Introduction to Brain Anatomy

  • Wieslaw L. NowinskiEmail author
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)


The human central nervous system (CNS), having been evolved over the last 600 million years, is the most complex living organ in the known universe. It has been extensively investigated over centuries, and a vast body of materials has been gathered in the print form and more recently also in electronic format. Neuroanatomy is presented in numerous textbooks [1–22], print brain atlases [23–51], and electronic brain atlases [52–74]. Several textbooks combine text with atlases [14, 15, 43, 44], and some provide neuroanatomy for various specialties including neurosurgery [1, 19, 22], neuroradiology [8, 17, 20], neurology [2], and neuroscience [18].



I am deeply grateful to Drs. J Talairach and P Tournoux for the insightful discussions about their atlases.

Numerous persons from our Biomedical Imaging Lab, A*STAR, Singapore, have contributed to the development of tools for atlas construction and atlas-assisted applications. The key contributors­ are BC Chua, A Thirunavuukarasuu, Y Marchenko, GY Qian, and I Volkau (the references [64, 65, 66, 67, 68, 69, 70, 76, 77, 78, 79, 80, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92] provide a more complete list of contributors). I thank Aminah Bivi for her editorial assistance.

I am also grateful to the reviewers: an anonymous reviewer and Dr. Joseph M. Corless, MD, PhD, Duke University Medical Center, for their valuable comments.

This work has been funded by A*STAR, Singapore.


Neuroanatomy Textbooks

  1. 1.
    Apuzzo, M.L.J., Todd, E.M., Trent Jr., H.W.: Surgery of the Human Cerebrum. Lippincott Williams & Wilkins, Philadelphia (2009)Google Scholar
  2. 2.
    Arslan, O.: Neuroanatomical Basis of Clinical Neurology. Parthenon, Lancaster (2001)CrossRefGoogle Scholar
  3. 3.
    Blumenfeld, H.: Neuroanatomy Through Clinical Cases. Sinauer Associates, Sunderland (2002)Google Scholar
  4. 4.
    Borden, N.M.: 3D Angiographic Atlas of Neurovascular Anatomy and Pathology. Cambridge University Press, Cambridge (2007)Google Scholar
  5. 5.
    Carpenter, M.B., Sutin, J.: Human Neuroanatomy. Williams and Wilkins, Baltimore (1983)Google Scholar
  6. 6.
    Grand, W., Hopkins, L.N.: Vasculature of the Brain and Cranial Base: Variations in Clinical Anatomy. Thieme, Stuttgart (1999)Google Scholar
  7. 7.
    Gray, H., Bannister, L.H., Berry, M.M., et al.: Gray’s Anatomy: The Anatomical Basis of Medicine and Surgery, 38th edn. Churchill Livingstone, Oxford (1995)Google Scholar
  8. 8.
    Harnsberger, H.R., Osborn, A.G., Ross, J., et al.: Diagnostic and Surgical Imaging Anatomy: Brain, Head and Neck, Spine. Amirsys, Salt Lake City (2006)Google Scholar
  9. 9.
    Hendelman, W.J.: Atlas of Functional Neuroanatomy. CRC Press LLC, Boca Raton (2000)CrossRefGoogle Scholar
  10. 10.
    Huber, P.: Cerebral Angiography, 2nd edn. Thieme, Stuttgart (1982)Google Scholar
  11. 11.
    Kretschmann, H.J., Weinrich, W.: Neurofunctional Systems. 3D Reconstructions with Correlated Neuroimaging. Thieme, Stuttgart (1998)Google Scholar
  12. 12.
    Kretschmann, H.J., Weinrich, W.: Cranial Neuroimaging and Clinical Neuroanatomy, 3rd edn. Thieme, Stuttgart (2004)Google Scholar
  13. 13.
    Lasjaunias, P., Berenstein, A., ter Brugge, K.G.: Surgical Neuroangiography: Clinical Vascular Anatomy and Variations, 2nd edn. Springer, Berlin (2001)Google Scholar
  14. 14.
    Martin, J.: Neuroanatomy. Text and Atlas. Appleton & Lange, Norwalk (1989)Google Scholar
  15. 15.
    Netter, F.H.: The Ciba Collection of Medical Illustrations, Volume 1: Nervous System, Part 1: Anatomy and Physiology. Ciba-Geigy, New Jersey (1991)Google Scholar
  16. 16.
    Nieuwennhuys, R., Voogd, J., van Huijzen, C.: The Human Central Nervous System. A Synopsis and Atlas, 4th edn. Springer, Berlin (2008)Google Scholar
  17. 17.
    Osborn, A.G., Ross, J., Crim, J., et al.: Expert Differential Diagnoses: Brain and Spine. Amirsys, Salt Lake City (2008)Google Scholar
  18. 18.
    Purves, D., Augustine, G.J., Fitzpatrick, D., et al.: Neuroscience, 4th edn. Sinauer Associates, Sunderland (2007)Google Scholar
  19. 19.
    Rhoton, A.L.: Cranial Anatomy and Surgical Approaches. The Congress of Neurological Surgeons, Schaumburg (2003)Google Scholar
  20. 20.
    Salamon, G., Huang, Y.P.: Radiological Anatomy of the Brain. Springer, Berlin (1976)Google Scholar
  21. 21.
    Stephens, R.B., Stilwell, D.L.: Arteries and Veins of the Human Brain. CC Thomas, Springfield (1969)Google Scholar
  22. 22.
    Yasargil, M.G.: Microneurosurgery, vol. 1. Thieme, Stuttgart (1984)Google Scholar

