Biomechanical Modeling of the Brain for Computer-Assisted Neurosurgery

  • K. MillerEmail author
  • A. Wittek
  • G. Joldes
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)


During neurosurgery, the brain significantly deforms. Despite the enormous complexity of the brain (see Chap. 2) many aspects of its response can be reasonably described in purely mechanical terms, such as displacements, strains and stresses. They can therefore be analyzed using established methods of continuum mechanics. In this chapter, we discuss approaches to biomechanical modeling of the brain from the perspective of two distinct applications: neurosurgical simulation and neuroimage registration in image-guided surgery. These two challenging applications are described below.1


Hydrated Harness Incompressibility 
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The financial support of the Australian Research Council (Grants No. DP0343112, DP0664534 and LX0560460), National Health and Medical Research Council Grant No. 1006031 and NIH (Grant No. 1-RO3-CA126466-01A1) is gratefully acknowledged. We thank our collaborators Dr Ron Kikinis and Dr Simon Warfield from Harvard Medical School and Dr Kiyoyuki Chinzei and Dr Toshikatsu Washio from Surgical Assist Technology Group of AIST, Japan, for help in various aspects of our work.

The medical images used in the present study (provided by Dr Simon Warfield) were obtained in the investigation supported by a research grant from the Whitaker Foundation and by NIH grants R21 MH67054, R01 LM007861, P41 RR13218 and P01 CA67165.

We thank Toyota Central R&D Labs. (Nagakute, Aichi, Japan) for providing the THUMS brain model.


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Intelligent Systems for Medicine Laboratory, School of Mechanical and Chemical EngineeringThe University of Western AustraliaCrawley/PerthAustralia
  2. 2.Intelligent Systems for Medicine Laboratory, School of Mechanical and Chemical EngineeringThe University of Western AustraliaCrawley/PerthAustralia

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