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Management of Venous Ulceration: Excision, Skin Grafting and Microsurgical Flaps

  • Chapter
Chronic Venous Insufficiency

Abstract

A regimen of leg elevation, compression bandaging and local wound care is successful in healing the majority of venous ulcers. Failure of a venous ulcer to heal with appropriate wound care or recurrence despite these measures leaves the physician with a challenge in which multiple factors must be addressed in order to achieve long-term wound closure. Most surgical interventions employed to address refractory venous ulceration have been directed at correcting underlying venous hypertension with the assumption that this would lead to resolution of the ulcer. However, even if successful control of venous hypertension in the extremity is achieved, a chronically scarred wound with compromised healing capacity may remain and require surgical reconstruction. Thus, the approach to reconstruction of the tissue defect associated with chronic venous ulceration is the subject of this chapter.

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References

  1. Hallbook T. Leg ulcer epidemiology. Acta Chir Scand Suppl 1988; 544:17–20

    PubMed  CAS  Google Scholar 

  2. Collins PS, Villavicencio JL, Abreu su et al. Abnormalities of lymphatic drainage in lower extremities: a lymphoscintigraphic study. J Vasc Surg 1989; 9(1):145–52

    PubMed  CAS  Google Scholar 

  3. Gingrass P, Grabb WC, Gingrass RP. Skin graft survival on avascular defects. Plast Reconstr Surg 1975; 55(1):65–70

    Article  PubMed  CAS  Google Scholar 

  4. Michel CC. Oxygen diffusion in oedematous tissue and through pen-capillary cuffs. Phlebology 1990; 5:223–30

    Google Scholar 

  5. Falanga V, Kirsner R, Katz MH et al. Pericapillary fibrin cuffs in venous ulceration. Persistence with treatment and during ulcer healing. J Dermatol Surg Oncol 1992; 18(5):409–14

    PubMed  CAS  Google Scholar 

  6. Fagrell B. Local microcirculation in chronic venous incompetence and leg ulcers. Vasc Surg 1979; 13(4):217–25

    Article  Google Scholar 

  7. Burnand K, Thomas ML, ODonnell T et al. Relation between postphlebitic changes in the deep veins and results of surgical treatment of venous ulcers. Lancet 1976; 1(7966):936–8.

    Article  PubMed  CAS  Google Scholar 

  8. Burnand KG, Whimster I, Naidoo A, et al. Pericapillary fibrin in the ulcer-bearing skin of the leg: the cause of lipodermatosclerosis and venous ulceration. Br Med J (Clin Res Ed) 1982; 285(6348):1071–2

    Article  CAS  Google Scholar 

  9. Burnand KG. The aetiology of venous ulceration. Acta Chir Scand Suppl 1988; 544:21–4

    PubMed  CAS  Google Scholar 

  10. Burnand KG. Aetiology of venous ulceration [see comments]. Br J Surg 1990; 77(5):483–4

    Article  PubMed  CAS  Google Scholar 

  11. Cornwall JV, Dore CJ, Lewis JD. Leg ulcers: epidemiology and aetiology. Br J Surg 1986; 73(9):693–6

    Article  PubMed  CAS  Google Scholar 

  12. Angel MF, Ramasastry SS, Swartz WM et al. The causes of skin ulcerations associated with venous insufficiency: a unifying hypothesis. Plast Reconstr Surg 1987; 79(2):289–97

    Article  PubMed  CAS  Google Scholar 

  13. Labropoulos N, Delis K, Nicolaides AN et al. The role of the distribution and anatomic extent of reflux in the development of signs and symptoms in chronic venous insufficiency. J Vasc Surg 1996; 23(3):504–10

