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Sphingosine and Sphingosine 1 Phosphate in the Brain

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Lipid Mediators and Their Metabolism in the Brain

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Abstract

Sphingosine is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain. It is found in sphingolipids (cerbroside, sulfatide, and ganglioside) as well as phospholipid (sphingomyelin) (Fig. 9.1). Sphingomyelin (SM) is the major membrane sphingolipid and is the precursor for ceramide and sphingosine. Like ceramide, sphingosine not only regulates activities of phospholipases (PLA2, PLC, and PLD), and protein kinases (PKC and PKA), but also ion channels, CB1 receptors, and SF1 nuclear receptors (Fig. 9.2).

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  1. Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, 43210, USA

    Akhlaq A. Farooqui

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  1. Akhlaq A. Farooqui
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Farooqui, A.A. (2011). Sphingosine and Sphingosine 1 Phosphate in the Brain. In: Lipid Mediators and Their Metabolism in the Brain. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9940-5_9

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