Epidemiologic Basis of the Role of Environmental Endocrine Disruptors in Breast Cancer

Chapter

Abstract

What can be said about the role of environmental ­endocrine disruptors in breast cancer from epidemiologic studies of humans? To address this question, we define endocrine disruptors, consider their sources in the environment, document the breast cancer trends in incidence and mortality over time, place exposures in the context of “windows of susceptibility,” discuss the strengths and limitations of the epidemiologic approach in environmental studies, and review studies in humans relevant to this question across a range of endocrine disruptors. We take a life-course perspective on breast cancer etiology that encompasses the known and potential impact of environmental factors early in development and during ­“windows of susceptibility” across the life span. Such an approach presents certain challenges for human epidemiologic studies, which are discussed. However, observational epidemiologic studies, natural experiments, and novel study designs, along with toxicological and mechanistic studies using animal models, are creating a fuller picture of the role of the environment in breast cancer. Recommendations for filling gaps in our current knowledge of this topic complete the chapter.

Keywords

Epidemiology Endocrine disrupting chemicals Breast cancer Environment 

References

  1. Ambrosone CB et al (2008) Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis. Cancer Epidemiol Biomarkers Prev 17:15–26PubMedGoogle Scholar
  2. Andersen HR et al (1999) Comparison of short-term estrogenicity tests for identification of hormone-disrupting chemicals. Environ Health Perspect 107(suppl 1):89–108PubMedGoogle Scholar
  3. Baker VA et al (1999) Safety evaluation of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo and in vitro assays. Food Chem Toxicol 37:13–22PubMedGoogle Scholar
  4. Becher H et al (1998) Quantitative cancer risk assessment for dioxins using an occupational cohort. Environ Health Perspect 106(suppl 2):663–670PubMedGoogle Scholar
  5. Berkey CS et al (1999) Adolescence and breast carcinoma risk. Cancer 85:2400–2409PubMedGoogle Scholar
  6. Biro FM et al (2006) Pubertal correlates in black and white girls. J Pediatr 148:234–240PubMedGoogle Scholar
  7. Biro FM et al (2010) Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls. Pediatrics 126:e583–e590Google Scholar
  8. Blanck HM et al (2000) Age at menarche and tanner stage in girls exposed in utero and postnatally to polybrominated biphenyl. Epidemiology 11:641–647PubMedGoogle Scholar
  9. Boice JD et al (1991) Diagnostic x-ray procedures and risk of leukemia, lymphoma, and multiple myeloma. J Am Med Assoc 265:1290–1294Google Scholar
  10. Boice JD Jr et al (1995) Breast cancer among radiologic technologists. JAMA 274:394–401PubMedGoogle Scholar
  11. Bonner MR et al (2005) Breast cancer risk and exposure in early life to polycyclic aromatic hydrocarbons using total suspended particulates as a proxy measure. Cancer Epidemiol Biomarkers Prev 14:53–60PubMedGoogle Scholar
  12. Brody JG et al (2007) Environmental pollutants and breast cancer: epidemiologic studies. Cancer 109:2667–2711PubMedGoogle Scholar
  13. Brotons JA et al (1995) Xenoestrogens released from lacquer coatings in food cans. Environ Health Perspect 103:608–612PubMedGoogle Scholar
  14. Buck Louis GM et al (2008) Environmental factors and puberty timing: expert panel research needs. Pediatrics 121(suppl 3):S192–S207PubMedGoogle Scholar
  15. Bueno de Mesquita HB et al (1993) Occupational exposure to phenoxy herbicides and chlorophenols and cancer mortality in The Netherlands. Am J Ind Med 23:289–300PubMedGoogle Scholar
  16. Calafat AM et al (2005) Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population. Environ Health Perspect 113:391–395PubMedGoogle Scholar
  17. Calafat AM et al (2007) Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and comparisons with NHANES 1999-2000. Environ Health Perspect 115:1596–1602PubMedGoogle Scholar
  18. Calle EE et al (2002) Organochlorines and breast cancer risk. CA Cancer J Clin 52:301–309PubMedGoogle Scholar