    Article  PubMed  CAS  Google Scholar 

  14. Fegan G. Skin-grafting leg ulcers. Lancet 1970; 1(7643):416

    Article  PubMed  CAS  Google Scholar 

  15. Reverdin JL. Greffe üpidermique. Bull Imp Soc Chir Paris 1869; 10:511

    Google Scholar 

  16. Reverdin JL. Sur la greffe üpidermique. Compt Rend Acad Sci (Paris) 1871; 73:1280

    Google Scholar 

  17. Thiersch C. Ueber hautverpflanzung. Zentralbl Chir 1886; 13:17

    Google Scholar 

  18. Wolfe JR. A new method of performing plastic operations. Br Med J 1875; 2:360

    Article  PubMed  CAS  Google Scholar 

  19. Gilliland EL, Nathwani N, Dore CJ et al. Bacterial colonisation of leg ulcers and its effect on the success rate of skin grafting. Ann R Coll Surg Engl 1988; 70(2):105–8

    PubMed  CAS  Google Scholar 

  20. Hauben DJ, Baruchin A, Mahler A. On the history of the free skin graft. Ann Plast Surg 1982; 9(3):242–5

    Article  PubMed  CAS  Google Scholar 

  21. Ratner D. Skin grafting. From here to there. Dermatol Clin 1998; 16(1):75–90

    PubMed  CAS  Google Scholar 

  22. Chick LR. Brief history and biology of skin grafting. Ann Plast Surg 1988; 21(4):358–65

    Article  PubMed  CAS  Google Scholar 

  23. Kirsner RS, Falanga V, Eaglstein WH. The biology of skin grafts. Skin grafts as pharmacologic agents [see comments]. Arch Dermatol 1993; 129(4):481–3

    Article  PubMed  CAS  Google Scholar 

  24. Smahel J. The healing of skin grafts. Clin Plast Surg 1977; 4(3):409–24

    PubMed  CAS  Google Scholar 

  25. Mir y Mir, L. Biology of the skin graft: New aspects to consider in its revascularization. Plast Reconstruct Surg 1951; 8(5):378–89

    Article  Google Scholar 

  26. Wright JK, Brawer MK. Survival of full-thickness skin grafts over avascular defects. Plast Reconstr Surg 1980; 66(3):428–32

    PubMed  CAS  Google Scholar 

  27. Huebscher W. Beitrage zur hautverpflanzung nach thiersch. Beitr Klin Chir 1888; 4:395

    Google Scholar 

  28. Converse JM, Ballantyne DL Jr., Rogers BO et al. Plasmatic circulation in skin grafts. Transpl Bull 1957; 4:154

    PubMed  CAS  Google Scholar 

  29. Converse JM, Uhlschmid GK, Ballantyne DL Jr.Plasmatic circulation in skin grafts. The phase of serum imbibition. Plast Reconstr Surg 1969; 43(5):495–9

    Article  PubMed  CAS  Google Scholar 

  30. Dahlstrom KK, Weis-Fogh US, Medgyesi S et al. The use of autologous fibrin adhesive in skin transplantation. Plast Reconstr Surg 1992; 89(5):968–72; discussion 973–6

    Article  PubMed  CAS  Google Scholar 

  31. Krizek TJ, Robson MC, Kho E. Bacterial growth and skin graft survival. Surg Forum 1968; 18:518

    Google Scholar 

  32. Birch J, Branemark PI, Nilsson K. The vascularization of a free full thickness skin graft. 3. An infrared thermographic study. Scand J Plast Reconstr Surg 1969; 3(1):18–22

    Article  PubMed  CAS  Google Scholar 

  33. Birch, J, Branemark P I, Lundskog J. The vascularization of a free full thickness skin graft. 2. A microangiographic study. Scand J Plast Reconstr Surg 1969; 3(1):11–17

    Article  PubMed  CAS  Google Scholar 

  34. Fifer TD, Pieper D, Hawtof D. Contraction rates of meshed, nonexpanded split-thickness skin grafts versus split-thickness sheet grafts. Ann Plast Surg 1993; 31(2):162–3

