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Transscleral Drug Delivery

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Drug Product Development for the Back of the Eye

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 2))

Abstract

The treatment of diseases of the posterior segment of the eye remains limited by the ability to deliver effective doses of drugs to target tissues in the posterior eye. Topical delivery as drops and systemic delivery require large doses and remain limited in delivering effective doses to the back of the eye. Intravitreal injection and implantation of intravitreal sustained-release delivery devices are effective but invasive, and both modes of delivery share potential risks of retinal detachment, endophtalmitis, hemorrhage, and cataract. Numerous studies have demonstrated that drugs and solutes can diffuse across the sclera in vitro and in situ when delivered by a periocular approach. Transscleral delivery could provide an effective alternative approach for delivering therapeutic agents to the posterior tissues of the eye.

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Acknowledgments

Supported in part by R24EY017045 and Research to Prevent Blindness Inc.

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Authors and Affiliations

  1. Emory University School of Medicine, Eye Center, Atlanta, GA, USA

    Dayle H. Geroski PhD

  2. Emory University Eye Center, Emory University, 1365 Clifton Road NE, Atlanta, GA, 30332, USA

    Henry F. Edelhauser PhD

Authors
  1. Dayle H. Geroski PhD
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  2. Henry F. Edelhauser PhD
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Corresponding author

Correspondence to Henry F. Edelhauser PhD .

Editor information

Editors and Affiliations

  1. School of Pharmacy, University of Colorado Denver, East 17th Avenue 12631, Aurora, 80045, Colorado, USA

    Uday B. Kompella

  2. School of Medicine, Emory University, Clifton Road NE., 1365, Atlanta, 30322, Georgia, USA

    Henry F. Edelhauser

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© 2011 American Association of Pharmaceutical Scientists

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Geroski, D.H., Edelhauser, H.F. (2011). Transscleral Drug Delivery. In: Kompella, U., Edelhauser, H. (eds) Drug Product Development for the Back of the Eye. AAPS Advances in the Pharmaceutical Sciences Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9920-7_7

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