  19. Cantor KP et al (1995) Occupational exposures and female breast cancer mortality in the United States. J Occup Environ Med 37:336–348PubMedGoogle Scholar
  20. Chepko G, Smith GH (1999) Mammary epithelial stem cells: our current understanding. J Mammary Gland Biol Neoplasia 4:35–52PubMedGoogle Scholar
  21. Choe SY et al (2003) Evaluation of estrogenicity of major heavy metals. Sci Total Environ 312:15–21PubMedGoogle Scholar
  22. Chou YY et al (2009) Phthalate exposure in girls during early puberty. J Pediatr Endocrinol Metab 22:69–77PubMedGoogle Scholar
  23. Clavel-Chapelon F (2002) Differential effects of reproductive factors on the risk of pre- and postmenopausal breast cancer. Results from a large cohort of French women. Br J Cancer 86:723–727PubMedGoogle Scholar
  24. Cohn BA et al (2003) DDT and DDE exposure in mothers and time to pregnancy in daughters. Lancet 361:2205–2206PubMedGoogle Scholar
  25. Cohn BA et al (2007) DDT and breast cancer in young women: new data on the significance of age at exposure. Environ Health Perspect 115:1406–1414PubMedGoogle Scholar
  26. Colditz GA, Frazier AL (1995) Models of breast cancer show that risk is set by events of early life: prevention efforts must shift focus. Cancer Epidemiol Biomarkers Prev 4:567–571PubMedGoogle Scholar
  27. Crain DA et al (2008) Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing. Fertil Steril 90:911–940PubMedGoogle Scholar
  28. de Waard F, Thijssen JH (2005) Hormonal aspects in the causation of human breast cancer: epidemiological hypotheses reviewed, with special reference to nutritional status and first pregnancy. J Steroid Biochem Mol Biol 97:451–458PubMedGoogle Scholar
  29. Demerath EW et al (2007) Genetic and environmental influences on infant weight and weight change: the Fels Longitudinal Study. Am J Hum Biol 19:692–702PubMedGoogle Scholar
  30. Denham M et al (2005) Relationship of lead, mercury, mirex, dichlorodiphenyldichloroethylene, hexachlorobenzene, and polychlorinated biphenyls to timing of menarche among Akwesasne Mohawk girls. Pediatrics 115:e127–e134PubMedGoogle Scholar
  31. Diallo R et al (2001) Monoclonality in normal epithelium and in hyperplastic and neoplastic lesions of the breast. J Pathol 193:27–32PubMedGoogle Scholar
  32. Diamanti-Kandarakis E et al (2009) Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev 30:293–342PubMedGoogle Scholar
  33. Eidemuller M et al (2009) Breast cancer risk among Swedish hemangioma patients and possible consequences of radiation-induced genomic instability. Mutat Res 669:48–55PubMedGoogle Scholar
  34. Ekbom A et al (1997) Intrauterine environment and breast cancer risk in women: a population-based study. J Natl Cancer Inst 89:71–76PubMedGoogle Scholar
  35. Ema M et al (2003) Decreased anogenital distance and increased incidence of undescended testes in fetuses of rats given monobenzyl phthalate, a major metabolite of butyl benzyl phthalate. Reprod Toxicol 17:407–412PubMedGoogle Scholar
  36. Engel LS et al (2005) Pesticide use and breast cancer risk among farmers’ wives in the agricultural health study. Am J Epidemiol 161:121–135PubMedGoogle Scholar
  37. Euling SY et al (2008) Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings. Pediatrics 121:S172–S191PubMedGoogle Scholar
  38. Falck F Jr et al (1992) Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch Environ Health 47:143–146PubMedGoogle Scholar
  39. Fenton SE (2006) Endocrine-disrupting compounds and mammary gland development: early exposure and later life consequences. Endocrinology 147:S18–S24PubMedGoogle Scholar
  40. Forman MR et al (2005) Through the looking glass at early-life exposures and breast cancer risk. Cancer Invest 23:609–624PubMedGoogle Scholar
  41. Friedman GD et al (2009) Pharmaceuticals that cause mammary gland tumors in animals: findings in women. Breast Cancer Res Treat 116:187–194PubMedGoogle Scholar
  42. Gammon MD, Santella RM (2008) PAH, genetic susceptibility and breast cancer risk: an update from the Long Island Breast Cancer Study Project. Eur J Cancer 44:636–640PubMedGoogle Scholar
  43. Gammon MD et al (2002a) The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer. Breast Cancer Res Treat 74:235–254PubMedGoogle Scholar