Print Brain Atlases

  1. 23.
    Afshar, E., Watkins, E.S., Yap, J.C.: Stereotactic Atlas of the Human Brainstem and Cerebellar Nuclei. Raven, New York (1978)Google Scholar
  2. 24.
    Andrew, J., Watkins, E.S.: A Stereotaxic Atlas of the Human Thalamus and Adjacent Structures. A Variability Study. Williams and Wilkins, Baltimore (1969)Google Scholar
  3. 25.
    Cho, Z.H.: 7.0 Tesla MRI Brain Atlas: In Vivo Atlas with Cryomacrotome Correlation. Springer, Heidelberg (2009)Google Scholar
  4. 26.
    DeArmond, S.J., Fusco, M.M., Dewey, M.M.: Structure of the Human Brain. A Photographics Atlas, 3rd edn. Oxford University Press, New York (1989)Google Scholar
  5. 27.
    Duvernoy, H.M.: The Human Brain. Surface, Three-Dimensional Sectional Anatomy with MRI, and Blood Supply. Springer, New York (1999)Google Scholar
  6. 28.
    Duvernoy, H.M.: The Human Hippocampus: An Atlas of Applied Anatomy. Bergman, Munch (1988)Google Scholar
  7. 29.
    England, M., Wakeley, J.: Color Atlas of the Brain and Spinal Cord, 2nd edn. Mosby, St Louis (2005)Google Scholar
  8. 30.
    Fix, J.D.: Atlas of the Human Brain and Spinal Cord. Aspen, Rockville (1987)Google Scholar
  9. 31.
    Haines, D.E.: Neuroanatomy: An Atlas of Structures, Sections, and Systems, 7th edn. Lippincott Williams & Wilkins, Baltimore (2008)Google Scholar
  10. 32.
    Kraus, G.E., Bailey, G.J.: Microsurgical Anatomy of the Brain. A Stereo Atlas. Wiliams & Wilkins, Baltimore (1994)Google Scholar
  11. 33.
    Mai, J.K., Assheur, J., Paxinos, G.: Atlas of the Human Brain, 2nd edn. Academic, San Diego (2003)Google Scholar
  12. 34.
    Mai, J.K., Paxinos, G., Voss, T.: Atlas of the Human Brain, 3rd edn. Academic, Oxford (2008)Google Scholar
  13. 35.
    McMinn, R.M.H., Hutchings, R.T., Pegington, J., et al.: Color Atlas of Human Anatomy, 3rd edn. Mosby Year Book, St. Louis (1993)Google Scholar
  14. 36.
    Morel, A., Magnin, M., Jeanmonod, D.: Multiarchitectonic and stereotactic atlas of the human thalamus. J. Comp. Neurol. 387, 588–630 (1997)CrossRefGoogle Scholar
  15. 37.
    Naidich, T.P., Duvernoy, H.M., Delman, B.N., et al.: Duvernoy’s Atlas of the Human Brain Stem and Cerebellum: High-Field MRI, Surface Anatomy, Internal Structure, Vascularization and 3D Sectional Anatomy. Springer, New York (2009)Google Scholar
