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Drug Product Development for the Back of the Eye pp 495–563Cite as

Druggable Targets and Therapeutic Agents for Disorders of the Back of the Eye

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Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 2))

Abstract

The retina and associated supportive tissues must perform large amounts of metabolic work to effectively process visual information. Metabolic imbalances in these tissues can lead to various diseases of the back of the eye that generally involve the interplay of three major processes: inflammation, neovascularization, and degeneration. Improved understanding of these processes within the back of the eye has led to the development of a rather large number of new therapeutics over the last decade and this process shows no sign of slowing down. This chapter summarizes emerging drug targets, new drugs, and drugs undergoing clinical trials for treating various back of the eye diseases including age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, infections, and autoimmune uveitis.

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Acknowledgments

This work was supported by the NIH grants R01EY018940 and R01EY017533.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, University of Colorado, 12850 East Montview Blvd., C238-V20, Aurora, CO, 80045, USA

    Robert I. Scheinman PhD

  2. Nanomedicine and Drug Delivery Laboratory, University of Colorado, Aurora, CO, USA

    Sunil K. Vooturi PhD

  3. Nanomedicine and Drug Delivery Laboratory Department of Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA

    Uday B. Kompella PhD

  4. Department of Ophthalmology, University of Colorado, Aurora, CO, USA

    Uday B. Kompella PhD

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  1. Robert I. Scheinman PhD
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Correspondence to Robert I. Scheinman PhD .

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  1. School of Pharmacy, University of Colorado Denver, East 17th Avenue 12631, Aurora, 80045, Colorado, USA

    Uday B. Kompella

  2. School of Medicine, Emory University, Clifton Road NE., 1365, Atlanta, 30322, Georgia, USA

    Henry F. Edelhauser

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Scheinman, R.I., Vooturi, S.K., Kompella, U.B. (2011). Druggable Targets and Therapeutic Agents for Disorders of the Back of the Eye. In: Kompella, U., Edelhauser, H. (eds) Drug Product Development for the Back of the Eye. AAPS Advances in the Pharmaceutical Sciences Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9920-7_21

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