  44. Gammon MD et al (2002b) Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts. Cancer Epidemiol Biomarkers Prev 11:677–685PubMedGoogle Scholar
  45. Gladen BC et al (2000) Pubertal growth and development and prenatal and lactational exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene. J Pediatr 136:490–496PubMedGoogle Scholar
  46. Grice MM et al (2007) Self-reported medical conditions in perfluorooctanesulfonyl fluoride manufacturing workers. J Occup Environ Med 49:722–729PubMedGoogle Scholar
  47. Guha N et al (2009) Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology study. Breast Cancer Res Treat 118:395–405PubMedGoogle Scholar
  48. Herbst AL et al (1971) Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 284:878–881PubMedGoogle Scholar
  49. Hiatt RA et al (2009) The breast cancer and the environment research centers: transdisciplinary research on the role of the environment in breast cancer etiology. Environ Health Perspect 117:1814–1822PubMedGoogle Scholar
  50. Hiroi H et al (2004) Differences in serum bisphenol a concentrations in premenopausal normal women and women with endometrial hyperplasia. Endocr J 51:595–600PubMedGoogle Scholar
  51. Hong EJ et al (2005) Conflict of estrogenic activity by various phthalates between in vitro and in vivo models related to the expression of Calbindin-D9k. J Reprod Dev 51:253–263PubMedGoogle Scholar
  52. Howdeshell KL et al (2003) Bisphenol A is released from used polycarbonate animal cages into water at room temperature. Environ Health Perspect 111:1180–1187PubMedGoogle Scholar
  53. Hoyer AP et al (1998) Organochlorine exposure and risk of breast cancer. Lancet 352:1816–1820PubMedGoogle Scholar
  54. Hunter DJ et al (1997) Non-dietary factors as risk factors for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer. Cancer Causes Control 8:49–56PubMedGoogle Scholar
  55. Jemal A et al (2010a) Cancer statistics, 2010. CA Cancer J Clin 60:277–300PubMedGoogle Scholar
  56. Jemal A et al (2010b) Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev 19:1893–1907PubMedGoogle Scholar
  57. John EM, Kelsey JL (1993) Radiation and other environmental exposures and breast cancer. Epidemiol Rev 15:157–162PubMedGoogle Scholar
  58. Kauppila A et al (2009) Birth intervals and breast cancer risk. Br J Cancer 101:1213–1217PubMedGoogle Scholar
  59. Kettles MK et al (1997) Triazine herbicide exposure and breast cancer incidence: an ecologic study of Kentucky counties. Environ Health Perspect 105:1222–1227PubMedGoogle Scholar
  60. Knight CH, Sorensen A (2001) Windows in early mammary development: critical or not? Reproduction 122:337–345PubMedGoogle Scholar
  61. Kogevinas M (2001) Human health effects of dioxins: cancer, reproductive and endocrine system effects. Hum Reprod Update 7:331–339PubMedGoogle Scholar
  62. Kohler BA et al (2011) Annual report to the nation on the status of cancer, 1975–2007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst 103:714–736PubMedGoogle Scholar
  63. Korde LA et al (2009) Childhood soy intake and breast cancer risk in Asian American women. Cancer Epidemiol Biomarkers Prev 18:1050–1059PubMedGoogle Scholar
  64. Krieger N et al (1994) Breast cancer and serum organochlorines: a prospective study among white, black, and Asian women. J Natl Cancer Inst 86:589–599PubMedGoogle Scholar
  65. Krishnan AV et al (1993) Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 132:2279–2286PubMedGoogle Scholar
  66. Kuehn BM (2010) National Children’s Study expands. JAMA 304:1776PubMedGoogle Scholar
  67. Laden F et al (2001) 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five U.S. studies. J Natl Cancer Inst 93:768–776PubMedGoogle Scholar
  68. Laden F et al (2002) Polychlorinated biphenyls, cytochrome P450 1A1, and breast cancer risk in the Nurses’ Health Study. Cancer Epidemiol Biomarkers Prev 11:1560–1565PubMedGoogle Scholar
  69. Land CE et al (2003) Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990. Radiat Res 160:707–717PubMedGoogle Scholar
  70. Lau C et al (2007) Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicol Sci 99:366–394PubMedGoogle Scholar