  16. 38.
    Ono, M., Kubik, S., Abernathey, C.D.: Atlas of the Cerebral Sulci. Thieme, Stuttgart (1990)Google Scholar
  17. 39.
    Orrison Jr., W.W.: Atlas of Brain Function, 2nd edn. Thieme, New-York (2008)Google Scholar
  18. 40.
    Putz, R.: Sobotta Atlas of Human Anatomy: Head, Neck, Upper Limb, Thorax, Abdomen, Pelvis, Lower Limb, 14th edn. Churchill Livingstone, Oxford (2008)Google Scholar
  19. 41.
    Schaltenbrand, G., Bailey, W.: Introduction to Stereotaxis with an Atlas of the Human Brain. Thieme, Stuttgart (1959)Google Scholar
  20. 42.
    Schaltenbrand, G., Wahren, W.: Atlas for Stereotaxy of the Human Brain. Thieme, Stuttgart (1977)Google Scholar
  21. 43.
    Schitzlein, H.N., Murtagh, F.R.: Imaging Anatomy of the Head and Spine. A Photographic Color Atlas of MRI, CT, Gross, and Microscopic Anatomy in Axial, Coronal, and Sagittal Planes, 2nd edn. Urban & Schwarzenberg, Baltimore (1990)Google Scholar
  22. 44.
    Schuenke, M., Schulte, E., Schumacher, U., et al.: Head and Neuroanatomy. Thieme Atlas of Anatomy. Thieme, New York (2007)Google Scholar
  23. 45.
    Speigel, E.A., Wycis, H.T.: Stereoencephalotomy: Part I. Methods and Stereotactic Atlas of the Human Brain. Grune and Stratton, New York (1952)Google Scholar
  24. 46.
    Szikla, G., Bouvier, G., Hori, T.: Angiography of the Human Brain Cortex: Atlas of Vascular Patterns and Stereotactic Localization. Springer, Berlin (1977)Google Scholar
  25. 47.
    Talairach, J., David, M., Tournoux, P.: Atlas d’Anatomie Stereotaxique des Noyaux Gris Centraux. Masson, Paris (1957)Google Scholar
  26. 48.
    Talairach, J., Tournoux, P.: Co-Planar Stereotactic Atlas of the Human Brain. Thieme, Stuttgart (1988)Google Scholar
  27. 49.
    Talairach, J., Tournoux, P.: Referentially Oriented Cerebral MRI Anatomy: Atlas of Stereotaxic Anatomical Correlations for Gray and White Matter. Thieme, Stuttgart (1993)Google Scholar
  28. 50.
    Van Buren, J.M., Borke, R.C.: Variations and Connections of the Human Thalamus. Springer, Berlin (1972)Google Scholar
  29. 51.
    Woolsey, T.A., Hanaway, J., Mokhtar, H.G.: The Brain Atlas: A Visual Guide to the Human Central Nervous System, 2nd edn. Wiley, New Jersey (2003)Google Scholar

