Smoking and coronary changes in patients with documented coronary artery disease
Cigarette smoking is one of the leading risk factors for coronary heart disease. Population-based studies have demonstrated that smokers have a two- to threefold increase in risk for sudden death from cardiac arrest as compared with non-smokers (Kannel & Thomas, 1982). Unstable angina pectoris is a dramatic clinical manifestation of coronary artery disease associated with the risk for developing myocardial infarct, especially among patients with disease involving many vessels (Freeman et al., 1989). The pathophysiological mechanisms underlying unstable angina pectoris are complex and include progression of atherosclerotic lesions, increased platelet aggregation, coronary thrombus formation and increased vasomotor tone (Brown et al., 1984; Kruskal et al., 1987; Haft et al., 1988), all leading to an imbalance between myocardial oxygen demand and supply.
KeywordsCigarette Smoking Coronary Stenosis Serum Lipid Profile Myocardial Oxygen Demand Total Cholesterol Concentration
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