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Growth Factors and Cytokines in Chronic Pancreatitis

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Book cover Pancreatic Disease

Abstract

The pathological appearances of chronic pancreatitis are characterised by parenchymal fibrosis, ductal stones and strictures, acinar cell atrophy and inflammatory infiltration by macrophages, neutrophils and lymphocytes. One of the key features of pancreatic fibrosis is an abundant presence of fibroblasts and an accumulation of a dense extracellular matrix which is rich in fibril-forming collagens type I and III. Deposition of extracellular matrix in a diseased pancreas must therefore be regarded as a wound-healing response, much as in fibrosis due to chronic injury in the lung, liver, kidney or joints.

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  1. S. K. Vyas
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Editors and Affiliations

  1. Southampton General Hospital, University Surgical Unit, Tremona Road, SO1 6HU, Southampton, UK

    C. D. Johnson MChir, FRCS (Senior Lecturer and Honorary Consultant Surgeon, Faculty of Medicine) (Senior Lecturer and Honorary Consultant Surgeon, Faculty of Medicine)

  2. Surgical Unit, Royal Infirmary, 16 Alexandra Parade, G4 OSF, Glasgow, UK

    C. W. Imrie ChB, FRCS (Consultant Surgeon) (Consultant Surgeon)

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Vyas, S.K. (1999). Growth Factors and Cytokines in Chronic Pancreatitis. In: Johnson, C.D., Imrie, C.W. (eds) Pancreatic Disease. Springer, London. https://doi.org/10.1007/978-1-4471-0801-6_16

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  • DOI: https://doi.org/10.1007/978-1-4471-0801-6_16

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1205-1

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