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Adverse Reproductive Outcome Potential of Cancer Therapies During Pregnancy

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Cancer and Pregnancy

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Abstract

A vast majority of chemotherapeutic drugs and radiation treatments for cancer are deleterious to the developing conceptus (placenta and embryo-fetus). Developing conceptuses and cancer tissues exhibit close similarities in biological characteristics, and both are exposed to treatment agents given through the maternal system during cancer therapy of pregnant women (Table 15.1). At present, a wide variety of chemotherapeutic drugs are used for cancer treatment.1 Chemotherapeutic drugs are genotoxic, damaging the genome, thereby affecting the expression of genes, preventing cell division and destroying cancer cells. These drugs are of different types and molecular processes, for killing of cancer cells may involve affecting DNA synthesis and its replication (antimetabolites), breaking and unwinding of the DNA strands (antibiotics) and cross-linking with DNA or other macromolecules (alkylating agents). Inhibiting functions of the mitotic apparatus associated with cell division (plant alkaloids) and influencing hormonal effects (antihormonal agents) are also important mechanisms of chemotherapeutic drugs. (See also chapters 11, 13.)

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Authors
  1. Mrinal K. Sanyal
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Editors and Affiliations

  1. Society for the Investigation of Early Pregnancy, 1697 Lark Lane, Cherry Hill, 08003-3157, NJ, USA

    Eytan R. Barnea MD, FACOG

  2. Department of Obstetric and Gynaecology, University College London Medical School, 86–96 Chenies Mews, WC1E 6HX, London, UK

    Eric Jauniaux MD, PhD

  3. Department of Obstetrics and Gynaecology, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA

    Peter E. Schwartz MD, FACOG

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© 2001 Springer-Verlag London Limited

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Sanyal, M.K. (2001). Adverse Reproductive Outcome Potential of Cancer Therapies During Pregnancy. In: Barnea, E.R., Jauniaux, E., Schwartz, P.E. (eds) Cancer and Pregnancy. Springer, London. https://doi.org/10.1007/978-1-4471-0707-1_15

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  • DOI: https://doi.org/10.1007/978-1-4471-0707-1_15

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1184-9

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