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Hydrogels for Ocular Posterior Segment Drug Delivery

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Drug Product Development for the Back of the Eye

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 2))

Abstract

This chapter discusses emerging hydrogel technology for drug delivery to the back of the eye to treat retinal diseases. The review includes design, characterization and optimization of hydrogels, and advantages and disadvantages of intravitreally and subconjunctivally administrated hydrogels for retinal therapy. Future direction of hydrogel technology for targeted and sustained delivery of drugs to the retina for individualized medicine is also laid out.

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Acknowledgments

The work was supported by the NIH, JDRF and Coulter Foundation grants. TWG is the Jack and Nancy Turner Professor.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Thomas Jefferson University, School of Pharmacy, Philadelphia, PA, USA

    Gauri P. Misra PhD

  2. Department of Ophthalmology, Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA

    Thomas W. Gardner PhD

  3. Department of Pharmaceutical Sciences, School of Pharmacy, Thomas Jefferson University, Philadelphia, PA, 19107, USA

    Tao L. Lowe PhD

  4. Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

    Tao L. Lowe PhD

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  1. Gauri P. Misra PhD
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  2. Thomas W. Gardner PhD
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  3. Tao L. Lowe PhD
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Correspondence to Tao L. Lowe PhD .

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Editors and Affiliations

  1. School of Pharmacy, University of Colorado Denver, East 17th Avenue 12631, Aurora, 80045, Colorado, USA

    Uday B. Kompella

  2. School of Medicine, Emory University, Clifton Road NE., 1365, Atlanta, 30322, Georgia, USA

    Henry F. Edelhauser

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© 2011 American Association of Pharmaceutical Scientists

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Misra, G.P., Gardner, T.W., Lowe, T.L. (2011). Hydrogels for Ocular Posterior Segment Drug Delivery. In: Kompella, U., Edelhauser, H. (eds) Drug Product Development for the Back of the Eye. AAPS Advances in the Pharmaceutical Sciences Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9920-7_12

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