    Article  PubMed  CAS  Google Scholar 

  35. Converse JM. Reconstructive plastic surgery, 2nd edn. WB Saunders, Philadelphia, 1977: 182–191, 3522–3525

    Google Scholar 

  36. Leigh IM, Purkis PE, Naysaria HA et al. Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes. Br J Dermatol 1987; 117(5):591–7

    Article  PubMed  CAS  Google Scholar 

  37. Vistnes LM. Grafting of skin. Surg Clin North Am 1977; 57(5):939–60

    PubMed  CAS  Google Scholar 

  38. Birch J, Branemark PI. The vascularization of a free full thickness skin graft. 1. A vital microscopic study. Scand J Plast Reconstr Surg 1969; 3(1):1–10

    Article  PubMed  CAS  Google Scholar 

  39. Rudolph R, Klein L. Healing processes in skin grafts. Surg Gynecol Obstet 1973; 136(4):641–54

    PubMed  CAS  Google Scholar 

  40. Hinshaw JR, Miller ER. Histology of healing split-thickness, full-thickness autogenous skin grafts and donor sites. Arch Surg 1965; 91(4):658–70

    Article  PubMed  CAS  Google Scholar 

  41. Teh BT. Why do skin grafts fail? Plast Reconstr Surg 1979; 63(3):323–32

    Article  PubMed  CAS  Google Scholar 

  42. Robson MC, Krizek TJ. Predicting skin graft survival. J Trauma 1973; 13(3):213–7

    Article  PubMed  CAS  Google Scholar 

  43. Steffe TJ, Caffee HH. Long term results following free tissue transfer for venous stasis ulcers. Ann Plast Surg 1998; in press

    Google Scholar 

  44. Michaelides P, Camisa C. The treatment of ulcers on legs with split-thickness skin grafts: report of a simple technique. J Dermatol Surg Oncol 1979; 5(12):961–5

    PubMed  CAS  Google Scholar 

  45. Townsend J. Skin-grafting leg ulcers. Lancet 1970; 1(7636):39

    Article  PubMed  CAS  Google Scholar 

  46. Millard LG, Roberts MM, Gatecliffe M. Chronic leg ulcers treated by the pinch graft method. Br J Dermatol 1977; 97(3): 289–95

    Article  PubMed  CAS  Google Scholar 

  47. Kirsner RS, Falanga V. Techniques of split-thickness skin grafting for lower extremity ulcerations [see comments]. J Dermatol Surg Oncol 1993; 19(8):779–83

    PubMed  CAS  Google Scholar 

  48. Kirsner RS, Mata SM, Falanga V et al. Split-thickness skin grafting of leg ulcers. The University of Miami Department of Dermatologys experience (1990–1993). Dermatol Surg 1995; 21(8):701–3

    Article  PubMed  CAS  Google Scholar 

  49. Ceilley RI, Rinek MA, Zuehlke RL. Pinch grafting for chronic ulcers on lower extremities. J Dermatol Surg Oncol 1977; 3(3):303–9

    PubMed  CAS  Google Scholar 

  50. Berretty PJ, Neumann HA, de Limpens AM et al. Treatment of ulcers on legs from venous hypertension by split-thickness skin grafts. J Dermatol Surg Oncol 1979; 5(12):966–70

    PubMed  CAS  Google Scholar 

  51. Mol MA, Nanninga PB, van Eendenburg JP et al. Grafting of venous leg ulcers. An intraindividual comparison between cultured skin equivalents and full-thickness skin punch grafts [see comments]. J Am Acad Dermatol 1991; 24(1):77–82

    Article  PubMed  CAS  Google Scholar 

  52. Picascia DD, Roenigk HH Jr. Surgical management of leg ulcers. Dermatol Clin. 1987; 5(2):303–12

    PubMed  CAS  Google Scholar 

  53. Poskitt KR, James AH, Lloyd-Davies ER et al. Pinch skin grafting or porcine dermis in venous ulcers: a randomised clinical trial. Br Med J (Clin Res Ed) 1987; 294(6573):674–6