  71. Lee SA et al (2009) Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women’s Health Study. Am J Clin Nutr 89:1920–1926PubMedGoogle Scholar
  72. Lopez-Carrillo L et al (2010) Exposure to phthalates and breast cancer risk in northern Mexico. Environ Health Perspect 118:539–544PubMedGoogle Scholar
  73. Lopez-Cervantes M et al (2004) Dichlorodiphenyldichloroethane burden and breast cancer risk: a meta-analysis of the epidemiologic evidence. Environ Health Perspect 112:207–214PubMedGoogle Scholar
  74. Mabry PL et al (2008) Interdisciplinarity and systems science to improve population health: a view from the NIH Office of Behavioral and Social Sciences Research. Am J Prev Med 35:S211–S224PubMedGoogle Scholar
  75. Madigan MP et al (1995) Proportion of breast cancer cases in the United States explained by well-established risk factors. J Natl Cancer Inst 87:1681–1685PubMedGoogle Scholar
  76. Maffini MV et al (2006) Endocrine disruptors and reproductive health: the case of bisphenol-A. Mol Cell Endocrinol 254–255:179–186PubMedGoogle Scholar
  77. Manz A et al (1991) Cancer mortality among workers in chemical plant contaminated with dioxin. Lancet 338:959–964PubMedGoogle Scholar
  78. Matthews JB et al (2001) In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta. Chem Res Toxicol 14:149–157PubMedGoogle Scholar
  79. McElroy JA et al (2006) Cadmium exposure and breast cancer risk. J Natl Cancer Inst 98:869–873PubMedGoogle Scholar
  80. Mettlin C (1999) Global breast cancer mortality statistics. CA Cancer J Clin 49:138–144PubMedGoogle Scholar
  81. Morello-Frosch R, Jesdale BM (2006) Separate and unequal: residential segregation and estimated cancer risks associated with ambient air toxics in U.S. metropolitan areas. Environ Health Perspect 114:386–393PubMedGoogle Scholar
  82. Morris JJ, Seifter E (1992) The role of aromatic hydrocarbons in the genesis of breast cancer. Med Hypotheses 38:177–184PubMedGoogle Scholar
  83. Moysich KB et al (1999) Polychlorinated biphenyls, cytochrome P4501A1 polymorphism, and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev 8:41–44PubMedGoogle Scholar
  84. Nie J et al (2007) Exposure to traffic emissions throughout life and risk of breast cancer: the Western New York Exposures and Breast Cancer (WEB) study. Cancer Causes Control 18:947–955PubMedGoogle Scholar
  85. Okasha M et al (2003) Exposures in childhood, adolescence and early adulthood and breast cancer risk: a systematic review of the literature. Breast Cancer Res Treat 78:223–276PubMedGoogle Scholar
  86. Olea N et al (1996) Estrogenicity of resin-based composites and sealants used in dentistry. Environ Health Perspect 104:298–305PubMedGoogle Scholar
  87. Olsen GW et al (2009) Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives. Reprod Toxicol 27:212–230PubMedGoogle Scholar
  88. Ott MG, Zober A (1996) Cause specific mortality and cancer incidence among employees exposed to 2,3,7,8-TCDD after a 1953 reactor accident. Occup Environ Med 53:606–612PubMedGoogle Scholar
  89. Ouyang F et al (2005) Serum DDT, age at menarche, and abnormal menstrual cycle length. Occup Environ Med 62:878–884PubMedGoogle Scholar
  90. Palmer JR et al (2006) Prenatal diethylstilbestrol exposure and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 15:1509–1514PubMedGoogle Scholar
  91. Park SK et al (2008) Intrauterine environments and breast cancer risk: meta-analysis and systematic review. Breast Cancer Res 10:R8PubMedGoogle Scholar
  92. Patisaul HB, Jefferson W (2010) The pros and cons of phytoestrogens. Front Neuroendocrinol 31(4):400–419PubMedGoogle Scholar
  93. Pesatori AC et al (2009) Cancer incidence in the population exposed to dioxin after the “Seveso accident”: twenty years of follow-up. Environ Health 8:39PubMedGoogle Scholar
  94. Petralia SA et al (1999) Risk of premenopausal breast cancer and patterns of established breast cancer risk factors among teachers and nurses. Am J Ind Med 35:137–141PubMedGoogle Scholar
  95. Polednak AP (1994) Trends in cancer incidence in Connecticut, 1935-1991. Cancer 74:2863–2872PubMedGoogle Scholar
