation and neoplastic disease (54,91,127). In several cancers including carcinoma of the breast and rectum, loss of basement membrane integrity is associated with an increased risk of metastases and a poorer prognosis (13,31). Pancreatic cancer is characterised by a strong desmoplastic reaction with proliferation of interstitial connective tissue (50) in particular type I collagen and fibronectin (63). In addition, however, loss of type IV collagen, the principal constituent of the basement membrane, is frequently observed indicating that proteolytic degradation may be an important feature of the invasive phenotype of pancreatic cancer (51,117).

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Authors
  1. James D. Evans
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  2. Anthony Kawesha
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  3. Paula Ghaneh
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  4. John P. Neoptolemos
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Editors and Affiliations

  1. Southampton General Hospital, University Surgical Unit, Tremona Road, SO1 6HU, Southampton, UK

    C. D. Johnson MChir, FRCS (Senior Lecturer and Honorary Consultant Surgeon, Faculty of Medicine) (Senior Lecturer and Honorary Consultant Surgeon, Faculty of Medicine)

  2. Surgical Unit, Royal Infirmary, 16 Alexandra Parade, G4 OSF, Glasgow, UK

    C. W. Imrie ChB, FRCS (Consultant Surgeon) (Consultant Surgeon)

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© 1999 Springer-Verlag London Limited

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Evans, J.D., Kawesha, A., Ghaneh, P., Neoptolemos, J.P. (1999). Metalloproteinases and Stromal Biology in Cancer. In: Johnson, C.D., Imrie, C.W. (eds) Pancreatic Disease. Springer, London. https://doi.org/10.1007/978-1-4471-0801-6_27

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  • DOI: https://doi.org/10.1007/978-1-4471-0801-6_27

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1205-1

  • Online ISBN: 978-1-4471-0801-6

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