    Article  CAS  Google Scholar 

  54. van den Hoogenband HM. Treatment of leg ulcers with split-thickness skin grafts. J Dermatol Surg Oncol 1984; 10(8):605–8

    PubMed  CAS  Google Scholar 

  55. Wheeland RG. The technique and current status of pinch grafting. J Dermatol Surg Oncol 1987; 13(8):873–80

    PubMed  CAS  Google Scholar 

  56. Dzubow LM. Skin grafts [comment]. Dermatol Surg. 1995; 21(3):202

    Article  PubMed  CAS  Google Scholar 

  57. Dinner MI, Peters CR. Surgical management of ulcers on the lower limbs. J Dermatol Surg Oncol 1978; 4(9):696–9

    PubMed  CAS  Google Scholar 

  58. Field LM. Grafts for ulcers on legs [letter]. J Dermatol Surg Oncol 1980; 6(3):164–5

    PubMed  CAS  Google Scholar 

  59. Macadam R, Berridge DC. Use of split-skin grafting in the treatment of chronic leg ulcers [letter; comment]. Ann R Coll Surg Engl 1995; 77(6):463–4

    PubMed  CAS  Google Scholar 

  60. Rivlin S. Skin-grafting leg ulcers. Lancet 1969; 2(7633):1310

    Article  PubMed  CAS  Google Scholar 

  61. Ruffieux P, Rommel L, Saurat JH. Long-term assessment of chronic leg ulcer treatment by autologous skin grafts. Dermatology 1997; 195(1):77–80

    Article  PubMed  CAS  Google Scholar 

  62. Vesterager L. Split-skin grafting for ulcers on legs. J Dermatol Surg Oncol 1980; 6(9):739–41

    PubMed  CAS  Google Scholar 

  63. Wood MK, Davies DM. Use of split-skin grafting in the treatment of chronic leg ulcers [see comments]. Ann R Coll Surg Engl 1995; 77(3):222–3

    PubMed  CAS  Google Scholar 

  64. Monk BE, Sarkany I. Outcome of treatment of venous stasis ulcers. Clin Exp Dermatol 1982; 7(4):397–400

    Article  PubMed  CAS  Google Scholar 

  65. Lofgren KA, Lofgren EP. Extensive ulcerations in the postphlebitic leg. Surg Clin North Am 1969; 49(5):1033–42

    PubMed  CAS  Google Scholar 

  66. Brown, JB, Byars, LT, and Blair, VP. A study of ulcerations of the lower extremity and their repair with thick split skin grafts. Surg Gynec Obstet 1936; 63:331–40

    Google Scholar 

  67. Lofgren, KA. Surgical management of chronic venous insufficiency. Acta Chir Scand Suppl 1988; 544:62–8

    PubMed  CAS  Google Scholar 

  68. Cockett, FB. the pathology and treatment of venous ulcers of the leg. BrJSurg 1956; 43(179):260–78

    Google Scholar 

  69. Linton, RR. The post-thrombotic ulceration of the lower extremity: its etiology and surgical treatment. Ann Surg 1953; 138:415

    PubMed  CAS  Google Scholar 

  70. De Palma, RG. Surgical therapy for venous stasis. Surgery 1974; 76(6):910–7

    Google Scholar 

  71. Negus, D, Friedgood, A. The effective management of venous ulceration. Br J Surg 1983; 70(10):623–7

    CAS  Google Scholar 

  72. Hansson, LO. Venous ulcers of the lower limb: A follow-up study five years after surgical treatment. Acta Chir Scand 1964; 128:269–277

    PubMed  CAS  Google Scholar 

  73. Jamieson, WG, DeRose, G, Harris, KA. Management of venous stasis ulcer: long-term follow-up. Can J Surg 1990; 33(3):222–3