Electronic Brain Atlases

  1. 52.
    A.D.A.M.: A.D.A.M Animated Dissection of Anatomy for Medicine. User’s Guide, A.D.A.M. (1996)Google Scholar
  2. 53.
    Bayer: Microvascular Atlas of the Head and Neck. CD-ROM for Macintosh and Windows (1996)Google Scholar
  3. 54.
    Berkovitz, B., Kirsch, C., Moxham, B., et al.: Interactive Head & Neck. CD-ROM PC and Mac compatible. Primal, London (2003)Google Scholar
  4. 55.
    Bertrand, G., Olivier, A., Thompson, C.J.: Computer display of stereotaxic brain maps and probe tracts. Acta. Neurochir. Suppl. 21, 235–243 (1974)Google Scholar
  5. 56.
    Dev, P., Coppa, G.P., Tancred, E.: BrainStorm: desiging in interactive neuroanatomy atlas. Radiology 185, 413 (1992)Google Scholar
  6. 57.
    Evans, A.C., Collins, L., Milner, B.: An MRI-based stereotactic atlas from 250 young normal subjects. Soc. Neurosci. Abstr. 18, 408 (1992)Google Scholar
  7. 58.
    Ganser, K.A., Dickhaus, H., Metzner, R., et al.: A deformable digital brain atlas system according to Talairach and Tournoux. Med. Image Anal. 8(1), 3–22 (2004)CrossRefGoogle Scholar
  8. 59.
    Greitz, T., Bohm, C., Holte, S., et al.: A computerized brain atlas: construction, ­anatomical content, and some applications. J. Comput. Assist. Tomogr. 15(1), 26–38 (1991)CrossRefGoogle Scholar
  9. 60.
    Hoehne, K.H.: VOXEL-MAN, Part 1: Brain and Skull, Version 2.0. Springer, Heidelberg (2001)Google Scholar
  10. 61.
    Kazarnovskaya, M.I., Borodkin, S.M., Shabalov, V.A.: 3-D computer model of subcortical structures of human brain. Comput. Biol. Med. 21, 451–457 (1991)CrossRefGoogle Scholar
  11. 62.
  12. 63.
    Nowinski, W.L., Bryan, R.N., Raghavan, R.: The Electronic Clinical Brain Atlas. Multiplanar Navigation of the Human Brain. Thieme, New York (1997)Google Scholar
  13. 64.
    Nowinski, W.L., Thirunavuukarasuu, A., Kennedy, D.N.: Brain Atlas for Functional Imaging. Clinical and Research Applications. Thieme, New York (2000)Google Scholar
  14. 65.
    Nowinski, W.L., Thirunavuukarasuu, A., Bryan, R.N.: The Cerefy Atlas of Brain Anatomy. An Introduction to Reading Radiological Scans for Students, Teachers, and Researchers. Thieme, New York (2002)Google Scholar
  15. 66.
    Nowinski, W.L., Thirunavuukarasuu, A.: The Cerefy Clinical Brain Atlas on CD-ROM. Thieme, New York (2004)Google Scholar
  16. 67.
    Nowinski, W.L., Thirunavuukarasuu, A., Benabid, A.L.: The Cerefy Clinical Brain Atlas: Enhanced Edition with Surgical Planning and Intraoperative Support. Thieme, New York (2005)Google Scholar
  17. 68.
    Nowinski, W.L., Thirunavuukarasuu, A., Volkau, I., et al.: The Cerefy Atlas of Cerebral Vasculature. Thieme, New York (2009)Google Scholar
  18. 69.
    Nowinski, W.L., Chua, B.C., Qian, G.Y., et al.: The Human Brain in 1492 Pieces. Structure, Vasculature, and Tracts. Thieme, New York (2011)Google Scholar
  19. 70.
    Nowinski, W.L., Thirunnavuukarasuu, A., Volkau, I., et al.: A three-dimensional interactive atlas of cerebral arterial variants. Neuroinformatics 7(4), 255–264 (2009)CrossRefGoogle Scholar
  20. 71.
    Sramka, M., Ruzicky, E., Novotny, M.: Computerized brain atlas in functional neurosurgery. Stereotact. Funct. Neurosurg. 69, 93–98 (1997)CrossRefGoogle Scholar
  21. 72.
    Sundsten, J.W., Brinkley, J.F., Eno, K., et al.: The Digital Anatomist. Interactive Brain Atlas. CD ROM for the Macintosh. University of Washington, Seattle (1994)Google Scholar
  22. 73.
    Yelnik, J., Bardinet, E., Dormont, D., et al.: A three-dimensional, histological and deformable atlas of the human basal ganglia. I. Atlas construction based on immunohistochemical and MRI data. Neuroimage 34(2), 618–638 (2007)CrossRefGoogle Scholar
  23. 74.
    Yoshida, M.: Three-dimensional maps by interpolation from the Schaltenbrand and Bailey atlas. In: Kelly, P.J., Kall, B.A. (eds.) Computers in Stereotactic Neurosurgery, pp. 143–152. Blackwell, Boston (1992)Google Scholar


