Skip to main content
SpringerLink
Log in

Suprachoroidal and Intrascleral Drug Delivery

  • Chapter
  • First Online:
Drug Product Development for the Back of the Eye

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 2))

Abstract

Local drug delivery to the eye minimizes systemic side effects and targets specific ocular tissue. In preclinical studies, transscleral and suprachoroidal delivery appear to achieve therapeutic drug tissue levels that target specific tissues, such as the choroid and macula. These routes allow minimally invasive sustained delivery of drugs to the ocular posterior segment while minimizing systemic drug levels and the associated side effects.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY, Sy JP, Schneider S (2006) Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 355:1432–1444

    Article  PubMed  CAS  Google Scholar 

  • Choy YB, Park JH, McCarey BE, Edelhauser HF, Prausnitz MR (2008) Mucoadhesive microdiscs engineered for ophthalmic drug delivery: effect of particle geometry and formulation on preocular residence time. Invest Ophthalmol Vis Sci 49:4808–4815

    Article  PubMed  Google Scholar 

  • Einmahl S, Savoldelli M, D’Hermies F, Tabatabay C, Gurny R, Behar-Cohen F (2002) Evaluation of a novel biomaterial in the suprachoroidal space of the rabbit eye. Invest Ophthalmol Vis Sci 43:1533–1539

    PubMed  Google Scholar 

  • Geroski DH, Edelhauser HF (2000) Drug delivery for posterior segment eye disease. Invest Ophthalmol Vis Sci 41:961–964

    PubMed  CAS  Google Scholar 

  • Gilger BC, Salmon JH (2010) Ocular posterior segment drug distribution from a single injection into the anterior suprachoroidal space. ARVO. Ft. Lauderdale, FL, Invest ophthalmol Vis Sci

    Google Scholar 

  • Gilger BC, Reeves KA, Salmon JH (2005) Ocular parameters related to drug delivery in the canine and equine eye: aqueous and vitreous humor volume and scleral surface area and thickness. Vet Ophthalmol 8:265–269

    Article  PubMed  CAS  Google Scholar 

  • Gilger BC, Salmon JH, Wilkie DA, Cruysberg LP, Kim J, Hayat M, Kim H, Kim S, Yuan P, Lee SS, Harrington SM, Murray PR, Edelhauser HF, Csaky KG, Robinson MR (2006) A novel bioerodible deep scleral lamellar cyclosporine implant for uveitis. Invest Ophthalmol Vis Sci 47:2596–2605

    Article  PubMed  Google Scholar 

  • Gragoudas ES, Adamis AP, Cunningham ET Jr, Feinsod M, Guyer DR (2004) Pegaptanib for neovascular age-related macular degeneration. N Engl J Med 351:2805–2816

    Article  PubMed  CAS  Google Scholar 

  • Jiang J, Geroski DH, Edelhauser HF, Prausnitz MR (2006) Measurement and prediction of lateral diffusion within human sclera. Invest Ophthalmol Vis Sci 47:3011–3016

    Article  PubMed  Google Scholar 

  • Jiang J, Gill HS, Ghate D, McCarey BE, Patel SR, Edelhauser HF, Prausnitz MR (2007) Coated microneedles for drug delivery to the eye. Invest Ophthalmol Vis Sci 48:4038–4043

    Article  PubMed  Google Scholar 

  • Jiang J, Moore JS, Edelhauser HF, Prausnitz MR (2009) Intrascleral drug delivery to the eye using hollow microneedles. Pharm Res 26:395–403

    Article  PubMed  CAS  Google Scholar 

  • Lewis RA, von Wolff K, Tetz M, Koerber N, Kearney JR, Shingleton BJ, Samuelson TW (2009) Canaloplasty: circumferential viscodilation and tensioning of Schlemm canal using a flexible microcatheter for the treatment of open-angle glaucoma in adults: two-year interim clinical study results. J Cataract Refract Surg 35:814–824

    Article  PubMed  Google Scholar 

  • Maurice DM, Polgar J (1977) Diffusion across the sclera. Exp Eye Res 25:577–582

    Article  PubMed  CAS  Google Scholar 

  • Olsen TW, Edelhauser HF, Lim JI, Geroski DH (1995) Human scleral permeability. Effects of age, cryotherapy, transscleral diode laser, and surgical thinning. Invest Ophthalmol Vis Sci 36:1893–1903

    PubMed  CAS  Google Scholar 

  • Olsen TW, Aaberg SY, Geroski DH, Edelhauser HF (1998) Human sclera: thickness and surface area. Am J Ophthalmol 125:237–241

    Article  PubMed  CAS  Google Scholar 

  • Olsen TW, Sanderson S, Feng X, Hubbard WC (2002) Porcine sclera: thickness and surface area. Invest Ophthalmol Vis Sci 43:2529–2532

    PubMed  Google Scholar 

  • Olsen TW, Feng X, Wabner K, Conston SR, Sierra DH, Folden DV, Smith ME, Cameron JD (2006) Cannulation of the suprachoroidal space: a novel drug delivery methodology to the posterior segment. Am J Ophthalmol 142:777–787

    Article  PubMed  CAS  Google Scholar 

  • Olsen TW, Feng X, Wabner K, Csaky KG, Cameron JD, Pambuccian S, Nguyen T (2010) Microcannula suprachoroidal versus intravitreal injections of bevacizumab in the pig model. ARVO, Fort Lauderdale, FL

    Google Scholar 

  • Robinson MR, Lee SS, Kim H, Kim S, Lutz RJ, Galban C, Bungay PM, Yuan P, Wang NS, Kim J, Csaky KG (2006) A rabbit model for assessing the ocular barriers to the transscleral delivery of triamcinolone acetonide. Exp Eye Res 82:479–487

    Article  PubMed  CAS  Google Scholar 

  • Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY (2006) Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355:1419–1431

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Emory Eye Center, Emory University School of Medicine, Atlanta, GA, USA

    Timothy W. Olsen MD

  2. Department of Ophthalmology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA

    Brian C. Gilger DVM MS Dipl. ACVO, Dipl. ABT

Authors
  1. Timothy W. Olsen MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brian C. Gilger DVM MS Dipl. ACVO, Dipl. ABT
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Timothy W. Olsen MD .

Editor information

Editors and Affiliations

  1. School of Pharmacy, University of Colorado Denver, East 17th Avenue 12631, Aurora, 80045, Colorado, USA

    Uday B. Kompella

  2. School of Medicine, Emory University, Clifton Road NE., 1365, Atlanta, 30322, Georgia, USA

    Henry F. Edelhauser

Rights and permissions

Reprints and permissions

Copyright information

© 2011 American Association of Pharmaceutical Scientists

About this chapter

Cite this chapter

Olsen, T.W., Gilger, B.C. (2011). Suprachoroidal and Intrascleral Drug Delivery. In: Kompella, U., Edelhauser, H. (eds) Drug Product Development for the Back of the Eye. AAPS Advances in the Pharmaceutical Sciences Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9920-7_8

Download citation

Publish with us

Policies and ethics

Societies and partnerships

Search

Navigation