    PubMed  CAS  Google Scholar 

  74. Field, P, Van Boxel, P. The role of the Linton flap procedure in the management of stasis dermatitis and ulceration in the lower limb. Surgery 1971; 70(6):920–6

    PubMed  CAS  Google Scholar 

  75. Robison, JG, Elliott, BM, Kaplan, AJ. Limitations of subfascial ligation for refractory chronic venous stasis ulceration. Ann Vasc Surg 1992; 6(1):9–14

    Article  PubMed  CAS  Google Scholar 

  76. Silver, D, Gleysteen, JJ, Rhodes, GR et al. Surgical treatment of the refractory postphlebitic ulcer. Arch Surg 1971; 103(5):554–60

    Article  PubMed  CAS  Google Scholar 

  77. Harma, M, Asko-Seljavaara, S, Lauharanta, J. Surgical treatment of chronic leg ulcers [letter]. Acta Derm Venereal 1994; 74(6):484–5

    CAS  Google Scholar 

  78. Andersen, MN, McDonald, KE. Results of surgical therapy of severe stasis ulceration of the legs. Ann Surg 1963; 157(2):281–6

    Article  PubMed  CAS  Google Scholar 

  79. Teplitsky, D, Shapiro, RN, and Robertson, GW. radical excision and skin grafting of leg ulcers. Plast Reconst Surg 1948; 3(2):189–96

    Article  CAS  Google Scholar 

  80. Cikrit, DF, Nichols, WK, Silver, D. Surgical management of refractory venous stasis ulceration. J Vasc Surg 1988; 7(3):473–8

    PubMed  CAS  Google Scholar 

  81. Porter, JM, Griffiths, RW, McNeill, DC. The surgical management of intractable venous ulceration in the lower limbs: excision, decompression of the limb and split-skin grafting. Br] Plast Surg 1984; 37(2):179–83

    Article  CAS  Google Scholar 

  82. Lofgren, KA, Lauvstad, WA, Bonnemaison, MF. Surgical treatment of large stasis ulcer: review of 129 cases. Mayo Clin Proc 1965; 40:560–3

    PubMed  CAS  Google Scholar 

  83. Julian, OC, Dye, WS, Schneewind, J. Surgical management of ulcerative stasis disease of the lower extremities. Arch Surg 1954; 68:757–68

    Article  CAS  Google Scholar 

  84. Andersen, MN, Stephens, JG. A controlled study of surgical treatment and pathogenesis of stasis ulcers. Ann Surg 1959; 150(1):57–62

    CAS  Google Scholar 

  85. Romans, J. The etiology and treatment of varicose ulcer of the leg. Surg Gynecol Obstet 1917; 24:300–11

    Google Scholar 

  86. Trier, WC, Peacock, EE, Jr., Madden, JW. Studies on the effectiveness of surgical management of chronic leg ulcers. Plast Reconstr Surg 1970; 45(1):20–3

    Article  PubMed  CAS  Google Scholar 

  87. Burke, JF, Yannas, IV, Quinby, WC, Jr et al. Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg 1981; 194(4):413–28

    Article  PubMed  CAS  Google Scholar 

  88. Heimbach, D, Luterman, A, Burke, J et al. Artificial dermis for major burns. A multi-center randomized clinical trial. Ann Surg 1988; 208(3):313–20

    Article  PubMed  CAS  Google Scholar 

  89. Gallico, GGd, OConnor, NE, Compton, CC et al. Permanent coverage of large burn wounds with autologous cultured human epithelium. N Engl J Med 1984; 311(7):448–51

    Article  PubMed  Google Scholar 

  90. Mahajan, R, Mosley, JG. Use of a semipermeable polyamide dressing over skin grafts to venous leg ulcers. Br] Surg 1995; 82(10):1359–60

    Article  CAS  Google Scholar 

  91. Woodruff, EA. Biobrane, a biosynthetic skin prosthesis. In: DL Wise (ed.), Burn Wound Coverings New York, NY; CRC, Inc, 1984

