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Commentary on Section II

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Immunology for Surgeons

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Abstract

In Chapter 5, Morrissey and colleagues fully discuss the immunologic basis of tissue typing in solid organ transplantation. This area along with the other chapters in this section combines an understanding of the clinical practice of transplantation with that of immune regulation and tolerance. As indicated by the authors, new advances in immunotherapy offer promise whereby donor-specific unresponsiveness or “tolerance” to solid organ transplantation may be realized in the near future. This elusive goal of tolerance has as its raison d’être the creation of a microenvironment or milieu in which the recipient may accept an allograft without immunosuppression, but remains immunocompetent to the ravenous infiltrations of infectious organisms and neoplastic transformation. Several animal models are in evolution whereby the limited exposure to immunosuppression within the period of engraftment provides donor-specific hyporesponsiveness (tolerance).

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Authors
  1. Kirby I. Bland
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Editors and Affiliations

  1. Kaplan Medical Center, PO Box 23273, King George PO Branch, 61231, Tel Aviv, Israel

    Andrew P. Zbar (Head of Colorectal Surgery,Senior Consultant Colorectal Surgeon) (Head of Colorectal Surgery,Senior Consultant Colorectal Surgeon)

  2. St James’s University Hospital, School of Medicine, Division of Surgery, University of Leeds, Clinical Sciences Building, Leeds, LS9 7TF, UK

    Pierre J. Guillou

  3. Department of Surgery, University of Alabama School of Medicine, Boshell Diabetes Building,1808 7th Avenue South, Birmingham, AL, 35233, USA

    Kirby I. Bland (Professor and Chairman Dept of Surgery) (Professor and Chairman Dept of Surgery)

  4. Oncology Unit 3rd Department Medicine, Athens Medical School Sotiria General Hospital, Athens, Greece

    Konstantinos N. Syrigos (Associate Professor of Medical Oncology, Head) (Associate Professor of Medical Oncology, Head)

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© 2002 Springer-Verlag London

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Bland, K.I. (2002). Commentary on Section II. In: Zbar, A.P., Guillou, P.J., Bland, K.I., Syrigos, K.N. (eds) Immunology for Surgeons. Springer, London. https://doi.org/10.1007/978-1-4471-0201-4_11

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  • DOI: https://doi.org/10.1007/978-1-4471-0201-4_11

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-482-6

  • Online ISBN: 978-1-4471-0201-4

  • eBook Packages: Springer Book Archive

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