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Transplacental Carcinogenesis: Role of Chemicals, Radiation and Viruses

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Cancer and Pregnancy

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Abstract

During the early 1960s, experimentalists were becoming more concerned about the unique sensitivity of the conceptus to induction of cancer following in utero exposure.1,2 Reports appeared that linked in utero exposure to ethylnitrosourea (ENU) and the induction of brain tumors, schwanoma and gliomas in adult rat offspring, lung tumors in mice and Wilms (renal) tumors in opossum pups.3,4,5 Rice and associates’ demonstrated that ENU given during pregnancy could result in the induction of choriocarcinoma in the mother Patas monkey. These were among the first reports of chemical induction of tumors in both offspring and mothers following in utero exposure. Of special note is that ENU has a biological half-life in the body of approximately 8–10 minutes. These examples of the unique sensitivity of the unborn to not only structural anomalies but also tumorigenesis has further raised interest in understanding the malleability of the developing organism in response to therapeutic, occupational and environmental exposures.

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Authors
  1. Orna Diav-Citrin
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  2. Asher Ornoy
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  3. Richard K. Miller
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Editors and Affiliations

  1. Society for the Investigation of Early Pregnancy, 1697 Lark Lane, Cherry Hill, 08003-3157, NJ, USA

    Eytan R. Barnea MD, FACOG

  2. Department of Obstetric and Gynaecology, University College London Medical School, 86–96 Chenies Mews, WC1E 6HX, London, UK

    Eric Jauniaux MD, PhD

  3. Department of Obstetrics and Gynaecology, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA

    Peter E. Schwartz MD, FACOG

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Diav-Citrin, O., Ornoy, A., Miller, R.K. (2001). Transplacental Carcinogenesis: Role of Chemicals, Radiation and Viruses. In: Barnea, E.R., Jauniaux, E., Schwartz, P.E. (eds) Cancer and Pregnancy. Springer, London. https://doi.org/10.1007/978-1-4471-0707-1_13

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  • DOI: https://doi.org/10.1007/978-1-4471-0707-1_13

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