  96. Pukkala E et al (2006) Breast cancer in Belarus and Ukraine after the Chernobyl accident. Int J Cancer 119:651–658PubMedGoogle Scholar
  97. Ramos JG et al (2001) Prenatal exposure to low doses of bisphenol A alters the periductal stroma and glandular cell function in the rat ventral prostate. Biol Reprod 65:1271–1277PubMedGoogle Scholar
  98. Rappaport SM, Smith MT (2010) Epidemiology. Environment and disease risks. Science 330:460–461PubMedGoogle Scholar
  99. Reynolds P et al (2004) Active smoking, household passive smoking, and breast cancer: evidence from the California Teachers Study. J Natl Cancer Inst 96:29–37PubMedGoogle Scholar
  100. Routledge EJ et al (2000) Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ERbeta. J Biol Chem 275:35986–35993PubMedGoogle Scholar
  101. Rudel RA, Perovich LJ (2009) Endocrine disrupting chemicals in indoor and outdoor air. Atmos Environ 43:170–181PubMedGoogle Scholar
  102. Rudel RA et al (2007) Chemicals causing mammary gland tumors in animals signal new directions for epidemiology, chemicals testing, and risk assessment for breast cancer prevention. Cancer 109:2635–2666PubMedGoogle Scholar
  103. Rudland PS (1993) Epithelial stem cells and their possible role in the development of the normal and diseased human breast. Histol Histopathol 8:385–404PubMedGoogle Scholar
  104. Russo IH, Russo J (1996) Mammary gland neoplasia in long-term rodent studies. Environ Health Perspect 104:938–967PubMedGoogle Scholar
  105. Russo J et al (2001) Cancer risk related to mammary gland structure and development. Microsc Res Tech 52:204–223PubMedGoogle Scholar
  106. Sagiv SK et al (2009) Polycyclic aromatic hydrocarbon-DNA adducts and survival among women with breast cancer. Environ Res 109:287–291PubMedGoogle Scholar
  107. Salehi F et al (2008) Review of the etiology of breast cancer with special attention to organochlorines as potential endocrine disruptors. J Toxicol Environ Health B Crit Rev 11:276–300PubMedGoogle Scholar
  108. Santodonato J (1997) Review of the estrogenic and antiestrogenic activity of polycyclic aromatic hydrocarbons: relationship to carcinogenicity. Chemosphere 34:835–848PubMedGoogle Scholar
  109. Selevan SG et al (2003) Blood lead concentration and delayed puberty in girls. N Engl J Med 348:1527–1536PubMedGoogle Scholar
  110. Shore RE et al (1986) Breast cancer among women given X-ray therapy for acute postpartum mastitis. J Natl Cancer Inst 77:689–696PubMedGoogle Scholar
  111. Shore RE et al (1993) Thyroid cancer among persons given x-ray treatment in infancy for an enlarged thymus gland. Am J Epidemiol 137:1068–1080PubMedGoogle Scholar
  112. Shu XO et al (2001) Association of body size and fat distribution with risk of breast cancer among Chinese women. Int J Cancer 94:449–455PubMedGoogle Scholar
  113. Shu XO et al (2009) Soy food intake and breast cancer survival. JAMA 302:2437–2443PubMedGoogle Scholar
  114. Sonnenschein C, Soto AM (1998) An updated review of environmental estrogen and androgen mimics and antagonists. J Steroid Biochem Mol Biol 65:143–150PubMedGoogle Scholar
  115. Soto AM et al (2008) Does breast cancer start in the womb? Basic Clin Pharmacol Toxicol 102:125–133PubMedGoogle Scholar
  116. Steenland K et al (1999) Cancer, heart disease, and diabetes in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Natl Cancer Inst 91:779–786PubMedGoogle Scholar
  117. Steenland K et al (2010) Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA). Environ Health Perspect 118:1100–1108PubMedGoogle Scholar
  118. Sturgeon SR et al (2004) Trends in breast cancer mortality rates by region of the United States, 1950-1999. Cancer Causes Control 15:987–995PubMedGoogle Scholar
  119. Sugiura-Ogasawara M et al (2005) Exposure to bisphenol A is associated with recurrent miscarriage. Hum Reprod 20:2325–2329PubMedGoogle Scholar
  120. Suzuki A et al (2002) Developmental effects of perinatal exposure to bisphenol-A and diethylstilbestrol on reproductive organs in female mice. Reprod Toxicol 16:107–116PubMedGoogle Scholar
  121. Swan SH et al (2005) Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect 113:1056–1061PubMedGoogle Scholar
  122. Takeuchi T et al (2004) Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction. Endocr J 51:165–169PubMedGoogle Scholar