  1. 75.
    Federative Committee on Anatomical Terminology (FCAT): Terminologia Anatomica. Thieme, Stuttgart (1999)Google Scholar
  2. 76.
    Nowinski, W.L., Volkau, I., Marchenko, Y., et al.: A 3D model of the human cerebrovasculature derived from 3 tesla 3 dimensional time-of-flight magnetic resonance angiography. Neuroinformatics 7(1), 23–36 (2009)CrossRefGoogle Scholar
  3. 77.
    Nowinski, W.L., Thirunavuukarasuu, A., Volkau, I., et al.: A new presentation and exploration of human cerebral vasculature correlated with surface and sectional neuroanatomy. Anat. Sci. Educ. 2(1), 24–33 (2009)CrossRefGoogle Scholar
  4. 78.
    Nowinski, W.L.: The cerefy brain atlases: continuous enhancement of the electronic Talairach-Tournoux brain atlas. Neuroinformatics 3(4), 293–300 (2005)CrossRefGoogle Scholar
  5. 79.
    Nowinski, W.L.: Electronic brain atlases: features and applications. In: Caramella, D., Bartolozzi, C. (eds.) 3D Image Processing: Techniques and Clinical Applications. Medical Radiology series, pp. 79–93. Springer, Berlin (2002)Google Scholar
  6. 80.
    Nowinski, W.L., Fang, A., Nguyen, B.T., et al.: Multiple brain atlas database and atlas-based neuroimaging system. Comput. Aided Surg. 2(1), 42–66 (1997)CrossRefGoogle Scholar
  7. 81.
    Marchenko, Y., Volkau, I., Nowinski, W.L.: Vascular editor: from images to 3D vascular ­models. J. Digit. Imaging 23(4), 386–398 (2010)CrossRefGoogle Scholar
  8. 82.
    Gelas, A., Valette, S., Prost, R., et al.: Variational implicit surface meshing. Comput. Graph. 33, 312–320 (2009)CrossRefGoogle Scholar
  9. 83.
    Volkau, I., Zheng, W., Aziz, A., et al.: Geometric modeling of the human normal cerebral arterial system. IEEE Trans. Med. Imaging 24, 529–539 (2005)CrossRefGoogle Scholar
  10. 84.
    Nowinski, W.L.: Anatomical and probabilistic functional atlases in stereotactic and functional neurosurgery. In: Lozano, A., Gildenberg, P., Tasker, R. (eds.) Textbook of Stereotactic and Functional Neurosurgery, 2nd edn, pp. 395–441. Springer, Berlin (2009)CrossRefGoogle Scholar
  11. 85.
    Nowinski, W.L., Qian, G., Bhanu Prakash, K.N., et al.: A CAD system for acute ischemic stroke image processing. Int. J. Comput. Assisted Radiol. Surg. 2(suppl 1), 220–222 (2007)Google Scholar
  12. 86.
    Nowinski, W.L., Qian, G., Bhanu Prakash, K.N., et al.: Analysis of ischemic stroke MR images by means of brain atlases of anatomy and blood supply territories. Acad Radiol. 13(8), 1025–1034 (2006)CrossRefGoogle Scholar
  13. 87.
    Nowinski, W.L., Belov, D.: The cerefy neuroradiology atlas: a Talairach-Tournoux atlas-based tool for analysis of neuroimages available over the internet. Neuroimage 20(1), 50–57 (2003)CrossRefGoogle Scholar
  14. 88.
    Nowinski, W.L., Thirunavuukarasuu, A.: A locus-driven mechanism for rapid and automated atlas-assisted analysis of functional images by using the Brain Atlas for Functional Imaging. Neurosurg Focus 15(1), Article 3 (2003)CrossRefGoogle Scholar
  15. 89.
    Nowinski, W.L., Benabid, A.L.: New directions in atlas-assisted stereotactic functional neurosurgery. In: Germano, I.M. (ed.) Advanced Techniques in Image-Guided Brain and Spine Surgery, pp. 162–174. Thieme, New York (2002)Google Scholar
  16. 90.
    Nowinski, W.L.: Computerized brain atlases for surgery of movement disorders. Semin. Neurosurg. 12(2), 183–194 (2001)CrossRefGoogle Scholar
  17. 91.
    Nowinski, W.L., Yang, G.L., Yeo, T.T.: Computer-aided stereotactic functional neurosurgery enhanced by the use of the multiple brain atlas database. IEEE Trans. Med. Imaging 19(1), 62–69 (2000)CrossRefGoogle Scholar
  18. 92.
    Nowinski, W.L., Chua, B.C., Volkau, I., et al.: Simulation and assessment of cerebrovascular damage in deep brain stimulation using a stereotactic atlas of vasculature and structure derived from multiple 3T and 7T scans. J. Neurosurg. 113, 1234–1241 (2010)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Biomedical Imaging Lab, ASTARSingaporeSingapore

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