    Google Scholar 

  92. Purdue, GF, Hunt, JL, Still, JM, Jr et al. A multicenter clinical trial of a biosynthetic skin replacement, Dermagraft-TC, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds. JBurn Care Rehabil 1997; 18(1 Pt 1):52–7

    Article  CAS  Google Scholar 

  93. Cooper, ML, Hansbrough, JF, Spielvogel, RL et al. In vivo optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic acid or polyglactin mesh. Biomaterials 1991; 12(2):243–8

    Article  PubMed  CAS  Google Scholar 

  94. Lees, V. Townsend, PL. Use of a pedicled fascial flap based on septocutaneous perforators of the posterior tibial artery for repair of distal lower limb defects. Br J Plast Surg 1992; 45(2):141–5

    Article  CAS  Google Scholar 

  95. Browse, NL, Burnand, KG, Thomas, ML. Diseases of the Veins, 2nd ed. London, Edward Arnold,1988: 424–7

    Google Scholar 

  96. Swartz, WM. Presented at the Proceedings of the Annual Meeting of the American Association of Plastic Surgeons. Scottsdale, AZ, 1989

    Google Scholar 

  97. Ramirez, OM. The effectiveness of the free muscle flap in the treatment of the recalcitrant venous stasis ulceration. Plast Surg Forum 1992; 15:77–78

    Google Scholar 

  98. Allen, RJ, Celentano, R, Dupin, C et al. Management of chronic venous insufficiency ulcers with free flaps: case study. Wounds 1989; 1:193–7

    Google Scholar 

  99. Dunn, RM, Fudem, GM, Walton, RL et al. Free flap valvular transplantation for refractory venous ulceration. J Vasc Surg 1994; 19(3):525–31

    Article  PubMed  CAS  Google Scholar 

  100. Aharinejad, S, Dunn, RM, Nourani, F et al. Morphological and clinical aspects of scapular fasciocutaneous free flap transfer for treatment of venous insufficiency in the lower extremity. ClinAnat 1998; 11(1):38–46

    CAS  Google Scholar 

  101. Aharinejad, S, Dunn, RM, Fudem, GM et al. The microvenous valvular anatomy of the human dorsal thoracic fascia. Plast Reconstr Surg 1997; 99(1):78–86

    Article  CAS  Google Scholar 

  102. Shimizu, T, Ohno, K, Michi, K. et al. Morphometric examination of the free scapular flap. Plast Reconstr Surg 1997; 99(7):1947–53

    Article  PubMed  CAS  Google Scholar 

  103. Dunn, RM, Fudem, GM, Vernadakis, AJ et al. The American Society of Reconstructive Microsurgery, Kamuela, Hawaii, 1999 (Accepted for presentation)

    Google Scholar 

  104. Weinzweig, N, Schlechter, B, Baraniewski, H et al. Lower-limb salvage in a patient with recalcitrant venous ulcerations. I Reconstr Microsurg 1997; 13(6):431–7

    Article  CAS  Google Scholar 

  105. Weinzweig, N, Schuler, J, Vitello, J. Simultaneous reconstruction of extensive soft-tissue defects of both lower limbs with free hemiflaps harvested from the omentum. Plast Reconstr Surg 1997; 99(3):757–62

    Article  PubMed  CAS  Google Scholar 

  106. Weinzweig, N, Schuler, J. Free tissue transfer in treatment of the recalcitrant chronic venous ulcer. Ann Plast Surg 1997; 38(6):611–9

    Article  PubMed  CAS  Google Scholar 

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Dunn, R.M., Rohrer, M.J., Vernadakis, A.J. (2000). Management of Venous Ulceration: Excision, Skin Grafting and Microsurgical Flaps. In: Ballard, J.L., Bergan, J.J. (eds) Chronic Venous Insufficiency. Springer, London. https://doi.org/10.1007/978-1-4471-0473-5_13

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