  123. Terry PD, Goodman M (2006) Is the association between cigarette smoking and breast cancer modified by genotype? A review of epidemiologic studies and meta-analysis. Cancer Epidemiol Biomarkers Prev 15:602–611PubMedGoogle Scholar
  124. Tokunaga M et al (1991) Follow-up studies of breast cancer incidence among atomic bomb survivors. J Radiat Res (Tokyo) 32 suppl:201–211Google Scholar
  125. Trichopoulos D et al (2005) Towards an integrated model for breast cancer etiology: the crucial role of the number of mammary tissue-specific stem cells. Breast Cancer Res 7:13–17PubMedGoogle Scholar
  126. Troisi R et al (2007) Cancer risk in women prenatally exposed to diethylstilbestrol. Int J Cancer 121:356–360PubMedGoogle Scholar
  127. Vasiliu O et al (2004) In utero exposure to organochlorines and age at menarche. Hum Reprod 19:1506–1512PubMedGoogle Scholar
  128. Williams EM et al (1990) Short term increase in risk of breast cancer associated with full term pregnancy. BMJ 300:578–579PubMedGoogle Scholar
  129. Windham GC et al (2004) Age at menarche in relation to maternal use of tobacco, alcohol, coffee, and tea during pregnancy. Am J Epidemiol 159:862–871PubMedGoogle Scholar
  130. Windham GC et al (2010) Body burdens of brominated flame retardants and other persistent organo-halogenated compounds and their descriptors in US girls. Environ Res 110:251–257PubMedGoogle Scholar
  131. Witorsch RJ, Thomas JA (2010) Personal care products and endocrine disruption: a critical review of the literature. Crit Rev Toxicol 40(suppl 3):1–30PubMedGoogle Scholar
  132. Wolff MS (2006) Endocrine disruptors: challenges for environmental research in the 21st century. Ann N Y Acad Sci 1076:228–238PubMedGoogle Scholar
  133. Wolff MS et al (1993) Blood levels of organochlorine residues and risk of breast cancer. J Natl Cancer Inst 85:648–652PubMedGoogle Scholar
  134. Wolff MS et al (1996) Breast cancer and environmental risk factors: epidemiological and experimental findings. Annu Rev Pharmacol Toxicol 36:573–596PubMedGoogle Scholar
  135. Wolff MS et al (2007) Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environ Health Perspect 115:116–121PubMedGoogle Scholar
  136. Wolff MS et al (2008) Environmental exposures and puberty in inner-city girls. Environ Res 107:393–400PubMedGoogle Scholar
  137. Wolff MS et al (2010) Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls. Environ Health Perspect 118:1039–1046PubMedGoogle Scholar
  138. Wu T et al (2002) Ethnic differences in the presence of secondary sex characteristics and menarche among US girls: the Third National Health and Nutrition Examination Survey, 1988-1994. Pediatrics 110:752–757PubMedGoogle Scholar
  139. Wu T et al (2003) Blood lead levels and sexual maturation in U.S. girls: the Third National Health and Nutrition Examination Survey, 1988-1994. Environ Health Perspect 111:737–741PubMedGoogle Scholar
  140. Wu AH et al (2008) Epidemiology of soy exposures and breast cancer risk. Br J Cancer 98:9–14PubMedGoogle Scholar
  141. Xu X et al (2010) Associations of serum concentrations of organochlorine pesticides with breast cancer and prostate cancer in U.S. adults. Environ Health Perspect 118:60–66PubMedGoogle Scholar
  142. Xue F, Michels KB (2007) Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence. Lancet Oncol 8:1088–1100PubMedGoogle Scholar
  143. Yabroff KR et al (2008) Estimates and projections of value of life lost from cancer deaths in the United States. J Natl Cancer Inst 100:1755–1762PubMedGoogle Scholar
  144. Ye X et al (2006) Parabens as urinary biomarkers of exposure in humans. Environ Health Perspect 114:1843–1846PubMedGoogle Scholar
  145. Zota AR et al (2010) Self-reported chemicals exposure, beliefs about disease causation, and risk of breast cancer in the Cape Cod Breast Cancer and Environment Study: a case-control study. Environ Health 9:40PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.University of California San FranciscoSan FranciscoUSA
  2. 2.Helen Diller Family Comprehensive Cancer CenterSan FranciscoUSA

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